E. coli K-12 / MG1655/ ATCC 47076 proteome

UniProt Name:
Putative type II secretion system protein E (T2SS protein E) (Putative general secretion pathway protein E) (Type II traffic warden ATPase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (By similarity) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
ATPase of the Type II secretion system (cryptic in K12) EspL (GspL homolog) protein interacts through its N-terminal cytoplasmic domain with EspL (GspL homolog) protein
References:
PMID: 16525507 PMID: 17255937 PMCID: PMC398259
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
P-loop containing nucleoside triphosphate hydrolases SCOP: 52539
Super Family:
P-loop containing nucleoside triphosphate hydrolases
SCOP: 52540

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UniProt Name:
Putative general secretion pathway protein A
Localization:
Integral Inner Membrane (Probable)
Notes:
C-terminus of GspA is in the periplasm. The protein fractionates with the inner membrane. Part of gsp locus.
References:
PMID: 21378198
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.105 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
P-loop containing nucleoside triphosphate hydrolases SCOP: 52539
Super Family:
PGBD-like
SCOP: 47090
P-loop containing nucleoside triphosphate hydrolases
SCOP: 52540

Orientation on the IM:
in/out (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative general secretion pathway protein B
Localization:
-
Notes:
-
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
2.3 ppm

Class:
-
Fold:
-
Super Family:
-

Orientation on the IM:
out/in (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein C (T2SS protein C) (Putative general secretion pathway protein C)
Localization:
Integral Inner Membrane (Probable)
Notes:
Homolog to type two secretion system proteins PulC. Potential component of type II secretion system. A representative PulC-PhoA hybrid protein fractionated mainly with the inner membrane upon isopycnic sucrose gradient centrifugation of membrane vesicles. PMID: 2677007 GspC is the inner membrane component of type II secretion system (T2SS). GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548
References:
PMID: 21931548 PMID: 2677007
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
All beta proteins
SCOP: 48724
Fold:
PDZ domain-like SCOP: 50155
Super Family:
PDZ domain-like
SCOP: 50156

Orientation on the IM:
out/in (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein F (T2SS protein F) (General secretion pathway protein F) (Protein transport protein HofF)
Localization:
Integral Inner Membrane (Experimental)
Notes:
Part of gsp locus. Homolog to type two secretion system proteins PulF.
References:
PMID: 15919996
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.127 ppm

Class:
-
Fold:
-
Super Family:
-

Orientation on the IM:
out/out (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein G (T2SS protein G) (Protein transport protein HofG) (Putative general secretion pathway protein G)
Localization:
-
Notes:
Homolog to major pilin PulG (T2SS). Potential component of type II secretion system. GspG is the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve secretion. Toget
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Pili subunits SCOP: 54522
Super Family:
Pili subunits
SCOP: 54523

Orientation on the IM:
in/out (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein H (T2SS protein H) (Protein transport protein HofH) (Putative general secretion pathway protein H)
Localization:
Integral Inner Membrane (Potential)
Notes:
GspH is one of four low abundance pseudopillins together with GspI, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve se
References:
PMID: 21890895
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.087 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Pili subunits SCOP: 54522
Super Family:
Pili subunits
SCOP: 54523

Orientation on the IM:
- (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein I (T2SS protein I) (Putative general secretion pathway protein I)
Localization:
Integral Inner Membrane (Experimental) Integral Inner Membrane (Potential)
Notes:
Potential component of type II secretion system. GspI is one of four low abundance pseudopillins together with GspH, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368
References:
PMID: 11266368 PMID: 21890895
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Pili subunits SCOP: 54522
Super Family:
Pili subunits
SCOP: 54523

Orientation on the IM:
out/in (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein L (T2SS protein L) (Putative general secretion pathway protein L)
Localization:
-
Notes:
Potential component of type II secretion system. EspL (GspL homolog) protein interacts through its N-terminal cytoplasmic domain with EspL (GspL homolog) protein
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
-
PaxDb:
1.13 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Ribonuclease H-like motif SCOP: 53066
Super Family:
Actin-like ATPase domain
SCOP: 53067

Orientation on the IM:
in/out (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Putative type II secretion system protein M (T2SS protein M) (Putative general secretion pathway protein M) (Transport protein PshM)
Localization:
-
Notes:
Potential component of type II secretion system.
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.266 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
RRF/tRNA synthetase additional domain-like SCOP: 55185
Super Family:
General secretion pathway protein M, EpsM
SCOP: 103054

Orientation on the IM:
out/in (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
Type 4 prepilin-like proteins leader peptide-processing enzyme [Includes: Leader peptidase (EC 3.4.23.43) (Prepilin peptidase); N-methyltransferase (EC 2.1.1.-)]
Localization:
Integral Inner Membrane (Experimental)
Notes:
Part of gsp locus. PMID: 15919996
References:
PMID: 15919996
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
-
Fold:
-
Super Family:
-

Orientation on the IM:
in/out (N-terminus/C-terminus)

Go to Complexes

UniProt Name:
DNA utilization protein HofQ
Localization:
Outer Membrane b-barrel protein (By similarity)
Notes:
Secretin family, homologous to the secretin of T2S (P45758 (GSPD_ECOLI)); homologus to ComE of H.influenza involved in DNA uptake
References:
PMID: 16707682
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
1.73 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Putative type II secretion system protein D (T2SS protein D) (Putative general secretion pathway protein D)
Localization:
Outer Membrane b-barrel protein (By similarity) Outer Membrane b-barrel protein (Experimental) Outer Membrane b-barrel protein (Probable)
Notes:
Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Homolog to type two secretion system proteins PulD. Potential outer membrane b-barel protein since it is homolog to pulD major component of type two secretion system. GspD is the outer membrane secretin of type II secretion system (T2SS) which forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548 PMID: 11266368
References:
PMID: 11266368 PMID: 21931548
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 19348461 PMID: 20222674 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.704 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Putative type II secretion system protein J (T2SS protein J) (Putative general secretion pathway protein J)
Localization:
Periplasmic (Experimental) Periplasmic (Potential)
Notes:
Potential component of type II secretion system. GspJ is one of four low abundance pseudopillins together with GspI, H and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368
References:
PMID: 11266368 PMID: 21890895
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.045 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Pili subunits SCOP: 54522
Super Family:
Pili subunits
SCOP: 54523

Go to Complexes

UniProt Name:
Putative type II secretion system protein K (T2SS protein K) (Putative general secretion pathway protein K)
Localization:
Periplasmic (Experimental) Periplasmic (Potential)
Notes:
Potential component of type II secretion system. GspK is one of four low abundance pseudopillins together with GspI, J and H. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368
References:
PMID: 11266368 PMID: 21890895
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.011 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Pili subunits SCOP: 54522
Super Family:
Pili subunits
SCOP: 54523
GspK insert domain-like
SCOP: 158544

Go to Complexes