STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

Table: Homologous proteins of type three secretion system (T3SS) within pathogens and the flagellum  Export to Excel  

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Homologous proteins of type three secretion system (T3SS) within pathogens and the flagellum


Structural sub assembly of injectisome
Subunit function/role
Common name
EPEC
Accession (Uniprot)
P. aeruginosa T3SS
Yersinia T3SS
Shigella flexneri
Salmonella sp. SPI 1
Salmonella enterica SPI 2
Chlamydia pneumoniae
Bordetella
P. syringae
R. solanacearum
Xanthomonas spp.
B. pseudomallei T3SS3
Flagellum
F1F0 ATPase
Translocators
Translocon pore protein
SctE1
EspD
B7UM93
PopB15
YopB
IpaB
SipB
SseC
CopB1/26, 7
BopB12
HrpK14
PopF1/PopF2
HrpK14
BipB13
 
 
Translocators
Translocon pore protein
SctB1
EspB
Q05129
PopD15
YopD
IpaC
SipC
SseD
CopD1/27
BopD12
 
XopA14
XopA14
BipC13
 
 
Translocators
Tip/filament protein
SctA1
EspA
B7UM94
PcrV15
LcrV
IpaD
SipD
SseD
CT584 or LcrV6, 7
Bsp228
 
 
 
BipD13
FliC3
 
Needle
Needle component
SctF1
EscF
B7UM90
PscF15
YscF
MxiH
PrgI
SsaG
CdsF6, 7
BscF11
HrpA
HrpY
HrpE14
BsaL13
 
 
OM ring
Secretin
SctC1
EscC
B7UMB3
PscC15
YscC
MxiD
InvG
SsaC
CdsC6, 7
BscC11
HrcC14
HrcC14
HrcC14
BsaO13
FlgI/FlgH * 2
 
 
Pilotin
 
 
 
ExsB15
VirG
MxiM
InvH
 
 
BscW11
 
 
 
 
 
 
OM-IM connector
Inner rod
SctI1
EscI
B7UMB0
PscI15
YscI
MxiI
PrgJ
SsaI
 
BscI11
HrpB
HrpJ
HrpB214
BsaK13
FlgB/FlgC/FlgF/FlgG4
 
Accessory enzyme
Muramidase
 
EtgA
B7UMB7
 
YsaH13
IpgF13
IagB13
IagB13
 
 
HrpH
 
 
BapC13
 
 
IM ring
Lipoprotein ring component
SctJ1
EscJ
B7UMB1
PscJ15
YscJ
MxiJ
PrgK
SsaJ
CdsJ7
BscJ11
HrcJ14
HrcJ14
HrcJ14
BsaJ13
FliF2
 
IM ring
Major IM ring component
SctD1
EscD
B7UM96
PscD15
YscD
MxiG
PrgH
SsaD
CdsD6, 7
BscD11
HrpQ
HrcD14 HrpW
HrcD14
BsaM13
FliG5
 
Export apparatus or Translocase
Translocase channel
SctR1
EscR
B7UMC1
PscR15
YscR
Spa24
InvL/SpaP
SsaR
CdsR7
BscR11
HrcR14
HrcR14
HrcR14
BsaW13
FliP2
 
Export apparatus or Translocase
Translocase channel
SctS1
EscS
B7UMC0
PscS15
YscS
Spa9
SpaQ
SsaS
CdsS7
BscS11
HrcS14
HrcS14
HrcS14
BsaX13
FliQ2
 
Export apparatus or Translocase
Translocase channel
SctT1
EscT
B7UMB9
PscT15
YscT
Spa29
InvN/SpaR
SsaT
CdsT7
BscT11
HrcT14
HrcT14
HrcT14
BsaY13
FliR2
 
Export apparatus or Translocase
Minor component, external to channel
SctU1
EscU
B7UMB8
PscU15
YscU
Spa40
SpaS
SsaU
CdsU7
BscU11
HrcU14
HrcU14
HrcU14
BsaZ13
FlhB2
 
Export apparatus or Translocase
Major component, external to channel
SctV1
EscV
B7UMA7
PcrD15
YscV (LcrD)
MxiA
InvA
SsaV
CdsV7
BscV11
HrcV
HrcV
HcrV14
BsaQ13
FlhA2
 
ATPase complex
External stator** connecting ATPase and Cytoplasmic ring
SctL1
EscL
B7UMC2
PscL15
YscL
MxiN
OrgB13
SsaK
CdsL6, 7
BscL11
HrcE
HrpF
HrcL14
OrgB13
FliH2
δ/b
ATPase complex
Hexameric ring-structure ATPase
SctN1
EscN
B7UMA6
PscN15
YscN
Spa47
InvC/SpaL
SsaN
CdsN6, 7
BscN11
HrcN14
HrcN14
HrcN14
BsaS13
FliI2
α/β
ATPase complex
Central stalk**, inserting in ATPase ring
SctO1
EscO
B7UMA5
PscO15
YscO
Spa13
InvI
SsaO
CdsO6, 7
 
HrpO
HrpD
HrpB714
HrpD or BsaU13
FliJ5
γ
Cytoplasmic ring
Component of 6 Pod assembly
SctQ1
SepQ
B7UMA3
PscQ15
YscQ
Spa33
SpaO
SsaQ
CdsQ6, 7
BscQ11
HrcQA+B14
HrcQ
HrcQA+B 14
BsaV13
FliN/FliM2
 
Cytoplasmic ring
Connector of Pods with SctD
SctK1
EscK
B7UMC3
PscK15
YscK
MxiK
OrgA13
 
 
 
HrpD
 
 
OrgA13
 
 
Gatekeeper
Gatekeeper/Affinity switch
SctW1
SepL
B7UM95
PopN15
YopN +TyeA
MxiC
InvE
SsaL
CopN6, 7
BopN12
HrpJ
HpaA14
HpaA14
BsaP13
 
 
Gatekeeper
Subunit 1 of SctW chaperone heterodimer
 
SepD
B7UMB2
 
 
 
 
SpiC16
 
 
HrpG
 
 
 
 
 
Gatekeeper
Subunit 2 of SctW chaperone heterodimer
 
CesL
B7UMA8
 
 
 
 
 
 
 
HrpV
 
 
 
 
 
Assembly regulators
Molecular ruler regulating needle/filament length
SctP1
EscP
B7UMA4
PscP15
YscP
Spa32
InvJ
SsaP
CdsP7
BscK11
HrpP
HpaP
HpaC14
BsaU13
FliK2
 
Chaperones
For early substrates (needle component)
 
EscG
B7UM89
PscG15
YscG15
 
 
 
 
 
 
 
 
 
 
 
Chaperones
For early substrates
 
EscE
B7UMC5
PscE15
YscE15
 
 
 
 
 
 
 
 
 
 
 
Chaperones
For middle substrates (filament component)
 
CesAB
B7UMC4
 
 
 
 
 
 
Btc229
 
 
 
 
 
 
Chaperones
For middle substrates (translocators)
 
CesD
B7UMB4
PcrH15
SycD15
IpgC15
SicA17
 
 
Scc2/Scc310
 
 
 
BicA13
 
 
Chaperones
For middle substrates (translocators)
 
CesD2
B7UM91
 
 
 
 
 
 
 
 
 
 
 
 
 
Chaperones
For late substrates (effectors)
 
CesF
B7UMA1
 
 
 
 
 
 
 
 
 
 
 
 
 
Chaperones
For late substrates (effectors)
 
CesT
P21244
 
SycE20
 
SigE18
 
 
 
 
 
 
 
 
 
Chaperones
For late substrates (effectors)
 
 
 
 
YsaK20
Spa1520
InvB20, 13
 
 
 
 
 
 
InvB20, 13
 
 
Chaperones
For flagellar substrate (FlgK)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
FlgN
 
Chaperones
For flagellar substrate (FliC)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
FliS
 
Chaperones
For flagellar substrate (FliD)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
FliT
 
Transcription regulators
Global Regulator
 
Ler
B7UMC6
 
 
 
 
 
 
 
 
 
 
 
 
 
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 ©2017 Copyright KU Leuven and FORTH/ICE-HT. Last Update: February 2019.