E.coli K-12 (MG1655) Exportome

UniProt Name:
Uncharacterized protein YmgJ
Localization:
-
Notes:
Weak signal peptide prediction. Function Unkown.
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Uncharacterized protein YjbT
Localization:
-
Notes:
Belongs to the yjbT family.
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.01 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Superoxide dismutase [Mn] (EC 1.15.1.1) (MnSOD)
Localization:
Periplasmic
Notes:
The superoxide dismutase SodA is targeted to the periplasm in a SecA-dependent manner by a novel mechanism in Rhizobium leguminosarum. SodM and SodF are <i>E.coli</i> proteins that are close homoloques of the RISodA. SodA does not possess a hydrophobic cleaved N-terminal signal peptide typically present in soluble proteins exported by the Sec-dependent (Sec) pathway or the twin-arginine translocation (TAT) pathway. TatC or SecB mutants in Rhizobium leguminosarum do not affect export of SodA to the periplasm. Inhibition of SecA ATPase activity by azide blocks SodA export to the periplasm.
References:
PMID: 21854464
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674 PMID: 19767571 PMID: 20803007 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
4185 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Long alpha-hairpin
SCOP: 46556
Fe,Mn superoxide dismutase (SOD), C-terminal domain
SCOP: 54718
Super Family:
Fe,Mn superoxide dismutase (SOD), N-terminal domain
SCOP: 46609
Fe,Mn superoxide dismutase (SOD), C-terminal domain
SCOP: 54719

Go to Complexes

UniProt Name:
Alkaline phosphatase (APase) (EC 3.1.3.1)
Localization:
Periplasmic
Notes:
Substrate of periplasmic disulfide oxidoreductases DsbA. Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Identified DsbA substrate PMID: 19953543 PMID: 7022451 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Disulfide bridges (190 200;308 358) Disulfide bridges (190 200;308 358) Disulfide bond-containing protein PMID: 25664544
References:
PMID: 14726535 PMID: 19953543 PMID: 25664544 PMID: 3009404 PMID: 3533724 PMID: 7022451
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 19348461 PMID: 20222674 PMID: 19767571 PMID: 18425732
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
19.6 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Alkaline phosphatase-like
SCOP: 53648
Super Family:
Alkaline phosphatase-like
SCOP: 53649

Go to Complexes

UniProt Name:
L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase)
Localization:
Periplasmic
Notes:
-
References:
PMID: 2407723 PMID: 25403562 PMID: 25664544 PMID: 387570 PMID: 8434007
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 16858726 PMID: 19767571 PMID: 20521846 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
119 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Glutaminase/Asparaginase
SCOP: 53773
Super Family:
Glutaminase/Asparaginase
SCOP: 53774

Go to Complexes

UniProt Name:
Beta-lactamase (EC 3.5.2.6) (Cephalosporinase)
Localization:
Periplasmic
Notes:
-
References:
PMID: 6795623
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674 PMID: 19767571
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
4.5 ppm

Class:
Multi-domain proteins (alpha and beta)
SCOP: 56572
Fold:
beta-lactamase/transpeptidase-like
SCOP: 56600
Super Family:
beta-lactamase/transpeptidase-like
SCOP: 56601

Go to Complexes

UniProt Name:
L-arabinose-binding periplasmic protein (ABP)
Localization:
Periplasmic
Notes:
-
References:
PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12488465 PMID: 20222674 PMID: 15115803 PMID: 18796603
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
262 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Periplasmic binding protein-like I SCOP: 53821
Super Family:
Periplasmic binding protein-like I
SCOP: 53822

Go to Complexes

UniProt Name:
Ribose import binding protein RbsB
Localization:
Periplasmic
Notes:
Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 PMID: 9298646
References:
PMID: 15911532 PMID: 19953543 PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
2

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 19348461 PMID: 20222674 PMID: 19003857 PMID: 16858726 PMID: 19767571 PMID: 18727129 PMID: 15115803 PMID: 17446557 PMID: 18796603 PMID: 18425732
Proteomics / Inner Membrane fraction:
PMID: 17446557

Protein molec/cell:
0
PaxDb:
1392 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Periplasmic binding protein-like I SCOP: 53821
Super Family:
Periplasmic binding protein-like I
SCOP: 53822

Go to Complexes

UniProt Name:
Maltose operon periplasmic protein
Localization:
Periplasmic
Notes:
-
References:
PMID: 2434655
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 12624733 PMID: 19348461 PMID: 20222674 PMID: 19767571 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
198 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Leucine-specific-binding protein (L-BP) (LS-BP)
Localization:
Periplasmic
Notes:
Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bridge (42 47) PMID: 8061609 Disulfide bond-containing protein PMID: 25664544
References:
PMID: 19953543 PMID: 22030350 PMID: 25664544 PMID: 8061609 PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
360 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Periplasmic binding protein-like I SCOP: 53821
Super Family:
Periplasmic binding protein-like I
SCOP: 53822

Go to Complexes

UniProt Name:
Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi)
Localization:
Periplasmic
Notes:
Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15502359
References:
PMID: 15502359 PMID: 18498364
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12488465 PMID: 20222674 PMID: 15115803
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
12.5 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
LuxS/MPP-like metallohydrolase SCOP: 63410
Super Family:
LuxS/MPP-like metallohydrolase
SCOP: 63411

Go to Complexes

UniProt Name:
CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase)
Localization:
-
Notes:
-
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 19348461 PMID: 20222674 PMID: 16967446 PMID: 19767571 PMID: 15115803
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
-
PaxDb:
4.82 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
HIT-like SCOP: 54196
Super Family:
HIT-like
SCOP: 54197

Go to Complexes

UniProt Name:
Protein UshA [Includes: UDP-sugar hydrolase (EC 3.6.1.45) (UDP-sugar diphosphatase) (UDP-sugar pyrophosphatase); 5'-nucleotidase (5'-NT) (EC 3.1.3.5)]
Localization:
Periplasmic
Notes:
-
References:
PMID: 25664544 PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 20222674 PMID: 19767571 PMID: 15115803 PMID: 17446557
Proteomics / Inner Membrane fraction:
PMID: 17309111

Protein molec/cell:
-
PaxDb:
122 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Metallo-dependent phosphatases SCOP: 56299
Super Family:
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
SCOP: 55816
Metallo-dependent phosphatases
SCOP: 56300

Go to Complexes

UniProt Name:
Periplasmic AppA protein [Includes: Phosphoanhydride phosphohydrolase (EC 3.1.3.2) (pH 2.5 acid phosphatase) (AP); 4-phytase (EC 3.1.3.26)]
Localization:
Periplasmic
Notes:
Identified DsbC substrate PMID: 19953543 PMID: 8387749 Disulfide bridge (99 130;155 430;200 210;404 413) Disulfide bond-containing protein PMID: 25664544
References:
PMID: 19953543 PMID: 25664544 PMID: 8387749
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
5.57 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Phosphoglycerate mutase-like SCOP: 53253
Super Family:
Phosphoglycerate mutase-like
SCOP: 53254

Go to Complexes

UniProt Name:
Iron(3+)-hydroxamate-binding protein FhuD (Ferric hydroxamate uptake protein D) (Ferrichrome-binding periplasmic protein) (Iron(III)-hydroxamate-binding protein FhuD)
Localization:
Periplasmic
Notes:
TAT secretion system. PMID: 8522527
References:
PMID: 17218314 PMID: 8522527
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.469 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Chelatase-like SCOP: 53799
Super Family:
Helical backbone metal receptor
SCOP: 53807

Go to Complexes

UniProt Name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC 3.1.3.6) (EC 3.1.4.16)
Localization:
Periplasmic
Notes:
Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. References: Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544
References:
PMID: 15911532 PMID: 18498364 PMID: 25664544 PMID: 3005231 PMID: 9298646
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 20222674 PMID: 19767571 PMID: 15115803 PMID: 18796603 PMID: 18425732
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
91.6 ppm

Class:
Alpha and beta proteins (a+b)
SCOP: 53931
Fold:
Metallo-dependent phosphatases SCOP: 56299
Super Family:
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
SCOP: 55816
Metallo-dependent phosphatases
SCOP: 56300

Go to Complexes

UniProt Name:
Uncharacterized protein YgdB
Localization:
-
Notes:
-
References:
-
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
-
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes

UniProt Name:
Glycerophosphodiester phosphodiesterase, periplasmic (Glycerophosphoryl diester phosphodiesterase, periplasmic) (EC 3.1.4.46)
Localization:
Periplasmic
Notes:
-
References:
PMID: 1851953 PMID: 2829735
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 16606699 PMID: 12624733 PMID: 12488465 PMID: 20222674 PMID: 16858726 PMID: 19767571 PMID: 15115803 PMID: 18796603
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
211 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
TIM beta/alpha-barrel SCOP: 51350
Super Family:
PLC-like phosphodiesterases
SCOP: 51695

Go to Complexes

UniProt Name:
Lysine/arginine/ornithine-binding periplasmic protein (LAO-binding protein)
Localization:
Periplasmic
Notes:
This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP. Phosphorylated by ArgKPMID: 2136858. Identified DsbA substrate PMID: 19953543 PMID: 9298647 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544
References:
PMID: 19953543 PMID: 2136858 PMID: 25664544 PMID: 9298646 PMID: 9298647
Pseudogene/Mobile Element:
-

mRNA molec/cell:
3

Proteomics:
PMID: 19348461 PMID: 20222674 PMID: 18727129 PMID: 15115803 PMID: 18796603 PMID: 18425732
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
1
PaxDb:
2133 ppm

Class:
Alpha and beta proteins (a/b)
SCOP: 51349
Fold:
Periplasmic binding protein-like II SCOP: 53849
Super Family:
Periplasmic binding protein-like II
SCOP: 53850

Go to Complexes

UniProt Name:
Flagellar P-ring protein (Basal body P-ring protein)
Localization:
Periplasmic
Notes:
P ring protein. Substrate of periplasmic disulfide oxidoreductases DsbA. Might be is co-translationally translocated through Sec translocon. Identified DsbA substrate PMID: 19953543 PMID: 12730325 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024
References:
PMID: 12631703 PMID: 12730325 PMID: 14726535 PMID: 15838024 PMID: 19953543
Pseudogene/Mobile Element:
-

mRNA molec/cell:
-

Proteomics:
PMID: 20222674
Proteomics / Inner Membrane fraction:
-

Protein molec/cell:
-
PaxDb:
0.45 ppm

Class:
-
Fold:
-
Super Family:
-

Go to Complexes