E. coli K-12 / MG1655/ ATCC 47076 proteome

UniProt Name:
Cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) (Cyclopropane fatty acid synthase) (EC 2.1.1.79)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Exhibites aberrant localization by microscopy in the absence of YidC.
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 20932056
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
83.7 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
S-adenosyl-L-methionine-dependent methyltransferases SCOP: 53334
Super Family:
S-adenosyl-L-methionine-dependent methyltransferases
SCOP: 53335

Go to Complexes

UniProt Name:
Cysteine desulfurase CsdA (EC 2.8.1.7) (Cysteine sulfinate desulfinase) (CSD) (EC 4.4.1.-) (Selenocysteine lyase) (EC 4.4.1.16)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
Assembly cofactor of ribosome; associate with the 50S subunit. Under cold-shock conditions CsdA participates as an alternative DEAD-box RNA helicase together with RNase E in a ???cold shock??? RNA degradosome (Prud???homme-Genereux et al., 2004). It is therefore possible that CsdA may associate with the inner membrane via RNAseE.
References:
PMID: 15554978 PMID: 21529161
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
10
PaxDb:
12.4 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
PLP-dependent transferase-like SCOP: 53382
Super Family:
PLP-dependent transferases
SCOP: 53383

Go to Complexes

UniProt Name:
Cysteine desulfurase IscS (EC 2.8.1.7) (NifS protein homolog) (ThiI transpersulfidase) (TusA transpersulfidase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
IscS is critical for iron-sulfur (Fe-S) cluster formation and repair. IscS transfers sulfur to the coregulated "scaffold" protein IscU (NifU), on which Fe-S clusters are assembled.
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 15115803 PMID: 20932056 PMID: 18796603
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
826
PaxDb:
1190 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
PLP-dependent transferase-like SCOP: 53382
Super Family:
PLP-dependent transferases
SCOP: 53383

Go to Complexes

UniProt Name:
Cysteine desulfurase (EC 2.8.1.7) (Selenocysteine beta-lyase) (SCL) (Selenocysteine lyase) (EC 4.4.1.16) (Selenocysteine reductase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
SufE protein and the SufBCD complex stimulate the sulfurylase activity of SufS probably through direct interaction.
References:
PMID: 12941942
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 19348461 PMID: 20222674 PMID: 19767571
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
75.2 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
PLP-dependent transferase-like SCOP: 53382
Super Family:
PLP-dependent transferases
SCOP: 53383

Go to Complexes

UniProt Name:
Cysteine desulfuration protein SufE
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
SufE protein and the SufBCD complex stimulate the sulfurylase activity of SufS. Probably through direct interaction .
References:
PMID: 12941942
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
11.5 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
SufE/NifU SCOP: 82648
Super Family:
SufE/NifU
SCOP: 82649

Go to Complexes

UniProt Name:
Cysteine synthase A (CSase A) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine sulfhydrylase A) (S-carboxymethylcysteine synthase) (EC 4.5.1.5) (Sulfate starvation-induced protein 5) (SSI5)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Potential) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
Trigger factor-sensitive aggregation. Experimentally detected by proteomics analysis of E.coli membrane fraction (Bernsel et al 2009). No transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius. Potential peripherally associated protein facing the cytoplasm or integral inner membrane protein. Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279
References:
PMID: 19766000 PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 16858726 PMID: 19767571 PMID: 20521846 PMID: 15115803 PMID: 18796603 PMID: 18425732
Proteomics / Inner Membrane fraction:
PMID: 17446557

Protein molec/cell:
-
PaxDb:
3999 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Tryptophan synthase beta subunit-like PLP-dependent enzymes
SCOP: 53685
Super Family:
Tryptophan synthase beta subunit-like PLP-dependent enzymes
SCOP: 53686

Go to Complexes

UniProt Name:
Cytochrome c biogenesis ATP-binding export protein CcmA (EC 3.6.3.41) (Heme exporter protein A)
Localization:
-
Notes:
-
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
P-loop containing nucleoside triphosphate hydrolases SCOP: 52539
Super Family:
P-loop containing nucleoside triphosphate hydrolases
SCOP: 52540

Go to Complexes

UniProt Name:
Cytosol aminopeptidase (EC 3.4.11.1) (Aminopeptidase A/I) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
-
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 19767571 PMID: 15115803 PMID: 20932056
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
185 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Phosphorylase/hydrolase-like SCOP: 53162
Super Family:
Macro domain-like
SCOP: 52949
Zn-dependent exopeptidases
SCOP: 53187

Go to Complexes

UniProt Name:
D-allose import ATP-binding protein AlsA (EC 3.6.3.17)
Localization:
-
Notes:
-
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 20222674 PMID: 16967446 PMID: 19767571
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
0
PaxDb:
1.69 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
P-loop containing nucleoside triphosphate hydrolases SCOP: 52539
Super Family:
P-loop containing nucleoside triphosphate hydrolases
SCOP: 52540

Go to Complexes

UniProt Name:
D-amino acid dehydrogenase (EC 1.4.99.-) (D-alanine dehydrogenase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. Exhibites aberrant localization by microscopy in the absence of YidC. Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279
References:
PMID: 23230279 PMID: 6102989
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 17137328 PMID: 19348461 PMID: 20222674 PMID: 19767571 PMID: 15115803 PMID: 20932056 PMID: 18796603
Proteomics / Inner Membrane fraction:
PMID: 17446557 PMID: 17309111

Protein molec/cell:
-
PaxDb:
83.5 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
FAD-linked reductases, C-terminal domain SCOP: 54372
Super Family:
FAD/NAD(P)-binding domain
SCOP: 51905
FAD-linked reductases, C-terminal domain
SCOP: 54373

Go to Complexes

UniProt Name:
D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
Trigger factor-sensitive aggregation. Experimentally detected by proteomics analysis of E.coli membrane fraction (Bernsel et al 2009). No transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius. Potential peripherally associated protein facing the cytoplasm or integral inner membrane protein.
References:
PMID: 19766000
Pseudogene/Mobile Element:
-

mRNA molec/cell:
25

Proteomics:
PMID: 12624733 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 15115803 PMID: 17446557 PMID: 20923772
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
58
PaxDb:
2359 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
TIM beta/alpha-barrel
SCOP: 51350
Super Family:
Aldolase
SCOP: 51569

Go to Complexes

UniProt Name:
D-tagatose-1,6-bisphosphate aldolase subunit GatZ
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Encoded in the phosphotransferase transport system the hexitol galactitol (Gat), binds to the gatY protein that encodes for a D-tagatose-1,6-bisphosphate aldolase. Trigger factor-sensitive aggregation. Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. Disulfide bond-containing protein PMID: 25664544
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
8

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 19348461 PMID: 20222674 PMID: 19003857 PMID: 16967446 PMID: 19767571 PMID: 15115803 PMID: 20932056 PMID: 17446557 PMID: 18796603
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
289
PaxDb:
1963 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
TIM beta/alpha-barrel
SCOP: 51350
Super Family:
Aldolase
SCOP: 51569

Go to Complexes

UniProt Name:
Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
-
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16858726 PMID: 19767571 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
397 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
TIM beta/alpha-barrel SCOP: 51350
Super Family:
Aldolase
SCOP: 51569

Go to Complexes

UniProt Name:
Der GTPase-activating protein YihI (GAP)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Assembly cofactor of ribosome; associates with Der.
References:
PMID: 21529161
Pseudogene/Mobile Element:
-

mRNA molec/cell:
3

Proteomics:
PMID: 16606699 PMID: 12488465 PMID: 20222674 PMID: 19767571 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
95
PaxDb:
201 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 17137328 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 20521846 PMID: 15115803 PMID: 20932056 PMID: 18796603
Proteomics / Inner Membrane fraction:
PMID: 17446557 PMID: 17309111

Protein molec/cell:
-
PaxDb:
122 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
TIM beta/alpha-barrel SCOP: 51350
Super Family:
FMN-linked oxidoreductases
SCOP: 51395

Go to Complexes

UniProt Name:
Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
-
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
0

Proteomics:
PMID: 12488465 PMID: 20222674 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
17
PaxDb:
62.8 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
IlvD/EDD N-terminal domain-like SCOP: 143974
Super Family:
LeuD/IlvD-like
SCOP: 52016
IlvD/EDD N-terminal domain-like
SCOP: 143975

Go to Complexes

UniProt Name:
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Probable)
Notes:
Trigger factor-sensitive aggregation. PMID: 6352260 Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279 Disulfide bridge (45 50) Disulfide bond-containing protein PMID: 25664544
References:
PMID: 16079137 PMID: 23230279 PMID: 6352260
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 16858726 PMID: 19767571 PMID: 16079137 PMID: 15115803 PMID: 20932056 PMID: 17446557 PMID: 18796603 PMID: 20923772
Proteomics / Inner Membrane fraction:
PMID: 16079137

Protein molec/cell:
485
PaxDb:
1496 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
CO dehydrogenase flavoprotein C-domain-like SCOP: 55423
Super Family:
FAD/NAD(P)-binding domain
SCOP: 51905
FAD/NAD-linked reductases, dimerisation (C-terminal) domain
SCOP: 55424

Go to Complexes

UniProt Name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Trigger factor-sensitive aggregation. Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279
References:
PMID: 15911532 PMID: 15919657 PMID: 23230279 PMID: 24742683
Pseudogene/Mobile Element:
-

mRNA molec/cell:
8

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 16858726 PMID: 19767571 PMID: 15919657 PMID: 15115803 PMID: 20932056
Proteomics / Inner Membrane fraction:
PMID: 15919657

Protein molec/cell:
850
PaxDb:
1446 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
CoA-dependent acyltransferases SCOP: 52776
Super Family:
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
SCOP: 47005
Single hybrid motif
SCOP: 51230
CoA-dependent acyltransferases
SCOP: 52777

Go to Complexes

UniProt Name:
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex)
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. PMID: 9298646
References:
PMID: 15919657 PMID: 23230279 PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 19767571 PMID: 15919657 PMID: 15115803 PMID: 20932056 PMID: 17446557
Proteomics / Inner Membrane fraction:
PMID: 15919657 PMID: 17446557

Protein molec/cell:
-
PaxDb:
673 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
SCOP: 47004
Barrel-sandwich hybrid
SCOP: 51229
CoA-dependent acyltransferases
SCOP: 52776
Super Family:
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
SCOP: 47005
Single hybrid motif
SCOP: 51230
CoA-dependent acyltransferases
SCOP: 52777

Go to Complexes

UniProt Name:
Dipeptide transport ATP-binding protein DppD
Localization:
Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm (Experimental)
Notes:
Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279
References:
PMID: 23230279
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 17595003 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 18796603
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
-
PaxDb:
49.7 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
P-loop containing nucleoside triphosphate hydrolases SCOP: 52539
Super Family:
P-loop containing nucleoside triphosphate hydrolases
SCOP: 52540

Go to Complexes