protein_epecprevious_nameaccCommon_namegene_epecmasslen_proteindomainsPositionstochiometrysubunit_sizeSecretion_mecheffect_mutationeffect_pedestal_virulence
SepL/B7UM95 SctWsepL393513 helical domainsGatekeeper/Affinity switchunknownunknownT3STranslocators not secreted, Effectors oversecreted-
EscVSepAB7UMA7 SctVescV756757 TM; large cytoplasmic domainMajor component, external to channel9676,8Sec--
EscU/B7UMB8 SctUescU393453 TM; large cytoplasmic domainMinor component, external to channel1 to 239.2-78.4Sec--
EscT/B7UMB9 SctTescT282585 TMTranslocase channel128,7Sec--
EscS/B7UMC0SctSescS9892 TMTranslocase channel19,9Sec--
EscR/B7UMC1 SctRescR242174 TMTranslocase channel5121,5Sec--
EscP/B7UMA4SctPorf1616138C-terminal conserved T3S4 domain (type III secretion and substrate specificity switch) that interacts with SctU C-terminusMolecular rulerunknownunknownT3SLess translocatorsNot affected
EscNSepBB7UMA6 SctNescN48446cytoplasmic; residues 103?371 contain a mixed ?/? Rossmann fold; highly helicalHexameric ring-structure ATPase6293,1No--
EscL/B7UMC2 SctLorf527231helical proteinExternal stator connecting ATPase and Cytoplasmic ring12326,2No--
EscK/B7UMC3SctKorf423199N/AConnector of Pods with SctD6140,8No--
EscJ/B7UMB1 SctJescJ201901 large TM, periplasm-facing lipoproteinLipoprotein ring component24498,2Sec, Lipoprotein--
EscI/B7UMB0 SctIrorf815142peripolasmic proteinInner rod345,9T3S--
EscF/B7UM90 SctFescF873helical proteinNeedle component120974T3S--
EspD/B7UM93 SctEespD393802 TM, mainly hydrophylicTranslocon pore protein8316T3SNot affected-
EscD/B7UM96 SctDescD454061 TMMajor IM ring component241087,2Sec--
EscC/B7UMB3SctCescC56512N-terminal periplasmic domain; secretin family proteinSecretin12 to 14674,4Sec--
EspBeaeBQ05129 SctBespB33321mainly hydrophylic and helicalTranslocon pore protein8264,8T3SNot affected-
EspA/B7UM94 SctAespA20192mainly helicalFilament protein28 per turn574T3SNot affected-
N/A/B7UMC9N/Arorf131272N/AN/AunknownunknownN/Aunknown+
EspGrorf2B7UMC8N/AespG43398cytoplasmicEffectormore than injectisomesunknownT3SNot affected+
Lerorf1B7UMC6N/Aler15129cytoplasmicGlobal Regulatormore than injectisomesunknownNoNo expression-
EscE/B7UMC5 N/Aorf2872cytoplasmicChaperone of EscFmore than injectisomesunknownNo--
CesAB/B7UMC4 N/Aorf312107cytoplasmicChaperone (translocators)more than injectisomesunknownNoNo EspA, less EspB-
EtgA/B7UMB7 N/Arorf317152peripolasmicMuramidaseunknownunknownSec-+
GrlR/B7UMB6 N/Aorf1013123cytoplasmicNegative regulatorunknownunknownNoNot affected+
GrlA/B7UMB5 N/Aorf1116137cytoplasmicPositive regulatorunknownunknownNoNo expression-
CesD/B7UMB4 N/AcesD17151cytoplasmicSubunit 2 of SctW chaperone heterodimer1 per SctWunknownNoTranslocators not secreted, Effectors oversecreted-
SepD/B7UMB2 N/Arorf617151cytoplasmicSubunit 1 of SctW chaperone heterodimer1 per SctWunknownNoTranslocators not secreted, Effectors oversecreted-
EspZ/SepZ/B7UMA9 N/AespZ/sepZ9982TMEffectormore than injectisomesunknownT3SNot affected+
Mpc/CesL/B7UMA8N/Aorf1213117cytoplasmicChaperone (effectors)1 per SctWunknownNo--
EscO/B7UMA5N/Aorf1514125cytoplasmicCentral stalk, inserting in ATPase ring114,7No--
EscQSepQB7UMA3N/AescQ34305cytoplasmicComponent of 6 Pod assembly12419,6No--
EspHorf18B7UMA2N/AespH19168secretedEffectormore than injectisomesunknownT3SNot affected+
CesFrorf10B7UMA1N/AcesF14120cytoplasmicChaperone (effectors)more than injectisomesunknownNoNot affected+
Map/B7UMA0 N/Aorf1922203secretedEffectormore than injectisomesunknownT3SNot affected+
TirHp90B7UM99N/Atir56550secretedEffectormore than injectisomesunknownT3SNot affected-
CesTorfUP21244 N/AcesT17156cytoplasmicChaperone (effectors)more than injectisomesunknownNoNot affected-
IntimineaeAP19809 N/Aeae102939secretedAttaching and effacing proteinmore than injectisomesunknownT3SNot affected-
CesD2/B7UM91 N/Aorf2715135cytoplasmicChaperone (translocators)more than injectisomesunknownNoLess EspDNot affected
EscG/B7UM89N/Aorf291092cytoplasmicChaperone of EscFmore than injectisomesunknownNo--
EspForfd4B7UM88N/AespF20206secretedEffectormore than injectisomesunknownT3SNot affected+