| entry | acc | gene | alt_gene | oln | protein_name | cm_loca | cm_notes | cm_refs | suboci_full | subloci | subloci_iim | nterm_cterm | bernsel | subloci_uniprot | subloci_echoL | organelle | target_chaperoning1 | 1st_ss | target_chaperoning2 | 2nd_ss | pseudo | common_core | basic_proteome | signalp_sp_exist | signalp_pos | signalp_cmax | lipop_pred | lipop_cleavage | lipop_score | lipop_rule | tmhmm | phobius_tms | phobius_sp_exist | phobius_prediction | psortb_loca | psortb_score | solubility |
| YKFM_ECOLI | A5A605 | ykfM | b4586 | integral IM protein (SEC in IM), YkfM | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Membrane | - | SRP | SEC | no | yes | N | 27 | 0.205 | TMH | 0 | 13.6098 | - | 3 | 3 | N | i12-32o52-75i96-119o | CytoplasmicMembrane | 10 | |||||||||
| YMGJ_ECOLI | A5A612 | ymgJ | b4594 | periplasmic protein (SEC through IM), YmgJ | Weak signal peptide prediction. Function Unkown. | Periplasmic | G | IM (predicted) | - | SEC | no | yes | N | 24 | 0.144 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n6-17c22/23o | Unknown | 2 | ||||||||||||
| YNCL_ECOLI | A5A615 | yncL | b4598 JW1439.1 | integral IM protein (SEC in IM), YncL | Integral Inner Membrane | Small membrane protein detected experimentally. Found to co-fractionate with the inner membrane. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.099 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-29o | CytoplasmicMembrane | 9 | ||||||
| YNEM_ECOLI | A5A616 | yneM | b4599 JW1527.1 | integral IM protein (SEC in IM), Small MgtS | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in). | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.123 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-25o | CytoplasmicMembrane | 9 | ||||||
| YDGU_ECOLI | A5A617 | ydgU | b4601 JW1589 | integral IM protein (SEC in IM), YdgU | Integral Inner Membrane | Small membrane protein detected experimentally. | PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | - | SRP | SEC | no | yes | N | 27 | 0.097 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-26o | Unknown | 2 | |||||||
| YNHF_ECOLI | A5A618 | ynhF | b4602 JW1649.1 | integral IM protein (SEC in IM), YnhF | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout). | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out, out/in | IM (predicted) | Cell inner membrane | - | SRP | SEC | no | yes | N | 27 | 0.105 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-28o | CytoplasmicMembrane | 9 | ||||||
| DINQ_ECOLI | A5A624 | dinQ | b4613 | integral IM protein (SEC in IM), DinQ | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | - | SRP | SEC | no | yes | N | 31 | 0.097 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i20-38o | Unknown | 2 | |||||||||
| TISB_ECOLI | A5A627 | tisB ysdB | ysdB | b4618 JW3649 | integral IM protein (SEC in IM), Small toxin TisB | Integral Inner Membrane | Potentially toxic protein. | PMID: 18761622 PMID: 19121005 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | - | SRP | SEC | pseudogene (Uniprot), pseudogene (Ecogene) | no | no | N | 23 | 0.099 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-25i | Unknown | 2 | ||||
| YJBT_ECOLI | A5A628 | yjbT | b4620 | periplasmic protein (SEC through IM), YjbT | Belongs to the yjbT family. | Periplasmic | G | N/A | - | SEC | no | yes | Y | 30 | 0.744 | SpI | 29 | 15.6556 | - | 1 | 0 | Y | n15-25c29/30o | Periplasmic | 9 | ||||||||||||
| YTCA_ECOLI | A5A630 | ytcA | b4622 | integral IM protein (SEC in IM), YtcA | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SEC | no | yes | N | 33 | 0.139 | TMH | 0 | 10.1309 | - | 2 | 2 | Y | n16-27c32/33o42-61i68-90o | CytoplasmicMembrane | 10 | ||||||||||
| YTHA_ECOLI | A8DYQ1 | ythA | b4655 JW5769.1 | integral IM protein (SEC in IM), YthA | Integral Inner Membrane | Small membrane protein detected experimentally | PMID: 19121005 | Integral Inner Membrane | B | Bin | in/out | N/A | Cell inner membrane | - | SEC | no | yes | N | 41 | 0.12 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i21-40o | CytoplasmicMembrane | 9 | |||||||
| YKGR_ECOLI | C1P5Z8 | ykgR | b4671 JW5035.1 | integral IM protein (SEC in IM), YkgR | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out). | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | - | SRP | SEC | no | yes | N | 21 | 0.096 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i12-30o | Unknown | 2 | ||||||
| YMIB_ECOLI | C1P5Z9 | ymiB | b4672 JW1278.1 | integral IM protein (SEC in IM), Putative YmiB | Integral Inner Membrane | B | Binout | in/out | N/A | Membrane | - | SRP | SEC | no | yes | N | 28 | 0.1 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i12-29o | Unknown | 2 | |||||||||
| RZOQ_ECOLI | C1P601 | rzoQ | b4689 JW1545.1 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Putative RzoQ | Inner Membrane Lipoprotein | E | N/A | Cell membrane | - | SEC | LOL | no | yes | N | 29 | 0.129 | SpII | 22 | 11.4311 | Pos+2=V | 0 | 0 | Y | n9-20c25/26o | Unknown | 2 | |||||||||||
| YOAK_ECOLI | C1P602 | yoaK | b4676 JW5292.1 | integral IM protein (SEC-YidC in IM), YoaK | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out, out/in | N/A | Cell inner membrane | - | SRP | SEC-YidC | no | yes | N | 29 | 0.152 | TMH | 0 | 3.55641 | - | 1 | 1 | N | o6-29i | CytoplasmicMembrane | 9 | ||||||
| YOAJ_ECOLI | C1P603 | yoaJ | b4675 JW5292.2 | integral IM protein (SEC-YidC in IM), YoaJ | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | - | SRP | SEC-YidC | no | yes | N | 19 | 0.098 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-23i | CytoplasmicMembrane | 9 | ||||||
| YOHP_ECOLI | C1P609 | yohP | b4679 JW5358.1 | integral IM protein (SEC in IM), YohP | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout). | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out, out/in | N/A | Cell inner membrane | - | SRP | SEC | no | yes | N | 25 | 0.1 | TMH | 0 | 0.568556 | - | 1 | 1 | N | o6-26i | CytoplasmicMembrane | 9 | ||||||
| YPDK_ECOLI | C1P610 | ypdK | b4680 JW2375.1 | integral IM protein (SEC in IM), YpdK | Integral Inner Membrane | Found to co-fractionate with the inner membrane. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | out/in | N/A | Cell inner membrane | - | SRP | SEC | no | yes | N | 17 | 0.106 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-22i | CytoplasmicMembrane | 9 | ||||||
| SHOB_ECOLI | C1P611 | shoB ryfB yphI | ryfB yphI | b4687 JW2546.1 | integral IM protein (SEC in IM), Small toxin ShoB | Integral Inner Membrane | PMID: 18710431 PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | N/A | Membrane | - | SRP | SEC | no | yes | N | 13 | 0.098 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-25o | CytoplasmicMembrane | 9 | ||||||
| YQFG_ECOLI | C1P614 | yqfG | b4684 JW5470.1 | integral IM protein (SEC in IM), YqfG | Integral Inner Membrane | Small protein detected experimentally. | PMID: 19121005 | Integral Inner Membrane | B | - | N/A | - | SRP | SEC | no | yes | N | 24 | 0.133 | TMH | 0 | 2.01664 | - | 1 | 0 | Y | n7-17c29/30o | CytoplasmicMembrane | 9 | ||||||||
| IBSD_ECOLI | C1P616 | ibsD | b4664 JW3023.1 | integral IM protein (SEC in IM), Small toxin IbsD | Integral Inner Membrane | Belongs to the toxic protein ibs family. Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | - | N/A | Membrane | - | SEC | no | yes | N | 18 | 0.098 | CYT | 0 | -0.200913 | - | 1 | 0 | Y | n4-9c13/14o | CytoplasmicMembrane | 9 | ||||||||
| PMRR_ECOLI | G3MTW7 | pmrR | b4703 JW4072.1 | integral IM protein (SEC in IM), Putative PmrR | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | - | SEC | no | N | 0.098 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i9-26o | Unknown | 2 | ||||||||||||
| YPDI_ECOLI | O32528 | ypdI | b2376 JW2373 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YpdI | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 24 | 0.415 | SpII | 18 | 12.5879 | Pos+2=N | 1 | 0 | Y | n5-16c23/24o | Unknown | 2 | 22 | ||||||||||
| YFJS_ECOLI | O52982 | yfjS | b2636 JW5921 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YfjS | Inner Membrane Lipoprotein | E | N/A | Cell inner membrane | Inner membrane lipoprotein | SEC | LOL | Prophage Integrase (EcoGene) | no | no | Y | 21 | 0.479 | SpII | 20 | 18.7233 | Pos+2=D | 0 | 0 | Y | n6-17c21/22o | Unknown | 2 | ||||||||||
| SODM_ECOLI | P00448 | sodA | b3908 JW3879 | periplasmic protein (SEC through IM), Superoxide dismutase SodA | Periplasmic | The superoxide dismutase SodA is targeted to the periplasm in a SecA-dependent manner by a novel mechanism in Rhizobium leguminosarum. SodM and SodF are <i>E.coli</i> proteins that are close homoloques of the RISodA. SodA does not possess a hydrophobic cleaved N-terminal signal peptide typically present in soluble proteins exported by the Sec-dependent (Sec) pathway or the twin-arginine translocation (TAT) pathway. TatC or SecB mutants in Rhizobium leguminosarum do not affect export of SodA to the periplasm. Inhibition of SecA ATPase activity by azide blocks SodA export to the periplasm. | PMID: 21854464 | Periplasmic | G | N/A | Cytoplasmic | SEC | yes | yes | N | 51 | 0.145 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 5 | ||||||||||
| PHSM_ECOLI | P00490 | malP | b3417 JW5689 | integral IM protein (SEC in IM), Maltodextrin phosphorylase MalP | Integral Inner Membrane | PMID: 15919657 | Integral Inner Membrane | B | - | Soluble IM Fraction | Cytoplasmic | SEC | yes | yes | N | 54 | 0.131 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | ||||||||||
| PTM3C_ECOLI | P00550 | mtlA | b3599 JW3573 | integral IM protein (SEC in IM), PTS system mannitol-specific EIICBA component MtlA | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. PMCID: PMC305875 The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. Once targeted to SecY, ribosome-associated nascent chains of the hybrid protein, however, remain untranslocated unless SecA is present. These results indicate that SRP and SecA cooperate in a sequential, non-overlapping manner. PMCID: PMC305875 | PMID: 15919657 PMID: 15919996 PMID: 9008159 PMID: 9260961 PMCID: PMC305875 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 23 | 0.115 | TMH | 0 | 11.9934 | - | 8 | 8 | N | i20-42o48-66i78-98o133-154i161-181o213-234i269-292o312-334i | CytoplasmicMembrane | 10 | 26 | |||||
| PPB_ECOLI | P00634 | phoA | b0383 JW0374 | periplasmic protein (SEC through IM), Alkaline phosphatase PhoA | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Identified DsbA substrate PMID: 19953543 PMID: 7022451 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Disulfide bridges (190 200;308 358) Disulfide bridges (190 200;308 358) Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 19953543 PMID: 25664544 PMID: 3009404 PMID: 3533724 PMID: 7022451 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | no | yes | Y | 22 | 0.408 | SpI | 21 | 3.05238 | - | 0 | 0 | Y | n5-16c21/22o | Periplasmic | 10 | 78 | |||||||
| LEP_ECOLI | P00803 | lepB | b2568 JW2552 | integral IM protein (SEC-YidC in IM), Signal peptidase I LepB | Integral Inner Membrane | Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. Lep was shown to be targeted to the membrane by the SRP pathway. PMID: 8985168 Disulfide bridge (171 177) | PMID: 15919996 PMID: 21778229 PMID: 2551889 PMID: 8985168 | Integral Inner Membrane | B | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SEC-YidC | yes | yes | N | 22 | 0.131 | SpII | 20 | 3.04951 | Pos+2=V | 2 | 0 | Y | n5-16c21/22o | CytoplasmicMembrane | 10 | 27 | |||||||
| LSPA_ECOLI | P00804 | lspA lsp | lsp | b0027 JW0025 | integral IM protein (SEC in IM), Signal peptidase II LspA | Integral Inner Membrane | Catalyzes the removal of signal peptides from prolipoproteins. | PMID: 15919996 PMID: 6368552 PMID: 6378662 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.135 | TMH | 0 | 7.83163 | - | 4 | 4 | N | i12-31o70-88i100-117o137-157i | CytoplasmicMembrane | 10 | 5 | ||||
| ASPG2_ECOLI | P00805 | ansB | b2957 JW2924 | periplasmic protein (SEC through IM), L-asparaginase 2 AnsB | Periplasmic | PMID: 2407723 PMID: 25403562 PMID: 25664544 PMID: 387570 PMID: 8434007 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.82 | SpI | 22 | 19.7315 | - | 1 | 0 | Y | n7-17c22/23o | Periplasmic | 10 | 49 | |||||||||
| AMPC_ECOLI | P00811 | ampC ampA | ampA | b4150 JW4111 | periplasmic protein (SEC through IM), Beta-lactamase AmpC | Periplasmic | PMID: 6795623 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 20 | 0.854 | SpI | 19 | 17.1519 | - | 0 | 0 | Y | n4-15c19/20o | Periplasmic | 10 | 26 | ||||||||
| MALF_ECOLI | P02916 | malF | b4033 JW3993 | integral IM protein (SEC in IM), Maltose/maltodextrin transport system permease MalF | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. MalF functions in maltose transport as a 1:1:2 complex with the integral inner membrane protein MalG and the peripheral inner membrane protein MalK. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 15919996 PMID: 18033289 PMID: 18456666 PMID: 25403562 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | YfgM | no | yes | N | 65 | 0.175 | TMH | 0 | 14.2023 | - | 8 | 8 | N | i14-34o40-58i67-91o277-303i315-340o371-392i426-447o484-506i | CytoplasmicMembrane | 10 | |||||
| PBPA_ECOLI | P02918 | mrcA ponA | ponA | b3396 JW3359 | integral IM protein (SEC in IM), Penicillin-binding 1A MrcA | Integral Inner Membrane | The formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA) in the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme, postulated to be responsible for controlled growth of the stress-bearing sacculus of E. coli. The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Uniprot annotation is Cell inner membrane; Single-pass type II membrane protein, Gene Ontology and Echolocation annotation is Membrane anchored. PMID: 3510188 | PMID: 10037771 PMID: 15919657 PMID: 21183073 PMID: 3510188 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 25 | 0.144 | TMH | 0 | 2.26474 | - | 1 | 0 | Y | n7-17c24/25o | CytoplasmicMembrane | 10 | 4 | ||||
| PBPB_ECOLI | P02919 | mrcB pbpF ponB | pbpF ponB | b0149 JW0145 | integral IM protein (SEC in IM), Penicillin-binding 1B MrcB | Integral Inner Membrane | The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Cell inner membrane; Single-pass type II membrane protein. Monoisotopic peripheral; Contains amphipathic a-helix. | PMID: 15919657 PMID: 19458048 PMID: 21183073 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Single-pass type II membrane protein | Membrane anchored | SRP | SEC | yes | yes | N | 3 | 0.105 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i65-86o | CytoplasmicMembrane | 10 | |||||
| LACY_ECOLI | P02920 | lacY | b0343 JW0334 | integral IM protein (SEC in IM), Lactose permease LacY | Integral Inner Membrane | Crystal structure of lactose permease indicated that the molecule is composed of N- and C-terminal domains, each with six transmembrane helices, symmetrically positioned within the permease PMID: 12893935. | PMID: 11266632 PMID: 12893935 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.125 | TMH | 0 | 18.848 | - | 11 | 12 | N | i12-34o46-66i75-95o101-122i143-162o168-187i222-239o259-279i291-310o316-337i349-369o381-401i | CytoplasmicMembrane | 10 | ||||||
| MELB_ECOLI | P02921 | melB mel-4 | mel-4 | b4120 JW4081 | integral IM protein (SEC in IM), Melibiose carrier MelB | Integral Inner Membrane | PMID: 15919996 PMID: 7703254 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 18 | 0.118 | TMH | 0 | 8.17946 | - | 12 | 12 | N | i12-31o37-57i78-100o106-130i150-171o177-198i236-258o270-290i297-318o324-353i374-397o409-432i | CytoplasmicMembrane | 10 | ||||||
| ARAF_ECOLI | P02924 | araF | b1901 JW1889 | periplasmic protein (SEC through IM), L-arabinose-binding periplasmic AraF | Periplasmic | PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.816 | SpI | 23 | 20.0244 | - | 0 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 86 | |||||||||
| RBSB_ECOLI | P02925 | rbsB prlB rbsP | prlB rbsP | b3751 JW3730 | periplasmic protein (SEC through IM), Ribose import binding RbsB | Periplasmic | Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 15911532 PMID: 19953543 PMID: 9298646 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SEC | SKP | no | yes | Y | 26 | 0.839 | SpI | 25 | 22.7093 | - | 0 | 0 | Y | n6-17c25/26o | Periplasmic | 10 | 93 | ||||||
| TONB_ECOLI | P02929 | tonB exbA | exbA | b1252 JW5195 | integral IM protein (SEC in IM), TonB | Integral Inner Membrane | PMID: 11967085 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane; Single-pass membrane protein; Periplasmic side | Membrane anchored | SEC | yes | yes | N | 43 | 0.176 | TMH | 0 | 3.06055 | - | 0 | 1 | N | i12-32o | Unknown | 2 | |||||||
| TOLC_ECOLI | P02930 | tolC colE1-i mtcB mukA refI | colE1-i mtcB mukA refI | b3035 JW5503 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), TolC | Outer Membrane b-barrel protein | Part of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. Also part of MacAB-TolC macrolide efflux transport system = [(TolC)3][MacB]2[MacA]. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000).The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 10806384 PMID: 10879525 PMID: 11266632 PMID: 12107133 PMID: 12624733 PMID: 15228545 PMID: 15911532 PMID: 16079137 PMID: 16352602 PMID: 16372265 PMID: 19254725 PMID: 19953543 PMID: 20932056 PMID: 21325274 PMID: 21778229 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SECB | SEC | SKP | BAM | yes | yes | Y | 23 | 0.712 | SpI | 22 | 10.2716 | - | 0 | 0 | Y | n4-14c22/23o | OuterMembrane | 10 | 15 | ||||
| OMPF_ECOLI | P02931 | ompF cmlB coa cry tolF | cmlB coa cry tolF | b0929 JW0912 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpF | Outer Membrane b-barrel protein | Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646 | PMID: 10806384 PMID: 11266632 PMID: 12488465 PMID: 12624733 PMID: 1380671 PMID: 15911532 PMID: 16079137 PMID: 17908933 PMID: 19343722 PMID: 19737520 PMID: 19953543 PMID: 20932056 PMID: 21541338 PMID: 22658749 PMID: 8626309 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | TF | SEC | SKP,SURA | BAM | yes | yes | Y | 23 | 0.883 | SpI | 22 | 19.9098 | - | 0 | 0 | Y | n6-17c22/23o | OuterMembrane | 10 | 18 | ||||
| PHOE_ECOLI | P02932 | phoE ompE | ompE | b0241 JW0231 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), PhoE | Outer Membrane b-barrel protein | PMID: 11266632 PMID: 1380671 PMID: 20932056 PMID: 216015 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | yes | yes | Y | 22 | 0.841 | SpI | 21 | 21.3546 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | 2 | |||||||
| MCP1_ECOLI | P02942 | tsr cheD | cheD | b4355 JW4318 | integral IM protein (SEC in IM), Methyl-accepting chemotaxis I Tsr | Integral Inner Membrane | PMID: 15919996 PMID: 22380631 | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.141 | SpI | 25 | 5.90497 | - | 2 | 1 | Y | n10-21c26/27o192-214i | CytoplasmicMembrane | 10 | 44 | |||||
| LAMB_ECOLI | P02943 | lamB malB | malB | b4036 JW3996 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Maltoporin LamB | Outer Membrane b-barrel protein | Potential pubstrate of periplasmic chaperones Skp. Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000). Experimentally verified trimeric beta-barrel. N-terminal region is in periplasm. Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 346375 Disulfide bridges between 47 and 63 PMID: 1988451 Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 15911532 PMID: 16079137 PMID: 16372265 PMID: 19343722 PMID: 1988451 PMID: 19953543 PMID: 20932056 PMID: 25664544 PMID: 346375 PMID: 7824948 PMID: 8626309 PMCID: PMC1993877 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP,SURA,DEGP | BAM | yes | yes | Y | 26 | 0.795 | SpI | 25 | 20.7922 | - | 0 | 0 | Y | n8-18c25/26o | OuterMembrane | 10 | 54 | |||||
| KEFC_ECOLI | P03819 | kefC trkC | trkC | b0047 JW0046 | integral IM protein (SEC in IM), Glutathione-regulated potassium-efflux system KefC | Integral Inner Membrane | PMID: 15919996 PMID: 2046548 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.112 | TMH | 0 | 7.67646 | - | 13 | 13 | N | o6-24i31-49o55-72i84-111o117-135i147-169o181-202i214-233o239-258i270-290o296-315i327-348o360-378i | CytoplasmicMembrane | 10 | ||||||
| GSPB_ECOLI | P03825 | gspB pinO pioO pno | pinO pioO pno | b3322 JW3284 | integral IM protein (SEC in IM), Putative general secretion pathway B GspB | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 43 | 0.123 | TMH | 0 | 3.27755 | - | 1 | 1 | N | o28-51i | Unknown | 2 | ||||||||
| MALM_ECOLI | P03841 | malM molA | molA | b4037 JW3997 | periplasmic protein (SEC through IM), Maltose operon periplasmic protein MalM | Periplasmic | PMID: 2434655 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.606 | SpI | 26 | 24.5925 | - | 0 | 0 | Y | n7-18c26/27o | Periplasmic | 10 | |||||||||
| KDPA_ECOLI | P03959 | kdpA | b0698 JW0686 | integral IM protein (SEC in IM), Potassium-transporting ATPase potassium-binding subunit KdpA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.183 | TMH | 0 | 0.239367 | - | 12 | 12 | Y | n5-16c20/21o59-82i94-115o135-155i167-190o253-271i283-301o327-349i356-374o380-398i418-437o484-505i526-548o | CytoplasmicMembrane | 10 | 10 | ||||||
| KDPB_ECOLI | P03960 | kdpB | b0697 JW0685 | integral IM protein (SEC in IM), Potassium-transporting ATPase ATP-binding subunit KdpB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 55 | 0.195 | CYT | 0 | -0.200913 | - | 7 | 6 | N | i35-56o62-82i219-240o252-274i616-636o656-681i | CytoplasmicMembrane | 10 | 8 | ||||||
| KDPC_ECOLI | P03961 | kdpC | b0696 JW0684 | integral IM protein (SEC in IM), Potassium-transporting ATPase KdpC subunit KdpC | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 39 | 0.2 | TMH | 0 | 11.3621 | - | 1 | 0 | Y | n7-18c30/31o | CytoplasmicMembrane | 10 | 18 | ||||||||
| FIMA1_ECOLI | P04128 | fimA pilA | pilA | b4314 JW4277 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), Type-1 protein, A chain FimA | Peripheral outer membrane protein facing the extra-cellular space | Fim operon (class ??1); Fimbrial Subunit. Experimentally verified signal peptide PMID: 2858471 Disulfide bridge (44 84) Disulfide bond-containing protein PMID: 25664544 | PMID: 20345943 PMID: 25664544 PMID: 2858471 PMID: 6147250 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | fimbriae | SEC | CU | yes | yes | Y | 24 | 0.78 | SpI | 23 | 25.7568 | - | 1 | 0 | Y | n5-16c23/24o | Extracellular | 10 | ||||||
| LIVK_ECOLI | P04816 | livK | b3458 JW3423 | periplasmic protein (SEC through IM), Leucine-specific-binding LivK | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bridge (42 47) PMID: 8061609 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 22030350 PMID: 25664544 PMID: 8061609 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 24 | 0.817 | SpI | 23 | 17.7516 | - | 0 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 78 | |||||||
| NLPA_ECOLI | P04846 | nlpA | b3661 JW3635 | IM lipoprotein (SEC through IM, inserted in OM by LOL), NlpA | Inner Membrane Lipoprotein | Proven signal peptidase II substrate. | PMID: 15174130 | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Cell inner membrane; Lipid-anchor | Inner membrane lipoprotein | SEC | LOL | yes | yes | Y | 23 | 0.355 | SpII | 23 | 21.7987 | Pos+2=D | 0 | 0 | Y | n10-21c26/27o | CytoplasmicMembrane | 10 | 77 | |||||||
| FLIC_ECOLI | P04949 | fliC flaF hag | flaF hag | b1923 JW1908 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), Flagellin FliC | Peripheral outer membrane protein facing the extra-cellular space | Flameint protein, flagellin. Flagella proteins contribute to the production of outer membrane vesicles. Analysis of E. coli W3110 OMVs revealed that they contain abundant levels of FliC. Compared to the parental strain expressing wild-type fliC, an E. coli strain with a fliC-null mutation produced reduced amounts of OMVs based on both protein and phosphate levels. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 12730325 | PMID: 12730325 PMID: 21541338 PMID: 24134841 | Peripheral outer membrane protein facing the extra-cellular space | F4 | Soluble IM Fraction | Secreted Bacterial flagellum | Cell surface appendage (Experimental) | flagellum | Flagellum | Fla | no | yes | N | 52 | 0.13 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 80 | |||||
| PTRA_ECOLI | P05458 | ptrA ptr | ptr | b2821 JW2789 | periplasmic protein (SEC through IM), Protease 3 PtrA | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15502359 | PMID: 15502359 PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic(experimental) | SEC | SURA | yes | yes | Y | 24 | 0.815 | SpI | 23 | 13.0719 | - | 0 | 0 | Y | n9-18c23/24o | Periplasmic | 10 | 66 | ||||||
| MCP3_ECOLI | P05704 | trg | b1421 JW1417 | integral IM protein (SEC in IM), Methyl-accepting chemotaxis III Trg | Integral Inner Membrane | PMID: 15919996 PMID: 22380631 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 40 | 0.259 | TMH | 0 | 7.8524 | - | 2 | 2 | N | i20-44o199-222i | CytoplasmicMembrane | 10 | 34 | ||||||
| FEPA_ECOLI | P05825 | fepA fep feuB | fep feuB | b0584 JW5086 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Ferrienterobactin receptor FepA | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10529396 Disulfide bond-containing protein PMID: 25664544 | PMID: 10529396 PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 19953543 PMID: 20932056 PMID: 25664544 PMID: 9886293 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP | BAM | yes | yes | Y | 23 | 0.836 | SpI | 22 | 11.5401 | - | 0 | 0 | Y | n7-17c22/23o | OuterMembrane | 10 | 11 | |||||
| BTUB_ECOLI | P06129 | btuB bfe cer dcrC | bfe cer dcrC | b3966 JW3938 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Vitamin B12 transporter BtuB | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 10806384 PMID: 11266632 PMID: 12595710 PMID: 12624733 PMID: 12652322 PMID: 15911532 PMID: 19953543 PMID: 2687240 PMID: 2982793 PMID: 9298646 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP | BAM | no | yes | Y | 21 | 0.828 | SpI | 20 | 21.8455 | - | 0 | 0 | Y | n5-16c20/21o | OuterMembrane | 10 | ||||||
| FTSQ_ECOLI | P06136 | ftsQ | b0093 JW0091 | integral IM protein (SEC in IM), Cell division FtsQ | Integral Inner Membrane | FtsQ could be localized to the division site in constricting cells. FtsQ insertion requires SecYEG, the transmembrane electrical potential, SecA, and the SRP pathway. PMID: 15546656 YidC plays a role in the membrane integration of the FtsQ protein as the hydrophobic region of FtsQ can be cross-linked to YidC. PMID: 15546656 | PMID: 11415986 PMID: 11703663 PMID: 11948172 PMID: 15165235 PMID: 15546656 PMID: 17693520 PMID: 2007547 PMID: 9829918 PMID: 9882666 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 41 | 0.115 | TMH | 0 | 1.18618 | - | 1 | 1 | N | i25-49o | Unknown | 2 | 24 | |||||
| CDH_ECOLI | P06282 | cdh | b3918 JW3889 | periplasmic protein (SEC through IM), CDP-diacylglycerol pyrophosphatase Cdh | Periplasmic | G | Soluble IM Fraction | Cell inner membrane; Single-pass membrane protein | Membrane anchored | SEC | yes | yes | N | 19 | 0.264 | SpI | 19 | 7.43557 | - | 1 | 0 | Y | n4-14c19/20o | CytoplasmicMembrane | 10 | 55 | |||||||||||
| BTUC_ECOLI | P06609 | btuC | b1711 JW1701 | integral IM protein (SEC-YidC in IM), Vitamin B12 import system permease BtuC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 11266632 PMID: 12004122 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 34 | 0.278 | TMH | 0 | 13.5896 | - | 9 | 9 | Y | n16-29c34/35o58-77i89-109o115-133i145-168o188-206i213-232o238-262i274-297o303-322i | CytoplasmicMembrane | 10 | ||||||
| BIRA_ECOLI | P06709 | birA bioR dhbB | bioR dhbB | b3973 JW3941 | nucleoid & integral IM protein (SEC in IM), Bifunctional ligase/repressor BirA | Integral Inner Membrane, Nucleoid | PMID: 23138451 PMID: 23387333 | Integral Inner Membrane, Nucleoid | B, N | IM (predicted) | Cytoplasmic | SRP | SEC | yes | yes | N | 26 | 0.122 | CYT | 0 | -0.200913 | - | 0 | 2 | N | i123-139o145-162i | Cytoplasmic | 10 | 37 | ||||||||
| FHUA_ECOLI | P06971 | fhuA tonA | tonA | b0150 JW0146 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Ferrichrome transporter/phage receptor FhuA | Outer Membrane b-barrel protein | SecB substrate; Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 3079747 Disulfide bridge (351 362;725 731) Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 15911532 PMID: 16352602 PMID: 19343722 PMID: 19953543 PMID: 25664544 PMID: 3079747 PMID: 9856937 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SECB | SEC | SURA,SKP | BAM | yes | yes | Y | 34 | 0.805 | SpI | 33 | 20.4987 | - | 0 | 0 | Y | n16-24c33/34o | OuterMembrane | 10 | 7 | ||||
| FHUB_ECOLI | P06972 | fhuB | b0153 JW0149 | integral IM protein (SEC in IM), Iron(3+)-hydroxamate import system permease FhuB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.415 | TMH | 0 | 12.8147 | - | 17 | 17 | Y | n5-20c38/39o62-79i91-111o117-137i144-167o194-212i224-241o247-265i277-299o305-326i347-369o389-411i423-443o449-468i480-499o567-594i606-623o635-655i | CytoplasmicMembrane | 10 | |||||||
| OMPC_ECOLI | P06996 | ompC meoA par | meoA par | b2215 JW2203 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpC | Outer Membrane b-barrel protein | Outer membrane protein related to resistance to ampicillin and tetracycline; Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 10806384 PMID: 12488465 PMID: 12624733 PMID: 15911532 PMID: 16372265 PMID: 17908933 PMID: 19737520 PMID: 19953543 PMID: 21541338 PMID: 22658749 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | TF | SEC | SKP | BAM | yes | yes | Y | 22 | 0.884 | SpI | 21 | 21.1188 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | 6 | ||||
| PNTA_ECOLI | P07001 | pntA | b1603 JW1595 | integral IM protein (SEC in IM), PntA | Integral Inner Membrane | PMID: 14660605 PMID: 15919996 PMID: 1932078 PMID: 3525165 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 40 | 0.111 | CYT | 0 | -0.200913 | - | 5 | 4 | N | i400-418o424-443i455-472o478-499i | CytoplasmicMembrane | 10 | 110 | ||||||
| MCP2_ECOLI | P07017 | tar cheM | cheM | b1886 JW1875 | integral IM protein (SEC in IM), Methyl-accepting chemotaxis II Tar | Integral Inner Membrane | Pole-derived membrane fragments were isolated by affinity capture of vesicles containing the chemotaxis protein, Tar. PMID: 3049536 PMID: 12826616 PMID: 17144658 | PMID: 12826616 PMID: 15919996 PMID: 17144658 PMID: 22380631 PMID: 3049536 | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 20 | 0.158 | TMH | 0 | 4.99054 | - | 2 | 1 | Y | n10-21c26/27o192-212i | CytoplasmicMembrane | 10 | 73 | ||||
| MCP4_ECOLI | P07018 | tap | b1885 JW1874 | integral IM protein (SEC in IM), Methyl-accepting chemotaxis IV Tap | Integral Inner Membrane | PMID: 15919996 PMID: 22380631 | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 35 | 0.179 | TMH | 0 | 6.20402 | - | 2 | 1 | Y | n10-21c34/35o187-209i | CytoplasmicMembrane | 10 | 5 | ||||||
| YFIB_ECOLI | P07021 | yfiB | b2605 JW2586 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative YfiB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 25 | 0.134 | SpII | 18 | 18.8761 | Pos+2=Q | 0 | 0 | Y | n5-16c20/21o | OuterMembrane | 9 | 74 | |||||||
| USHA_ECOLI | P07024 | ushA | b0480 JW0469 | periplasmic protein (SEC through IM), UshA | Periplasmic | PMID: 25664544 PMID: 9298646 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 26 | 0.748 | SpI | 25 | 11.3752 | - | 0 | 0 | Y | n7-18c25/26o | Periplasmic | 10 | 77 | |||||||||
| PPA_ECOLI | P07102 | appA | b0980 JW0963 | periplasmic protein (SEC through IM), AppA | Periplasmic | Identified DsbC substrate PMID: 19953543 PMID: 8387749 Disulfide bridge (99 130;155 430;200 210;404 413) Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 8387749 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBC | yes | yes | Y | 23 | 0.793 | SpI | 22 | 13.6965 | - | 0 | 0 | Y | n3-13c22/23o | Periplasmic | 10 | 66 | |||||||
| PUTP_ECOLI | P07117 | putP | b1015 JW1001 | integral IM protein (SEC in IM), Sodium/proline symporter PutP | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 PMID: 3302614 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 28 | 0.128 | TMH | 0 | 13.7134 | - | 12 | 12 | N | i7-26o66-88i127-152o164-186i193-213o233-256i277-296o325-350i371-391o403-422i429-449o455-473i | CytoplasmicMembrane | 10 | |||||||
| PSTA_ECOLI | P07654 | pstA phoT | phoT | b3726 JW3704 | integral IM protein (SEC in IM), Phosphate transport system permease PstA | Integral Inner Membrane | PMID: 15919996 PMID: 3881386 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 14 | 0.135 | TMH | 0 | 14.9057 | - | 6 | 6 | N | i29-50o89-111i123-145o151-169i201-222o267-290i | CytoplasmicMembrane | 10 | ||||||
| FHUD_ECOLI | P07822 | fhuD | b0152 JW0148 | periplasmic protein (TAT-SEC through IM), Iron(3+)-hydroxamate-binding FhuD | Periplasmic | TAT secretion system. PMID: 8522527 | PMID: 17218314 PMID: 8522527 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | Y | 31 | 0.749 | SpI | 30 | 8.81274 | - | 0 | 0 | Y | n12-23c30/31o | Periplasmic | 10 | |||||||||
| FIMF_ECOLI | P08189 | fimF | b4318 JW4281 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), FimF | Peripheral outer membrane protein facing the extra-cellular space | Fim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (38 78) Disulfide bond-containing protein PMID: 25664544 | PMID: 15372038 PMID: 19820722 PMID: 20345943 PMID: 25664544 PMID: 2890081 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | fimbriae | SEC | CU | no | yes | Y | 23 | 0.871 | SpI | 22 | 17.2366 | - | 0 | 0 | Y | n6-17c22/23o | Extracellular | 9 | |||||||
| FIMG_ECOLI | P08190 | fimG | b4319 JW4282 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), FimG | Peripheral outer membrane protein facing the extra-cellular space | Fim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (39 77) Disulfide bond-containing protein PMID: 25664544 | PMID: 15372038 PMID: 19820722 PMID: 20345943 PMID: 25664544 PMID: 2890081 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | fimbriae | SEC | CU | no | yes | Y | 24 | 0.773 | SpI | 23 | 18.1281 | - | 1 | 0 | Y | n7-18c23/24o | Extracellular | 9 | 73 | ||||||
| FIMH_ECOLI | P08191 | fimH | b4320 JW4283 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), Type 1 fimbrin D-mannose specific adhesin FimH | Peripheral outer membrane protein facing the extra-cellular space | Fim operon (class ??1); Potential tip-adhesin. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 1971261 PMID: 2900235 PMID: 2890081 | PMID: 1971261 PMID: 19820722 PMID: 20345943 PMID: 24140205 PMID: 2890081 PMID: 2900235 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | fimbriae | SEC | CU | no | yes | Y | 20 | 0.539 | SpI | 21 | 14.3197 | - | 0 | 0 | Y | n4-14c19/20o | Unknown | 4 | 19 | ||||||
| GLPT_ECOLI | P08194 | glpT | b2240 JW2234 | integral IM protein (SEC in IM), Glycerol-3-phosphate transporter GlpT | Integral Inner Membrane | PMID: 11266632 PMID: 12893935 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 52 | 0.128 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i26-44o64-82i94-113o119-138i159-183o189-208i254-272o292-311i323-342o348-373i385-405o417-437i | CytoplasmicMembrane | 10 | |||||||
| CPDB_ECOLI | P08331 | cpdB | b4213 JW4171 | periplasmic protein (SEC through IM), 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase CpdB | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. References: Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 18498364 PMID: 25664544 PMID: 3005231 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | no | yes | Y | 20 | 0.787 | SpI | 19 | 14.5002 | - | 0 | 0 | Y | n4-14c19/20o | Periplasmic | 10 | 82 | |||||||
| CRED_ECOLI | P08369 | creD cet | cet | b4400 JW4363 | integral IM protein (SEC-YidC in IM), CreD | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 29 | 0.114 | TMH | 0 | 4.58166 | - | 6 | 5 | Y | n11-22c34/35o295-313i325-343o349-368i375-396o402-420i | CytoplasmicMembrane | 10 | 28 | ||||
| YGDB_ECOLI | P08370 | ygdB | b2824 JW5450 | periplasmic protein (SEC through IM), YgdB | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | N | 27 | 0.147 | SpI | 26 | 7.55205 | - | 1 | 0 | Y | n10-23c35/36o | Unknown | 2 | 7 | ||||||||||||
| PPDB_ECOLI | P08371 | ppdB ygdC | ygdC | b2825 JW5451 | integral IM protein (SEC in IM), Prepilin peptidase-dependent B PpdB | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Membrane anchored | SRP | SEC | yes | yes | N | 36 | 0.136 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o13-34i | Unknown | 2 | 23 | ||||||||
| PPDC_ECOLI | P08372 | ppdC ygdA | ygdA | b2823 JW2791 | integral IM protein (SEC in IM), Prepilin peptidase-dependent C PpdC | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Membrane anchored | SRP | SEC | yes | yes | N | 30 | 0.122 | TMH | 0 | 6.3414 | - | 1 | 1 | N | o16-33i | Unknown | 2 | 24 | ||||||||
| SPPA_ECOLI | P08395 | sppA | b1766 JW1755 | integral IM protein (SEC in IM), Protease 4 SppA | Integral Inner Membrane | PMID: 18476724 PMID: 3522590 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 48 | 0.115 | TMH | 0 | 6.31524 | - | 1 | 1 | N | i21-43o | CytoplasmicMembrane | 10 | 14 | ||||||
| PHOR_ECOLI | P08400 | phoR nmpB | nmpB | b0400 JW0390 | integral IM protein (SEC in IM), Phosphate regulon sensor PhoR PhoR | Integral Inner Membrane | PMID: 15919996 PMID: 2187152 | Integral Inner Membrane | B | Bpoly | in/in | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 24 | 0.17 | TMH | 0 | 20.4877 | - | 1 | 2 | N | i12-36o42-59i | CytoplasmicMembrane | 10 | 13 | |||||
| CREC_ECOLI | P08401 | creC phoM | phoM | b4399 JW4362 | integral IM protein (SEC-YidC in IM), Sensor CreC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 25 | 0.159 | SpI | 27 | -0.123855 | - | 2 | 1 | Y | n7-18c24/25o184-206i | CytoplasmicMembrane | 10 | 16 | ||||
| DACC_ECOLI | P08506 | dacC | b0839 JW0823 | periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacC | Peripheral inner membrane protein facing the periplasm | Putative amphiphilic alpha-helical anchor at the C-terminusPMID: 8162192. PMID: 9858669 DacC(PBP-6) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. PMID: 9371419 | PMID: 8162192 PMID: 9371419 PMID: 9858669 | Peripheral inner membrane protein facing the periplasm | F2 | Soluble IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SEC | yes | yes | Y | 28 | 0.887 | SpI | 27 | 18.4084 | - | 0 | 0 | Y | n11-22c27/28o | CytoplasmicMembrane | 9 | 21 | ||||||||
| CVPA_ECOLI | P08550 | cvpA dedE | dedE | b2313 JW2310 | integral IM protein (SEC in IM), Colicin V production CvpA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 31 | 0.117 | TMH | 0 | 6.39839 | - | 4 | 4 | N | o6-25i32-52o64-87i99-120o | CytoplasmicMembrane | 10 | ||||||
| DSDX_ECOLI | P08555 | dsdX orf445 yfdA yfdD | orf445 yfdA yfdD | b2365 JW2362 | integral IM protein (SEC in IM), D-serine transporter DsdX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 33 | 0.118 | TMH | 0 | 11.5143 | - | 12 | 12 | N | o6-23i30-47o59-77i98-128o140-158i178-198o225-244i256-282o302-322i343-365o385-408i420-444o | CytoplasmicMembrane | 10 | 12 | |||||
| PTV3B_ECOLI | P08722 | bglF bglC bglS | bglC bglS | b3722 JW3700 | integral IM protein (SEC in IM), PTS system beta-glucoside-specific EIIBCA component BglF | Integral Inner Membrane | In the absence of ??-glucosidase, associates with BglG to form a pro-form membrane complex that maintains BglG inactive. | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.16 | CYT | 0 | -0.200913 | - | 10 | 12 | N | i100-121o141-160i172-190o210-230i242-263o269-292i299-322o328-347i354-375o381-400i407-424o430-452i | CytoplasmicMembrane | 10 | |||||
| HEMX_ECOLI | P09127 | hemX | b3803 JW3775 | integral IM protein (SEC in IM), HemX | Integral Inner Membrane | PMID: 16079137 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 50 | 0.207 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i36-57o | CytoplasmicMembrane | 10 | |||||||
| OMPT_ECOLI | P09169 | ompT | b0565 JW0554 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Protease 7 OmpT | Outer Membrane b-barrel protein | SecB substrate. Trigger factor-sensitive aggregation. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 9298646 | PMID: 10806384 PMID: 11266632 PMID: 11566868 PMID: 12624733 PMID: 15911532 PMID: 16352602 PMID: 19737520 PMID: 21541338 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SECB,TF | SEC | BAM | Prophage Integrase (EcoGene) | no | no | Y | 21 | 0.295 | SpI | 20 | 7.49489 | - | 0 | 0 | Y | n5-16c20/21o | OuterMembrane | 10 | 3 | |||||
| PTW3C_ECOLI | P09323 | nagE pstN | pstN | b0679 JW0665 | integral IM protein (SEC in IM), PTS system N-acetylglucosamine-specific EIICBA component NagE | Integral Inner Membrane | PMID: 15919657 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 45 | 0.132 | TMH | 0 | 3.42438 | - | 10 | 12 | N | i12-32o38-61i68-88o94-112i132-153o165-185i192-212o232-252i259-276o282-306i313-331o337-359i | CytoplasmicMembrane | 10 | 1 | |||||
| MOTA_ECOLI | P09348 | motA flaJ | flaJ | b1890 JW1879 | integral IM protein (SEC in IM), Motility A MotA | Integral Inner Membrane | Interacts with flagellar brake protein YcgR in the flagellar basal bodies or FliM or FliG. | PMID: 15919996 PMID: 19364805 PMID: 20303158 PMID: 20346719 PMID: 23193105 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.167 | TMH | 0 | 4.42407 | - | 4 | 4 | Y | n2-11c16/17o32-49i70-87o171-189i201-220o | CytoplasmicMembrane | 10 | 18 | ||||
| GLPG_ECOLI | P09391 | glpG | b3424 JW5687 | integral IM protein (SEC in IM), Rhomboid protease GlpG | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 11266632 PMID: 15919996 PMID: 16216077 PMID: 17051161 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 16 | 0.202 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i96-115o135-160i172-188o194-212i224-242o248-267i | CytoplasmicMembrane | 10 | ||||||
| GLPQ_ECOLI | P09394 | glpQ | b2239 JW2233 | periplasmic protein (SEC through IM), Glycerophosphodiester phosphodiesterase, periplasmic GlpQ | Periplasmic | PMID: 1851953 PMID: 2829735 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 26 | 0.712 | SpI | 25 | 17.875 | - | 0 | 0 | Y | n8-18c25/26o | Periplasmic | 10 | 39 | |||||||||
| DEDD_ECOLI | P09549 | dedD | b2314 JW5378 | integral IM protein (SEC in IM), Cell division DedD | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 30 | 0.117 | SpI | 27 | 0.354359 | - | 1 | 1 | N | i9-27o | Unknown | 2 | |||||||||
| ARGT_ECOLI | P09551 | argT | b2310 JW2307 | periplasmic protein (SEC through IM), Lysine/arginine/ornithine-binding periplasmic ArgT | Periplasmic | This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP. Phosphorylated by ArgKPMID: 2136858. Identified DsbA substrate PMID: 19953543 PMID: 9298647 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 2136858 PMID: 25664544 PMID: 9298646 PMID: 9298647 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.595 | SpI | 22 | 19.5206 | - | 0 | 0 | Y | n4-14c22/23o | Periplasmic | 10 | |||||||||
| UHPB_ECOLI | P09835 | uhpB | b3668 JW3643 | integral IM protein (SEC in IM), Signal transduction histidine-kinase/phosphatase UhpB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.141 | TMH | 0 | 16.0266 | - | 7 | 9 | N | o6-28i40-60o80-100i112-132o138-162i183-201o207-224i231-249o255-273i | CytoplasmicMembrane | 10 | 19 | ||||||
| UHPC_ECOLI | P09836 | uhpC | b3667 JW3642 | integral IM protein (SEC in IM), sensor UhpC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 52 | 0.143 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i26-45o65-84i96-114o120-143i155-179o185-203i245-265o285-308i320-338o344-365i377-401o407-431i | CytoplasmicMembrane | 10 | |||||||
| UBIB_ECOLI | P0A6A0 | ubiB aarF yigQ yigR yigS | aarF yigQ yigR yigS | b3835 JW3812 | integral IM protein (SEC in IM), Probable kinase UbiB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 50 | 0.114 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i501-518o524-542i | CytoplasmicMembrane | 10 | 17 | |||||
| CLSA_ECOLI | P0A6H8 | clsA cls nov yciJ | cls nov yciJ | b1249 JW1241 | integral IM protein (SEC in IM), Cardiolipin synthase A ClsA | Integral Inner Membrane | In E. coli, the cls and ybhO genes (renamed clsA and clsB, respectively) each encode a CL (cardiolipin) synthase (Cls) that catalyzes the condensation of two PG molecules to form CL and glycerol. PMID: 22988102 | PMID: 15919996 PMID: 22988102 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.149 | TMH | 0 | 5.41966 | - | 2 | 2 | N | o6-25i37-58o | CytoplasmicMembrane | 10 | 3 | ||||
| CYSZ_ECOLI | P0A6J3 | cysZ | b2413 JW2406 | integral IM protein (SEC-YidC in IM), Sulfate transporter CysZ | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996 | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | yes | yes | N | 18 | 0.111 | TMH | 0 | 5.82324 | - | 4 | 5 | N | i31-51o71-92i143-163o169-188i209-242o | CytoplasmicMembrane | 10 | 19 | |||||
| DSBB_ECOLI | P0A6M2 | dsbB roxB ycgA | roxB ycgA | b1185 JW5182 | integral IM protein (SEC-YidC in IM), Disulfide bond formation B DsbB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC PMID: 22108384. The crystal structure revealed a transmembrane (TM) four-helix-bundle structure of DsbBPMID: 18406599. DsbB oxidizes the periplasmic protein DsbA, which in turn oxidizes the cysteines in other periplasmic proteins to make disulfide bondsPMID: 8430071. Gene fusion approaches were used to show that (i) DsbB is a membrane protein which spans the membrane four times and (ii) both the N- and C-termini of the protein are in the cytoplasmPMID: 7957076. The structure of DsbB revealed four transmembrane helices and one short horizontal helix juxtaposed with Cys130 in the mobile periplasmic loopPMID: 17110337. Disulfide bridge (41 44;104 130) PMID: 10064586 | PMID: 10064586 PMID: 11266632 PMID: 15919996 PMID: 17110337 PMID: 18406599 PMID: 22108384 PMID: 7957076 PMID: 8430071 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 25 | 0.286 | TMH | 0 | 4.8983 | - | 4 | 4 | N | i12-33o45-64i71-89o145-166i | CytoplasmicMembrane | 10 | 15 | ||||
| ENO_ECOLI | P0A6P9 | eno | b2779 JW2750 | cytoplasmic peripheral IM protein facing the cytoplasm & peripheral OM protein facing the extra-cellular space (SEC through IM), Enolase Eno | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm, Peripheral outer membrane protein facing the extra-cellular space | When modified at Lys342 possibly secreted by an unknown mechanism, no evidence of signal peptide) Homodimer, stabilized by Mg2+; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Essential for the degradation of carbohydrates via glycolysis. Also a component of the RNA degradosome. The covalent binding to the substrate at Lys-342 causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. Interacts with the C-terminal region of the endoribonuclease RNase EIn the RNA degradosome. Fractions of enolase are present in both the cytoplasm and on the cell surface. As part of the bacterial cytoskeleton in the cytoplasm,Is organized as extended coiled structures that wind around the cell, from one cell pole to the other. When covalently bound to the substrate at Lys-342, the inactive enolase is secreted, and remains attached to the bacterial cell surface. PMID: 8610017 PMID: 9600841 PMID: 9740056 PMID: 9732527 PMID: 12035760 Detected in acossiation with the inner membrane (sequential biochemical fractionations coupled with high resolution mass spectrometry). PMID: 23230279 | PMID: 12035760 PMID: 15003462 PMID: 17242352 PMID: 18337249 PMID: 23230279 PMID: 8610017 PMID: 9600841 PMID: 9732527 PMID: 9740056 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm, Peripheral outer membrane protein facing the extra-cellular space | A, F1, F4 | Soluble IM Fraction | Cytoplasm; cytoskeleton Secreted Cell surface | Cytoplasmic (Experimental) | SEC | yes | yes | N | 42 | 0.139 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | 100 | ||||||||
| FLGH_ECOLI | P0A6S0 | flgH fla FVIII flaY | fla FVIII flaY | b1079 JW5153 | Flagellar OM lipoprotein (SEC through IM), inserted in OM by LOL), L-ring FlgH | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. L ring protein. PMID: 15174130 | PMID: 12631703 PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | flagellum | SEC | LOL | yes | yes | Y | 24 | 0.235 | SpII | 21 | 17.0713 | Pos+2=A | 0 | 0 | Y | n14-25c33/34o | OuterMembrane | 10 | 24 | |||||
| FLGI_ECOLI | P0A6S3 | flgI fla FIX flaM | fla FIX flaM | b1080 JW1067 | Flagellar periplasmic protein (SEC through IM), P-ring FlgI | Periplasmic | P ring protein. Substrate of periplasmic disulfide oxidoreductases DsbA. Might be is co-translationally translocated through Sec translocon. Identified DsbA substrate PMID: 19953543 PMID: 12730325 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 12631703 PMID: 12730325 PMID: 14726535 PMID: 15838024 PMID: 19953543 | Periplasmic | G | N/A | Periplasm Bacterial flagellum basal body | Periplasmic (Experimental) | flagellum | SRP (exp) | SEC | DSBA | Fla | no | yes | Y | 20 | 0.783 | SpI | 19 | 15.6262 | - | 0 | 0 | Y | n4-14c19/20o | Periplasmic | 10 | 63 | |||
| FTSB_ECOLI | P0A6S5 | ftsB ygbQ | ygbQ | b2748 JW2718 | integral IM protein (SEC in IM), Cell division FtsB | Integral Inner Membrane | PMID: 11972052 PMID: 15165235 | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 23 | 0.157 | CYT | 0 | -0.200913 | - | 1 | 0 | Y | n4-14c18/19o | CytoplasmicMembrane | 9 | 25 | |||||
| MRAY_ECOLI | P0A6W3 | mraY murX | murX | b0087 JW0085 | integral IM protein (SEC in IM), Phospho-N-acetylmuramoyl-pentapeptide-transferase MraY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.151 | CYT | 0 | -0.200913 | - | 10 | 10 | N | o20-40i73-90o96-114i134-152o172-193i200-219o239-256i263-284o290-311i338-357o | CytoplasmicMembrane | 10 | ||||||
| YCIB_ECOLI | P0A710 | yciB ispZ | ispZ | b1254 JW1246 | integral IM protein (SEC in IM), Probable intracellular septation A YciB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.173 | TMH | 0 | 7.58982 | - | 5 | 5 | N | o20-39i51-68o74-96i117-139o151-170i | CytoplasmicMembrane | 10 | ||||||
| KDGT_ECOLI | P0A712 | kdgT | b3909 JW5560 | integral IM protein (SEC in IM), 2-keto-3-deoxygluconate permease KdgT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 67 | 0.134 | TMH | 0 | 12.8678 | - | 10 | 10 | N | i12-29o35-57i78-97o103-127i139-164o170-187i194-211o223-243i255-274o286-309i | CytoplasmicMembrane | 10 | |||||||
| MSCL_ECOLI | P0A742 | mscL yhdC | yhdC | b3291 JW3252 | integral IM protein (YidC in IM), Large-conductance mechanosensitive channel MscL | Integral Inner Membrane | PMID: 15919996 PMID: 17113597 PMID: 22108384 PMID: 8890153 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | YidC | yes | yes | N | 39 | 0.143 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i21-52o72-96i | CytoplasmicMembrane | 10 | 66 | |||||
| RSXA_ECOLI | P0A766 | rsxA rnfA ydgL | rnfA ydgL | b1627 JW1619 | integral IM protein (SEC in IM), Ion-translocating oxidoreductase complex subunit A RsxA | Integral Inner Membrane | PMID: 15919996 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein(experimental) | SRP | SEC | yes | yes | N | 21 | 0.118 | TMH | 0 | 7.31415 | - | 6 | 6 | N | o6-26i38-59o65-87i99-122o134-155i167-191o | CytoplasmicMembrane | 10 | ||||||
| MNTH_ECOLI | P0A769 | mntH yfeP | yfeP | b2392 JW2388 | integral IM protein (SEC in IM), Divalent metal cation transporter MntH | Integral Inner Membrane | PMID: 14607838 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 28 | 0.129 | TMH | 0 | 9.54648 | - | 11 | 11 | N | i21-40o52-75i95-116o122-144i156-176o196-216i237-263o283-313i325-343o349-370i391-410o | CytoplasmicMembrane | 10 | ||||||
| GPMB_ECOLI | P0A7A2 | gpmB ytjC | ytjC | b4395 JW4358 | integral IM protein (SEC in IM), Probable phosphoglycerate mutase GpmB | Large potential TM 146-168aa | Integral Inner Membrane | B | Binout | out/in | N/A | Membrane anchored | SRP | SEC | no | yes | N | 17 | 0.117 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o146-168i | Cytoplasmic | 9 | 56 | |||||||
| PSIE_ECOLI | P0A7C8 | psiE yjbA | yjbA | b4030 JW3990 | integral IM protein (SEC in IM), PsiE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 43 | 0.143 | TMH | 0 | 4.00332 | - | 4 | 4 | N | i12-35o55-74i86-105o111-128i | CytoplasmicMembrane | 10 | ||||||
| DCTA_ECOLI | P0A830 | dctA | b3528 JW3496 | integral IM protein (SEC-YidC in IM), Aerobic C4-dicarboxylate transport protein DctA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 19 | 0.136 | TMH | 0 | 5.74612 | - | 8 | 8 | N | i9-27o47-64i76-99o141-164i184-208o220-242i326-344o350-373i | CytoplasmicMembrane | 10 | ||||||
| TATE_ECOLI | P0A843 | tatE ybeC | ybeC | b0627 JW0622 | integral IM protein (SEC in IM), Sec-independent translocase TatE | Integral Inner Membrane | TatA paralog TatE can substitute for TatA and support translocation of Tat substrates including AmiA, AmiC, and TorA. | PMID: 22190680 | Integral Inner Membrane | B | Bout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 43 | 0.118 | CYT | 0 | -0.200913 | - | 1 | 0 | Y | n9-20c29/30o | CytoplasmicMembrane | 9 | 127 | ||||
| TOLB_ECOLI | P0A855 | tolB | b0740 JW5100 | periplasmic & peripheral OM protein (SEC through IM), Tol-Pal system TolB | Periplasmic, Peripheral outer membrane protein facing the periplasm | SecB substrate. Might be is co-translationally translocated through Sec translocon. PMID: 17233825 PMID: 7929011 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 15838024 PMID: 16352602 PMID: 17233825 PMID: 7929011 | Periplasmic, Peripheral outer membrane protein facing the periplasm | G, F3 | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SECB, SRP | SEC | no | yes | N | 22 | 0.555 | SpI | 21 | 7.66433 | - | 0 | 0 | Y | n7-16c21/22o | Periplasmic | 10 | 31 | |||||||
| YFBV_ECOLI | P0A8D9 | yfbV | b2295 JW2292 | integral IM protein (SEC in IM), UPF0208 YfbV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.122 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i46-64o70-90i | CytoplasmicMembrane | 10 | 38 | ||||||
| ZUPT_ECOLI | P0A8H3 | zupT ygiE | ygiE | b3040 JW3008 | integral IM protein (SEC in IM), Zinc transporter ZupT | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 59 | 0.198 | TMH | 0 | 10.378 | - | 6 | 7 | N | o6-25i32-50o62-81i125-150o170-192i199-215o235-256i | CytoplasmicMembrane | 10 | 27 | |||||||
| YIHY_ECOLI | P0A8K8 | yihY | b3886 JW3857 b2268 | integral IM protein (SEC in IM), UPF0761 YihY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 60 | 0.127 | CYT | 0 | -0.200913 | - | 6 | 7 | N | o39-61i73-91o103-120i141-160o180-200i212-234o240-266i | CytoplasmicMembrane | 10 | |||||||
| FRDC_ECOLI | P0A8Q0 | frdC | b4152 JW4113 | integral IM protein (SEC in IM), Fumarate reductase subunit C FrdC | Integral Inner Membrane | Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3. N-terminal region is in cytoplasm. Helix A and B connected by very short turns to an interfacial helix (N51-L63)PMID: 24057063. | PMID: 10373108 PMID: 11266632 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 59 | 0.224 | TMH | 0 | 1.78374 | - | 3 | 3 | N | i26-48o68-88i109-130o | CytoplasmicMembrane | 10 | 9 | |||||
| FRDD_ECOLI | P0A8Q3 | frdD | b4151 JW4112 | integral IM protein (SEC in IM), Fumarate reductase subunit D FrdD | Integral Inner Membrane | Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 10373108. | PMID: 10373108 PMID: 11266632 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 52 | 0.162 | TMH | 0 | 15.5267 | - | 3 | 3 | N | i12-45o57-78i99-118o | CytoplasmicMembrane | 10 | 7 | |||||
| YCJF_ECOLI | P0A8R7 | ycjF | b1322 JW1315 | integral IM protein (SEC in IM), UPF0283 YcjF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.1 | CYT | 0 | -0.200913 | - | 3 | 4 | N | i70-87o99-120i214-236o256-275i | CytoplasmicMembrane | 10 | 10 | ||||||
| USPB_ECOLI | P0A8S5 | uspB yhiO | yhiO | b3494 JW3461 | integral IM protein (SEC in IM), Universal stress B UspB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.13 | TMH | 0 | 0.843073 | - | 2 | 2 | N | o6-24i90-110o | CytoplasmicMembrane | 10 | 57 | |||||
| FLIE_ECOLI | P0A8T5 | fliE fla AI flaN | fla AI flaN | b1937 JW1921 | Flagellar periplasmic peripheral IM protein (Flagellum secreted through IM), hook-basal body complex FliE | Peripheral inner membrane protein facing the periplasm | MS-ring rod junction protein | PMID: 10809679 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Bacterial flagellum basal body | Cytoplasmic | flagellum | Flagellum | no | yes | N | 41 | 0.269 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 10 | 62 | ||||||
| YCEI_ECOLI | P0A8X2 | yceI | b1056 JW1043 | periplasmic protein (SEC through IM), YceI | Periplasmic | PMID: 22030350 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.827 | SpI | 22 | 23.1728 | - | 0 | 0 | Y | n4-15c22/23o | Unknown | 2 | 69 | |||||||||
| YCCT_ECOLI | P0A8X4 | yccT | b0964 JW0947 | periplasmic protein (SEC through IM), UPF0319 YccT | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 21 | 0.531 | SpI | 20 | 6.4525 | - | 0 | 0 | Y | n3-14c20/21o | Unknown | 2 | 60 | ||||||||||||
| BLC_ECOLI | P0A901 | blc yjeL | yjeL | b4149 JW4110 | OM lipoprotein (SEC through IM, inserted in OM by LOL), Blc | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130 | PMID: 15174130 PMID: 20932056 PMID: 21541338 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 19 | 0.216 | SpII | 18 | 14.624 | Pos+2=S | 0 | 0 | Y | n3-15c20/21o | OuterMembrane | 10 | 52 | ||||||
| BAMC_ECOLI | P0A903 | bamC dapX nlpB | dapX nlpB | b2477 JW2462 | OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamC | Outer Membrane Lipoprotein | Outer membrane protein related to resistance to ampicillin and tetracycline. Part of bam complex. Forms subcomplex with BamCE. Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 | PMID: 10806384 PMID: 12488465 PMID: 12624733 PMID: 15174130 PMID: 15911532 PMID: 16079137 PMID: 16372265 PMID: 20932056 PMID: 21139201 PMID: 21370981 PMID: 21541338 PMID: 21823654 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 32 | 0.177 | SpII | 24 | 17.2458 | Pos+2=S | 0 | 0 | Y | n13-23c27/28o | OuterMembrane | 10 | 86 | ||||||
| SLYB_ECOLI | P0A905 | slyB | b1641 JW1633 | OM lipoprotein (SEC through IM, inserted in OM by LOL), SlyB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 | PMID: 10806384 PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 22 | 0.181 | SpII | 17 | 19.9051 | Pos+2=V | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 9 | ||||||||
| MIPA_ECOLI | P0A908 | mipA yeaF | yeaF | b1782 JW1771 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), MltA-interacting protein MipA | Outer Membrane b-barrel protein | MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complexPMID: 10037771. MipA couples both enzymes to one another in vivo, it is likely to give rise to a membrane adhesion site as depicted. Such contacts between the membranes. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000,Thein 2010)PMID: 15911532PMID: 10806384PMID: 12624733PMID: 20932056 PMID: 10037771 | PMID: 10037771 PMID: 10806384 PMID: 12624733 PMID: 15911532 PMID: 16079137 PMID: 20932056 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | yes | yes | Y | 23 | 0.835 | SpI | 22 | 21.2923 | - | 0 | 0 | Y | n6-17c22/23o | OuterMembrane | 10 | 11 | ||||||
| OMPA_ECOLI | P0A910 | ompA con tolG tut | con tolG tut | b0957 JW0940 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpA | Outer Membrane b-barrel protein | Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Trigger factor-sensitive aggregation. Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. The Lipid Bilayer-Inserted Membrane Protein BamA of Escherichia coli Facilitates Insertion and Folding of Outer Membrane Protein A from Its Complex with Skp. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 SecA is sufficient to transport a secretory protein with hydrophobic signal sequence across SecYEG, but efficient translocation requires SRP in Addition PMID: 24717922 Disulfide bridge (311 323) Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 11266632 PMID: 12488465 PMID: 12624733 PMID: 16079137 PMID: 17908933 PMID: 19343722 PMID: 19737520 PMID: 19953543 PMID: 20932056 PMID: 21541338 PMID: 21778229 PMID: 23641708 PMID: 24717922 PMID: 25664544 PMID: 7813480 PMID: 8626309 PMID: 9298646 PMID: 9808047 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | TF | SEC | SKP,SURA,DEGP,DSBA | BAM | yes | yes | Y | 22 | 0.872 | SpI | 21 | 28.1613 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | 10 | ||||
| PAL_ECOLI | P0A912 | pal excC | excC | b0741 JW0731 | OM lipoprotein (SEC through IM), inserted in OM by LOL), PG-associated Pal | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 10806384 PMID: 9298646 | PMID: 10806384 PMID: 12624733 PMID: 15174130 PMID: 15911532 PMID: 19364805 PMID: 20932056 PMID: 23193105 PMID: 9298646 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 29 | 0.5 | SpII | 21 | 21.6668 | Pos+2=S | 0 | 0 | Y | n6-14c18/19o | OuterMembrane | 10 | 81 | ||||||
| OMPW_ECOLI | P0A915 | ompW yciD | yciD | b1256 JW1248 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpW | Outer Membrane b-barrel protein | Outer membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 9298646 | PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 15911532 PMID: 16372265 PMID: 16414958 PMID: 20932056 PMID: 9298646 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | yes | yes | Y | 22 | 0.754 | SpI | 21 | 26.4914 | - | 0 | 0 | Y | n4-15c21/22o | OuterMembrane | 10 | 42 | ||||||
| OMPX_ECOLI | P0A917 | ompX ybiG | ybiG | b0814 JW0799 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpX | Outer Membrane b-barrel protein | SecB substrate. Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646 | PMID: 10545325 PMID: 10806384 PMID: 11266632 PMID: 12488465 PMID: 15911532 PMID: 16352602 PMID: 19343722 PMID: 19737520 PMID: 19953543 PMID: 20932056 PMID: 21541338 PMID: 22658749 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SECB,TF | SEC | SURA,SKP | BAM | yes | yes | Y | 24 | 0.63 | SpI | 23 | 26.0753 | - | 1 | 0 | Y | n4-15c23/24o | OuterMembrane | 10 | 14 | ||||
| PA1_ECOLI | P0A921 | pldA | b3821 JW3794 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Phospholipase A1 PldA | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 PMID: 6397464 | PMID: 10537112 PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 19953543 PMID: 20932056 PMID: 6397463 PMID: 6397464 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP | BAM | yes | yes | Y | 21 | 0.528 | SpI | 20 | 7.74532 | - | 0 | 0 | Y | n3-14c20/21o | OuterMembrane | 10 | 9 | ||||||
| PGPB_ECOLI | P0A924 | pgpB | b1278 JW1270 | integral IM protein (SEC in IM), Phosphatidylglycerophosphatase B PgpB | Integral Inner Membrane | PgpB protein has phosphatidyl glycerophosphate phosphatase activity higher in the cytoplasmic membrane, while it has phosphatidic acid and lysophosphatidic acid phosphatase activities higher in the outer membrane. | PMID: 15919996 PMID: 2846511 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.144 | TMH | 0 | 17.4928 | - | 6 | 6 | N | i12-29o49-68i75-96o157-178i185-206o212-230i | CytoplasmicMembrane | 10 | ||||||
| TSX_ECOLI | P0A927 | tsx nupA | nupA | b0411 JW0401 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Nucleoside-specific channel-forming Tsx | Outer Membrane b-barrel protein | Outer membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384 | PMID: 10806384 PMID: 12624733 PMID: 15911532 PMID: 16372265 PMID: 19953543 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | Prophage Transposase | yes | no | Y | 23 | 0.882 | SpI | 22 | 24.8185 | - | 0 | 0 | Y | n4-14c22/23o | OuterMembrane | 10 | 0 | |||||
| WZA_ECOLI | P0A930 | wza | b2062 JW2047 | OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM), inserted in OM by LOL), Putative polysaccharide export Wza | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | Has a helical structure that crosses membrane. The transmembrane region of Wza is an alpha-helical barrel. Proven pignal peptidase II substrate. It has been demostrated that it can be also secreted and be surface exposed. PMID: 15174130 | PMID: 10619844 PMID: 15174130 PMCID: PMC3315050 | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | I, F4 | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 26 | 0.13 | SpII | 20 | 12.3938 | Pos+2=T | 0 | 0 | Y | n11-21c25/26o | OuterMembrane | 9 | 44 | |||||||
| GFCE_ECOLI | P0A932 | gfcE yccZ | yccZ | b0983 JW0966 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative polysaccharide export GfcE | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 23 | 0.202 | SpII | 20 | 15.093 | Pos+2=T | 0 | 0 | Y | n10-21c26/27o | OuterMembrane | 9 | 59 | ||||||
| MLTA_ECOLI | P0A935 | mltA mlt ygdM | mlt ygdM | b2813 JW2784 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase A MltA | Outer Membrane Lipoprotein | The formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA). In the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme. Postulated to be responsible for controlled growth of the stress-bearing sacculus of <i>E.coli</i>. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) PMID: 15174130 SRP recognizes the first signal anchor sequence of a polytopic membrane protein (MtlA) resulting in cotranslational targeting of MtlA to SecY and phospholipids of the plasma membrane. PMID: 10619852 Possible interaction of SRP with the secretory protein pOmpA is prevented by the association of trigger factor with nascent pOmpA. PMID: 10619852 | PMID: 10037771 PMID: 10619852 PMID: 12624733 PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | pseudogene (Ochman & Davalos, 2006) | no | yes | Y | 20 | 0.191 | SpII | 20 | 22.7365 | Pos+2=S | 0 | 0 | Y | n9-19c23/24o | OuterMembrane | 10 | 35 | |||||
| BAME_ECOLI | P0A937 | bamE smpA | smpA | b2617 JW2598 | OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamE | Outer Membrane Lipoprotein | Part of BAM complex. Forms subcomplex with BamCE. | PMID: 17404237 PMID: 20932056 PMID: 21139201 PMID: 21370981 PMID: 21823654 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 24 | 0.197 | SpII | 19 | 19.5033 | Pos+2=S | 0 | 0 | Y | n5-16c20/21o | OuterMembrane | 9 | 44 | ||||||
| BAMA_ECOLI | P0A940 | bamA yaeT yzzN yzzY | yaeT yzzN yzzY | b0177 JW0172 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), assembly factor BamA | Outer Membrane b-barrel protein | Part of bam complexPMID: 21823654PMID: 21370981. Folding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamAPMID: 23641708. Outer membrane protein determined by 2D gel electrophoresis (PMID: 15911532,PMID: 12624733,PMID: 20932056) Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 10806384 PMID: 12624733 PMID: 16079137 PMID: 19525348 PMID: 19953543 PMID: 20932056 PMID: 21370981 PMID: 21823654 PMID: 23641708 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ss-barrel protein(experimental) | SEC | BAM | yes | yes | Y | 21 | 0.641 | SpI | 20 | 10.5737 | - | 0 | 0 | Y | n6-13c20/21o | OuterMembrane | 10 | 32 | ||||||
| ESSD_ECOLI | P0A9R2 | essD ybcR | ybcR | b0554 JW0543 | integral IM protein (SEC in IM), Prophage lysis S homolog EssD | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | yes | no | N | 38 | 0.193 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i7-25o37-58i | Unknown | 2 | 14 | |||||||
| PLAP_ECOLI | P0AA47 | plaP yeeF | yeeF | b2014 JW5330 | integral IM protein (SEC in IM), Low-affinity putrescine importer PlaP | Integral Inner Membrane | Old gene name YeeF. | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.148 | TMH | 0 | 8.96423 | - | 12 | 12 | N | i20-42o54-73i94-116o128-146i158-179o199-217i237-260o287-315i336-355o361-383i395-413o419-437i | CytoplasmicMembrane | 10 | |||||
| YFDV_ECOLI | P0AA49 | yfdV | b2372 JW2369 | integral IM protein (SEC in IM), transporter YfdV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 57 | 0.126 | CYT | 0 | -0.200913 | - | 10 | 10 | N | o6-23i35-55o67-90i97-117o129-150i175-196o202-222i234-253o259-278i290-309o | CytoplasmicMembrane | 10 | |||||||
| QMCA_ECOLI | P0AA53 | qmcA ybbK | ybbK | b0489 JW0478 | integral IM protein (SEC in IM), QmcA | Integral Inner Membrane | PMID: 16573693 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 18 | 0.11 | TMH | 0 | 1.35378 | - | 1 | 0 | Y | n2-13c18/19o | Unknown | 2 | 13 | |||||
| YOBA_ECOLI | P0AA57 | yobA | b1841 JW1830 | periplasmic protein (SEC through IM), YobA | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 27 | 0.511 | SpI | 26 | 13.4937 | - | 0 | 0 | Y | n11-21c26/27o | Periplasmic | 9 | ||||||||||||
| YGHB_ECOLI | P0AA60 | yghB | b3009 JW2976 | integral IM protein (SEC in IM) of DedA family, YghB | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.338 | TMH | 0 | 0.0786812 | - | 4 | 6 | N | o20-38i45-62o68-88i123-143o155-176i188-212o | CytoplasmicMembrane | 10 | 8 | |||||
| YQJA_ECOLI | P0AA63 | yqjA | b3095 JW3066 | integral IM protein (SEC in IM) of DedA family, YqjA | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.127 | TMH | 0 | 4.47784 | - | 6 | 6 | N | o20-38i45-62o68-88i123-143o155-176i188-212o | CytoplasmicMembrane | 10 | 3 | |||||
| RHTA_ECOLI | P0AA67 | rhtA ybiF | ybiF | b0813 JW0798 | integral IM protein (SEC in IM), Threonine/homoserine exporter RhtA | Integral Inner Membrane | PMID: 12648727 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.17 | TMH | 0 | 6.46418 | - | 10 | 9 | Y | n10-18c22/23o38-59i71-89o95-115i122-139o145-165i177-196o202-225i237-258o264-283i | CytoplasmicMembrane | 10 | ||||||
| YEDA_ECOLI | P0AA70 | yedA | b1959 JW1942 | integral IM protein (SEC in IM), transporter YedA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.125 | TMH | 0 | 11.0617 | - | 10 | 9 | Y | n6-16c21/22o37-56i68-86o98-117i124-143o149-169i176-199o211-233i245-262o268-290i | CytoplasmicMembrane | 10 | |||||||
| YHBE_ECOLI | P0AA73 | yhbE | b3184 JW3151 | integral IM protein (SEC in IM), transporter YhbE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.149 | TMH | 0 | 0.144382 | - | 10 | 10 | N | i7-26o38-56i71-91o103-120i132-151o157-177i189-205o217-236i248-269o281-299i | CytoplasmicMembrane | 10 | |||||||
| DGOT_ECOLI | P0AA76 | dgoT yidT | yidT | b3691 JW5859 | integral IM protein (SEC-YidC in IM), D-galactonate transporter DgoT | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 43 | 0.138 | TMH | 0 | 4.18214 | - | 11 | 12 | N | i15-35o55-75i82-98o104-122i142-163o169-188i242-263o283-304i316-332o338-362i369-392o404-424i | CytoplasmicMembrane | 10 | |||||
| EXUT_ECOLI | P0AA78 | exuT | b3093 JW3064 | integral IM protein (SEC in IM), Hexuronate transporter ExuT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 18 | 0.107 | TMH | 0 | 0.456812 | - | 11 | 12 | N | i47-66o86-109i116-136o142-162i174-199o205-224i277-299o305-325i345-362o368-389i401-424o430-452i | CytoplasmicMembrane | 10 | |||||||
| GARP_ECOLI | P0AA80 | garP yhaU | yhaU | b3127 JW3096 | integral IM protein (SEC in IM), Probable galactarate transporter GarP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.195 | TMH | 0 | 3.99251 | - | 11 | 12 | N | i12-32o52-73i85-103o109-130i151-173o179-199i251-270o290-314i326-345o351-372i379-406o412-434i | CytoplasmicMembrane | 10 | ||||||
| CODB_ECOLI | P0AA82 | codB | b0336 JW0327 | integral IM protein (SEC-YidC in IM), Cytosine permease CodB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 38 | 0.154 | TMH | 0 | 12.7134 | - | 12 | 12 | N | i20-40o52-74i95-118o130-147i152-173o193-212i224-253o259-278i299-318o324-345i357-379o385-402i | CytoplasmicMembrane | 10 | ||||||
| DSBE_ECOLI | P0AA86 | dsbE ccmG yejQ | ccmG yejQ | b2195 JW2183 | integral IM protein (SEC in IM), Thiol:disulfide interchange DsbE | Integral Inner Membrane | PMID: 16364305 PMID: 9537397 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane; Single-pass membrane protein; Periplasmic side | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 29 | 0.264 | SpI | 27 | 8.59712 | - | 1 | 0 | Y | n6-21c30/31o | CytoplasmicMembrane | 10 | 69 | |||||
| YEAY_ECOLI | P0AA91 | yeaY | b1806 JW1795 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YeaY | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 27 | 0.138 | SpII | 22 | 14.0614 | Pos+2=V | 0 | 0 | Y | n10-20c25/26o | OuterMembrane | 9 | 25 | |||||||
| YPDA_ECOLI | P0AA93 | ypdA | b2380 JW5388 | integral IM protein (SEC in IM), Sensor histidine kinase YpdA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 16 | 0.103 | TMH | 0 | 1.16348 | - | 6 | 6 | N | o6-25i45-64o76-99i106-128o140-161i173-191o | CytoplasmicMembrane | 10 | |||||||
| YACC_ECOLI | P0AA95 | yacC | b0122 JW0118 | periplasmic protein (SEC through IM), YacC | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.239 | SpI | 24 | 10.6167 | - | 0 | 0 | Y | n7-17c22/23o | Unknown | 2 | 21 | ||||||||||||
| YAFK_ECOLI | P0AA99 | yafK | b0224 JW0214 | periplasmic protein (SEC through IM), Putative L,D-transpeptidase YafK | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 20 | 0.74 | SpI | 19 | 10.678 | - | 1 | 0 | Y | n4-22c27/28o | Unknown | 2 | 25 | ||||||||||||
| YAGU_ECOLI | P0AAA1 | yagU | b0287 JW0281 | integral IM protein (SEC in IM), YagU | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.316 | SpI | 29 | 3.31288 | - | 3 | 4 | N | i14-35o98-120i132-150o162-182i | CytoplasmicMembrane | 10 | 44 | ||||||
| ECPA_ECOLI | P0AAA3 | ecpA matB yagZ | matB yagZ | b0293 JW0287 | Fimbrial periplasmic protein (SEC through IM), Common pilus major fimbrillin subunit EcpA | Periplasmic | Putative chaperone???usher fimbrial operon yag (class ??); Fimbrial Subunit (yagZ). PMID: 16522795 | PMID: 16522795 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic (Experimental) | fimbriae | SEC | no | yes | Y | 23 | 0.863 | SpI | 22 | 25.6343 | - | 0 | 0 | Y | n5-15c22/23o | Unknown | 2 | 34 | ||||||
| YMCE_ECOLI | P0AAA5 | ymcE sfa | sfa | b0991 JW0975 | integral IM protein (SEC in IM), YmcE | Integral Inner Membrane | B | Bout | in/out | N/A | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 46 | 0.141 | TMH | 0 | 4.44945 | - | 1 | 0 | Y | n15-25c29/30o | Unknown | 2 | 100 | |||||||
| WZXE_ECOLI | P0AAA7 | wzxE wzx yifJ | wzx yifJ | b3792 JW3766 | integral IM protein (SEC in IM), Lipid III flippase WzxE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.139 | TMH | 0 | 5.34268 | - | 12 | 11 | Y | n6-16c21/22o45-67i79-105o117-138i145-164o176-195i216-237o257-278i299-322o334-355i362-382o394-412i | CytoplasmicMembrane | 10 | ||||||
| ZRAP_ECOLI | P0AAA9 | zraP yjaI zra | yjaI zra | b4002 JW5546 | periplasmic protein (SEC through IM), Zinc resistance-associated protein ZraP | Periplasmic | PMID: 9694902 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.74 | SpI | 26 | 28.6968 | - | 1 | 0 | Y | n7-18c26/27o | Periplasmic | 10 | |||||||||
| YBHL_ECOLI | P0AAC4 | ybhL | b0786 JW0769 | integral IM protein (SEC in IM), YbhL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.151 | TMH | 0 | 5.60898 | - | 7 | 7 | N | i20-42o57-77i89-107o113-131i143-161o167-186i207-230o | CytoplasmicMembrane | 10 | |||||||
| YCCA_ECOLI | P0AAC6 | yccA | b0970 JW0953 | integral IM protein (SEC in IM), Modulator of FtsH protease YccA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.268 | TMH | 0 | 7.78202 | - | 7 | 7 | N | i20-41o47-67i74-94o106-126i133-154o160-184i196-216o | CytoplasmicMembrane | 10 | |||||||
| MTR_ECOLI | P0AAD2 | mtr | b3161 JW3130 | integral IM protein (SEC in IM), Tryptophan-specific transport Mtr | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 47 | 0.192 | TMH | 0 | 19.2156 | - | 11 | 11 | N | i12-34o40-65i86-107o127-145i152-170o190-207i228-246o284-309i321-340o346-367i388-410o | CytoplasmicMembrane | 10 | |||||||
| TYRP_ECOLI | P0AAD4 | tyrP | b1907 JW1895 | integral IM protein (SEC in IM), Tyrosine-specific transport TyrP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 29 | 0.164 | TMH | 0 | 11.6392 | - | 11 | 10 | Y | n6-17c29/30o39-58i78-100o120-141i148-169o181-204i216-235o273-298i310-330o336-355i376-399o | CytoplasmicMembrane | 10 | |||||||
| SDAC_ECOLI | P0AAD6 | sdaC dcrA | dcrA | b2796 JW2767 | integral IM protein (SEC in IM), Serine transporter SdaC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 36 | 0.132 | TMH | 0 | 10.9503 | - | 11 | 11 | N | i24-43o49-67i100-120o140-157i164-187o207-229i250-273o300-324i345-364o370-394i406-428o | CytoplasmicMembrane | 10 | ||||||
| TDCC_ECOLI | P0AAD8 | tdcC | b3116 JW3087 | integral IM protein (SEC in IM), Threonine/serine transporter TdcC | Integral Inner Membrane | Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 15919996 PMID: 25403562 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | YfgM | yes | yes | N | 35 | 0.131 | TMH | 0 | 9.58087 | - | 11 | 11 | N | i23-42o48-66i97-116o136-155i167-186o206-234i255-278o317-337i358-379o391-409i421-440o | CytoplasmicMembrane | 10 | |||||
| CYCA_ECOLI | P0AAE0 | cycA dagA ytfD | dagA ytfD | b4208 JW4166 | integral IM protein (SEC-YidC in IM), D-serine/D-alanine/glycine transporter CycA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 53 | 0.108 | TMH | 0 | 3.35425 | - | 12 | 12 | N | i28-45o51-71i108-130o136-154i166-187o207-231i252-274o286-311i347-365o371-397i417-435o441-460i | CytoplasmicMembrane | 10 | |||||
| PROY_ECOLI | P0AAE2 | proY yajM | yajM | b0402 JW5055 | integral IM protein (SEC in IM), Proline-specific permease ProY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.136 | TMH | 0 | 6.32309 | - | 12 | 12 | N | i16-34o40-59i95-118o124-142i154-176o196-218i239-258o278-298i330-350o356-377i398-421o427-445i | CytoplasmicMembrane | 10 | ||||||
| ARCD_ECOLI | P0AAE5 | ydgI | b1605 JW1597 | nucleoid & integral IM protein (SEC in IM), Putative arginine/ornithine antiporter YdgI | Integral Inner Membrane, Nucleoid | PMID: 15919996 PMID: 23138451 | Integral Inner Membrane, Nucleoid | B, N | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.206 | TMH | 0 | 8.33129 | - | 13 | 12 | Y | n5-16c25/26o41-61i82-107o127-145i157-178o204-222i234-257o283-311i332-352o358-378i385-402o408-426i441-459o | CytoplasmicMembrane | 10 | ||||||||
| CADB_ECOLI | P0AAE8 | cadB | b4132 JW4093 | integral IM protein (SEC-YidC in IM), Probable cadaverine/lysine antiporter CadB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 18 | 0.152 | TMH | 0 | 9.00829 | - | 12 | 12 | N | i7-28o40-58i94-115o121-139i146-169o189-208i220-238o258-283i323-344o350-371i383-401o407-424i | CytoplasmicMembrane | 10 | ||||||
| POTE_ECOLI | P0AAF1 | potE | b0692 JW0679 | integral IM protein (SEC in IM), Putrescine transporter PotE PotE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 50 | 0.144 | TMH | 0 | 5.94665 | - | 12 | 12 | N | i12-30o42-60i90-110o122-140i152-172o184-204i225-249o276-300i321-345o351-374i386-404o410-428i | CytoplasmicMembrane | 10 | |||||||
| MDLB_ECOLI | P0AAG5 | mdlB mdl | mdl | b0449 JW5061 | integral IM protein (SEC in IM), Multidrug resistance-like ATP-binding MdlB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.136 | SpI | 37 | 4.21577 | - | 4 | 4 | Y | n25-32c37/38o61-81i138-161o167-185i250-273o | CytoplasmicMembrane | 10 | 6 | |||||
| FTSH_ECOLI | P0AAI3 | ftsH hflB mrsC std tolZ | hflB mrsC std tolZ | b3178 JW3145 | integral IM protein (SEC in IM), ATP-dependent zinc metalloprotease FtsH | Integral Inner Membrane | Trigger factor-sensitive aggregation. PMID: 8444797 PMID: 1925026 PMID: 8106505 PMID: 8106505 PMID: 7781608 | PMID: 15919657 PMID: 15919996 PMID: 1925026 PMID: 19737520 PMID: 7500942 PMID: 7781608 PMID: 8106505 PMID: 8444797 PMID: 8947034 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP,TF | SEC | no | yes | N | 24 | 0.152 | SpI | 21 | 2.2847 | - | 2 | 1 | Y | n5-16c21/22o98-119i | CytoplasmicMembrane | 10 | 41 | ||||
| YNFG_ECOLI | P0AAJ1 | ynfG | b1589 JW1581 | periplasmic peripheral IM protein (TAT via piggyback through IM), Probable anaerobic dimethyl sulfoxide reductase chain YnfG | Peripheral inner membrane protein facing the periplasm | The physiological substrate and relevance of the YnfFGH S- and N-oxide reductase is unknown. DmsB paralog. So far, hydroxy pyridine N-oxide is the best substrate for YnfFGH. ynfFGH are expressed anaerobically. YnfG can function with DmsAC, replacing DmsB a as the electron transfer subunit. The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. PMID: 14522592 | PMID: 14522592 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasmic | TAT (piggyback) | yes | yes | N | 44 | 0.106 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 5 | 38 | |||||||||
| FDNH_ECOLI | P0AAJ3 | fdnH | b1475 JW1471 | integral IM protein (SEC in IM), Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit FdnH | Integral Inner Membrane | Part of the formate dehydrogenase N (FDH-N) of Escherichia coli which is a membrane-bound enzyme comprising FdnG, FdnH, and FdnI subunits. PMID: 11884747 PMID: 16858726 | PMID: 11266632 PMID: 11884747 PMID: 15342602 PMID: 16858726 | Integral Inner Membrane | B | Bin | in/out | IM (predicted) | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 24 | 0.116 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i260-279o | CytoplasmicMembrane | 10 | 80 | |||||
| HYBA_ECOLI | P0AAJ8 | hybA | b2996 JW2964 | periplasmic peripheral IM protein (TAT-SEC through IM), Hydrogenase-2 operon HybA | Peripheral inner membrane protein facing the periplasm | TAT secretion system. Part of membrane-associated hydrogenase 4 complex. PMID: 9738917 | PMID: 15911532 PMID: 21890895 PMID: 22313414 PMID: 9738917 | Peripheral inner membrane protein facing the periplasm | F2 | IM (predicted) | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | Y | 27 | 0.442 | SpI | 26 | 19.7463 | - | 0 | 1 | Y | n9-20c26/27o293-311i | CytoplasmicMembrane | 9 | 39 | ||||||||
| NRFC_ECOLI | P0AAK7 | nrfC yjcJ | yjcJ | b4072 JW4033 | periplasmic protein (TAT through IM), NrfC | Periplasmic | TAT secretion system. PMID: 15280383 | PMID: 15280383 PMID: 17218314 | Periplasmic | G | N/A | Periplasmic (Experimental) | TAT | yes | yes | N | 28 | 0.447 | SpI | 27 | 7.45987 | - | 0 | 0 | Y | n8-19c27/28o | Cytoplasmic | 10 | 23 | ||||||||
| NAPG_ECOLI | P0AAL3 | napG yojA yojB | yojA yojB | b2205 JW2193 | periplasmic protein (TAT through IM), Ferredoxin-type NapG | Periplasmic | TAT secretion system. PMID: 11967083 | PMID: 11967083 PMID: 17218314 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT | yes | yes | N | 42 | 0.316 | SpI | 41 | 0.19393 | - | 0 | 0 | Y | n21-32c41/42o | Cytoplasmic | 8 | 20 | |||||||
| YKGJ_ECOLI | P0AAL9 | ykgJ | b0288 JW0282 | periplasmic protein (SEC through IM), YkgJ | Periplasmic | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | N | 27 | 0.286 | SpI | 24 | 4.7292 | - | 0 | 0 | N | i | Unknown | 2 | 33 | |||||||||||
| CYBH_ECOLI | P0AAM1 | hyaC | b0974 JW0956 | integral IM protein (SEC in IM), Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit HyaC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.112 | TMH | 0 | 10.0819 | - | 4 | 6 | N | o20-40i61-80o100-116i128-151o157-174i186-203o | CytoplasmicMembrane | 10 | |||||||
| DGCC_ECOLI | P0AAP1 | dgcC adrA yaiC | adrA yaiC | b0385 JW0376 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcC | Integral Inner Membrane | PMID: 10760159 PMID: 12673057 PMID: 16585767 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein(experimental) | SRP | SEC | yes | yes | N | 20 | 0.116 | CYT | 0 | -0.200913 | - | 5 | 5 | N | i43-61o67-85i106-130o142-167i174-193o | CytoplasmicMembrane | 10 | 22 | |||||
| YAIY_ECOLI | P0AAP7 | yaiY | b0379 JW0370 | integral IM protein (SEC in IM), YaiY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.177 | TMH | 0 | -0.122448 | - | 2 | 2 | N | i25-48o68-95i | CytoplasmicMembrane | 10 | 39 | ||||||
| YAIZ_ECOLI | P0AAQ0 | yaiZ | b0380 JW5053 | integral IM protein (SEC in IM), YaiZ | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 18 | 0.115 | TMH | 0 | 6.70305 | - | 2 | 2 | N | i12-32o38-59i | CytoplasmicMembrane | 9 | 72 | ||||||||
| YBAN_ECOLI | P0AAR5 | ybaN | b0468 JW0457 | integral IM protein (SEC in IM), YbaN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 49 | 0.172 | TMH | 0 | 11.6864 | - | 4 | 4 | N | i5-25o31-52i73-91o97-115i | CytoplasmicMembrane | 10 | 15 | ||||||
| YBAV_ECOLI | P0AAR8 | ybaV | b0442 JW0432 | periplasmic protein (SEC through IM), YbaV | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 26 | 0.681 | SpI | 25 | 23.157 | - | 0 | 0 | Y | n7-17c25/26o | CytoplasmicMembrane | 9 | |||||||||||||
| YLAC_ECOLI | P0AAS0 | ylaC | b0458 JW5063 | integral IM protein (SEC in IM), YlaC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.106 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i36-55o61-79i | CytoplasmicMembrane | 10 | 60 | ||||||
| YBBJ_ECOLI | P0AAS3 | ybbJ | b0488 JW5065 | integral IM protein (SEC in IM), YbbJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.17 | TMH | 0 | 18.8226 | - | 3 | 3 | N | o6-23i30-49o55-72i | CytoplasmicMembrane | 10 | 12 | ||||||
| YBDG_ECOLI | P0AAT4 | ybdG mscM | mscM | b0577 JW0566 | integral IM protein (SEC in IM), Miniconductance mechanosensitive channel YbdG | Integral Inner Membrane | Mechanosensitive channel of miniconductance activity (MscM). | PMID: 15919996 PMID: 20616037 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.102 | CYT | 0 | -0.200913 | - | 5 | 5 | N | o23-48i68-87o107-127i139-160o166-183i | CytoplasmicMembrane | 10 | 11 | ||||
| YBFA_ECOLI | P0AAU2 | ybfA | b0699 JW0688 | integral IM protein (SEC in IM), YbfA | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 22 | 0.331 | TMH | 0 | 2.48449 | - | 1 | 1 | N | o12-33i | CytoplasmicMembrane | 9 | 12 | |||||||||
| YBFB_ECOLI | P0AAU5 | ybfB | b0702 JW0691 | integral IM protein (SEC in IM), YbfB | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 29 | 0.135 | TMH | 0 | 15.1783 | - | 3 | 3 | N | o6-24i45-68o80-101i | CytoplasmicMembrane | 10 | 35 | ||||||||
| YBGE_ECOLI | P0AAV0 | ybgE | b0735 JW0725 | integral IM protein (SEC in IM), YbgE | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.437 | TMH | 0 | 3.17076 | - | 3 | 3 | N | o17-34i46-67o73-96i | CytoplasmicMembrane | 10 | 27 | |||||||||
| YBGS_ECOLI | P0AAV6 | ybgS | b0753 JW0736 | periplasmic protein (SEC through IM), YbgS | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 25 | 0.845 | SpI | 24 | 32.7676 | - | 0 | 0 | Y | n6-17c24/25o | Periplasmic | 9 | ||||||||||
| YBHQ_ECOLI | P0AAW5 | ybhQ | b0791 JW0774 | integral IM protein (SEC in IM), YbhQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.117 | TMH | 0 | 7.89577 | - | 4 | 4 | N | i12-32o38-58i79-96o102-120i | CytoplasmicMembrane | 10 | |||||||
| ACRZ_ECOLI | P0AAW9 | acrZ ybhT | ybhT | b0762 JW5102 | integral IM protein (SEC-YidC in IM), Multidrug efflux pump accessory AcrZ | Integral Inner Membrane | Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC-YidC | no | yes | N | 21 | 0.157 | TMH | 0 | 1.49031 | - | 1 | 1 | N | i7-29o | CytoplasmicMembrane | 9 | 28 | ||||
| YBIJ_ECOLI | P0AAX3 | ybiJ | b0802 JW0787 | periplasmic protein (SEC through IM), YbiJ | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 23 | 0.811 | SpI | 22 | 21.8351 | - | 1 | 0 | Y | n7-18c22/23o | Unknown | 2 | ||||||||||||
| MCBA_ECOLI | P0AAX6 | mcbA ybiM | ybiM | b0806 JW5106 | periplasmic protein (SEC through IM), McbA | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 23 | 0.869 | SpI | 22 | 18.838 | - | 1 | 0 | Y | n4-14c22/23o | Unknown | 2 | |||||||||||
| YBIS_ECOLI | P0AAX8 | ybiS | b0819 JW0803 | periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YbiS | Peripheral outer membrane protein facing the periplasm | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YbiS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 | PMID: 18498364 PMID: 22030350 PMID: 23832002 PMID: 9298646 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 25 | 0.584 | SpI | 24 | 19.8413 | - | 1 | 0 | Y | n8-19c24/25o | Unknown | 2 | 40 | |||||||
| YBJH_ECOLI | P0AAY4 | ybjH | b0843 JW0827 | periplasmic protein (SEC through IM), YbjH | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.874 | SpI | 22 | 25.9172 | - | 1 | 0 | Y | n6-17c22/23o | Unknown | 2 | 10 | ||||||||||||
| YBJO_ECOLI | P0AAZ0 | ybjO | b0858 JW0842 | integral IM protein (SEC in IM), YbjO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 18 | 0.159 | TMH | 0 | 4.12536 | - | 4 | 4 | N | i21-44o64-87i94-111o131-151i | CytoplasmicMembrane | 10 | 32 | ||||||
| ELYC_ECOLI | P0AB01 | elyC ycbC | ycbC | b0920 JW0903 | integral IM protein (SEC in IM), Envelope biogenesis factor ElyC | Integral Inner Membrane | Shown to play a critical role in the metabolism of the essential lipid carrier used for the biogenesis of cell wall and other bacterial surface polysaccharides. | PMCID: PMC3879167 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 60 | 0.155 | TMH | 0 | 9.49418 | - | 2 | 2 | N | o12-32i41-59o | CytoplasmicMembrane | 9 | 24 | ||||
| YCBK_ECOLI | P0AB06 | ycbK | b0926 JW0909 | periplasmic protein (TAT through IM), YcbK | Periplasmic | TAT secretion system. | PMID: 17218314 | Periplasmic | G | N/A | Periplasmic | TAT | yes | yes | N | 31 | 0.559 | SpI | 30 | 8.29508 | - | 1 | 0 | Y | n11-22c30/31o | Unknown | 2 | 11 | |||||||||
| YMBA_ECOLI | P0AB10 | ymbA | b0952 JW5127 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Intertransport PqiC YmbA | putative protase (enterobacterium homolog) | Inner Membrane Lipoprotein | E | N/A | Cell outer membrane | Cytoplasmic | SEC | LOL | yes | yes | N | 20 | 0.205 | SpII | 15 | 22.8198 | Pos+2=S | 0 | 0 | Y | n4-14c19/20o | Unknown | 2 | 82 | |||||||||
| YCCF_ECOLI | P0AB12 | yccF | b0961 JW0944 | integral IM protein (SEC in IM), YccF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.116 | TMH | 0 | 2.25765 | - | 3 | 3 | N | i7-33o69-90i102-123o | CytoplasmicMembrane | 10 | |||||||
| EFEO_ECOLI | P0AB24 | efeO ycdO | ycdO | b1018 JW1003 | periplasmic protein (SEC through IM), Iron uptake system component EfeO | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 12107143 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544 | PMID: 12107143 PMID: 16551627 PMID: 19953543 PMID: 22030350 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 27 | 0.767 | SpI | 26 | 18.2235 | - | 0 | 0 | Y | n9-18c26/27o | Periplasmic | 10 | 42 | ||||||
| YCEB_ECOLI | P0AB26 | yceB | b1063 JW1050 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YceB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 55 | 0.134 | SpII | 18 | 16.4921 | Pos+2=N | 0 | 0 | Y | n4-15c19/20o | Unknown | 2 | 45 | |||||||
| YCEK_ECOLI | P0AB31 | yceK | b1050 JW5151 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YceK | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 31 | 0.129 | SpII | 15 | 5.35698 | Pos+2=G | 0 | 0 | Y | n3-13c18/19o | Unknown | 2 | |||||||||
| YCFJ_ECOLI | P0AB35 | ycfJ | b1110 JW1096 | integral IM protein (SEC in IM), YcfJ | Integral Inner Membrane | B | - | N/A | Membrane | Membrane anchored | SRP | SEC | yes | yes | N | 36 | 0.275 | SpI | 23 | 8.09735 | - | 1 | 0 | Y | n6-17c21/22o | Unknown | 2 | ||||||||||
| LPOB_ECOLI | P0AB38 | lpoB ycfM | ycfM | b1105 JW5157 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Penicillin-binding activator LpoB | Outer Membrane Lipoprotein | The two OM Lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 PMID: 21183073 PMID: 21183074 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.258 | SpII | 19 | 23.7759 | Pos+2=V | 0 | 0 | Y | n8-18c22/23o | Unknown | 2 | 96 | ||||||
| BHSA_ECOLI | P0AB40 | bhsA comC ycfR | comC ycfR | b1112 JW1098 | periplasmic peripheral OM protein (SEC through IM), Multiple stress resistance BhsA | Peripheral outer membrane protein facing the periplasm | By membrane fractionation, ComC was shown to be localized in the outer membrane. | PMID: 22089859 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Cell outer membrane | Periplasmic | SEC | yes | yes | Y | 23 | 0.773 | SpI | 22 | 21.6297 | - | 0 | 0 | Y | n6-14c22/23o | Unknown | 2 | 70 | |||||||
| YMGD_ECOLI | P0AB46 | ymgD | b1171 JW5177 | periplasmic protein (SEC through IM), YmgD | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.656 | SpI | 19 | 14.7848 | - | 0 | 0 | Y | n4-14c19/20o | Unknown | 2 | 86 | |||||||||
| YCHH_ECOLI | P0AB49 | ychH | b1205 JW1196 | integral IM protein (SEC in IM), YchH | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.123 | TMH | 0 | 12.8445 | - | 2 | 2 | N | i12-29o41-59i | CytoplasmicMembrane | 9 | 73 | |||||||||
| LAPB_ECOLI | P0AB58 | LapB yciM | yciM | b1280 JW1272 | integral IM protein (SEC in IM), polysaccharide assembly B LapB | Integral Inner Membrane | Potential TAT secreted protein. Required to maintain cell envelope integrity. Heat shock protein that is involved in the assembly of LPS PMID: 24722986 Heat shock protein that is involved in the assembly of LPS PMID: 24722986 Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). A specific interaction was also observed between WaaC and LapB. LapB potentially coordinates assembly of proteins involved in LPS synthesis at the plasma membrane and regulates turnover of LpxC. PMID: 25403562 | PMID: 24187084 PMID: 25403562 | Integral Inner Membrane | B | - | Soluble IM Fraction | Cell inner membrane | Periplasmic | SEC | yes | yes | N | 25 | 0.264 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n4-11c16/17o | Cytoplasmic | 8 | 9 | ||||||
| PNTB_ECOLI | P0AB67 | pntB | b1602 JW1594 | integral IM protein (SEC in IM), NAD(P) transhydrogenase subunit beta PntB | Integral Inner Membrane | PMID: 14660605 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.125 | TMH | 0 | 9.6368 | - | 9 | 9 | N | o6-24i36-51o57-74i86-105o125-143i163-180o186-207i214-234o240-260i | CytoplasmicMembrane | 10 | |||||||
| APBE_ECOLI | P0AB85 | apbE yojK yojL | yojK yojL | b2214 JW5368 | IM lipoprotein (SEC through IM), inserted in OM by LOL), FAD:FMN transferase ApbE | Inner Membrane Lipoprotein | Proven signal peptidase II substrate. | PMID: 15174130 | Inner Membrane Lipoprotein | E | IM (predicted) | Cell inner membrane | Inner membrane lipoprotein | SEC | LOL | yes | yes | N | 28 | 0.154 | SpII | 19 | 12.0176 | Pos+2=D | 0 | 0 | Y | n8-18c22/23o | Unknown | 2 | 65 | ||||||
| ARSB_ECOLI | P0AB93 | arsB arsF | arsF | b3502 JW3469 | integral IM protein (SEC in IM), Arsenical pump ArsB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 44 | 0.23 | TMH | 0 | 8.42262 | - | 11 | 10 | Y | n2-17c35/36o51-70i91-109o115-132i139-163o175-198i222-240o246-263i275-296o316-334i401-423o | CytoplasmicMembrane | 10 | ||||||
| ATP6_ECOLI | P0AB98 | atpB papD uncB | papD uncB | b3738 JW3716 | integral IM protein (SEC-YidC in IM), ATP synthase subunit a AtpB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 10806384 | PMID: 10806384 PMID: 15263011 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | yes | yes | N | 67 | 0.123 | CYT | 0 | -0.200913 | - | 5 | 5 | N | o36-60i100-118o147-166i211-233o239-264i | CytoplasmicMembrane | 10 | 7 | ||||
| ATPF_ECOLI | P0ABA0 | atpF papF uncF | papF uncF | b3736 JW3714 | integral IM protein (SEC in IM), ATP synthase subunit b AtpF | Integral Inner Membrane | PMID: 15263011 PMID: 21541338 PMID: 6278247 | Integral Inner Membrane | B | Bin | out/in | Soluble IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | no | yes | N | 32 | 0.35 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-26i | CytoplasmicMembrane | 10 | 19 | |||||
| ATMA_ECOLI | P0ABB8 | mgtA corB mgt | corB mgt | b4242 JW4201 | integral IM protein (SEC in IM), Magnesium-transporting ATPase, P-type 1 MgtA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.122 | CYT | 0 | -0.200913 | - | 7 | 8 | N | i89-112o118-137i291-309o315-342i768-791o803-821i833-857o869-891i | CytoplasmicMembrane | 10 | 50 | |||||
| ATPZ_ECOLI | P0ABC0 | atpI uncI | uncI | b3739 JW5611 | integral IM protein (SEC-YidC in IM), ATP synthase I AtpI | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 64 | 0.113 | TMH | 0 | 4.01303 | - | 4 | 3 | Y | n14-25c30/31o40-59i71-94o100-122i | CytoplasmicMembrane | 10 | 34 | ||||
| HFLC_ECOLI | P0ABC3 | hflC hflA | hflA | b4175 JW4133 | integral IM protein (SEC in IM), Modulator of FtsH protease HflC | Integral Inner Membrane | N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691 | PMID: 16834335 PMID: 8947034 PMID: 9792691 | Integral Inner Membrane | B | Bin | out/in | Soluble IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | Prophage Transposase (by homology to BL21) | yes | yes | N | 25 | 0.135 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-23i | Cytoplasmic | 8 | 46 | |||
| HFLK_ECOLI | P0ABC7 | hflK hflA | hflA | b4174 JW4132 | integral IM protein (SEC in IM), Modulator of FtsH protease HflK | Integral Inner Membrane | Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691 | PMID: 21541338 PMID: 8947034 PMID: 9792691 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | Prophage Transposase | yes | no | N | 3 | 0.101 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i80-100o | Unknown | 5 | 20 | |||
| BETT_ECOLI | P0ABC9 | betT | b0314 JW0306 | integral IM protein (SEC in IM), High-affinity choline transport protein BetT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.108 | TMH | 0 | 11.6116 | - | 12 | 12 | N | i16-35o55-79i91-115o143-166i194-215o235-253i265-290o319-338i350-368o403-422i448-467o479-497i | CytoplasmicMembrane | 10 | |||||||
| YEAV_ECOLI | P0ABD1 | yeaV | b1801 JW5293 | integral IM protein (SEC in IM), transporter YeaV | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 19 | 0.119 | TMH | 0 | 2.33182 | - | 10 | 11 | Y | n2-13c18/19o34-59i80-104o136-158i170-191o203-221i228-246o258-277i289-308o348-371i392-412o418-438i | CytoplasmicMembrane | 10 | |||||||||
| C561_ECOLI | P0ABE5 | cybB | b1418 JW5224 | integral IM protein (SEC-YidC in IM), Cytochrome b561 CybB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 23 | 0.142 | TMH | 0 | 7.83021 | - | 4 | 4 | N | i12-33o39-62i82-106o143-162i | CytoplasmicMembrane | 10 | 31 | |||||
| PGSA_ECOLI | P0ABF8 | pgsA | b1912 JW1897 | integral IM protein (SEC in IM), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 12558186 PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 35 | 0.17 | TMH | 0 | 12.5336 | - | 4 | 6 | N | i7-27o33-52i64-83o89-108i120-142o148-169i | CytoplasmicMembrane | 10 | 7 | |||||
| CDSA_ECOLI | P0ABG1 | cdsA cds | cds | b0175 JW5810 | integral IM protein (SEC in IM), Phosphatidate cytidylyltransferase CdsA | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 15919996 | PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP (exp) | SEC | yes | yes | N | 30 | 0.287 | TMH | 0 | 18.3357 | - | 8 | 8 | Y | n6-13c18/19o28-44i56-73o93-113i120-141o153-171i192-210o216-234i264-282o | CytoplasmicMembrane | 10 | |||||
| FTSW_ECOLI | P0ABG4 | ftsW | b0089 JW0087 | integral IM protein (SEC in IM), Probable PG glycosyltransferase FtsW | Integral Inner Membrane | Interacts directly with FtsN. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex. | PMID: 11807049 PMID: 12423747 PMID: 15919996 PMID: 20497333 PMID: 20847002 PMID: 9603865 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 67 | 0.137 | TMH | 0 | 10.7628 | - | 10 | 9 | Y | n15-26c32/33o48-66i87-104o110-129i175-192o198-215i222-239o307-328i340-364o376-395i | CytoplasmicMembrane | 10 | ||||||
| RODA_ECOLI | P0ABG7 | mrdB rodA | rodA | b0634 JW0629 | integral IM protein (SEC in IM), PG glycosyltransferase MrdB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.198 | TMH | 0 | 6.46483 | - | 9 | 9 | N | o20-38i50-68o74-95i136-154o160-176i183-202o263-289i310-332o338-359i | CytoplasmicMembrane | 10 | ||||||
| MRED_ECOLI | P0ABH4 | mreD | b3249 JW3218 | integral IM protein (SEC in IM), Rod shape-determining MreD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.118 | TMH | 0 | 15.556 | - | 5 | 5 | N | o6-25i37-54o74-92i104-128o134-152i | CytoplasmicMembrane | 10 | |||||||
| CORA_ECOLI | P0ABI4 | corA | b3816 JW3789 | integral IM protein (SEC-YidC in IM), Magnesium transport CorA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. Single particle electron microscopy analysis and two-dimensional crystals of PPD (large soluble periplasmic domain) of CorA indicated that E. coli CorA PPD is a pyramid-like homotetramer with a central cavity. | PMID: 15919996 PMID: 16835234 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 27 | 0.101 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i255-278o290-310i | CytoplasmicMembrane | 10 | 65 | |||||
| CYOB_ECOLI | P0ABI8 | cyoB | b0431 JW0421 | integral IM protein (SEC-YidC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 1 CyoB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 11017202 PMID: 11266632 PMID: 15919996 PMID: 22108384 PMID: 6365921 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 31 | 0.108 | TMH | 0 | 10.2812 | - | 14 | 14 | N | o16-38i59-79o103-126i146-170o190-213i233-255o275-298i310-334o346-368i380-403o415-436i457-479o491-518i593-626o | CytoplasmicMembrane | 10 | ||||||
| CYOA_ECOLI | P0ABJ1 | cyoA | b0432 JW0422 | integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 2 CyoA | Integral Inner Membrane | Proven signal peptidase II substrate PMID: 15174130. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 The SRP interacts with the first TM of CyoA (rather than with its signal sequence) to mediate targeting of CyoA to the Sec/YidC insertion site in the inner membrane. PMID: 16481320 Efficient insertion of in vitro synthesized pre-CyoA into proteoliposomes requires YidC, SecYEG, and SecA and occurs independently of the proton motive force. PMID: 16513637 | PMID: 11017202 PMID: 11266632 PMID: 15174130 PMID: 15919657 PMID: 15919996 PMID: 16079137 PMID: 16481320 PMID: 16513637 PMID: 21541338 PMID: 6365921 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.189 | TMH | 0 | 11.3494 | - | 3 | 2 | Y | n10-22c27/28o43-67i88-108o | CytoplasmicMembrane | 10 | 19 | |||||
| CYOC_ECOLI | P0ABJ3 | cyoC | b0430 JW0420 | integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 3 CyoC | Integral Inner Membrane | PMID: 11017202 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 14 | 0.175 | TMH | 0 | 3.44396 | - | 5 | 5 | N | i29-50o70-91i98-118o138-165i177-201o | CytoplasmicMembrane | 10 | |||||||
| CYOD_ECOLI | P0ABJ6 | cyoD | b0429 JW0419 | integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 4 CyoD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 44 | 0.15 | TMH | 0 | 14.0581 | - | 3 | 3 | N | o18-37i44-68o80-100i | CytoplasmicMembrane | 10 | |||||||
| CYDA_ECOLI | P0ABJ9 | cydA cyd-1 | cyd-1 | b0733 JW0722 | integral IM protein (SEC in IM), Cytochrome bd-I ubiquinol oxidase subunit 1 CydA | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 15013751 PMID: 15919657 PMID: 15919996 PMID: 16079137 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 37 | 0.106 | TMH | 0 | 9.54728 | - | 9 | 9 | N | o20-42i54-71o91-116i128-151o184-208i220-238o388-409i421-444o471-494i | CytoplasmicMembrane | 10 | |||||
| CYDB_ECOLI | P0ABK2 | cydB cyd-2 | cyd-2 | b0734 JW0723 | integral IM protein (SEC in IM), Cytochrome bd-I ubiquinol oxidase subunit 2 CydB | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 15013751 PMID: 15919996 PMID: 16079137 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 29 | 0.118 | TMH | 0 | 10.5085 | - | 8 | 8 | N | i9-28o77-99i119-141o161-181i202-226o264-283i290-315o335-360i | CytoplasmicMembrane | 10 | |||||
| CSGB_ECOLI | P0ABK7 | csgB | b1041 JW1024 | Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Minor curlin subunit CsgB | Peripheral outer membrane protein facing the extra-cellular space | Curli component. CsgB localization requires at least one component of the curli secretion apparatus, CsgF. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041 | PMID: 16704339 PMID: 19131513 PMID: 21645131 PMID: 9312041 PMID: 9383186 PMCID: PMC2630086 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | Curli | SEC | Curli | yes | yes | Y | 22 | 0.53 | SpI | 21 | 16.29 | - | 0 | 0 | Y | n5-13c21/22o | Extracellular | 9 | |||||||
| NRFA_ECOLI | P0ABK9 | nrfA | b4070 JW4031 | periplasmic protein (SEC through IM), Cytochrome c-552 NrfA | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 PMID: 793493 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.665 | SpI | 26 | 14.744 | - | 0 | 0 | Y | n11-21c26/27o | Periplasmic | 10 | 25 | ||||||||
| NRFB_ECOLI | P0ABL1 | nrfB yjcI | yjcI | b4071 JW4032 | periplasmic protein (SEC through IM), Cytochrome c-type NrfB | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 15280383 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 33 | 0.498 | SpI | 25 | 6.62799 | - | 0 | 0 | Y | n7-18c23/24o | Periplasmic | 9 | 16 | |||||||
| NAPB_ECOLI | P0ABL3 | napB yejY | yejY | b2203 JW5367 | periplasmic protein (SEC through IM), nitrate reductase, electron transfer subunit NapB | Periplasmic | Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 PMID: 10234835 Disulfide bond-containing protein PMID: 25664544 | PMID: 10234835 PMID: 10548535 PMID: 11844760 PMID: 17130127 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 28 | 0.825 | SpI | 27 | 14.6891 | - | 0 | 0 | Y | n9-20c27/28o | Periplasmic | 10 | ||||||||
| NAPC_ECOLI | P0ABL5 | napC yejX | yejX | b2202 JW2190 | integral IM protein (SEC in IM), Cytochrome c-type NapC | Integral Inner Membrane | Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 Electrons are fed into the NapAB dimer from a membrane-anchored tetra-heme cytochrome c,encoded by the napC gene. PMID: 8830238 PMID: 12186631 | PMID: 11844760 PMID: 12186631 PMID: 8830238 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane; Single-pass membrane protein | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 52 | 0.116 | TMH | 0 | 6.01984 | - | 1 | 1 | N | i21-44o | CytoplasmicMembrane | 10 | 14 | ||||
| CCMB_ECOLI | P0ABL8 | ccmB yejV | yejV | b2200 JW2188 | integral IM protein (SEC-YidC in IM), Heme exporter B CcmB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 20 | 0.11 | TMH | 0 | 9.26722 | - | 6 | 6 | N | i21-39o45-70i82-103o123-145i157-180o192-215i | CytoplasmicMembrane | 10 | 4 | ||||
| CCMC_ECOLI | P0ABM1 | ccmC yejT yejU | yejT yejU | b2199 JW2187 | integral IM protein (SEC-YidC in IM), Heme exporter C CcmC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983 | PMID: 11384983 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 29 | 0.15 | TMH | 0 | 14.9856 | - | 6 | 6 | N | i21-43o63-84i91-113o133-149i161-182o202-221i | CytoplasmicMembrane | 10 | |||||
| CCMD_ECOLI | P0ABM5 | ccmD yojM | yojM | b2198 JW2186 | integral IM protein (SEC in IM), Heme exporter D CcmD | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 7 | 0.153 | TMH | 0 | 3.24028 | - | 1 | 1 | N | o12-37i | CytoplasmicMembrane | 9 | 66 | |||||||
| CCMH_ECOLI | P0ABM9 | ccmH yejP | yejP | b2194 JW2182 | integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmH | Integral Inner Membrane | Might be is co-translationally translocated through Sec translocon. CcmH is a periplasm-resident oxidoreductase anchored to the inner membrane by two transmembrane segments. Both N- and C-terminal domains are located and function in the periplasmic compartment. PMID: 22789558 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 15838024 PMID: 15919996 PMID: 22789558 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | Y | 19 | 0.795 | SpI | 18 | 8.87226 | - | 3 | 2 | Y | n3-13c18/19o102-120i147-166o | CytoplasmicMembrane | 10 | 41 | ||||
| KDGL_ECOLI | P0ABN1 | dgkA | b4042 JW4002 | integral IM protein (SEC in IM), Diacylglycerol kinase DgkA | Integral Inner Membrane | PMID: 15919996 PMID: 2984194 PMID: 8071224 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 54 | 0.112 | CYT | 0 | -0.200913 | - | 2 | 3 | N | i30-51o57-80i100-121o | CytoplasmicMembrane | 10 | 31 | ||||||
| DCUA_ECOLI | P0ABN5 | dcuA genA | genA | b4138 JW5735 | integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 28 | 0.186 | TMH | 0 | 7.74612 | - | 11 | 11 | N | o6-38i45-66o86-109i130-152o164-190i225-243o255-277i289-306o326-345i357-381o410-431i | CytoplasmicMembrane | 10 | ||||||
| DCUB_ECOLI | P0ABN9 | dcuB genF | genF | b4123 JW4084 | integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 68 | 0.125 | TMH | 0 | 8.74519 | - | 11 | 10 | Y | n2-13c17/18o27-44i51-71o91-118i139-162o174-195i236-254o266-288i300-318o342-372i421-445o | CytoplasmicMembrane | 10 | ||||||
| DCUC_ECOLI | P0ABP3 | dcuC | b0621 JW0613/JW0616 | integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 56 | 0.117 | TMH | 0 | 0.537839 | - | 12 | 12 | N | i5-22o28-46i79-98o118-144i156-175o195-218i238-260o266-288i309-333o339-363i406-424o436-458i | CytoplasmicMembrane | 10 | 3 | ||||||
| DEDA_ECOLI | P0ABP6 | dedA | b2317 JW2314 | integral IM protein (SEC-YidC in IM) of DedA family, DedA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 22108384 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 20 | 0.121 | CYT | 0 | -0.200913 | - | 4 | 4 | N | i27-49o69-92i156-178o190-208i | CytoplasmicMembrane | 10 | ||||||
| YIJE_ECOLI | P0ABT8 | yijE | b3943 JW5557 | integral IM protein (SEC in IM), Probable cystine transporter YijE YijE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.12 | TMH | 0 | 7.7108 | - | 10 | 10 | N | i12-29o35-59i71-91o97-118i125-141o153-171i183-205o217-239i246-266o272-289i | CytoplasmicMembrane | 10 | |||||||
| EXBB_ECOLI | P0ABU7 | exbB | b3006 JW2974 | integral IM protein (SEC in IM), Biopolymer transport ExbB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.153 | CYT | 0 | -0.200913 | - | 3 | 3 | N | o21-43i132-157o177-198i | CytoplasmicMembrane | 10 | 14 | ||||||
| TOLQ_ECOLI | P0ABU9 | tolQ fii | fii | b0737 JW0727 | integral IM protein (SEC in IM), Tol-Pal system TolQ | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 8300535 PMID: 8331075 | PMID: 15919996 PMID: 8300535 PMID: 8331075 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP (exp) | SEC | yes | yes | N | 34 | 0.244 | TMH | 0 | 2.05597 | - | 3 | 3 | N | o15-35i139-159o171-192i | CytoplasmicMembrane | 10 | 9 | ||||
| EXBD_ECOLI | P0ABV2 | exbD | b3005 JW2973 | integral IM protein (SEC in IM), Biopolymer transport ExbD | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Single-pass type II membrane protein | Membrane anchored | SRP | SEC | yes | yes | N | 42 | 0.15 | TMH | 0 | 0.162291 | - | 1 | 1 | N | o20-41i | CytoplasmicMembrane | 9 | 47 | ||||||||
| TOLR_ECOLI | P0ABV6 | tolR | b0738 JW0728 | integral IM protein (SEC in IM), Tol-Pal system TolR | Integral Inner Membrane | PMID: 7744737 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 37 | 0.197 | TMH | 0 | 0.527259 | - | 1 | 1 | N | i21-39o | CytoplasmicMembrane | 9 | 23 | ||||||
| SFMA_ECOLI | P0ABW5 | sfmA | b0530 JW0519 | Fimbrial periplasmic protein (SEC through IM), SfmA | Periplasmic | Potential fimbrial sfm operon (class ??1); Fimbrial Subunit. Disulfide bridge (41 81) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | yes | yes | Y | 23 | 0.832 | SpI | 22 | 21.4596 | - | 0 | 0 | Y | n6-17c22/23o | Extracellular | 10 | 83 | ||||||
| FLGB_ECOLI | P0ABW9 | flgB fla FII flbA | fla FII flbA | b1073 JW1060 | Flagellar periplasmic protein (Flagellum secreted through IM), basal body rod FlgB | Periplasmic | Proximal rod protein. PMID: 12730325 FlgG is a distal component of the basal body rod. While FlgF was highly soluble, FlgB, FlgC, FlgG and FliE tended to self or cross-aggregate into fibrils in solutions at neutral pH or below, at high ionic strength, or at high protein concentration. PMID: 15136044 | PMID: 12631703 PMID: 12730325 PMID: 15136044 | Periplasmic | G | N/A | Bacterial flagellum basal body | Periplasmic (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 34 | 0.201 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 10 | 93 | |||||
| FLGC_ECOLI | P0ABX2 | flgC fla FIII flaW | fla FIII flaW | b1074 JW1061 | Flagellar periplasmic protein (Flagellum secreted through IM), basal body rod FlgC | Periplasmic | Proximal rod protein. PMID: 12730325 FlgB, FlgC, FlgF, and FlgG are four proteins that comprise the rod section of the basal-body assembly of the flagellar motor. The rod is a rotational component which is situated transverse to the outer membrane and peptidoglycan layers and is circumscribed by a set of four rings which lie in a horizontal plane within the inner and outer membranes of the cell envelope. PMID: 2181149 FlgG is a distal component of the basal body rod. While FlgF was highly soluble, FlgB, FlgC, FlgG and FliE tended to self or cross-aggregate into fibrils in solutions at neutral pH or below, at high ionic strength, or at high protein concentration. PMID: 15136044 | PMID: 12631703 PMID: 12730325 PMID: 15136044 PMID: 2181149 | Periplasmic | G | N/A | Bacterial flagellum basal body | Periplasmic (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 32 | 0.201 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 10 | 43 | |||||
| FLGG_ECOLI | P0ABX5 | flgG fla FVII flaL | fla FVII flaL | b1078 JW1065 | Flagellar periplasmic protein (Flagellum secreted through IM), basal body rod FlgG | Periplasmic | Distal rod protein PMID: 12730325 FlgB, FlgC, FlgF, and FlgG are four proteins that comprise the rod section of the basal-body assembly of the flagellar motor. The rod is a rotational component which is situated transverse to the outer membrane and peptidoglycan layers and is circumscribed by a set of four rings which lie in a horizontal plane within the inner and outer membranes of the cell envelope. PMID: 2181149 FlgG is a distal component of the basal body rod. While FlgF was highly soluble, FlgB, FlgC, FlgG and FliE tended to self or cross-aggregate into fibrils in solutions at neutral pH or below, at high ionic strength, or at high protein concentration. PMID: 15136044 | PMID: 12631703 PMID: 12730325 PMID: 15136044 PMID: 2181149 | Periplasmic | G | N/A | Bacterial flagellum basal body | Periplasmic (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 24 | 0.123 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 78 | |||||
| FLIL_ECOLI | P0ABX8 | fliL cheC1 fla AI fla QI | cheC1 fla AI fla QI | b1944 JW1928 | integral IM protein (SEC in IM), FliL | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Outer membrane Lipoprotein | SRP | SEC | no | yes | N | 43 | 0.268 | SpII | 26 | 10.5269 | Pos+2=A | 1 | 1 | N | i14-35o | CytoplasmicMembrane | 10 | 35 | |||||||
| SURA_ECOLI | P0ABZ6 | surA | b0053 JW0052 | periplasmic protein (SEC through IM), Chaperone SurA | Periplasmic | PMID: 14506253 PMID: 19525348 PMID: 21370981 PMID: 22030350 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 21 | 0.795 | SpI | 20 | 15.5107 | - | 0 | 0 | Y | n7-15c20/21o | Periplasmic | 10 | 86 | |||||||||
| BAMD_ECOLI | P0AC02 | bamD yfiO | yfiO | b2595 JW2577 | OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamD | Outer Membrane Lipoprotein | Part of bam complex. Forms subcomplex with BamCE. Outer membrane protein related to resistance to ampicillin and tetracycline. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16372265 | PMID: 12488465 PMID: 15174130 PMID: 15911532 PMID: 16079137 PMID: 16372265 PMID: 16824102 PMID: 20932056 PMID: 21139201 PMID: 21370981 PMID: 21823654 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein(experimental) | SEC | LOL | yes | yes | Y | 24 | 0.171 | SpII | 19 | 27.0165 | Pos+2=S | 0 | 0 | Y | n7-17c22/23o | OuterMembrane | 10 | 22 | ||||||
| FLIP_ECOLI | P0AC05 | fliP flaR | flaR | b1948 JW1932 | Flagellar integral IM protein (SEC in IM), biosynthetic FliP | Integral Inner Membrane | A cleavable signal peptide is required for the full function of FliP protein. | PMID: 15194505 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | flagellum | SRP | SEC | no | yes | Y | 22 | 0.692 | TMH | 0 | 13.015 | - | 5 | 4 | Y | n4-15c21/22o45-74i86-105o185-211i223-244o | CytoplasmicMembrane | 10 | ||||
| FLIQ_ECOLI | P0AC07 | fliQ flaQ | flaQ | b1949 JW1933 | Flagellar integral IM protein (SEC in IM), biosynthetic FliQ | Integral Inner Membrane | B | Binout | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | flagellum | SRP | SEC | no | yes | N | 41 | 0.283 | TMH | 0 | 14.373 | - | 2 | 1 | Y | n16-35c40/41o56-74i | CytoplasmicMembrane | 10 | 30 | ||||||
| FOCA_ECOLI | P0AC23 | focA ycaE | ycaE | b0904 JW0887 | integral IM protein (SEC in IM), Probable formate transporter 1 FocA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.124 | TMH | 0 | 1.35944 | - | 6 | 6 | N | i35-55o75-98i118-141o161-180i192-212o255-277i | CytoplasmicMembrane | 10 | ||||||
| NIRC_ECOLI | P0AC26 | nirC | b3367 JW3330 | integral IM protein (SEC in IM), Nitrite transporter NirC NirC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.428 | TMH | 0 | 4.72286 | - | 6 | 6 | N | i25-47o59-80i101-126o146-169i181-206o226-248i | CytoplasmicMembrane | 10 | |||||||
| FTSX_ECOLI | P0AC30 | ftsX ftsS | ftsS | b3462 JW3427 | integral IM protein (SEC in IM), Cell division FtsX | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 10048040 PMID: 14729705 PMID: 15919996 PMID: 3323846 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 39 | 0.105 | CYT | 0 | -0.200913 | - | 4 | 4 | N | o72-95i214-240o272-290i323-342o | CytoplasmicMembrane | 10 | 23 | ||||
| DHSD_ECOLI | P0AC44 | sdhD | b0722 JW0712 | integral IM protein (SEC in IM), Succinate dehydrogenase hydrophobic anchor subunit SdhD | Integral Inner Membrane | PArt of colisuccinate dehydrogenase (SQR) composed of two hydrophilic subunits, a flavoprotein (SdhA) and iron-sulfur protein (SdhB) subunit, and two hydrophobic membrane anchor subunits, SdhC and SdhD. | PMID: 11266632 PMID: 12560550 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.133 | TMH | 0 | 10.7371 | - | 3 | 3 | N | i17-39o59-80i92-113o | CytoplasmicMembrane | 10 | 44 | |||||
| KDTA_ECOLI | P0AC75 | waaA kdtA | kdtA | b3633 JW3608 | integral IM protein (SEC in IM), 3-deoxy-D-manno-octulosonic acid transferase WaaA | Integral Inner Membrane | Involved in lipopolysaccharide biosynthesis PMID: 2651435 PMID: 1577828. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) to the lipid A precursor of LPS (in Aquifex aeolicus) PMID: 22474366. | PMID: 1577828 PMID: 15866922 PMID: 19275539 PMID: 22474366 PMID: 2651435 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 64 | 0.121 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o6-23i | Unknown | 2 | 15 | ||||
| WECA_ECOLI | P0AC78 | wecA rfe | rfe | b3784 JW3758 | integral IM protein (SEC in IM), Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase WecA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.115 | CYT | 0 | -0.200913 | - | 11 | 11 | N | o6-24i45-66o72-89i101-119o131-149i161-179o185-206i213-232o244-263i294-315o321-342i | CytoplasmicMembrane | 10 | ||||||
| GNTP_ECOLI | P0AC94 | gntP yjiB | yjiB | b4321 JW4284 | integral IM protein (SEC in IM), High-affinity gluconate transporter GntP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.178 | TMH | 0 | 7.17039 | - | 13 | 12 | N | i7-23o29-49i61-79o99-132i139-157o177-201i222-249o261-280i301-320o340-373i380-402o422-446i | CytoplasmicMembrane | 10 | ||||||
| GNTU_ECOLI | P0AC96 | gntU | b4476 JW5686 | integral IM protein (SEC in IM), Low-affinity gluconate transporter GntU | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | yes | N | 31 | 0.139 | TMH | 0 | 10.5274 | - | 13 | 12 | N | i5-22o28-47i59-80o100-128i140-163o175-197i226-250o262-282i303-320o340-373i385-408o428-445i | CytoplasmicMembrane | 10 | ||||||
| SATP_ECOLI | P0AC98 | satP yaaH | yaaH | b0010 JW0009 | integral IM protein (SEC in IM), Succinate-acetate/proton symporter SatP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.122 | TMH | 0 | 9.07966 | - | 6 | 6 | N | i12-31o37-56i63-84o96-116i123-143o149-169i | CytoplasmicMembrane | 10 | ||||||
| HEMY_ECOLI | P0ACB7 | hemY | b3802 JW3774 | integral IM protein (SEC in IM), HemY | Integral Inner Membrane | Trigger factor-sensitive aggregation. | PMID: 15919996 PMID: 19737520 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP,TF | SEC | yes | yes | N | 23 | 0.235 | TMH | 0 | 10.5296 | - | 2 | 1 | Y | n4-17c26/27o42-62i | CytoplasmicMembrane | 10 | 19 | |||||
| MBHM_ECOLI | P0ACE0 | hybC | b2994 JW2962 | periplasmic peripheral IM protein (TAT via piggyback through IM), Hydrogenase-2 large chain HybC | Peripheral inner membrane protein facing the periplasm | The protein is attached to this location through a 5kDa segment of its small subunit hybO that is has a TAT signal peptide. Secreted using the TAT system (piggyback). PMID: 10224080 An active tryptic fragment of membrane-bound hydrogenase isoenzyme 2 from anaerobically grown Escherichia coli has been purified. This indicates that HYD2 is attached to the periplasmic side of the cytoplasmic membrane.PMID: 3516690 The intracellular availability of nickel is essential for the processing of the large subunit and for the transmembrane translocation of HYD2. PMID: 8772179 PMID: 9738917 Disulfide bond-containing protein PMID: 25664544 | PMID: 10224080 PMID: 25664544 PMID: 3516690 PMID: 8772179 PMID: 9738917 | Peripheral inner membrane protein facing the periplasm | F2 | Soluble IM Fraction | Cell membrane; Peripheral membrane protein | Periplasmic (Experimental) | TAT (piggyback) | yes | yes | N | 34 | 0.139 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | CytoplasmicMembrane | 10 | 28 | ||||||||
| HOKC_ECOLI | P0ACG4 | hokC gef | gef | b4412 JW5002 b0018.1 | periplasmic protein (SEC through IM), Toxic HokC | Periplasmic | Potentially toxic protein. | PMID: 19121005 PMID: 21890895 | Periplasmic | G | N/A | Cell inner membrane | Periplasmic | SEC | no | yes | N | 22 | 0.361 | SpI | 21 | 5.3199 | - | 1 | 0 | Y | n8-16c21/22o | Periplasmic | 9 | 32 | |||||||
| HOKD_ECOLI | P0ACG6 | hokD relF | relF | b1562 JW1554 | periplasmic protein (SEC through IM), Toxic HokD | Periplasmic | G | N/A | Cell inner membrane | Periplasmic | SEC | Prophage Integrase (EcoGene) | no | no | N | 23 | 0.157 | SpI | 22 | 2.62207 | - | 1 | 0 | Y | n8-19c26/27o | Periplasmic | 9 | ||||||||||
| LPXL_ECOLI | P0ACV0 | lpxL htrB waaM | htrB waaM | b1054 JW1041 | integral IM protein (SEC in IM), Lipid A biosynthesis lauroyltransferase LpxL | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 20 | 0.104 | TMH | 0 | 1.65586 | - | 1 | 2 | N | i12-30o36-52i | CytoplasmicMembrane | 10 | 11 | |||||||
| LPXP_ECOLI | P0ACV2 | lpxP ddg | ddg | b2378 JW2375 | integral IM protein (SEC-YidC in IM), Lipid A biosynthesis palmitoleoyltransferase LpxP | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 22108384 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC-YidC | yes | yes | N | 49 | 0.166 | TMH | 0 | 1.68704 | - | 1 | 1 | N | o20-46i | CytoplasmicMembrane | 9 | 9 | ||||
| LAPA_ECOLI | P0ACV4 | LapA yciS | yciS | b1279 JW1271 | integral IM protein (SEC in IM), polysaccharide assembly A LapA | Integral Inner Membrane | YciS (LapA) possibly participates both in lateral elongation of peptidoglycan and septum formation.PMID: 24722986 C-terminal tagging with the alkaline phosphatase and green fluorescent protein in order to define the periplasmic or cytoplasmic locations of the C termini. PMID: 15919996 Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). PMID: 25403562 | PMID: 15919996 PMID: 25403562 | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.34 | TMH | 0 | 11.7404 | - | 2 | 1 | Y | n4-16c21/22o45-67i | CytoplasmicMembrane | 10 | 36 | ||||
| YDBJ_ECOLI | P0ACW2 | ydbJ | b4529 JW5215 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YdbJ | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 25 | 0.374 | SpII | 16 | 17.2226 | Pos+2=S | 0 | 0 | Y | n3-14c19/20o | Unknown | 2 | 24 | |||||||||||
| YDCA_ECOLI | P0ACW4 | ydcA | b1419 JW1416 | periplasmic protein (SEC through IM), YdcA | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 21 | 0.761 | SpI | 20 | 12.9463 | - | 0 | 0 | Y | n4-15c20/21o | Unknown | 2 | ||||||||||
| YDGC_ECOLI | P0ACX0 | ydgC | b1607 JW1599 | integral IM protein (SEC in IM), YdgC | Integral Inner Membrane | Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996 | PMID: 15919996 PMID: 16429150 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | in/out, out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.169 | TMH | 0 | 3.73379 | - | 4 | 3 | Y | n7-17c21/22o31-47i59-79o85-108i | CytoplasmicMembrane | 10 | 23 | |||||
| YEAL_ECOLI | P0ACY6 | yeaL | b1789 JW1778 | integral IM protein (SEC in IM), UPF0756 YeaL | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 25 | 0.203 | TMH | 0 | 8.39191 | - | 4 | 4 | Y | n4-12c16/17o26-46i53-71o83-100i112-145o | CytoplasmicMembrane | 10 | |||||||||
| YEBS_ECOLI | P0AD03 | yebS | b1833 JW1822 | integral IM protein (SEC in IM), Intertransport YebS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 57 | 0.112 | CYT | 0 | -0.200913 | - | 8 | 8 | N | i66-84o120-141i162-179o185-208i266-291o311-339i360-378o384-406i | CytoplasmicMembrane | 10 | |||||||
| BTSS_ECOLI | P0AD14 | btsS yehU | yehU | b2126 JW5353 | integral IM protein (SEC in IM), Sensor histidine kinase BtsS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.144 | TMH | 0 | 6.36838 | - | 6 | 6 | N | i7-24o44-62i74-93o105-129i141-163o175-195i | CytoplasmicMembrane | 10 | 2 | |||||
| YOHC_ECOLI | P0AD17 | yohC | b2135 JW5356 | integral IM protein (SEC in IM), YohC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 45 | 0.135 | TMH | 0 | 2.03436 | - | 5 | 5 | N | i33-53o65-91i103-122o128-149i170-190o | CytoplasmicMembrane | 10 | 16 | ||||||
| YOHK_ECOLI | P0AD19 | yohK | b2142 JW2130 | integral IM protein (SEC in IM), YohK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 24 | 0.211 | TMH | 0 | 1.42711 | - | 6 | 4 | Y | n7-18c23/24o33-52i91-112o132-162i206-230o | CytoplasmicMembrane | 10 | |||||||
| YEJM_ECOLI | P0AD27 | yejM yejN | yejN | b2188 JW2176 | integral IM protein (SEC in IM), YejM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 68 | 0.133 | TMH | 0 | 14.6981 | - | 5 | 5 | N | i21-39o51-73i85-103o135-157i169-191o | CytoplasmicMembrane | 10 | 2 | |||||
| YFCA_ECOLI | P0AD30 | yfcA | b2327 JW2324 | integral IM protein (SEC in IM), Probable transporter YfcA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 54 | 0.218 | TMH | 0 | 11.5476 | - | 7 | 8 | N | i7-28o53-73i85-105o111-127i139-158o164-183i195-217o237-255i | CytoplasmicMembrane | 10 | |||||||
| PGPC_ECOLI | P0AD42 | pgpC yfhB | yfhB | b2560 JW5408 | integral IM protein (SEC in IM), Phosphatidylglycerophosphatase C PgpC | Integral Inner Membrane | Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 25403562 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | YfgM | no | yes | N | 52 | 0.106 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o36-54i | CytoplasmicMembrane | 9 | 8 | |||
| YFHG_ECOLI | P0AD44 | yfhG | b2555 JW2539 | OM lipoprotein (TAT-SEC through IM, inserted in OM by LOL), YfhG | Outer Membrane Lipoprotein | TAT secretion system. | PMID: 17218314 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | TAT,SEC | LOL | yes | yes | Y | 23 | 0.159 | SpII | 25 | 6.96106 | Pos+2=V | 0 | 0 | Y | n13-24c29/30o | Unknown | 2 | 55 | ||||||||
| YPHA_ECOLI | P0AD47 | yphA | b2543 JW2527 | integral IM protein (SEC in IM), YphA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 58 | 0.13 | TMH | 0 | 13.6817 | - | 4 | 4 | N | i12-33o53-74i81-100o120-137i | CytoplasmicMembrane | 10 | |||||||
| IVY_ECOLI | P0AD59 | ivy ykfE | ykfE | b0220 JW0210 | periplasmic protein (SEC through IM), Inhibitor of vertebrate lysozyme Ivy | Periplasmic | Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 11278658 Disulfide bridge (85 90) Disulfide bond-containing protein PMID: 25664544 | PMID: 11278658 PMID: 25664544 PMID: 9868784 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 29 | 0.849 | SpI | 28 | 16.6514 | - | 0 | 0 | Y | n13-23c28/29o | Periplasmic | 10 | 27 | |||||||
| MRDA_ECOLI | P0AD65 | mrdA pbpA | pbpA | b0635 JW0630 | integral IM protein (SEC in IM), PG D,D-transpeptidase MrdA | Integral Inner Membrane | PMID: 1103132 PMID: 15919657 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Soluble IM Fraction, Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 37 | 0.174 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i21-40o | CytoplasmicMembrane | 9 | 8 | |||||
| FTSI_ECOLI | P0AD68 | ftsI pbpB | pbpB | b0084 JW0082 | integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI | Integral Inner Membrane | The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein. Localizes to potential division sites in filamentous cells. Interacts directly with FtsN and ZapA. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex. | PMID: 11703663 PMID: 20497333 PMID: 20847002 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 37 | 0.141 | SpI | 45 | 3.45111 | - | 1 | 1 | N | i20-44o | CytoplasmicMembrane | 9 | 22 | ||||
| LIVJ_ECOLI | P0AD96 | livJ | b3460 JW3425 | periplasmic protein (SEC through IM), Leu/Ile/Val-binding LivJ | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 19953543 PMID: 22030350 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 24 | 0.832 | SpI | 23 | 20.6668 | - | 0 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 96 | |||||||
| BRNQ_ECOLI | P0AD99 | brnQ | b0401 JW0391 | integral IM protein (SEC-YidC in IM), Branched-chain amino acid transport system 2 carrier BrnQ | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 25 | 0.304 | TMH | 0 | 15.0757 | - | 12 | 12 | N | i12-29o41-64i76-98o118-138i150-171o191-212i224-246o281-307i314-333o339-359i371-389o409-426i | CytoplasmicMembrane | 10 | ||||||
| TESA_ECOLI | P0ADA1 | tesA apeA pldC | apeA pldC | b0494 JW0483 | periplasmic protein (SEC through IM), Thioesterase 1/protease 1/lysophospholipase L1 TesA | Periplasmic | PMID: 8098033 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | N | 27 | 0.484 | SpI | 26 | 11.0906 | - | 1 | 0 | Y | n12-22c26/27o | Periplasmic | 10 | 40 | ||||||||
| NLPD_ECOLI | P0ADA3 | nlpD | b2742 JW2712 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein hydrolase activator NlpD | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell inner membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 25 | 0.134 | SpII | 25 | 21.9047 | Pos+2=S | 0 | 0 | Y | n13-24c29/30o | OuterMembrane | 9 | 85 | |||||||
| YAJG_ECOLI | P0ADA5 | yajG | b0434 JW0424 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YajG | Outer Membrane Lipoprotein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 9298646 | PMID: 15911532 PMID: 20932056 PMID: 9298646 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 20 | 0.403 | SpII | 17 | 19.0402 | Pos+2=A | 0 | 0 | Y | n5-15c19/20o | Unknown | 2 | ||||||||
| OSMB_ECOLI | P0ADA7 | osmB | b1283 JW1275 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Osmotically-inducible B OsmB | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 24 | 0.336 | SpII | 23 | 22.8573 | Pos+2=S | 0 | 0 | Y | n9-17c22/23o | CytoplasmicMembrane | 9 | ||||||||
| OSME_ECOLI | P0ADB1 | osmE anr | anr | b1739 JW1728 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Osmotically-inducible putative OsmE | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell inner membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.207 | SpII | 20 | 20.0226 | Pos+2=T | 1 | 0 | Y | n7-18c23/24o | Unknown | 2 | 98 | ||||||
| ECNA_ECOLI | P0ADB4 | ecnA | b4410 JW5737 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Entericidin A EcnA | Outer Membrane Lipoprotein | Small membrane protein detected experimentally. Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 19121005 | Outer Membrane Lipoprotein | I | N/A | Cell membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 23 | 0.254 | SpII | 18 | 14.5257 | Pos+2=N | 0 | 0 | Y | n5-16c21/22o | CytoplasmicMembrane | 10 | ||||||||
| ECNB_ECOLI | P0ADB7 | ecnB yjeU | yjeU | b4411 JW4108 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Entericidin B EcnB | Outer Membrane Lipoprotein | Potentially toxic protein. Proven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130 | PMID: 15174130 PMID: 19121005 PMID: 20932056 PMID: 21541338 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 22 | 0.27 | SpII | 21 | 17.5085 | Pos+2=N | 1 | 0 | Y | n5-15c20/21o | CytoplasmicMembrane | 10 | |||||||
| LPTE_ECOLI | P0ADC1 | lptE rlpB | rlpB | b0641 JW0636 | OM lipoprotein (SEC through IM), inserted in OM by LOL), LPS-assembly LptE | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 16861298 | PMID: 15174130 PMID: 16861298 PMID: 20932056 PMID: 22901060 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 25 | 0.125 | SpII | 18 | 17.3262 | Pos+2=G | 0 | 0 | Y | n4-15c20/21o | OuterMembrane | 10 | 80 | ||||||
| LOLC_ECOLI | P0ADC3 | lolC ycfU | ycfU | b1116 JW5161 | integral IM protein (SEC in IM), Lipoprotein-releasing system TM protein LolC | Integral Inner Membrane | PMID: 10783239 PMID: 15276320 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 19 | 0.179 | TMH | 0 | 2.37377 | - | 4 | 5 | N | o25-48i269-290o310-336i343-360o366-385i | CytoplasmicMembrane | 10 | 29 | |||||
| LPTG_ECOLI | P0ADC6 | lptG yjgQ | yjgQ | b4262 JW5760 | integral IM protein (SEC in IM), polysaccharide export system permease LptG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.105 | TMH | 0 | 4.7678 | - | 6 | 6 | N | i12-33o66-84i105-125o279-298i305-322o334-356i | CytoplasmicMembrane | 10 | 9 | |||||
| YJJB_ECOLI | P0ADD2 | yjjB | b4363 JW4327 | integral IM protein (SEC in IM), UPF0442 YjjB | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.153 | TMH | 0 | 7.02974 | - | 3 | 5 | N | o6-27i34-52o58-75i87-109o129-151i | CytoplasmicMembrane | 10 | 11 | ||||||||
| YJJP_ECOLI | P0ADD5 | yjjP | b4364 JW5796 | integral IM protein (SEC in IM), YjjP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.178 | CYT | 0 | -0.200913 | - | 3 | 5 | N | i114-135o141-158i170-189o195-214i226-252o | CytoplasmicMembrane | 10 | 16 | ||||||
| TAMA_ECOLI | P0ADE4 | tamA yftM ytfM | yftM ytfM | b4220 JW4179 | OM b-barrel protein (SEC through IM, inserted in OM by BAM and TAM), Translocation and assembly module subunit TamA | Outer Membrane b-barrel protein | Part of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria. | PMID: 17214547 PMID: 22466966 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | BAM | yes | yes | Y | 22 | 0.861 | SpI | 21 | 11.5811 | - | 0 | 0 | Y | n7-15c21/22o | OuterMembrane | 10 | |||||||
| YGFZ_ECOLI | P0ADE8 | ygfZ yzzW | yzzW | b2898 JW2866 | cytoplasmic & periplasmic protein (SEC through IM), tRNA-modifying YgfZ | Cytoplasmic, Periplasmic | Subcellular localization analysis of cytotoxic necrotizing factor 1 <a href="http://www.uniprot.org/uniprot/Q1R2U0">(CNF1)</a> demonstrated that YgfZ, a periplasmic protein, contributes to secretion of CNF1 (a normally cytoplasmic protein) into outer-membrane vesicles (OMVs) in pathogenic E.coli strain RS218 O18:K1:H7 PMID: 22174383. PMID: 9298646 | PMID: 22174383 PMID: 9298646 | Cytoplasmic, Periplasmic | A, G | N/A | Cytoplasm | Cytoplasmic (Experimental) | SEC | yes | yes | N | 31 | 0.252 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 2 | 82 | |||||||
| YHHN_ECOLI | P0ADI9 | yhhN | b3468 JW3433 | integral IM protein (SEC in IM), YhhN | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.165 | TMH | 0 | 7.64349 | - | 6 | 6 | Y | n3-14c18/19o34-64i76-96o102-123i130-152o158-177i189-207o | CytoplasmicMembrane | 10 | |||||||||
| BCSF_ECOLI | P0ADJ5 | bcsF yhjT | yhjT | b3537 JW5663 | integral IM protein (SEC in IM), Cellulose biosynthesis BcsF | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 26 | 0.211 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-25i | Unknown | 2 | 68 | |||||||
| YIAA_ECOLI | P0ADJ8 | yiaA | b3562 JW3534 | integral IM protein (SEC in IM), YiaA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 22 | 0.118 | TMH | 0 | 7.26426 | - | 4 | 4 | N | i12-30o42-62i74-94o106-125i | CytoplasmicMembrane | 10 | 59 | ||||||
| YIAF_ECOLI | P0ADK0 | yiaF | b3554 JW5655 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YiaF | Uncharacterized protein yiaF - echolocation Occurrence of signal peptide determined by LipoP signal sequence shown based upon lipoP, not possible to determine which membrane based on +2 amino acid rule. | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Membrane Lipoprotein | SEC | LOL | yes | yes | N | 28 | 0.132 | SpII | 25 | 10.3533 | Pos+2=F | 1 | 0 | Y | n10-21c26/27o | Unknown | 2 | 67 | ||||||||||
| YIAW_ECOLI | P0ADK4 | yiaW | b3587 JW3559 | integral IM protein (SEC in IM), YiaW | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.107 | TMH | 0 | 11.1792 | - | 2 | 2 | N | o6-25i46-66o | CytoplasmicMembrane | 10 | 20 | ||||||
| NEPI_ECOLI | P0ADL1 | nepI yicM | yicM | b3662 JW5938 | integral IM protein (SEC in IM), Purine ribonucleoside efflux pump NepI NepI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.151 | TMH | 0 | 8.80109 | - | 12 | 12 | N | i21-44o56-75i87-106o112-133i145-164o176-196i217-239o254-275i282-301o307-329i341-363o369-389i | CytoplasmicMembrane | 10 | ||||||
| YICN_ECOLI | P0ADL3 | yicN | b3663 JW5637 | integral IM protein (SEC in IM), YicN | Echolocation says Membrane anchored, one or two TMH predicted, if signal peptide is also predicted these TMH(s) are not removed as it is probably not cleaved. | Integral Inner Membrane | B | - | N/A | Membrane anchored | SRP | SEC | yes | yes | N | 27 | 0.132 | CYT | 0 | -0.200913 | - | 1 | 0 | Y | n6-17c21/22o | Unknown | 2 | 23 | |||||||||
| YIDG_ECOLI | P0ADL6 | yidG | b3675 JW3651 | integral IM protein (SEC in IM), YidG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.125 | TMH | 0 | 5.45771 | - | 3 | 3 | N | i21-39o45-65i91-116o | CytoplasmicMembrane | 10 | 21 | ||||||
| YIDH_ECOLI | P0ADM0 | yidH | b3676 JW3652 | integral IM protein (SEC in IM), YidH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.135 | TMH | 0 | 1.23486 | - | 3 | 3 | N | i21-39o54-72i93-114o | CytoplasmicMembrane | 10 | 20 | ||||||
| YIDQ_ECOLI | P0ADM4 | yidQ | b3688 JW5633 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YidQ | Inner Membrane Lipoprotein | PMID: 11274153 | Inner Membrane Lipoprotein | E | N/A | Outer membrane Lipoprotein(experimental) | SEC | LOL | yes | yes | Y | 27 | 0.185 | SpII | 20 | 16.396 | Pos+2=S | 0 | 0 | Y | n5-18c26/27o | Unknown | 2 | 114 | |||||||||
| YIDX_ECOLI | P0ADM6 | yidX | b3696 JW5858 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YidX | Outer Membrane Lipoprotein | I | N/A | Membrane | Outer membrane Lipoprotein | SEC | LOL | pseudogene (Ochman & Davalos, 2006) | no | yes | Y | 29 | 0.411 | SpII | 23 | 20.6632 | Pos+2=I | 1 | 0 | Y | n11-21c26/27o | Unknown | 2 | 54 | |||||||||
| YIFL_ECOLI | P0ADN6 | yifL | b4558 JW3781 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YifL | Outer Membrane Lipoprotein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16397293 | PMID: 15911532 PMID: 16397293 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 24 | 0.159 | SpII | 19 | 27.2584 | Pos+2=G | 1 | 0 | Y | n7-18c23/24o | Unknown | 2 | ||||||||
| YIGM_ECOLI | P0ADP5 | yigM | b3827 JW3803 | integral IM protein (SEC in IM), Biotin transporter YigM | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 20 | 0.164 | TMH | 0 | 6.74192 | - | 10 | 9 | Y | n2-13c19/20o29-47i59-81o87-105i112-130o136-158i170-190o202-222i234-253o259-276i | CytoplasmicMembrane | 10 | |||||||||
| YIID_ECOLI | P0ADQ2 | yiiD | b3888 JW3859 | integral IM protein (SEC in IM), YiiD | Integral Inner Membrane | Copurifies with trigger factor in pull down assays. | PMID: 19737520 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cytoplasmic | SRP,TF | SEC | no | yes | N | 29 | 0.101 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o219-240i | Cytoplasmic | 8 | 53 | ||||||
| YGAM_ECOLI | P0ADQ7 | ygaM | b2672 JW2647 | integral IM protein (SEC in IM), YgaM | Integral Inner Membrane | YgaM is paralogous to YqjD and binds to ribsomes in a similar manner to YqjD. PMID: 22661687 | PMID: 22661687 | Integral Inner Membrane | B | Bin | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 40 | 0.127 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i87-106o | Unknown | 2 | 50 | |||||
| YQAA_ECOLI | P0ADR0 | yqaA | b2689 JW2664 | integral IM protein (SEC in IM), YqaA | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996 | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 19 | 0.233 | TMH | 0 | 5.40517 | - | 4 | 3 | Y | n4-12c17/18o41-65i86-110o116-141i | CytoplasmicMembrane | 10 | 4 | |||||
| YGDD_ECOLI | P0ADR2 | ygdD | b2807 JW2778 | integral IM protein (SEC in IM), UPF0382 YgdD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.249 | TMH | 0 | 14.4685 | - | 4 | 3 | Y | n7-20c24/25o40-61i68-91o97-121i | CytoplasmicMembrane | 10 | |||||||
| YGGE_ECOLI | P0ADS6 | yggE | b2922 JW2889 | periplasmic protein (SEC through IM), YggE | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.409 | SpI | 21 | 16.0009 | - | 0 | 0 | Y | n5-16c21/22o | Periplasmic | 9 | 111 | ||||||||||||
| YGGN_ECOLI | P0ADS9 | yggN | b2958 JW2925 | periplasmic protein (SEC through IM), YggN | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 14726535 | PMID: 14726535 PMID: 19953543 | Periplasmic | G | N/A | Periplasmic(experimental) | SEC | DSBA | yes | yes | Y | 21 | 0.797 | SpI | 20 | 21.2471 | - | 0 | 0 | Y | n6-16c20/21o | Unknown | 2 | 80 | ||||||||
| YGIM_ECOLI | P0ADT8 | ygiM | b3055 JW3027 | integral IM protein (SEC in IM), YgiM | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Membrane | Membrane anchored | SRP | SEC | yes | yes | Y | 23 | 0.542 | SpI | 22 | 18.2018 | - | 1 | 1 | Y | n6-17c22/23o173-195i | Unknown | 2 | 12 | ||||||||
| YGIW_ECOLI | P0ADU5 | ygiW | b3024 JW2992 | periplasmic protein (SEC through IM), YgiW | Periplasmic | SecB substrate. PMID: 9298646 | PMID: 16352602 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SECB | SEC | yes | yes | Y | 21 | 0.877 | SpI | 20 | 26.1756 | - | 0 | 0 | Y | n4-15c20/21o | Unknown | 2 | 28 | |||||||
| LPTA_ECOLI | P0ADV1 | lptA yhbN | yhbN | b3200 JW3167 | periplasmic protein (SEC through IM), polysaccharide export system LptA | Periplasmic | PMID: 17056748 PMID: 18480051 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic(experimental) | SEC | yes | yes | Y | 28 | 0.838 | SpI | 27 | 24.4302 | - | 0 | 0 | Y | n12-23c27/28o | Unknown | 2 | 23 | ||||||||
| MLAC_ECOLI | P0ADV7 | mlaC yrbC | yrbC | b3192 JW3159 | periplasmic protein (SEC through IM), Interphospholipid transport system binding MlaC | Periplasmic | PMID: 15911532 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.509 | SpI | 21 | 14.0896 | - | 0 | 0 | Y | n8-16c21/22o | Unknown | 2 | 61 | ||||||||
| LPTC_ECOLI | P0ADV9 | lptC yrbK | yrbK | b3199 JW3166 | integral IM protein (SEC in IM), polysaccharide export system LptC | Integral Inner Membrane | Echolocation says Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold) | PMID: 18424520 PMID: 20720015 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 26 | 0.212 | SpI | 25 | 7.46611 | - | 1 | 0 | Y | n7-18c27/28o | Unknown | 2 | 51 | ||||
| YHCB_ECOLI | P0ADW3 | yhcB | b3233 JW5539 | integral IM protein (SEC in IM), YhcB | Integral Inner Membrane | Has been isolated from inner membrane preparations in a complex with one subunit each of CydA and CydB, suggesting that YhcB is in fact a subunit of the cytochrome bd ubiquinol oxidase complex. YhcB was demonstrated to interact with RodZ as well as several other proteins involved in cell shape maintenance and an inner membrane protein YciS of unknown function, using bacterial two-hybrid system.These observations seem to indicate that YhcB is involved in the biogenesis of cell envelope and the maintenance of cell shape together with RodZ. <a href="http:/ | PMID: 15919657 PMID: 16079137 PMID: 21210718 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 21 | 0.134 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-24i | CytoplasmicMembrane | 9 | 83 | |||||
| YHHA_ECOLI | P0ADX7 | yhhA | b3448 JW3413 | periplasmic protein (SEC through IM), YhhA | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 18 | 0.377 | SpI | 17 | 14.5283 | - | 0 | 0 | Y | n4-11c17/18o | Unknown | 2 | 107 | ||||||||||||
| PPID_ECOLI | P0ADY1 | ppiD ybaU | ybaU | b0441 JW0431 | integral IM protein (SEC in IM), Peptidyl-prolyl cis-trans isomerase D PpiD | Integral Inner Membrane | By in vivo and in vitro site-directed cross-linking, it has been demostrated that the periplasmic chaperone PpiD is located in front of the lateral gate of SecY, through which transmembrane domains exit the SecY channel. Blue native PAGE analyses verify the presence of a SecYEG-PpiD complex in native Escherichia coli membranes. PMID: 24951590 Consistent with a coupling between translocation across the SecYEG translocon and folding by periplasmic chaperones, a lack of PpiD retards the release of a translocating outer membrane protein into the periplasm. PMID: 18439025 | PMID: 16079137 PMID: 18439025 PMID: 24951590 PMID: 9670013 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.199 | TMH | 0 | 3.55242 | - | 1 | 1 | N | i12-35o | CytoplasmicMembrane | 10 | 52 | ||||
| YAJC_ECOLI | P0ADZ7 | yajC | b0407 JW0397 | integral IM protein (SEC in IM), Sec translocon accessory complex subunit YajC | Integral Inner Membrane | Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 | PMID: 16079137 PMID: 21541338 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 17 | 0.156 | TMH | 0 | -0.000234246 | - | 1 | 1 | N | o20-39i | CytoplasmicMembrane | 10 | 41 | |||||
| ACRA_ECOLI | P0AE06 | acrA lir mtcA | lir mtcA | b0463 JW0452 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug efflux pump subunit AcrA | Inner Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 10894736 | PMID: 10894736 PMID: 15174130 PMID: 15228545 PMID: 16079137 | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Cell inner membrane | Inner membrane lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 22 | 0.194 | SpII | 24 | 19.636 | Pos+2=D | 0 | 0 | Y | n6-16c21/22o | CytoplasmicMembrane | 10 | 64 | ||||||
| AMPE_ECOLI | P0AE14 | ampE | b0111 JW0107 | integral IM protein (SEC in IM), AmpE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 23 | 0.115 | CYT | 0 | -0.200913 | - | 4 | 4 | Y | n2-12c16/17o40-58i65-85o148-168i266-283o | CytoplasmicMembrane | 10 | 3 | ||||||
| AMPG_ECOLI | P0AE16 | ampG | b0433 JW0423 | integral IM protein (SEC-YidC in IM), AmpG | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 38 | 0.305 | TMH | 0 | 12.6077 | - | 14 | 14 | N | i15-38o44-61i82-101o107-131i143-165o177-195i225-250o262-281i288-309o321-342i354-376o382-402i423-445o465-485i | CytoplasmicMembrane | 10 | ||||||
| APHA_ECOLI | P0AE22 | aphA napA yjbP | napA yjbP | b4055 JW4015 | periplasmic protein (SEC through IM), Class B acid phosphatase AphA | Periplasmic | PMID: 9011040 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 26 | 0.643 | SpI | 25 | 14.5914 | - | 0 | 0 | Y | n7-17c25/26o | Unknown | 2 | |||||||||
| ARAE_ECOLI | P0AE24 | araE | b2841 JW2809 | integral IM protein (SEC-YidC in IM), Arabinose-proton symporter AraE | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 45 | 0.136 | TMH | 0 | 7.37397 | - | 12 | 12 | N | i23-51o63-84i91-110o116-137i149-167o179-198i258-281o297-317i329-348o360-384i405-422o428-446i | CytoplasmicMembrane | 10 | ||||||
| ARAH_ECOLI | P0AE26 | araH | b4460 JW1887 | integral IM protein (SEC-YidC in IM), L-arabinose transport system permease AraH | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | pseudogene (Ochman & Davalos, 2006) | no | yes | N | 47 | 0.147 | TMH | 0 | 13.0464 | - | 9 | 10 | N | i21-42o54-72i79-96o102-124i131-150o170-191i222-240o252-269i276-295o301-317i | CytoplasmicMembrane | 10 | |||||
| ARTM_ECOLI | P0AE30 | artM | b0861 JW0845 | integral IM protein (SEC-YidC in IM), Arginine ABC transporter permease ArtM | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 27 | 0.106 | TMH | 0 | 12.0162 | - | 5 | 5 | N | o20-39i51-70o82-100i155-176o188-211i | CytoplasmicMembrane | 10 | ||||||
| ARTQ_ECOLI | P0AE34 | artQ | b0862 JW0846 | integral IM protein (SEC-YidC in IM), Arginine ABC transporter permease ArtQ | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 30 | 0.173 | TMH | 0 | 17.1037 | - | 4 | 5 | N | o12-35i42-68o101-118i161-182o202-223i | CytoplasmicMembrane | 10 | 26 | |||||
| YQAE_ECOLI | P0AE42 | yqaE | b2666 JW2641 | integral IM protein (SEC in IM), UPF0057 YqaE | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.14 | TMH | 0 | 6.73627 | - | 2 | 1 | N | o23-48i | CytoplasmicMembrane | 10 | |||||||||
| YTFL_ECOLI | P0AE45 | ytfL | b4218 JW4177 | integral IM protein (SEC in IM), UPF0053 YtfL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.622 | SpI | 26 | 9.49148 | - | 4 | 3 | Y | n5-18c26/27o56-80i100-119o139-162i | CytoplasmicMembrane | 10 | 48 | ||||||
| CITT_ECOLI | P0AE74 | citT ybdS | ybdS | b0612 JW0604 | integral IM protein (SEC in IM), Citrate/succinate antiporter CitT | Integral Inner Membrane | PMID: 9696764 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 58 | 0.164 | TMH | 0 | 13.6692 | - | 13 | 14 | N | i7-27o33-50i57-74o94-117i138-155o161-178i190-213o233-259i288-304o310-329i341-361o381-412i424-443o463-486i | CytoplasmicMembrane | 10 | ||||||
| CPXA_ECOLI | P0AE82 | cpxA ecfB eup ssd | ecfB eup ssd | b3911 JW3882 | integral IM protein (SEC-YidC in IM), Sensor histidine kinase CpxA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 19 | 0.111 | TMH | 0 | 1.20569 | - | 2 | 2 | N | o6-27i165-184o | CytoplasmicMembrane | 10 | 16 | ||||
| CPXP_ECOLI | P0AE85 | cpxP yiiO | yiiO | b4484 JW5558 | periplasmic peripheral IM protein (SEC through IM), CpxP | Peripheral inner membrane protein facing the periplasm | PMID: 10972835 PMID: 17904518 PMID: 21317318 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasm | Membrane associated (Experimental) | SEC | pseudogene (Ochman & Davalos, 2006) | yes | yes | Y | 22 | 0.806 | SpI | 21 | 16.0374 | - | 0 | 0 | Y | n3-14c21/22o | Periplasmic | 10 | 104 | |||||||
| CREA_ECOLI | P0AE91 | creA yjjD | yjjD | b4397 JW4360 | periplasmic protein (SEC through IM), CreA | Periplasmic | Identified DsbA substrate PMID: 19953543 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | DSBA | yes | yes | Y | 22 | 0.8 | SpI | 21 | 14.9398 | - | 0 | 0 | Y | n6-16c21/22o | Unknown | 2 | ||||||||
| CSGE_ECOLI | P0AE95 | csgE | b1039 JW1022 | Curli related periplasmic protein (SEC through IM), Curli production assembly/transport component CsgE | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Curli secretion specificity factor. CsgE provides substrate specificity to the curli secretion pore CsgG, and acts directly on the secretion substrate CsgA to prevent premature subunit assembly. PMID: 9928475 | PMID: 16704339 PMID: 18498364 PMID: 19131513 PMID: 21645131 PMID: 9928475 | Periplasmic | G | N/A | Periplasmic (Experimental) | Curli | SEC | SURA | yes | yes | Y | 23 | 0.789 | SpI | 22 | 3.89784 | - | 0 | 0 | Y | n7-17c22/23o | Unknown | 2 | 15 | |||||||
| CSGF_ECOLI | P0AE98 | csgF | b1038 JW1021 | Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Curli production assembly/transport component CsgF | Peripheral outer membrane protein facing the extra-cellular space | Curli component. CsgF is secreted to the cell surface, where it mediates the cell-association and protease-resistance of the CsgB nucleator, suggesting that CsgF is required for specific localization and/or chaperoning of CsgB for full nucleator activity. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9928475 | PMID: 16522795 PMID: 16704339 PMID: 19131513 PMID: 21645131 PMID: 9928475 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Cell outer membrane | Periplasmic (Experimental) | Curli | SEC | Curli | yes | yes | Y | 20 | 0.853 | SpI | 19 | 13.9164 | - | 1 | 0 | Y | n6-14c19/20o | Extracellular | 9 | 30 | ||||||
| CSGG_ECOLI | P0AEA2 | csgG | b1037 JW1020 | Curli related OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM), inserted in OM by LOL), Curli production assembly/transport component CsgG | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | Curli component. Proven signal peptidase II substrate. CsgG is an outer membrane protein required for the secretion of the two curli structural subunits CsgA and CsgB. CsgG is a lipoprotein that spans the outermembrane and assembles into an oligomeric annular-shaped structure with an inner diameter of approximately 2 nm (Margery L. Evans and Matthew R. Chapman in press). Overexpression of CsgG results in increased sensitivity to the small antibiotic erythromycin (740Da) but not the larger vancomycin (1440Da) suggesting that CsgG has a pore-like activity (Robinson et al 2006). PMID: 15174130 | PMID: 15174130 PMID: 16420357 PMID: 16704339 PMID: 19131513 PMID: 21645131 | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | I, F4 | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | Curli | SEC | LOL | yes | yes | Y | 20 | 0.544 | SpII | 15 | 12.9163 | Pos+2=L | 0 | 0 | Y | n4-13c18/19o | CytoplasmicMembrane | 9 | 44 | ||||||
| CYOE_ECOLI | P0AEA5 | cyoE | b0428 JW0418 | integral IM protein (SEC in IM), Protoheme IX farnesyltransferase CyoE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 58 | 0.11 | TMH | 0 | 2.59686 | - | 9 | 9 | N | i12-30o36-60i80-102o108-127i134-156o162-183i209-227o233-252i264-285o | CytoplasmicMembrane | 10 | |||||||
| CYSW_ECOLI | P0AEB0 | cysW | b2423 JW2416 | integral IM protein (SEC in IM), Sulfate transport system permease CysW | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.154 | TMH | 0 | 13.7791 | - | 6 | 6 | N | i20-43o63-89i101-124o144-162i202-228o248-268i | CytoplasmicMembrane | 10 | 52 | ||||||
| DACA_ECOLI | P0AEB2 | dacA pfv | pfv | b0632 JW0627 | periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacA | Peripheral inner membrane protein facing the periplasm | Anchored to inner membrane by C-terminal tailPMID: 2194801. Using natural isotope abundance NMR, the structure of the PBP 5 anchor peptide within a micelle was determinedPMID: 20192190. The structure conforms to a helix-bend-helix-turn-helix motif and reveals that the anchor enters the membrane so as to form an amphiphilic structure within the interface of the hydrophilic/hydrophobic boundary regions near the lipid head groups. PBP-5 deletion mutants exhibit irregular distribution of MreB at the deformed zones PMID: 20545860. PMID: 3279397 PMID: 8424800 DacA(PBP-5) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. A pH dependent loss of alpha-helical conformation in the peptide corresponding to the PBP5 C-terminus was found to correlate with the susceptibility of PBP5 to membrane extraction. PMID: 9371419 | PMID: 20192190 PMID: 20545860 PMID: 2194801 PMID: 24057063 PMID: 3279397 PMID: 8424800 PMID: 9371419 | Peripheral inner membrane protein facing the periplasm | F2 | Soluble IM Fraction | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side | Membrane anchored (Experimental) | SEC | yes | yes | Y | 30 | 0.737 | SpI | 29 | 17.6151 | - | 0 | 0 | Y | n13-24c29/30o | CytoplasmicMembrane | 9 | 8 | |||||||
| YNAI_ECOLI | P0AEB5 | ynaI | b1330 JW1323 | integral IM protein (SEC in IM), Low conductance mechanosensitive channel YnaI | Integral Inner Membrane | PMID: 15919996 PMID: 22874652 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.127 | TMH | 0 | 7.65863 | - | 4 | 5 | N | o12-30i42-65o77-96i117-134o140-159i | CytoplasmicMembrane | 10 | 14 | ||||||
| YOAE_ECOLI | P0AEC0 | yoaE | b1816 JW1805 | integral IM protein (SEC in IM), UPF0053 YoaE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.115 | TMH | 0 | 1.99313 | - | 7 | 7 | N | o12-36i48-69o81-101i122-148o154-172i184-207o213-231i | CytoplasmicMembrane | 10 | 10 | ||||||
| ARCB_ECOLI | P0AEC3 | arcB | b3210 JW5536 | integral IM protein (SEC in IM), Aerobic respiration control sensor ArcB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.18 | TMH | 0 | 9.51619 | - | 2 | 2 | N | o20-46i58-77o | CytoplasmicMembrane | 10 | |||||||
| BARA_ECOLI | P0AEC5 | barA | b2786 JW2757 | integral IM protein (SEC-YidC in IM), Signal transduction histidine-kinase BarA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 34 | 0.123 | TMH | 0 | 7.64299 | - | 2 | 2 | N | o12-31i177-199o | CytoplasmicMembrane | 10 | 56 | |||||
| DCUS_ECOLI | P0AEC8 | dcuS yjdH | yjdH | b4125 JW4086 | integral IM protein (SEC-YidC in IM), Sensor histidine kinase DcuS | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 48 | 0.105 | TMH | 0 | 5.80308 | - | 2 | 2 | N | i21-41o183-205i | CytoplasmicMembrane | 10 | 35 | ||||
| DCRB_ECOLI | P0AEE1 | dcrB yhhR | yhhR | b3472 JW5682 | IM lipoprotein (SEC through IM, inserted in OM by LOL), DcrB | Inner Membrane Lipoprotein | PMID: 12558182 PMID: 15911532 | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Periplasm | Inner membrane lipoprotein | SEC | LOL | yes | yes | N | 30 | 0.169 | SpII | 19 | 21.1 | Pos+2=D | 0 | 0 | Y | n8-15c20/21o | Periplasmic | 10 | 100 | |||||||
| DEGS_ECOLI | P0AEE3 | degS hhoB htrH | hhoB htrH | b3235 JW3204 | periplasmic protein (SEC through IM), Serine endoprotease DegS | Periplasmic | Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 | PMID: 11442831 PMID: 17360428 | Periplasmic | G | Soluble IM Fraction | Cell inner membrane | Membrane anchored | SEC | yes | yes | N | 28 | 0.167 | SpI | 28 | 4.49468 | - | 1 | 0 | Y | n9-20c28/29o | Periplasmic | 9 | 75 | |||||||
| DGAL_ECOLI | P0AEE5 | mglB GBP | GBP | b2150 JW2137 | periplasmic protein (SEC through IM), D-galactose-binding periplasmic MglB | Periplasmic | Potential Skp substrate PMID: 19953543 PMID: 7012152 PMID: 9298646 | PMID: 19953543 PMID: 7012152 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SKP | no | yes | Y | 24 | 0.861 | SpI | 23 | 23.7963 | - | 1 | 0 | Y | n5-16c23/24o | Periplasmic | 10 | 75 | ||||||
| DPPB_ECOLI | P0AEF8 | dppB | b3543 JW3512 | integral IM protein (SEC in IM), Dipeptide transport system permease DppB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.168 | TMH | 0 | 6.13051 | - | 6 | 6 | N | i9-30o100-123i135-160o201-221i259-285o305-331i | CytoplasmicMembrane | 10 | |||||||
| DPPC_ECOLI | P0AEG1 | dppC | b3542 JW3511 | integral IM protein (SEC-YidC in IM), Dipeptide transport system permease DppC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 59 | 0.13 | TMH | 0 | 0.391748 | - | 5 | 5 | N | o32-53i102-127o147-173i215-244o264-287i | CytoplasmicMembrane | 10 | 4 | |||||
| DSBA_ECOLI | P0AEG4 | dsbA dsf ppfA | dsf ppfA | b3860 JW3832 | periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbA | Periplasmic | Periplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential ??-barrel protein LptD. DsbA is co-translationally translocated through Sec translocon. PMID: 9298646 DsbA, is a substrate for the SRP pathway. PMID: 15838024 DsbA, is a substrate for the SRP pathway. PMID: 13129941 Disulfide bridge (49 52) PMID: 9300489 Disulfide bond-containing protein PMID: 25664544 | PMID: 13129941 PMID: 15838024 PMID: 18406599 PMID: 19525348 PMID: 20615876 PMID: 25664544 PMID: 9298646 PMID: 9300489 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SRP (exp) | SEC | yes | yes | Y | 20 | 0.75 | SpI | 19 | 16.7987 | - | 0 | 0 | Y | n4-15c19/20o | Periplasmic | 10 | 71 | ||||||
| DSBC_ECOLI | P0AEG6 | dsbC xprA | xprA | b2893 JW2861 | periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbC | Periplasmic | Periplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential ??-barrel protein LptD. PMID: 9298646 Disulfide bridge (118 121;161 183) PMID: 10700276 Disulfide bond-containing protein PMID: 25664544 | PMID: 10700276 PMID: 18406599 PMID: 20615876 PMID: 25664544 PMID: 8168498 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 21 | 0.778 | SpI | 20 | 21.5074 | - | 0 | 0 | Y | n4-15c20/21o | Periplasmic | 10 | 82 | |||||||
| RSEP_ECOLI | P0AEH1 | rseP ecfE yaeL | ecfE yaeL | b0176 JW0171 | integral IM protein (SEC in IM), Regulator of sigma-E protease RseP | Integral Inner Membrane | Fluorescent fusions of RseP have been monitored via fluorescence microscopy. RseP has been found to generally associated with the membrane. | PMID: 11689431 PMID: 11750129 PMID: 11867724 PMID: 15919996 PMID: 17272300 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.109 | TMH | 0 | 3.00034 | - | 4 | 4 | N | o6-29i98-119o376-396i426-444o | CytoplasmicMembrane | 10 | 16 | ||||
| ELAB_ECOLI | P0AEH5 | elaB yfbD | yfbD | b2266 JW2261 | integral IM protein (SEC in IM), ElaB | Integral Inner Membrane | ElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. ElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. Probably binds to the membrane and ribosomes in a manner similar to that of YqjD PMID: 22661687. | PMID: 22661687 | Integral Inner Membrane | B | Bout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 33 | 0.125 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o81-99i | Unknown | 2 | 99 | ||||
| YJIG_ECOLI | P0AEH8 | yjiG | b4329 JW4292 | integral IM protein (SEC in IM), YjiG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 36 | 0.157 | TMH | 0 | 2.83449 | - | 3 | 4 | N | i21-39o59-77i89-110o130-152i | CytoplasmicMembrane | 10 | 2 | ||||||
| EMRB_ECOLI | P0AEJ0 | emrB | b2686 JW2661 | integral IM protein (SEC-YidC in IM), Multidrug export EmrB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996 | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | yes | yes | N | 36 | 0.208 | TMH | 0 | 5.07213 | - | 13 | 13 | N | i12-33o53-72i81-100o106-128i140-161o167-189i201-220o232-251i272-291o303-324i336-353o365-390i480-498o | CytoplasmicMembrane | 10 | ||||||
| ENVZ_ECOLI | P0AEJ4 | envZ ompB perA tpo | ompB perA tpo | b3404 JW3367 | integral IM protein (SEC in IM), Osmolarity sensor EnvZ | Integral Inner Membrane | Contains HAMP an intrinsically disordered domain. EnvZ HAMP domain by itself is unable to form a stable structure and that this structural fragility may be important for its role in signal transduction. | PMID: 15522865 PMID: 15919996 PMID: 17635923 PMID: 2668953 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.263 | TMH | 0 | 7.11037 | - | 2 | 2 | N | i12-39o160-179i | CytoplasmicMembrane | 10 | |||||
| FDNI_ECOLI | P0AEK7 | fdnI | b1476 JW1472 | integral IM protein (SEC in IM), Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit FdnI | Integral Inner Membrane | PMID: 11266632 PMID: 11884747 PMID: 11929547 PMID: 15342602 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 37 | 0.156 | TMH | 0 | 22.1464 | - | 4 | 4 | N | i21-43o55-76i117-138o150-174i | CytoplasmicMembrane | 10 | 35 | ||||||
| FDOI_ECOLI | P0AEL0 | fdoI | b3892 JW3863 | integral IM protein (SEC in IM), Formate dehydrogenase, cytochrome b556(fdo) subunit FdoI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.115 | TMH | 0 | 16.4965 | - | 4 | 4 | N | i20-43o55-73i113-133o145-172i | CytoplasmicMembrane | 10 | 16 | ||||||
| FEPB_ECOLI | P0AEL6 | fepB | b0592 JW0584 | periplasmic protein (SEC through IM), Ferrienterobactin-binding periplasmic protein FepB | Periplasmic | PMID: 10986237 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.581 | SpI | 26 | 13.3736 | - | 0 | 0 | Y | n10-21c26/27o | Periplasmic | 10 | 30 | |||||||||
| FLGM_ECOLI | P0AEM4 | flgM | b1071 JW1058 | Flagellar cytoplasmic & extra-cellular protein (Flagellum secreted), Negative regulator of flagellin synthesis FlgM | Cytoplasmic, Extra-cellular | Anti-sigma28 factor. FlgM is an anti-sigma factor that binds and inactivates sigma28 (FliA_Ecoli). Once the hook and basal body is assembled, FlgM is secreted by the flagellar export system thereby freeing sigma28 to activate transcription. | PMID: 10322161 PMID: 12631703 PMID: 9988479 | Cytoplasmic, Extra-cellular | A, X | N/A | Cytoplasmic | Flagellum | Fla | yes | yes | N | 49 | 0.115 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | 89 | ||||||||
| FLIY_ECOLI | P0AEM9 | fliY yzzR | yzzR | b1920 JW1905 | periplasmic protein (SEC through IM), L-cystine-binding FliY | Periplasmic | PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | N | 30 | 0.555 | SpI | 29 | 10.7798 | - | 0 | 0 | Y | n10-21c29/30o | Periplasmic | 10 | 96 | ||||||||
| FTSL_ECOLI | P0AEN4 | ftsL mraR yabD | mraR yabD | b0083 JW0081 | IM lipoprotein (SEC through IM), Cell division FtsL | Inner Membrane Lipoprotein | Localizes to potential division sites in filamentous cells. Proven pignal peptidase II substrate. PMID: 1332942 | PMID: 10027987 PMID: 11703663 PMID: 11948172 PMID: 1332942 PMID: 15165235 PMID: 15174130 PMID: 21890895 | Inner Membrane Lipoprotein | E | IM (predicted) | Cell inner membrane | Membrane anchored (Experimental) | SEC | yes | yes | N | 24 | 0.167 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o35-57i | Cytoplasmic | 8 | 25 | |||||||
| GALP_ECOLI | P0AEP1 | galP | b2943 JW2910 | integral IM protein (SEC in IM), Galactose-proton symporter GalP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.158 | TMH | 0 | 14.2152 | - | 12 | 12 | N | i15-44o56-77i84-103o109-130i142-160o172-192i251-274o290-310i322-342o348-373i385-406o418-436i | CytoplasmicMembrane | 10 | |||||||
| GLNH_ECOLI | P0AEQ3 | glnH | b0811 JW0796 | periplasmic protein (SEC through IM), Glutamine-binding periplasmic GlnH | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 | PMID: 18498364 PMID: 22030350 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 23 | 0.851 | SpI | 22 | 19.9168 | - | 0 | 0 | Y | n7-18c22/23o | Periplasmic | 10 | 62 | |||||||
| GLNP_ECOLI | P0AEQ6 | glnP | b0810 JW0795 | integral IM protein (SEC in IM), Glutamine transport system permease GlnP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.119 | TMH | 0 | 7.24978 | - | 3 | 5 | N | o23-42i54-78o90-113i125-144o190-209i | CytoplasmicMembrane | 10 | |||||||
| GLPF_ECOLI | P0AER0 | glpF | b3927 JW3898 | integral IM protein (SEC in IM), Glycerol uptake facilitator GlpF | Integral Inner Membrane | PMID: 11039922 PMID: 11266632 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.125 | TMH | 0 | 9.6263 | - | 6 | 6 | N | i12-34o46-79i86-108o145-166i178-202o230-251i | CytoplasmicMembrane | 10 | |||||||
| GLTJ_ECOLI | P0AER3 | gltJ | b0654 JW0649 | integral IM protein (SEC in IM), Glutamate/aspartate import permease GltJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.108 | TMH | 0 | 9.38551 | - | 5 | 5 | N | o24-50i71-88o108-127i179-199o211-233i | CytoplasmicMembrane | 10 | |||||||
| GLTK_ECOLI | P0AER5 | gltK | b0653 JW0648 | integral IM protein (SEC in IM), Glutamate/aspartate import permease GltK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.129 | TMH | 0 | 7.84867 | - | 5 | 5 | N | o20-44i65-83o95-112i153-178o198-219i | CytoplasmicMembrane | 10 | |||||||
| GLTS_ECOLI | P0AER8 | gltS gltC | gltC | b3653 JW3628 | integral IM protein (SEC in IM), Sodium/glutamate symporter GltS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 27 | 0.145 | CYT | 0 | -0.200913 | - | 9 | 11 | Y | n7-18c26/27o36-52i72-90o96-119i126-148o160-184i215-239o245-268i275-297o303-323i335-357o369-394i | CytoplasmicMembrane | 10 | ||||||
| HDEA_ECOLI | P0AES9 | hdeA yhhC yhiB | yhhC yhiB | b3510 JW3478 | periplasmic protein (SEC through IM), Acid stress chaperone HdeA | Periplasmic | Experimentally verified gene-product. Verified that the signal peptide is cleaved. Falls into an unstructured form that is essential for its chaperone activity. The protein is dimeric at neutral pH but dissociates into a partially unfolded monomer at pH 2.0 PMID: 20080625. PMID: 8455549 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bridge (39 87) Disulfide bond-containing protein PMID: 25664544 | PMID: 10623550 PMID: 17085547 PMID: 20080625 PMID: 25403562 PMID: 25664544 PMID: 8455549 PMID: 9868784 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | YfgM | yes | yes | Y | 22 | 0.698 | SpI | 21 | 16.385 | - | 1 | 0 | Y | n4-15c21/22o | Unknown | 2 | 108 | ||||||
| HDEB_ECOLI | P0AET2 | hdeB yhhD yhiC | yhhD yhiC | b3509 JW5669 | periplasmic protein (SEC through IM), Acid stress chaperone HdeB | Periplasmic | Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 8455550 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bond-containing protein PMID: 25664544 | PMID: 17085547 PMID: 25403562 PMID: 25664544 PMID: 8455550 PMID: 9868784 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | YfgM | yes | yes | Y | 30 | 0.837 | SpI | 29 | 16.8932 | - | 0 | 0 | Y | n10-21c29/30o | Unknown | 2 | 63 | ||||||
| HDED_ECOLI | P0AET5 | hdeD yhiA | yhiA | b3511 JW3479 | integral IM protein (SEC in IM), HdeD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.139 | TMH | 0 | 3.36767 | - | 6 | 6 | N | i23-42o48-69i76-97o103-124i136-155o161-187i | CytoplasmicMembrane | 10 | ||||||
| HISJ_ECOLI | P0AEU0 | hisJ | b2309 JW2306 | periplasmic protein (SEC through IM), Histidine-binding periplasmic HisJ | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 19953543 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 23 | 0.792 | SpI | 22 | 20.7158 | - | 1 | 0 | Y | n4-14c22/23o | Periplasmic | 10 | ||||||||
| HISM_ECOLI | P0AEU3 | hisM | b2307 JW2304 | integral IM protein (SEC in IM), Histidine transport system permease HisM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.123 | TMH | 0 | 10.1822 | - | 4 | 3 | N | o20-45i57-79o200-221i | CytoplasmicMembrane | 10 | |||||||
| SKP_ECOLI | P0AEU7 | skp hlpA ompH | hlpA ompH | b0178 JW0173 | periplasmic protein (SEC through IM), Chaperone Skp | Periplasmic | Folding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamA. PMID: 2167239 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 | PMID: 1838129 PMID: 19525348 PMID: 21370981 PMID: 2167239 PMID: 22030350 PMID: 2318304 PMID: 23641708 PMID: 8730870 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic(experimental) | SEC | yes | yes | Y | 21 | 0.881 | SpI | 20 | 22.0906 | - | 0 | 0 | Y | n4-15c20/21o | Periplasmic | 10 | 48 | |||||||
| HYFE_ECOLI | P0AEW1 | hyfE | b2485 JW2470 | integral IM protein (SEC in IM), Hydrogenase-4 component E HyfE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 54 | 0.165 | TMH | 0 | 4.55769 | - | 7 | 7 | N | o6-24i31-54o60-80i92-114o126-143i152-171o177-196i | CytoplasmicMembrane | 10 | |||||||
| KGTP_ECOLI | P0AEX3 | kgtP witA | witA | b2587 JW2571 | integral IM protein (SEC in IM), Alpha-ketoglutarate permease KgtP | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | no | yes | N | 9 | 0.105 | TMH | 0 | 2.8422 | - | 12 | 12 | N | i21-42o62-84i96-116o122-139i160-183o195-214i244-266o278-299i311-331o337-360i372-393o405-423i | CytoplasmicMembrane | 10 | |||||
| LIVH_ECOLI | P0AEX7 | livH | b3457 JW3422 | integral IM protein (SEC in IM), High-affinity branched-chain amino acid transport system permease LivH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 45 | 0.186 | TMH | 0 | 16.6878 | - | 8 | 8 | N | o20-39i46-64o70-89i105-122o158-175i204-230o242-270i282-301o | CytoplasmicMembrane | 10 | |||||||
| MALE_ECOLI | P0AEX9 | malE | b4034 JW3994 | periplasmic & peripheral IM protein (SEC through IM), Maltose/maltodextrin-binding periplasmic MalE | Peripheral inner membrane protein facing the periplasm, periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. MalE is maintained in an unfolded conformation by the cytoplasmic chaperone SecB. Potential Skp substrate PMID: 19953543 PMID: 9298646 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 18498364 PMID: 1989077 PMID: 19953543 PMID: 25403562 PMID: 3009404 PMID: 9298646 | Peripheral inner membrane protein facing the periplasm, periplasmic | F2, G | N/A | Periplasm | Periplasmic (Experimental) | SecB | SEC | SURA,SKP,YfgM | yes | yes | Y | 27 | 0.712 | SpI | 26 | 17.3972 | - | 0 | 0 | Y | n9-17c26/27o | Periplasmic | 10 | 96 | ||||||
| MARC_ECOLI | P0AEY1 | marC ydeB ydeC | ydeB ydeC | b1529 JW1522 | integral IM protein (SEC in IM), UPF0056 MarC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 38 | 0.16 | TMH | 0 | 10.7793 | - | 5 | 5 | N | o12-32i44-62o68-89i151-172o192-214i | CytoplasmicMembrane | 10 | 5 | |||||
| MDFA_ECOLI | P0AEY8 | mdfA cmlA cmr | cmlA cmr | b0842 JW0826 | integral IM protein (SEC-YidC in IM), Multidrug transporter MdfA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 32 | 0.122 | TMH | 0 | 6.20433 | - | 12 | 12 | N | i15-33o53-72i84-103o109-130i142-164o170-188i221-246o258-275i287-308o314-335i347-367o379-399i | CytoplasmicMembrane | 10 | |||||
| MLTD_ECOLI | P0AEZ7 | mltD dniR yafG | dniR yafG | b0211 JW5018 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase D MltD | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 15174133 | PMID: 15174130 PMID: 15174133 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 27 | 0.22 | SpII | 15 | 18.5563 | Pos+2=Q | 0 | 0 | Y | n5-13c18/19o | Unknown | 2 | 29 | ||||||
| MODB_ECOLI | P0AF01 | modB chlJ | chlJ | b0764 JW0747 | integral IM protein (SEC in IM), Molybdenum transport system permease ModB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 34 | 0.137 | TMH | 0 | 8.18777 | - | 5 | 5 | N | o20-37i49-70o90-115i136-158o198-220i | CytoplasmicMembrane | 10 | 20 | |||||
| MOTB_ECOLI | P0AF06 | motB | b1889 JW1878 | integral IM protein (SEC in IM), Motility B MotB | Integral Inner Membrane | MotB has one membrane-spanning alpha-helix but the majority of the molecule is in the periplasmic space with a peptidoglycan-binding domain near its C-terminus PMID: 2447650 | PMID: 12730325 PMID: 19364805 PMID: 23193105 PMID: 2447650 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 32 | 0.155 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o28-47i | CytoplasmicMembrane | 7 | 33 | |||||
| MURJ_ECOLI | P0AF16 | murJ mviN yceN | mviN yceN | b1069 JW1056 | integral IM protein (SEC in IM), Lipid II flippase MurJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.165 | SpI | 23 | 0.241812 | - | 13 | 13 | N | o27-45i82-110o130-154i161-182o188-205i236-262o274-292i313-334o354-371i383-402o408-429i441-466o478-501i | CytoplasmicMembrane | 10 | ||||||
| NARV_ECOLI | P0AF32 | narV | b1465 JW1460 | integral IM protein (SEC in IM), Respiratory nitrate reductase 2 gamma chain NarV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.114 | TMH | 0 | 10.9916 | - | 5 | 5 | N | o12-29i50-69o89-111i132-151o180-199i | CytoplasmicMembrane | 10 | |||||||
| YIIR_ECOLI | P0AF34 | yiiR | b3921 JW3892 | integral IM protein (SEC in IM), YiiR | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.144 | TMH | 0 | 5.06913 | - | 4 | 4 | N | i20-38o44-63i75-93o99-121i | CytoplasmicMembrane | 10 | 49 | |||||||||
| YIJD_ECOLI | P0AF40 | yijD | b3964 JW3936 | integral IM protein (SEC in IM), YijD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.345 | TMH | 0 | 8.09717 | - | 4 | 3 | Y | n10-21c26/27o36-51i63-83o89-108i | CytoplasmicMembrane | 10 | 21 | ||||||
| YJBB_ECOLI | P0AF43 | yjbB | b4020 JW3980 | integral IM protein (SEC in IM), YjbB | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.13 | TMH | 0 | 1.33234 | - | 8 | 8 | Y | n2-13c17/18o45-64i76-98o104-121i133-151o171-194i206-226o238-262i274-294o | CytoplasmicMembrane | 10 | 4 | ||||||||
| YJBE_ECOLI | P0AF45 | yjbE | b4026 JW3986 | periplasmic protein (SEC through IM), YjbE | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 22 | 0.853 | SpI | 21 | 25.8362 | - | 0 | 0 | Y | n4-15c21/22o | Extracellular | 9 | |||||||||||||
| GHXP_ECOLI | P0AF52 | ghxP yjcD | yjcD | b4064 JW4025 | integral IM protein (SEC in IM), Guanine/hypoxanthine permease GhxP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 59 | 0.114 | CYT | 0 | -0.200913 | - | 13 | 13 | N | i29-49o55-74i81-101o107-129i141-165o171-195i202-220o256-280i301-321o333-350i357-378o390-416i428-448o | CytoplasmicMembrane | 10 | ||||||
| YJCH_ECOLI | P0AF54 | yjcH | b4068 JW4029 | integral IM protein (SEC in IM), YjcH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.119 | TMH | 0 | 4.65174 | - | 2 | 2 | N | i25-51o63-84i | CytoplasmicMembrane | 10 | 54 | ||||||
| YJCO_ECOLI | P0AF56 | yjcO | b4078 JW4039 | periplasmic protein (SEC through IM), Sel1-repeat-containing YjcO | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 18 | 0.752 | SpI | 17 | 13.9637 | - | 0 | 0 | Y | n4-13c17/18o | Unknown | 2 | 82 | |||||||||
| YJEI_ECOLI | P0AF70 | yjeI | b4144 JW5736 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YjeI | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130 | PMID: 12488465 PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 28 | 0.443 | SpII | 18 | 20.5638 | Pos+2=S | 0 | 0 | Y | n6-17c22/23o | Unknown | 2 | 87 | ||||||||
| YJET_ECOLI | P0AF73 | yjeT | b4176 JW4134 | integral IM protein (SEC in IM), YjeT | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.108 | TMH | 0 | 4.78812 | - | 2 | 1 | Y | n3-13c17/18o41-60i | CytoplasmicMembrane | 9 | 19 | ||||||||
| YJFL_ECOLI | P0AF80 | yjfL | b4184 JW4142 | integral IM protein (SEC in IM), UPF0719 YjfL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.123 | TMH | 0 | 8.65955 | - | 4 | 4 | N | o6-28i49-69o75-97i109-128o | CytoplasmicMembrane | 10 | 19 | ||||||
| YJFN_ECOLI | P0AF82 | yjfN | b4188 JW5742 | periplasmic protein (SEC through IM), YjfN | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | N | 20 | 0.293 | SpI | 21 | 7.51366 | - | 0 | 0 | Y | n4-15c23/24o | Unknown | 2 | 104 | |||||||||||
| YJFY_ECOLI | P0AF86 | yjfY | b4199 JW4157 | periplasmic protein (SEC through IM), YjfY | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 21 | 0.833 | SpI | 20 | 15.6931 | - | 0 | 0 | Y | n5-15c20/21o | Unknown | 2 | 93 | |||||||||||
| LPTF_ECOLI | P0AF98 | lptF yjgP | yjgP | b4261 JW4218 | integral IM protein (SEC in IM), polysaccharide export system permease LptF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.124 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i16-39o59-76i97-119o268-289i296-316o328-348i | CytoplasmicMembrane | 10 | 13 | |||||
| NARX_ECOLI | P0AFA2 | narX narR | narR | b1222 JW1213 | integral IM protein (SEC in IM), Nitrate/nitrite sensor NarX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.224 | SpI | 33 | 4.68578 | - | 2 | 2 | N | i12-36o154-174i | CytoplasmicMembrane | 10 | 44 | |||||
| NFRB_ECOLI | P0AFA5 | nfrB | b0569 JW0558 | integral IM protein (SEC in IM), Bacteriophage adsorption B NfrB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 20 | 0.134 | CYT | 0 | -0.200913 | - | 4 | 4 | N | o12-42i365-384o390-410i422-443o | CytoplasmicMembrane | 10 | 7 | ||||||
| NHAB_ECOLI | P0AFA7 | nhaB | b1186 JW1175 | integral IM protein (SEC in IM), Na(+)/H(+) antiporter NhaB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.149 | TMH | 0 | 10.0118 | - | 12 | 12 | N | o20-47i59-77o89-108i120-141o147-165i202-219o239-260i299-331o351-368i389-413o453-471i478-498o | CytoplasmicMembrane | 10 | |||||||
| NIKC_ECOLI | P0AFA9 | nikC | b3478 JW3443 | integral IM protein (SEC in IM), Nickel transport system permease NikC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 25 | 0.156 | TMH | 0 | 10.244 | - | 6 | 6 | N | i12-32o75-100i121-148o177-196i203-222o242-260i | CytoplasmicMembrane | 10 | |||||||
| NLPI_ECOLI | P0AFB1 | nlpI yhbM | yhbM | b3163 JW3132 | OM lipoprotein (SEC through IM, inserted in OM by LOL), NlpI | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 Induction of NlpI inhibits nucleoid division and halts cell growth. Elevation of NlpI expression enhances the transcription and the outer membrane localization of the heat shock protein IbpA and IbpB. NlpI physically interacts with IbpB. The C-terminus of NlpI is critical for the enhancement in IbpA and IbpB production, and the N-terminus of NlpI is required for the outer membrane localization of NlpI, IbpA, and IbpB. PMID: 25699035 | PMID: 15174130 PMID: 25699035 | Outer Membrane Lipoprotein | I | N/A | Cell membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 26 | 0.209 | SpII | 18 | 14.4676 | Pos+2=S | 0 | 0 | Y | n8-19c31/32o | CytoplasmicMembrane | 10 | 56 | ||||||
| NUOA_ECOLI | P0AFC3 | nuoA | b2288 JW2283 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit A NuoA | Integral Inner Membrane | Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 | PMID: 15919996 PMID: 21541338 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.182 | TMH | 0 | 12.5237 | - | 3 | 3 | N | o12-37i68-88o100-122i | CytoplasmicMembrane | 10 | 48 | |||||
| NUOH_ECOLI | P0AFD4 | nuoH | b2282 JW2277 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit H NuoH | Integral Inner Membrane | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 33 | 0.139 | TMH | 0 | 7.32865 | - | 8 | 9 | N | i12-32o52-69i81-100o112-133i154-174o186-207i234-257o269-289i301-322o | CytoplasmicMembrane | 10 | |||||||
| NUOJ_ECOLI | P0AFE0 | nuoJ | b2280 JW2275 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit J NuoJ | Integral Inner Membrane | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.504 | TMH | 0 | 10.2272 | - | 5 | 4 | Y | n3-14c18/19o28-49i56-74o94-112i133-158o | CytoplasmicMembrane | 10 | 82 | ||||||
| NUOK_ECOLI | P0AFE4 | nuoK | b2279 JW2274 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit K NuoK | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.166 | TMH | 0 | 8.16488 | - | 3 | 3 | N | o6-24i29-54o60-81i | CytoplasmicMembrane | 10 | ||||||
| NUOM_ECOLI | P0AFE8 | nuoM | b2277 JW2272 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit M NuoM | Integral Inner Membrane | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 59 | 0.116 | TMH | 0 | 6.38779 | - | 14 | 14 | N | o6-23i30-48o77-103i115-134o140-159i180-199o219-244i256-274o286-307i314-333o345-363i383-405o417-440i461-481o | CytoplasmicMembrane | 10 | |||||||
| NUON_ECOLI | P0AFF0 | nuoN | b2276 JW2271 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit N NuoN | Integral Inner Membrane | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 61 | 0.262 | TMH | 0 | 9.81822 | - | 14 | 14 | N | o6-28i35-55o75-93i105-122o128-147i159-181o201-226i238-259o271-290i297-316o328-351i371-394o406-426i447-470o | CytoplasmicMembrane | 10 | |||||||
| NUPC_ECOLI | P0AFF2 | nupC cru | cru | b2393 JW2389 | integral IM protein (SEC in IM), Nucleoside permease NupC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 27 | 0.126 | TMH | 0 | 0.463943 | - | 8 | 9 | N | o6-23i30-48o87-108i167-187o193-212i242-271o277-298i341-361o381-399i | CytoplasmicMembrane | 10 | ||||||
| NUPG_ECOLI | P0AFF4 | nupG | b2964 JW2932 | integral IM protein (SEC in IM), Nucleoside permease NupG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.127 | TMH | 0 | 10.0497 | - | 12 | 12 | N | i12-31o37-58i70-89o95-116i137-155o161-179i211-235o255-275i282-300o306-327i348-369o381-402i | CytoplasmicMembrane | 10 | |||||||
| OPPB_ECOLI | P0AFH2 | oppB | b1244 JW1236 | integral IM protein (SEC in IM), Oligopeptide transport system permease OppB | Integral Inner Membrane | Opp-LacZ hybrid proteins were used to show that OppB, OppC and OppD are membrane-associated proteins. PMID: 2821267 | PMID: 15919996 PMID: 2821267 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 48 | 0.124 | TMH | 0 | 3.13181 | - | 6 | 6 | N | i12-30o100-121i133-161o173-192i228-254o274-300i | CytoplasmicMembrane | 10 | ||||||
| OPPC_ECOLI | P0AFH6 | oppC | b1245 JW1237 | integral IM protein (SEC in IM), Oligopeptide transport system permease OppC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 64 | 0.213 | TMH | 0 | 0.755301 | - | 6 | 6 | N | i40-64o103-128i140-158o164-183i218-247o267-290i | CytoplasmicMembrane | 10 | |||||||
| OSMY_ECOLI | P0AFH8 | osmY | b4376 JW4338 | periplasmic & extra-cellular protein (SEC through IM), Osmotically-inducible Y OsmY | Periplasmic, Extra-cellular | The most efficient excreting fusion partner, OsmY, was used as a carrier protein to excrete heterologous proteins into the medium. PMID: 18727129 The OsmY protein is an Escherichia coli 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions, in particular, helping to provide protection against osmotic shock. One hypothesis is that OsmY prevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane PMID: 12175925 | PMID: 12878000 PMID: 1317380 PMID: 18727129 PMID: 9298646 | Periplasmic, Extra-cellular | G, X | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 29 | 0.787 | SpI | 28 | 23.4143 | - | 0 | 0 | Y | n12-23c28/29o | Periplasmic | 10 | 108 | ||||||||
| PBP7_ECOLI | P0AFI5 | pbpG yohB | yohB | b2134 JW5355 | periplasmic protein (SEC through IM), D-alanyl-D-alanine endopeptidase PbpG | Periplasmic | PMID: 7721700 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 26 | 0.58 | SpI | 25 | 17.1021 | - | 0 | 0 | Y | n6-17c25/26o | Periplasmic | 10 | 82 | ||||||||
| PERM_ECOLI | P0AFI9 | perM yfgO | yfgO | b2493 JW2478 | integral IM protein (SEC in IM), Putative permease PerM | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.135 | TMH | 0 | 20.7793 | - | 7 | 7 | N | o20-51i72-93o151-177i217-236o242-270i282-301o307-332i | CytoplasmicMembrane | 10 | 26 | |||||||
| PITA_ECOLI | P0AFJ7 | pitA pit | pit | b3493 JW3460 | integral IM protein (SEC in IM), Low-affinity inorganic phosphate transporter 1 PitA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 39 | 0.147 | TMH | 0 | 8.59981 | - | 10 | 9 | N | o12-32i52-76o96-116i123-143o155-177i208-227o233-255i379-402o474-494i | CytoplasmicMembrane | 10 | ||||||
| PNUC_ECOLI | P0AFK2 | pnuC | b0751 JW0734 | integral IM protein (SEC in IM), Nicotinamide riboside transporter PnuC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.115 | TMH | 0 | 3.57186 | - | 6 | 7 | N | o22-40i47-65o71-88i109-139o159-178i185-205o211-226i | CytoplasmicMembrane | 10 | |||||||
| POTB_ECOLI | P0AFK4 | potB | b1125 JW1111 | integral IM protein (SEC in IM), Spermidine/putrescine transport system permease PotB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.107 | TMH | 0 | 5.71787 | - | 6 | 7 | N | o6-26i54-78o90-108i120-138o144-163i184-214o242-262i | CytoplasmicMembrane | 10 | |||||||
| POTC_ECOLI | P0AFK6 | potC | b1124 JW1110 | integral IM protein (SEC in IM), Spermidine/putrescine transport system permease PotC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 60 | 0.118 | TMH | 0 | 10.8409 | - | 6 | 6 | N | i12-30o64-86i98-122o128-151i172-195o230-252i | CytoplasmicMembrane | 10 | |||||||
| POTD_ECOLI | P0AFK9 | potD | b1123 JW1109 | periplasmic protein (SEC through IM), Spermidine/putrescine-binding periplasmic PotD | Periplasmic | Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 | PMID: 1939142 PMID: 22030350 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.865 | SpI | 23 | 25.0348 | - | 0 | 0 | Y | n8-18c23/24o | Periplasmic | 10 | |||||||||
| POTI_ECOLI | P0AFL1 | potI | b0857 JW0841 | integral IM protein (SEC in IM), Putrescine transport system permease PotI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.124 | TMH | 0 | 14.5424 | - | 6 | 7 | N | i12-35o60-90i102-129o141-163i184-206o212-232i244-264o | CytoplasmicMembrane | 10 | |||||||
| PPIA_ECOLI | P0AFL3 | ppiA rot rotA | rot rotA | b3363 JW3326 | periplasmic protein (SEC through IM), Peptidyl-prolyl cis-trans isomerase A PpiA | Periplasmic | Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 | PMID: 2190212 PMID: 22030350 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 25 | 0.753 | SpI | 24 | 24.1414 | - | 0 | 0 | Y | n4-15c24/25o | Periplasmic | 10 | 73 | |||||||
| PQIA_ECOLI | P0AFL9 | pqiA pqi5A | pqi5A | b0950 JW0933 | integral IM protein (SEC in IM), Intertransport PqiA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 33 | 0.119 | CYT | 0 | -0.200913 | - | 8 | 8 | N | i53-76o96-122i142-160o166-185i257-277o304-329i350-371o377-400i | CytoplasmicMembrane | 10 | ||||||
| PROX_ECOLI | P0AFM2 | proX proU | proU | b2679 JW2654 | periplasmic protein (SEC through IM), Glycine betaine/proline betaine-binding periplasmic ProX | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Identified DsbA substrate PMID: 19953543 PMID: 3305496 Disulfide bridge (157 163) Disulfide bond-containing protein PMID: 25664544 | PMID: 18498364 PMID: 19953543 PMID: 25664544 PMID: 3305496 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA,DSBA | yes | yes | Y | 22 | 0.863 | SpI | 21 | 16.9579 | - | 0 | 0 | Y | n5-16c21/22o | Periplasmic | 10 | 52 | ||||||
| PSIF_ECOLI | P0AFM4 | psiF | b0384 JW5054 | periplasmic protein (SEC through IM), Phosphate starvation-inducible PsiF | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.376 | SpI | 21 | 13.709 | - | 1 | 0 | Y | n5-16c21/22o | Unknown | 2 | 44 | |||||||||
| PSPB_ECOLI | P0AFM9 | pspB | b1305 JW1298 | integral IM protein (SEC in IM), Phage shock B PspB | Integral Inner Membrane | Defects in yidC and sec secretion induce psp operon. PMID: 14594846 | PMID: 14594846 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Single-pass membrane protein | Membrane anchored | SRP | SEC | Prophage Transposase (by homology to BL21) | no | yes | N | 30 | 0.112 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-24i | CytoplasmicMembrane | 10 | 62 | ||||
| PSPC_ECOLI | P0AFN2 | pspC | b1306 JW1299 | integral IM protein (SEC in IM), Phage shock C PspC | Integral Inner Membrane | Defects in yidC and sec secretion induce psp operon. PMID: 14594846 | PMID: 14594846 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | Prophage Transposase | yes | no | N | 25 | 0.142 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o39-64i | CytoplasmicMembrane | 9 | 29 | ||||
| YADH_ECOLI | P0AFN6 | yadH | b0128 JW0124 | integral IM protein (SEC in IM), transport permease YadH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.101 | TMH | 0 | 8.75539 | - | 6 | 7 | Y | n4-9c14/15o24-46i58-84o104-132i139-164o170-191i203-221o227-248i | CytoplasmicMembrane | 10 | 4 | ||||||
| YADS_ECOLI | P0AFP0 | yadS | b0157 JW0153 | integral IM protein (SEC in IM), UPF0126 YadS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.24 | TMH | 0 | 2.68818 | - | 7 | 7 | N | o6-23i30-50o62-79i91-110o116-137i149-168o174-190i | CytoplasmicMembrane | 10 | |||||||
| YBHR_ECOLI | P0AFP9 | ybhR | b0792 JW5803 | integral IM protein (SEC in IM), Probable multidrug ABC transporter permease YbhR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.153 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i21-41o173-197i218-243o255-277i284-302o345-363i | CytoplasmicMembrane | 10 | |||||||
| YBHS_ECOLI | P0AFQ2 | ybhS | b0793 JW0777 | integral IM protein (SEC in IM), Probable multidrug ABC transporter permease YbhS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 67 | 0.102 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i29-47o182-205i232-255o261-283i295-314o346-370i | CytoplasmicMembrane | 10 | 7 | ||||||
| DAUA_ECOLI | P0AFR2 | dauA ychM | ychM | b1206 JW5189 | integral IM protein (SEC in IM), C4-dicarboxylic acid transporter DauA | Integral Inner Membrane | PMID: 15919996 PMID: 23278959 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 69 | 0.11 | CYT | 0 | -0.200913 | - | 11 | 9 | N | o33-53i60-80o100-118i130-152o172-198i210-231o278-300i358-388o408-438i | CytoplasmicMembrane | 10 | ||||||
| YCJO_ECOLI | P0AFR7 | ycjO | b1311 JW1304 | integral IM protein (SEC in IM), ABC transporter permease YcjO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.147 | TMH | 0 | 12.2234 | - | 6 | 5 | Y | n14-25c30/31o77-98i110-130o163-189i210-233o265-283i | CytoplasmicMembrane | 10 | |||||||
| YDCV_ECOLI | P0AFR9 | ydcV | b1443 JW1438 | integral IM protein (SEC in IM), ABC transporter permease YdcV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.134 | TMH | 0 | 8.81303 | - | 6 | 6 | N | i12-33o71-91i103-127o133-153i189-212o232-256i | CytoplasmicMembrane | 10 | |||||||
| LSRD_ECOLI | P0AFS1 | lsrD ydeZ | ydeZ | b1515 JW1508 | integral IM protein (SEC in IM), Autoinducer 2 import system permease LsrD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.162 | TMH | 0 | 9.62635 | - | 9 | 9 | Y | n9-17c23/24o33-56i63-82o88-110i117-140o160-181i212-234o240-260i267-286o292-310i | CytoplasmicMembrane | 10 | ||||||
| TQSA_ECOLI | P0AFS5 | tqsA ydgG | ydgG | b1601 JW1593 | integral IM protein (SEC in IM), AI-2 transport TqsA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.372 | TMH | 0 | 8.36419 | - | 8 | 8 | N | i12-31o37-55i62-83o144-165i197-218o224-246i258-279o299-325i | CytoplasmicMembrane | 10 | ||||||
| YDIK_ECOLI | P0AFS7 | ydiK | b1688 JW1678 | integral IM protein (SEC in IM), Putative transport YdiK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.172 | TMH | 0 | 13.7653 | - | 9 | 9 | N | i12-31o37-53i65-86o160-179i191-208o214-235i247-271o277-295i307-334o | CytoplasmicMembrane | 10 | |||||||
| MEPM_ECOLI | P0AFS9 | mepM yebA | yebA | b1856 JW5304 | integral IM protein (SEC in IM), Murein DD-endopeptidase MepM MepM | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 12 | 0.112 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i21-39o | Unknown | 2 | 33 | |||||||
| YECS_ECOLI | P0AFT2 | yecS | b1918 JW1903 | integral IM protein (SEC in IM), L-cystine transport system permease YecS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 70 | 0.103 | TMH | 0 | 8.62641 | - | 3 | 3 | N | o21-45i57-78o186-206i | CytoplasmicMembrane | 10 | 4 | ||||||
| YEJB_ECOLI | P0AFU0 | yejB | b2178 JW2166 | integral IM protein (SEC in IM), ABC transporter permease YejB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.157 | TMH | 0 | 4.74055 | - | 6 | 6 | N | i9-30o135-156i168-194o224-247i282-309o329-355i | CytoplasmicMembrane | 10 | |||||||
| YFBS_ECOLI | P0AFU2 | yfbS | b2292 JW2289 | integral IM protein (SEC in IM), transporter YfbS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.196 | TMH | 0 | 7.38351 | - | 10 | 10 | N | i5-22o28-45i57-83o95-124i136-155o175-195i470-493o513-538i550-568o588-608i | CytoplasmicMembrane | 10 | |||||||
| YIBH_ECOLI | P0AFV0 | yibH | b3597 JW3571 | integral IM protein (SEC in IM), YibH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Membrane anchored | SRP | SEC | yes | yes | N | 53 | 0.113 | TMH | 0 | 2.25888 | - | 2 | 1 | Y | n3-13c18/19o28-49i | CytoplasmicMembrane | 10 | 23 | ||||||
| YHID_ECOLI | P0AFV2 | yhiD yhhE | yhhE | b3508 JW5670 | integral IM protein (SEC in IM), Putative magnesium transporter YhiD | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 55 | 0.254 | CYT | 0 | -0.200913 | - | 5 | 5 | N | o6-22i34-54o69-87i92-112o118-138i | CytoplasmicMembrane | 10 | 28 | |||||||
| MEPS_ECOLI | P0AFV4 | mepS spr yeiV | spr yeiV | b2175 JW2163 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase MepS | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 34 | 0.288 | SpII | 26 | 11.4182 | Pos+2=S | 0 | 0 | Y | n14-24c29/30o | Unknown | 2 | 36 | ||||||
| RSEA_ECOLI | P0AFX7 | rseA mclA yfiJ | mclA yfiJ | b2572 JW2556 | integral IM protein (SEC in IM), Anti-sigma-E factor RseA | Integral Inner Membrane | Responce to stress complex RpoE-RseA-RseB. Overproduction of N-terminal domain of RseA alone was shown to inhibit ??E activity. RseC which is an inner membrane protein, positively modulates ??E activity. The periplasmic domain of RseA interacts with RseB while its cytoplasmic domain interacts with RpoE, thereby sequestering RpoE away from the transcription complex. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters ??E in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA reveals that RseA functions by sterically occluding the two primary binding determinants on sigma(E) for core RNA polymerase. PMID: 12718891 | PMID: 11777003 PMID: 12183369 PMID: 12718891 PMID: 17360428 PMID: 9159522 PMID: 9159523 | Integral Inner Membrane | B | - | IM (predicted-detected) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 62 | 0.226 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 2 | 59 | |||||
| RSEB_ECOLI | P0AFX9 | rseB | b2571 JW2555 | periplasmic protein (SEC through IM), Sigma-E factor regulatory RseB | Periplasmic | Responce to stress complex RpoE-RseA-RseB. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters ??E in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 PMID: 11777003 | PMID: 11777003 PMID: 17360428 PMID: 9159522 PMID: 9159523 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.61 | SpI | 23 | 10.5992 | - | 0 | 0 | Y | n4-16c28/29o | Periplasmic | 9 | 15 | ||||||||
| SANA_ECOLI | P0AFY2 | sanA yeiF | yeiF | b2144 JW2132 | integral IM protein (SEC in IM), SanA | Integral Inner Membrane | Related to vancomycin resistance and when overexpressed, is able to complement the permeability defects of a vancomycin-susceptible mutant. | PMID: 8550448 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane; Single-pass membrane protein | Periplasmic | SRP | SEC | yes | yes | N | 23 | 0.14 | TMH | 0 | 6.95693 | - | 1 | 0 | Y | n5-18c22/23o | CytoplasmicMembrane | 10 | 10 | ||||
| SBMA_ECOLI | P0AFY6 | sbmA | b0377 JW0368 | integral IM protein (SEC in IM), Peptide antibiotic transporter SbmA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.182 | TMH | 0 | 18.7145 | - | 8 | 8 | N | i12-30o58-78i85-112o140-164i206-227o239-263i309-326o332-353i | CytoplasmicMembrane | 10 | |||||||
| TRKH_ECOLI | P0AFZ7 | trkH | b3849 JW5576 | integral IM protein (SEC in IM), Trk system potassium uptake TrkH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | yes | N | 41 | 0.127 | TMH | 0 | 6.71344 | - | 10 | 11 | N | i12-32o38-57i69-90o136-163i184-204o241-262i274-294o331-363i396-417o423-444i456-481o | CytoplasmicMembrane | 10 | ||||||
| WZZE_ECOLI | P0AG00 | wzzE wzz yifC | wzz yifC | b3785 JW5601 | integral IM protein (SEC in IM), ECA polysaccharide chain length modulation protein WzzE | Integral Inner Membrane | PMID: 15919996 PMID: 16199561 PMID: 16816184 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 47 | 0.253 | TMH | 0 | 8.70367 | - | 2 | 2 | N | o31-50i323-342o | CytoplasmicMembrane | 10 | 19 | |||||
| SOHB_ECOLI | P0AG14 | sohB | b1272 JW1264 | integral IM protein (SEC in IM), Probable protease SohB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Single-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.141 | CYT | 0 | -0.200913 | - | 2 | 1 | N | o12-32i | CytoplasmicMembrane | 10 | 8 | ||||||
| YIBN_ECOLI | P0AG27 | yibN | b3611 JW3586 | integral IM protein (SEC in IM), YibN | Integral Inner Membrane | PMID: 15919657 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Membrane anchored | SRP | SEC | yes | yes | N | 36 | 0.109 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o12-30i | Unknown | 2 | 48 | |||||||
| RHTB_ECOLI | P0AG34 | rhtB yigK | yigK | b3824 JW5585 | integral IM protein (SEC in IM), Homoserine/homoserine lactone efflux protein RhtB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein (Experimental) | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | no | yes | N | 25 | 0.247 | TMH | 0 | 11.1132 | - | 5 | 4 | Y | n7-18c23/24o39-65i116-138o144-168i188-205o | CytoplasmicMembrane | 10 | |||||
| RHTC_ECOLI | P0AG38 | rhtC yigJ | yigJ | b3823 JW5586 | integral IM protein (SEC in IM), Threonine efflux protein RhtC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | yes | N | 25 | 0.144 | TMH | 0 | 8.74493 | - | 6 | 6 | N | o6-26i38-63o69-87i119-140o152-174i186-204o | CytoplasmicMembrane | 10 | |||||
| RMUC_ECOLI | P0AG71 | rmuC yigN | yigN | b3832 JW3809 | integral IM protein (SEC in IM), DNA recombination RmuC | Integral Inner Membrane | Based on the fact that RmuC is a DNA recombination enzyme we conluded that its N-terminus lays in the periplasm. | PMID: 16011798 | Integral Inner Membrane | B | Bin | out/in | N/A | Cytoplasmic | SRP | SEC | yes | yes | N | 29 | 0.536 | SpI | 28 | 1.08238 | - | 1 | 1 | N | o6-25i | Unknown | 2 | 15 | |||||
| SUBI_ECOLI | P0AG78 | sbp | b3917 JW3888 | periplasmic protein (SEC through IM), Sulfate-binding Sbp | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646 | PMID: 18498364 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 20 | 0.802 | SpI | 19 | 15.2757 | - | 0 | 0 | Y | n4-14c19/20o | Periplasmic | 10 | 70 | |||||||
| UGPB_ECOLI | P0AG80 | ugpB | b3453 JW3418 | periplasmic protein (SEC through IM), sn-glycerol-3-phosphate-binding periplasmic UgpB | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 3062310 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 3062310 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 24 | 0.804 | SpI | 23 | 17.1867 | - | 0 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 64 | |||||||
| PSTS_ECOLI | P0AG82 | pstS phoS | phoS | b3728 JW3706 | periplasmic protein (SEC through IM), Phosphate-binding PstS | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Copurifies with trigger factor in pull down assays. PMID: 9298646 | PMID: 18498364 PMID: 19737520 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TF | SEC | SURA | yes | yes | Y | 26 | 0.546 | SpI | 25 | 23.9055 | - | 1 | 0 | Y | n6-17c25/26o | Periplasmic | 10 | 79 | |||||
| SECD_ECOLI | P0AG90 | secD | b0408 JW0398 | integral IM protein (SEC in IM), translocase subunit SecD | Integral Inner Membrane | PMID: 15919657 PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.158 | TMH | 0 | 1.57163 | - | 6 | 6 | N | i7-25o453-472i477-497o503-524i545-571o577-605i | CytoplasmicMembrane | 10 | 36 | ||||||
| SECF_ECOLI | P0AG93 | secF | b0409 JW0399 | integral IM protein (SEC in IM), translocase subunit SecF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 3 | 0.112 | TMH | 0 | 2.24012 | - | 6 | 6 | N | i24-43o142-163i170-191o197-217i248-266o272-297i | CytoplasmicMembrane | 10 | |||||||
| SECE_ECOLI | P0AG96 | secE prlG | prlG | b3981 JW3944 | integral IM protein (SEC in IM), translocase subunit SecE | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 48 | 0.137 | TMH | 0 | 7.80526 | - | 3 | 3 | N | o16-36i43-61o95-119i | CytoplasmicMembrane | 10 | 7 | ||||
| SECG_ECOLI | P0AG99 | secG | b3175 JW3142 | integral IM protein (SEC in IM), Protein-export SecG | Integral Inner Membrane | PMID: 15919657 PMID: 15919996 | Integral Inner Membrane | B | Binout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.153 | TMH | 0 | 11.5638 | - | 2 | 1 | Y | n4-22c27/28o51-70i | CytoplasmicMembrane | 10 | 49 | ||||||
| SECY_ECOLI | P0AGA2 | secY prlA | prlA | b3300 JW3262 | integral IM protein (SEC in IM), translocase subunit SecY | Integral Inner Membrane | PMID: 15919996 PMID: 3004955 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 47 | 0.104 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i23-44o75-98i119-139o154-174i186-203o215-237i274-296o316-337i373-391o397-418i | CytoplasmicMembrane | 10 | ||||||
| UHPT_ECOLI | P0AGC0 | uhpT | b3666 JW3641 | integral IM protein (SEC in IM), Hexose-6-phosphate:phosphate antiporter UhpT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 53 | 0.105 | TMH | 0 | 0.582302 | - | 12 | 12 | N | i28-45o65-85i97-117o123-148i160-183o189-210i260-278o298-318i327-345o351-380i392-411o423-446i | CytoplasmicMembrane | 10 | |||||||
| SLT_ECOLI | P0AGC3 | slt sltY | sltY | b4392 JW4355 | periplasmic protein (SEC through IM), Soluble lytic murein transglycosylase Slt | Periplasmic | Disulfide bridge (133 166) Disulfide bond-containing protein PMID: 25664544 | PMID: 1938883 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 28 | 0.803 | SpI | 27 | 12.0915 | - | 0 | 0 | Y | n11-22c27/28o | Periplasmic | 10 | 10 | |||||||
| MLTF_ECOLI | P0AGC5 | mltF yfhD | yfhD | b2558 JW2542 | periplasmic peripheral OM protein (SEC through IM), Membrane-bound lytic murein transglycosylase F MltF | Peripheral outer membrane protein facing the periplasm | PMID: 18234673 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Cell outer membrane | Periplasmic | SEC | no | yes | N | 33 | 0.227 | SpI | 30 | 3.07095 | - | 1 | 0 | Y | n9-20c32/33o | Cytoplasmic | 9 | 10 | ||||||||
| SMP_ECOLI | P0AGC7 | ytjB smp | smp | b4387 JW4350 | integral IM protein (SEC in IM), YtjB | Integral Inner Membrane | Has an aminoterminal stop transfer or signal sequence hydrophobic region and a second hydrophobic region near the C-terminus that may function as a stop transfer sequence; The protein was shown to fractionate with the bacterial membrane. No processing of t | PMID: 2684780 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | no | no | N | 30 | 0.128 | SpI | 30 | 7.66045 | - | 1 | 1 | Y | n13-24c29/30o164-184i | CytoplasmicMembrane | 10 | 63 | |||
| SODC_ECOLI | P0AGD1 | sodC | b1646 JW1638 | periplasmic protein (SEC through IM), Superoxide dismutase SodC | Periplasmic | Disulfide bridge (74 169) PMID: 9405149 Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 PMID: 8626323 PMID: 9405149 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 20 | 0.82 | SpI | 19 | 16.2903 | - | 0 | 0 | Y | n4-14c19/20o | Periplasmic | 10 | |||||||||
| SODF_ECOLI | P0AGD3 | sodB | b1656 JW1648 | periplasmic protein (SEC through IM), Superoxide dismutase SodB | Periplasmic | The superoxide dismutase SodA is targeted to the periplasm in a SecA-dependent manner by a novel mechanism in Rhizobium leguminosarum. SodM and SodF are <i>E.coli</i> proteins that are close homoloques of the RISodA. SodA does not possess a hydrophobic cleaved N-terminal signal peptide typically present in soluble proteins exported by the Sec-dependent (Sec) pathway or the twin-arginine translocation (TAT) pathway. TatC or SecB mutants in Rhizobium leguminosarum do not affect export of SodA to the periplasm. Inhibition of SecA ATPase activity by azide blocks SodA export to the periplasm. | Periplasmic | G | N/A | Cytoplasmic | SEC | yes | yes | N | 17 | 0.122 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 9 | 77 | ||||||||||
| SSTT_ECOLI | P0AGE4 | sstT ygjU | ygjU | b3089 JW3060 | integral IM protein (SEC in IM), Serine/threonine transporter SstT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.148 | TMH | 0 | 7.50816 | - | 8 | 8 | N | i18-36o42-72i84-106o149-166i187-209o215-240i290-315o327-352i | CytoplasmicMembrane | 10 | 15 | |||||
| XYLE_ECOLI | P0AGF4 | xylE | b4031 JW3991 | integral IM protein (SEC in IM), D-xylose-proton symporter XylE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.155 | TMH | 0 | 6.47202 | - | 12 | 11 | Y | n13-24c32/33o56-78i90-109o129-151i163-186o198-220i270-293o313-334i346-364o370-395i407-426o446-463i | CytoplasmicMembrane | 10 | |||||||
| YHHJ_ECOLI | P0AGH1 | yhhJ | b3485 JW5677 | integral IM protein (SEC in IM), transport permease YhhJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.231 | SpI | 40 | 1.57995 | - | 5 | 6 | N | i174-200o220-244i256-281o287-306i318-337o343-364i | CytoplasmicMembrane | 10 | 6 | ||||||
| SAPB_ECOLI | P0AGH3 | sapB | b1293 JW1286 | integral IM protein (SEC in IM), Putrescine export system permease SapB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.197 | TMH | 0 | 16.0324 | - | 5 | 6 | N | i9-29o82-101i113-141o175-193i245-263o283-305i | CytoplasmicMembrane | 10 | 9 | ||||||
| SAPC_ECOLI | P0AGH5 | sapC | b1292 JW1285 | integral IM protein (SEC in IM), Putrescine export system permease SapC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.132 | TMH | 0 | 5.59827 | - | 5 | 6 | N | i31-54o99-123i144-169o189-208i220-241o261-283i | CytoplasmicMembrane | 10 | 10 | ||||||
| PSTC_ECOLI | P0AGH8 | pstC phoW | phoW | b3727 JW3705 | integral IM protein (SEC in IM), Phosphate transport system permease PstC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 3 | 0.109 | TMH | 0 | 4.7509 | - | 6 | 6 | N | i21-43o75-100i112-143o163-186i227-249o282-304i | CytoplasmicMembrane | 10 | ||||||
| RBSC_ECOLI | P0AGI1 | rbsC | b3750 JW3729 | integral IM protein (SEC in IM), Ribose import permease RbsC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 58 | 0.121 | TMH | 0 | 6.39117 | - | 8 | 10 | N | i23-43o49-68i75-93o99-119i126-144o170-190i221-240o252-270i275-292o298-316i | CytoplasmicMembrane | 10 | 18 | ||||||
| XYLH_ECOLI | P0AGI4 | xylH | b3568 JW3540 | integral IM protein (SEC in IM), Xylose transport system permease XylH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.13 | TMH | 0 | 4.89182 | - | 10 | 11 | N | i25-45o65-83i90-107o113-132i139-156o176-196i217-235o241-259i290-306o326-357i369-385o | CytoplasmicMembrane | 10 | |||||||
| UBIA_ECOLI | P0AGK1 | ubiA cyr | cyr | b4040 JW4000 | integral IM protein (SEC in IM), 4-hydroxybenzoate octaprenyltransferase UbiA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 36 | 0.118 | TMH | 0 | 6.00125 | - | 7 | 7 | N | i23-40o46-70i99-132o152-182i210-229o235-252i273-289o | CytoplasmicMembrane | 10 | ||||||
| YHHT_ECOLI | P0AGM0 | yhhT | b3474 JW5680 | integral IM protein (SEC in IM), Putative transport YhhT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.162 | TMH | 0 | 5.38885 | - | 8 | 8 | N | i12-31o37-55i62-87o133-163i197-215o221-246i253-275o295-315i | CytoplasmicMembrane | 10 | 4 | ||||||
| YICG_ECOLI | P0AGM2 | yicG | b3646 JW3621 | integral IM protein (SEC in IM), UPF0126 YicG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.368 | CYT | 0 | -0.200913 | - | 7 | 7 | N | o6-23i30-52o64-82i89-109o115-136i148-167o173-191i | CytoplasmicMembrane | 10 | |||||||
| URAA_ECOLI | P0AGM7 | uraA | b2497 JW2482 | integral IM protein (SEC in IM), Uracil permease UraA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.107 | TMH | 0 | 3.93213 | - | 12 | 13 | N | i20-38o44-60i67-83o89-108i120-147o159-176i183-202o225-250i262-281o301-319i331-354o366-384i391-409o | CytoplasmicMembrane | 10 | |||||||
| XANP_ECOLI | P0AGM9 | xanP yicE | yicE | b3654 JW3629 | integral IM protein (SEC in IM), Xanthine permease XanP | Integral Inner Membrane | PMID: 15919996 PMID: 16096267 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 66 | 0.123 | CYT | 0 | -0.200913 | - | 11 | 11 | N | o36-58i70-89o128-146i158-181o193-212i219-240o260-280i350-372o378-396i408-427o439-458i | CytoplasmicMembrane | 10 | 9 | |||||
| MLTC_ECOLI | P0C066 | mltC yggZ | yggZ | b2963 JW5481 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase C MltC | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.3 | SpII | 16 | 14.8852 | Pos+2=S | 0 | 0 | Y | n5-15c20/21o | Unknown | 2 | 17 | ||||||
| PROP_ECOLI | P0C0L7 | proP | b4111 JW4072 | integral IM protein (SEC in IM), Proline/betaine transporter ProP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.105 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i41-59o65-86i98-116o122-146i167-186o198-217i257-278o298-318i327-346o352-376i388-411o417-438i | CytoplasmicMembrane | 10 | |||||||
| MSCS_ECOLI | P0C0S1 | mscS yggB | yggB | b2924 JW2891 | integral IM protein (SEC in IM), Small-conductance mechanosensitive channel MscS | Integral Inner Membrane | PMID: 10202137 PMID: 11266632 PMID: 12015316 PMID: 12446901 PMID: 12767977 PMID: 15919657 PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 52 | 0.15 | TMH | 0 | -0.184901 | - | 3 | 3 | N | o24-45i65-85o97-125i | CytoplasmicMembrane | 10 | 42 | |||||
| MEPA_ECOLI | P0C0T5 | mepA | b2328 JW2325 | periplasmic protein (SEC through IM), Penicillin-insensitive murein endopeptidase MepA | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbC substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 2187143 Disulfide bridge (44 265;187 235;216 223) Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 19953543 PMID: 2187143 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA,DSBC | yes | yes | Y | 20 | 0.847 | SpI | 19 | 22.606 | - | 0 | 0 | Y | n4-14c19/20o | Periplasmic | 10 | 16 | |||||||
| DEGP_ECOLI | P0C0V0 | degP htrA ptd | htrA ptd | b0161 JW0157 | periplasmic protein (SEC through IM), serine endoprotease DegP | Periplasmic | SecB substrate. Substrate of periplasmic disulfide oxidoreductases DsbA. HtrA was not detected by the immunoblotting technique in the periplasm or in the fraction of soluble proteins but was found in the inner membrane. DegP oligomerizes as a hexameric cage but in its presence DegP reorganizes into 12 and 24-mer cages with large chambers that house the substrate for degradation or refolding. Size exclusion chromatography and electron microscopy show that the size of the substrate molecule is the main factor conditioning the oligomeric state adopted by the enzyme. Identified DsbA substrate PMID: 19953543 PMID: 2180903 Disulfide bridges between 83 and 95 PMID: 12878036 Disulfide bridge (83 95) PMID: 12878036 Disulfide bond-containing protein PMID: 25664544 | PMID: 12878036 PMID: 14726535 PMID: 16352602 PMID: 19525348 PMID: 19953543 PMID: 21370981 PMID: 21526129 PMID: 2180903 PMID: 25664544 PMID: 9083020 | Periplasmic | G | N/A | Cell inner membrane | Periplasmic (Experimental) | SECB | SEC | DSBA | yes | yes | Y | 27 | 0.841 | SpI | 26 | 28.3128 | - | 0 | 0 | Y | n4-19c26/27o | Periplasmic | 10 | 31 | |||||
| EMTA_ECOLI | P0C960 | emtA mltE sltZ ycgP | mltE sltZ ycgP | b1193 JW5821 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Endo-type membrane-bound lytic murein transglycosylase A EmtA | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 49 | 0.204 | SpII | 15 | 18.8581 | Pos+2=S | 0 | 0 | Y | n5-13c18/19o | CytoplasmicMembrane | 9 | 15 | ||||||
| EPTC_ECOLI | P0CB39 | eptC cptA yijP | cptA yijP | b3955 JW3927 | integral IM protein (SEC in IM), Phosphoethanolamine transferase EptC | Integral Inner Membrane | PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 9 | 0.182 | TMH | 0 | 12.4414 | - | 5 | 5 | N | i20-39o45-63i70-91o120-139i151-169o | CytoplasmicMembrane | 10 | 26 | |||||
| YMIA_ECOLI | P0CB62 | ymiA | b4522 JW1267.1 | integral IM protein (SEC in IM), YmiA | Integral Inner Membrane | Small membrane protein detected experimentally | PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | N/A | Membrane | - | SEC | no | yes | N | 35 | 0.102 | TMH | 0 | 1.19842 | - | 1 | 1 | N | i20-41o | CytoplasmicMembrane | 9 | |||||||
| UIDB_ECOLI | P0CE44 | uidB gusB uidP | gusB uidP | b1616 JW1608 | integral IM protein (SEC in IM), Glucuronide carrier homolog UidB | Integral Inner Membrane | PMID: 15774881 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 61 | 0.197 | TMH | 0 | 5.96454 | - | 12 | 12 | N | i12-35o41-60i81-101o113-136i148-170o182-201i230-257o263-284i296-316o322-343i376-393o405-427i | CytoplasmicMembrane | 10 | ||||||
| ACFD_ECOLI | P0CK95 | yghJ | b4466 JW5925 ECK2968 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Putative AcfD homolog YghJ | Inner Membrane Lipoprotein | E | N/A | Cell membrane | Inner membrane lipoprotein | SEC | LOL | no | yes | Y | 23 | 0.283 | SpII | 23 | 37.591 | Pos+2=D | 0 | 0 | Y | n10-21c26/27o | Unknown | 6 | |||||||||||
| RCSC_ECOLI | P0DMC5 | rcsC | b2218 JW5917/JW5920 | integral IM protein (SEC in IM), Sensor histidine kinase RcsC | Integral Inner Membrane | Fusions of rcsC to phoA that resulted in PhoA+ strains demonstrated that RcsC is a transmembrane protein with a periplasmic N-terminal domain and cytoplasmic C-terminal domain. | PMID: 15919996 PMID: 2404948 | Integral Inner Membrane | B | Binout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.159 | TMH | 0 | 3.16217 | - | 2 | 1 | Y | n20-31c40/41o314-334i | CytoplasmicMembrane | 10 | ||||||
| PHNE1_ECOLI | P0DP69 | phnE1 | b4104 JW4065 | integral IM protein (SEC in IM), Putative cryptic phosphonate transport system permease PhnE1 | Integral Inner Membrane | Integral Inner Membrane | B | N/A | Cell inner membrane | - | SEC | pseudogene (Uniprot) | N | 0.119 | CYT | 0 | 0.401335 | - | 3 | 3 | Y | i30-50o92-116i137-157o | Unknown | ||||||||||||||
| PHNE2_ECOLI | P0DP70 | phnE phnE2 | phnE2 | b4104 JW4065 b4103 | integral IM protein (SEC in IM), Putative cryptic phosphonate transport system permease PhnE2 | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot) | no | yes | N | 36 | 0.143 | TMH | 0 | 8.60214 | - | 6 | 6 | N | i12-33o75-99i120-143o179-197i206-224o230-250i | CytoplasmicMembrane | 10 | 7 | ||||
| LDRA_ECOLI | P0DPD0 | ldrA | b4419 JW5957 | integral IM protein (SEC in IM), Small toxic polypeptide LdrA | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 21 | 0.125 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-31i | CytoplasmicMembrane | 9 | ||||||
| LDRC_ECOLI | P0DPD1 | ldrC | b4423 JW5959 | integral IM protein (SEC in IM), Small toxic polypeptide LdrC | Integral Inner Membrane | Integral Inner Membrane | B | N/A | Cell inner membrane | - | SEC | N | 0.125 | CYT | 0 | -0.200913 | - | 1 | 1 | Y | o6-31i | Unknown | |||||||||||||||
| RLPA_ECOLI | P10100 | rlpA | b0633 JW0628 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Endolytic PG transglycosylase RlpA RlpA | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Contains a SPOR domain. PMID: 15174130 | PMID: 12488465 PMID: 15174130 PMID: 15911532 PMID: 19880599 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 20 | 0.14 | SpII | 17 | 19.3561 | Pos+2=T | 0 | 0 | Y | n5-15c20/21o | Unknown | 2 | ||||||||
| FADL_ECOLI | P10384 | fadL ttr | ttr | b2344 JW2341 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Long-chain fatty acid transport FadL | Outer Membrane b-barrel protein | Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 1987139 | PMID: 10806384 PMID: 11266632 PMID: 12624733 PMID: 15178802 PMID: 15911532 PMID: 16079137 PMID: 19343722 PMID: 1987139 PMID: 19953543 PMID: 20932056 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SURA,SKP | BAM | yes | yes | Y | 26 | 0.796 | SpI | 25 | 16.4528 | - | 0 | 0 | Y | n10-20c25/26o | OuterMembrane | 10 | 1 | |||||
| IAP_ECOLI | P10423 | iap | b2753 JW2723 | periplasmic peripheral IM protein (SEC through IM), Alkaline phosphatase isozyme conversion Iap | Peripheral inner membrane protein facing the periplasm | PMID: 3316184 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Membrane associated (Experimental) | SEC | yes | yes | Y | 25 | 0.707 | SpI | 24 | 13.6553 | - | 0 | 0 | Y | n9-20c24/25o | Unknown | 4 | 25 | ||||||||||
| NARK_ECOLI | P10903 | narK | b1223 JW1214 | integral IM protein (SEC in IM), Nitrate/nitrite transporter NarK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 60 | 0.17 | TMH | 0 | 0.305282 | - | 12 | 12 | N | i38-62o74-92i104-124o130-158i178-197o217-234i255-278o290-308i320-339o351-377i404-425o437-457i | CytoplasmicMembrane | 10 | |||||||
| UGPA_ECOLI | P10905 | ugpA | b3452 JW3417 | integral IM protein (SEC in IM), sn-glycerol-3-phosphate transport system permease UgpA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.107 | TMH | 0 | 13.7961 | - | 6 | 6 | N | i12-31o78-100i112-130o157-181i206-228o267-288i | CytoplasmicMembrane | 10 | |||||||
| UGPE_ECOLI | P10906 | ugpE | b3451 JW3416 | integral IM protein (SEC in IM), sn-glycerol-3-phosphate transport system permease UgpE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.2 | TMH | 0 | 9.6685 | - | 6 | 7 | N | i7-31o81-105i112-133o145-166i187-210o216-238i250-272o | CytoplasmicMembrane | 10 | 28 | ||||||
| YIAB_ECOLI | P11286 | yiaB | b3563 JW5654 | integral IM protein (SEC in IM), YiaB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 50 | 0.132 | TMH | 0 | 7.23112 | - | 4 | 4 | N | i7-26o32-50i62-87o93-110i | CytoplasmicMembrane | 10 | 38 | ||||||
| YFIL_ECOLI | P11289 | yfiL | b2602 JW5412 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YfiL | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 26 | 0.211 | SpII | 16 | 12.903 | Pos+2=Q | 0 | 0 | Y | n5-14c19/20o | Unknown | 2 | 59 | ||||||||
| NARI_ECOLI | P11350 | narI chlI | chlI | b1227 JW1218 | integral IM protein (SEC in IM), Respiratory nitrate reductase 1 gamma chain NarI | Integral Inner Membrane | Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (nitrate reductase A; NarGHI) PMID: 12910261. Part of the nitrate reductase A (NarGHI) of Escherichia coli which is membrane anchored through the NarI subunit. NarH is the electron transfer subunit. PMID: 12910261 In vivo associations of Escherichia coli NarJ with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG. PMID: 19295650 When E. coli is grown anaerobically in the presence of high levels of nitrate, the respiratory chain that is formed is terminated by NarGHI otherwise known as the quinol nitrate oxidoreductase. PMID: 2674654 The heterotrimeric NarGHI has an ?????? structure encoded by narGHI respectively. The ?? and ?? subunits can be purified as a soluble NarGH dimer in the cytoplasm showing that these 2 subunits associate to form a stable subcomplex before association with the membrane ?? subunit. PMID: 3371362 PMID: 3053688 | PMID: 11266632 PMID: 12910261 PMID: 15919996 PMID: 19295650 PMID: 2674654 PMID: 3053688 PMID: 3371362 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 19 | 0.113 | TMH | 0 | 11.8819 | - | 5 | 5 | N | o6-26i47-69o89-109i129-148o179-198i | CytoplasmicMembrane | 10 | |||||
| FUCP_ECOLI | P11551 | fucP | b2801 JW2772 | integral IM protein (SEC in IM), L-fucose-proton symporter FucP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 42 | 0.298 | TMH | 0 | 0.0692344 | - | 12 | 12 | N | i21-41o61-85i92-111o117-134i155-177o210-228i262-282o294-315i327-345o351-373i385-405o411-431i | CytoplasmicMembrane | 10 | |||||||
| DAMX_ECOLI | P11557 | damX yhfB | yhfB | b3388 JW3351 | integral IM protein (SEC in IM), Cell division DamX | Integral Inner Membrane | Contain a SPOR Domain. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 | PMID: 19880599 PMID: 21541338 PMID: 23290046 | Integral Inner Membrane | B | Binout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 68 | 0.101 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i103-124o | Unknown | 2 | |||||
| ARGO_ECOLI | P11667 | argO yggA | yggA | b2923 JW2890 | integral IM protein (SEC in IM), Arginine exporter ArgO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein(experimental) | SRP | SEC | yes | yes | N | 25 | 0.273 | TMH | 0 | 6.65864 | - | 6 | 6 | N | o6-26i38-61o67-88i109-127o147-170i182-199o | CytoplasmicMembrane | 10 | 18 | |||||
| FECA_ECOLI | P13036 | fecA | b4291 JW4251 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Fe(3+) dicitrate transport FecA | Outer Membrane b-barrel protein | Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 2836368 | PMID: 11266632 PMID: 11872840 PMID: 12624733 PMID: 15911532 PMID: 19343722 PMID: 19953543 PMID: 20932056 PMID: 2836368 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SURA,SKP | BAM | no | yes | Y | 34 | 0.831 | SpI | 33 | 18.814 | - | 0 | 0 | Y | n19-29c33/34o | OuterMembrane | 10 | 1 | ||||||
| TREA_ECOLI | P13482 | treA osmA | osmA | b1197 JW1186 | periplasmic protein (SEC through IM), trehalase TreA | Periplasmic | Potential Skp substrate PMID: 19953543 PMID: 2671658 Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 2671658 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SKP | yes | yes | Y | 31 | 0.702 | SpI | 30 | 17.5054 | - | 0 | 0 | Y | n13-26c30/31o | Periplasmic | 10 | 70 | ||||||
| CSRD_ECOLI | P13518 | csrD yhdA | yhdA | b3252 JW3221 | integral IM protein (SEC in IM), RNase E specificity factor CsrD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.172 | TMH | 0 | 5.84825 | - | 2 | 2 | N | i7-31o130-155i | CytoplasmicMembrane | 9 | 4 | |||||
| CHIA_ECOLI | P13656 | chiA yheB | yheB | b3338 JW3300 | periplasmic & extra-cellular protein (SEC through IM), TSS secreted over OM), Probable bifunctional chitinase/lysozyme ChiA | Periplasmic, Extra-cellular | Can be fully secreted when the cryptic T2S system is expressed. PMID: 10760150 Disulfide bridge (628 673) Disulfide bond-containing protein PMID: 25664544 | PMID: 10760150 PMID: 11118204 PMID: 25664544 | Periplasmic, Extra-cellular | G, X | N/A | Periplasm | Periplasmic (Experimental) | SEC | T2S | no | yes | Y | 25 | 0.672 | SpI | 24 | 20.7505 | - | 0 | 0 | Y | n11-20c24/25o | Periplasmic | 10 | |||||||
| NHAA_ECOLI | P13738 | nhaA ant | ant | b0019 JW0018 | integral IM protein (SEC in IM), Na(+)/H(+) antiporter NhaA | Integral Inner Membrane | Structure of a Na+/H+ antiporter. A negatively charged ion funnel opens to the cytoplasm and ends in the middle of the membrane at the putative ion-binding site PMID: 15988517. | PMID: 11266632 PMID: 15919996 PMID: 15988517 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.227 | TMH | 0 | 7.93195 | - | 11 | 11 | N | i12-39o59-79i91-114o126-145i154-175o181-200i207-238o258-276i288-312o324-351i363-380o | CytoplasmicMembrane | 10 | |||||
| PROW_ECOLI | P14176 | proW | b2678 JW2653 | integral IM protein (SEC-YidC in IM), Glycine betaine/proline betaine transport system permease ProW | Integral Inner Membrane | PMID: 10949305 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 24 | 0.12 | CYT | 0 | -0.200913 | - | 6 | 6 | N | o97-118i125-143o149-171i192-219o271-291i303-320o | CytoplasmicMembrane | 10 | 5 | ||||||
| ZRAS_ECOLI | P14377 | zraS hydH | hydH | b4003 JW3967 | integral IM protein (SEC in IM), Sensor ZraS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.129 | TMH | 0 | 7.59471 | - | 2 | 2 | N | i12-35o202-222i | CytoplasmicMembrane | 10 | ||||||
| FECB_ECOLI | P15028 | fecB | b4290 JW4250 | periplasmic & peripheral IM protein (SEC through IM), Fe(3+) dicitrate-binding periplasmic FecB | Peripheral inner membrane protein facing the periplasm, periplasmic | PMID: 2651410 | Peripheral inner membrane protein facing the periplasm, periplasmic | F2, G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.843 | SpI | 21 | 8.42911 | - | 0 | 0 | Y | n7-16c21/22o | Periplasmic | 9 | 8 | |||||||||
| FECD_ECOLI | P15029 | fecD | b4288 JW4248 | integral IM protein (SEC in IM), Fe(3+) dicitrate transport system permease FecD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 28 | 0.121 | TMH | 0 | 10.0321 | - | 7 | 7 | Y | n4-19c31/32o55-76i85-103o109-126i138-158o226-256i268-290o296-315i | CytoplasmicMembrane | 10 | 4 | ||||||
| FECC_ECOLI | P15030 | fecC | b4289 JW4249 | integral IM protein (SEC in IM), Fe(3+) dicitrate transport system permease FecC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.15 | TMH | 0 | 7.31223 | - | 8 | 9 | Y | n8-27c36/37o60-81i93-111o117-140i152-171o177-194i201-220o240-270i282-304o310-328i | CytoplasmicMembrane | 10 | |||||||
| CSTA_ECOLI | P15078 | cstA ybdC | ybdC | b0598 JW0590 | integral IM protein (SEC-YidC in IM), Peptide transporter CstA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 21 | 0.185 | TMH | 0 | 8.48745 | - | 18 | 16 | N | i7-26o32-52i93-111o117-138i159-185o191-209i221-240o260-277i284-305o325-345i373-393o470-494i515-534o546-571i578-598o648-671i | CytoplasmicMembrane | 10 | |||||
| FLK_ECOLI | P15286 | flk div | div | b2321 JW2318 | integral IM protein (SEC in IM), regulator Flk | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 54 | 0.104 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o313-330i | CytoplasmicMembrane | 9 | 61 | |||||||
| DHG_ECOLI | P15877 | gcd | b0124 JW0120 | integral IM protein (SEC in IM), Quinoglucose dehydrogenase Gcd | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 PMID: 8419307 PMID: 8509415 PMID: 8554505 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.121 | TMH | 0 | 21.0845 | - | 5 | 5 | N | i12-35o41-58i65-81o87-106i113-140o | CytoplasmicMembrane | 9 | 18 | ||||||
| AROP_ECOLI | P15993 | aroP | b0112 JW0108 | integral IM protein (SEC-YidC in IM), Aromatic amino acid transport AroP | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 44 | 0.121 | TMH | 0 | 9.5384 | - | 12 | 12 | N | i20-41o47-63i84-105o125-142i154-176o196-220i241-263o283-300i332-353o359-379i400-422o428-446i | CytoplasmicMembrane | 10 | ||||||
| PANF_ECOLI | P16256 | panF | b3258 JW3226 | integral IM protein (SEC in IM), Sodium/pantothenate symporter PanF | Integral Inner Membrane | Prediction of one very weak transmembrane region. | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.187 | TMH | 0 | 8.73514 | - | 13 | 13 | N | o6-24i45-63o75-94i122-144o156-178i190-213o233-253i273-298o318-341i369-386o392-417i424-442o448-466i | CytoplasmicMembrane | 10 | ||||||
| HYCC_ECOLI | P16429 | hycC hevC | hevC | b2723 JW2693 | integral IM protein (SEC in IM), Formate hydrogenlyase subunit 3 HycC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.168 | TMH | 0 | 11.9962 | - | 14 | 16 | N | o6-26i33-58o78-96i108-124o130-146i153-173o197-218i230-251o257-280i292-312o332-349i370-395o415-435i456-480o500-521i587-605o | CytoplasmicMembrane | 10 | ||||||
| HYCD_ECOLI | P16430 | hycD hevD | hevD | b2722 JW2692 | integral IM protein (SEC in IM), Formate hydrogenlyase subunit 4 HycD | Integral Inner Membrane | PMID: 15919996 PMID: 1625581 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 30 | 0.198 | CYT | 0 | -0.200913 | - | 8 | 8 | N | o6-27i62-85o97-119i131-149o169-188i224-242o248-273i285-306o | CytoplasmicMembrane | 10 | ||||||
| PHND_ECOLI | P16682 | phnD psiD | psiD | b4105 JW4066 | periplasmic protein (SEC through IM), Phosphonates-binding periplasmic protein PhnD | Periplasmic | PMID: 16751609 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.567 | SpI | 26 | 16.4228 | - | 0 | 0 | Y | n6-21c26/27o | Periplasmic | 10 | |||||||||
| CYSP_ECOLI | P16700 | cysP | b2425 JW2418 | periplasmic protein (SEC through IM), Thiosulfate-binding protein CysP | Periplasmic | PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 26 | 0.741 | SpI | 25 | 14.3932 | - | 0 | 0 | Y | n10-20c25/26o | Periplasmic | 10 | 61 | |||||||||
| CYST_ECOLI | P16701 | cysU cysT | cysT | b2424 JW2417 | integral IM protein (SEC-YidC in IM), Sulfate transport system permease CysT | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 37 | 0.285 | TMH | 0 | 14.8684 | - | 7 | 5 | N | o12-37i58-84o104-125i137-156o242-263i | CytoplasmicMembrane | 10 | 117 | ||||
| FHUE_ECOLI | P16869 | fhuE | b1102 JW1088 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), FhuE receptor FhuE | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 3032906 | PMID: 10806384 PMID: 3032906 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | no | yes | Y | 37 | 0.821 | SpI | 36 | 20.6615 | - | 0 | 0 | Y | n19-30c36/37o | OuterMembrane | 10 | 0 | |||||||
| MREC_ECOLI | P16926 | mreC | b3250 JW3219 | integral IM protein (SEC in IM), Cell shape-determining MreC | Integral Inner Membrane | PMID: 15612918 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 25 | 0.114 | TMH | 0 | 2.1577 | - | 1 | 0 | Y | n15-23c28/29o | Unknown | 2 | 35 | ||||||
| CIRA_ECOLI | P17315 | cirA cir feuA | cir feuA | b2155 JW2142 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Colicin I receptor CirA | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 10430870 Disulfide bond-containing protein PMID: 25664544 | PMID: 10430870 PMID: 10806384 PMID: 12624733 PMID: 15911532 PMID: 19953543 PMID: 20932056 PMID: 25664544 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | DSBA,SKP | BAM | yes | yes | Y | 26 | 0.695 | SpI | 25 | 11.8271 | - | 0 | 0 | Y | n10-20c25/26o | OuterMembrane | 10 | 46 | |||||
| PTQC_ECOLI | P17334 | chbC celB | celB | b1737 JW1726 | integral IM protein (SEC-YidC in IM), PTS system N,N'-diacetylchitobiose-specific EIIC component ChbC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 28 | 0.124 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i35-55o86-107i114-133o145-167i187-207o235-258i301-320o332-352i359-384o404-429i | CytoplasmicMembrane | 10 | 5 | ||||
| CYNX_ECOLI | P17583 | cynX | b0341 JW0332 | integral IM protein (SEC-YidC in IM), Cyanate transport CynX | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 55 | 0.147 | CYT | 0 | -0.200913 | - | 12 | 11 | Y | n2-10c18/19o34-55i67-85o91-113i125-147o153-173i201-224o230-251i263-281o287-309i321-339o354-372i | CytoplasmicMembrane | 10 | ||||||
| YFAA_ECOLI | P17994 | yfaA pufY | pufY | b2230 JW2224 | periplasmic protein (SEC through IM), YfaA | Periplasmic | G | Soluble IM Fraction | Periplasmic | SEC | no | yes | N | 31 | 0.233 | SpI | 30 | 5.42187 | - | 1 | 1 | N | i12-31o | CytoplasmicMembrane | 9 | 89 | |||||||||||
| PNCB_ECOLI | P18133 | pncB | b0931 JW0914 | periplasmic protein (SEC through IM), Nicotinate phosphoribosyltransferase PncB | Periplasmic | PncB is localized in the periplasm although it does not possess a signal peptide. | PMID: 346557 | Periplasmic | G | N/A | Cytoplasmic | SEC | no | yes | N | 61 | 0.11 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | 32 | |||||||||
| PGPA_ECOLI | P18200 | pgpA yajN | yajN | b0418 JW0408 | integral IM protein (SEC in IM), Phosphatidylglycerophosphatase A PgpA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 45 | 0.137 | TMH | 0 | 13.1049 | - | 3 | 5 | N | i21-51o57-75i87-104o110-126i138-162o | CytoplasmicMembrane | 10 | 23 | |||||
| YJJA_ECOLI | P18390 | yjjA | b4360 JW5795 | periplasmic protein (SEC through IM), YjjA | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 26 | 0.86 | SpI | 25 | 23.6068 | - | 0 | 0 | Y | n8-19c25/26o | Unknown | 2 | 100 | |||||||||
| RSTB_ECOLI | P18392 | rstB uspT | uspT | b1609 JW1601 | integral IM protein (SEC in IM), Sensor RstB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.112 | TMH | 0 | 2.20306 | - | 2 | 2 | N | o6-27i136-157o | CytoplasmicMembrane | 10 | 53 | |||||
| DMSA_ECOLI | P18775 | dmsA | b0894 JW5118 | periplasmic peripheral IM protein (TAT-SEC through IM), Dimethyl sulfoxide reductase DmsA | Peripheral inner membrane protein facing the periplasm | TAT signal peptide, dmsABC complex. Part of the anaerobic dimethylsulphoxide (DMSO) reductase DmsABC. The DmsC polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the DMSO enzyme to the membrane. PMID: 3062312 There are contradictory experiments although it seems that the senario of the DmsABC complex facing the cytoplasm is more favoured. PMID: 11389150 The hydrophobic region of the DmsA twin-arginine leader peptide determines specificity with chaperone DmsD. PMID: 24093457 Fluorescence analysis of these YFP chimeras revealed a wide range of interactions such as the one between the Tat substrate dimethyl sulfoxide reductase (DmsA) and its dedicated proofreading chaperone DmsD. PMID: 20169075 The localization of DmsAB was compared in a strain expressing a partial DmsC subunit (pDMSC59X) with full-length DmsC originating from the chromosomal copy of the dms operon. In those experiments some DmsAB was reported in the periplasm in the absence of full-length DmsC, leading us to suggest that DmsC might serve a stop-transfer role. PMID: 9546395 TTnphoA fusions, and electron paramagnetic resonance monitoring the effects of the probe dysprosium(III) on an engineered 3Fe4S cluster in DmsB indicated that DmsAB faces the cytoplasm PMID: 2170332 PMID: 3280546 PMID: 3062312 Interacts with DmsD, a redox enzyme maturation protein (REMP). PMID: 20153451 | PMID: 11389150 PMID: 17218314 PMID: 20153451 PMID: 20169075 PMID: 2170332 PMID: 24093457 PMID: 3062312 PMID: 3280546 PMID: 9546395 | Peripheral inner membrane protein facing the periplasm | F2 | Soluble IM Fraction | Cell membrane | Periplasmic (Experimental) | DmsD | TAT,SEC | yes | yes | N | 46 | 0.537 | SpI | 45 | 5.24058 | - | 0 | 0 | N | i | CytoplasmicMembrane | 10 | 22 | |||||||
| DMSB_ECOLI | P18776 | dmsB | b0895 JW0878 | periplasmic peripheral IM protein (TAT via piggyback through IM), Anaerobic dimethyl sulfoxide reductase chain B DmsB | Peripheral inner membrane protein facing the periplasm | TAT (piggyback); DmsB is co-exported bound to Tat substrate DmsA. Part of the anaerobic dimethylsulphoxide (DMSO) reductase DmsABC. The DmsC polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the DMSO enzyme to the membrane. PMID: 3062312 There are contradictory experiments although it seems that the senario of the DmsABC complex facing the cytoplasm is more favoured. PMID: 11389150 The localization of DmsAB was compared in a strain expressing a partial DmsC subunit (pDMSC59X) with full-length DmsC originating from the chromosomal copy of the dms operon. In those experiments some DmsAB was reported in the periplasm in the absence of full-length DmsC, leading us to suggest that DmsC might serve a stop-transfer role. PMID: 9546395 TTnphoA fusions, and electron paramagnetic resonance monitoring the effects of the probe dysprosium(III) on an engineered 3Fe4S cluster in DmsB indicated that DmsAB faces the cytoplasm PMID: 2170332 | PMID: 11389150 PMID: 2170332 PMID: 3062312 PMID: 9546395 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cytoplasmic | TAT (piggyback) | yes | yes | N | 44 | 0.107 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 5 | 27 | |||||||||
| DMSC_ECOLI | P18777 | dmsC | b0896 JW0879 | integral IM protein (SEC in IM), Anaerobic dimethyl sulfoxide reductase chain C DmsC | Integral Inner Membrane | DMSO reductase subunit C,Periplasmic. Has a membrane bound anchor. Part of the anaerobic dimethylsulphoxide (DMSO) reductase DmsABC. The DmsC polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the DMSO enzyme to the membrane. PMID: 3062312 There are contradictory experiments although it seems that the senario of the DmsABC complex facing the cytoplasm is more favoured. PMID: 11389150 The localization of DmsAB was compared in a strain expressing a partial DmsC subunit (pDMSC59X) with full-length DmsC originating from the chromosomal copy of the dms operon. In those experiments some DmsAB was reported in the periplasm in the absence of full-length DmsC, leading us to suggest that DmsC might serve a stop-transfer role. PMID: 9546395 TTnphoA fusions, and electron paramagnetic resonance monitoring the effects of the probe dysprosium(III) on an engineered 3Fe4S cluster in DmsB indicated that DmsAB faces the cytoplasm PMID: 2170332 PMID: 15919996 | PMID: 11389150 PMID: 15919996 PMID: 2170332 PMID: 3062312 PMID: 9546395 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.177 | TMH | 0 | 13.558 | - | 8 | 8 | N | o12-32i44-68o88-105i117-137o149-171i183-203o223-243i255-277o | CytoplasmicMembrane | 10 | ||||||
| GGT_ECOLI | P18956 | ggt | b3447 JW3412 | periplasmic protein (SEC through IM), Glutathione hydrolase proenzyme Ggt | Periplasmic | Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 1360205 PMID: 25403562 PMID: 2570061 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | YfgM | yes | yes | Y | 26 | 0.723 | SpI | 25 | 20.0548 | - | 0 | 0 | Y | n10-21c25/26o | Periplasmic | 10 | 36 | |||||||
| PTOCB_ECOLI | P19642 | malX | b1621 JW1613 | integral IM protein (SEC in IM), PTS system maltose-specific EIICB component MalX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 44 | 0.116 | TMH | 0 | 7.8693 | - | 8 | 10 | N | i21-42o62-89i96-116o136-161i182-205o295-313i320-337o343-362i369-391o397-419i | CytoplasmicMembrane | 10 | 5 | ||||||
| AGP_ECOLI | P19926 | agp | b1002 JW0987 | periplasmic protein (SEC through IM), Glucose-1-phosphatase Agp | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 2153660 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 23 | 0.88 | SpI | 22 | 21.9324 | - | 0 | 0 | Y | n5-16c22/23o | Periplasmic | 10 | 62 | ||||||||
| TOLA_ECOLI | P19934 | tolA cim excC lky | cim excC lky | b0739 JW0729 | integral IM protein (SEC in IM), Tol-Pal system TolA | Integral Inner Membrane | The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF. The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 7744737 Disulfide bridge (363 388) Disulfide bond-containing protein PMID: 25664544 | PMID: 15919657 PMID: 20816983 PMID: 25664544 PMID: 7744737 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.131 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i12-31o | Unknown | 2 | 50 | ||||
| PTFBC_ECOLI | P20966 | fruA ptsF | ptsF | b2167 JW2154 | integral IM protein (SEC in IM), PTS system fructose-specific EIIB'BC component FruA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.169 | CYT | 0 | -0.200913 | - | 9 | 9 | N | i230-256o268-291i303-329o349-368i389-410o430-451i463-482o488-507i519-551o | CytoplasmicMembrane | 10 | 7 | |||||
| SPEA_ECOLI | P21170 | speA | b2938 JW2905 | periplasmic protein (SEC through IM), Biosynthetic arginine decarboxylase SpeA | Periplasmic | Trigger factor-sensitive aggregation. Experimentally detected by proteomics analysis of E.coli membrane fraction PMID: 19766000. No transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius. Potential peripherally associated protein facing the cytoplasm or integral inner membrane protein. PMID: 2198270 Selective disruption of the cell envelope and an assessment of Spea activity or immunoprecipitable SpeA in various fractions demonstrated its location between the cytoplasmic membrane and peptidoglycan layer. PMID: 3894328 | PMID: 15919657 PMID: 19737520 PMID: 19766000 PMID: 2198270 PMID: 3894328 | Periplasmic | G | Soluble IM Fraction | Periplasm | Cytoplasmic | TF | SEC | yes | yes | N | 27 | 0.129 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 10 | 48 | |||||||
| RNI_ECOLI | P21338 | rna rnsA | rnsA | b0611 JW0603 | periplasmic protein (SEC through IM), Ribonuclease I Rna | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbA substrate PMID: 19953543 PMID: 2253883 Disulfide bridge (103 159) | PMID: 14726535 PMID: 19953543 PMID: 2253883 | Periplasmic | G | N/A | Periplasm Cytoplasm | Periplasmic (Experimental) | SEC | DSBA,DSBC | yes | yes | Y | 24 | 0.538 | SpI | 25 | 15.6073 | - | 0 | 0 | Y | n8-18c23/24o | Periplasmic | 10 | 31 | ||||||
| GLTP_ECOLI | P21345 | gltP | b4077 JW4038 | integral IM protein (SEC in IM), Proton/glutamate-aspartate symporter GltP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.123 | TMH | 0 | 11.2813 | - | 10 | 10 | N | i7-27o47-72i84-106o160-181i202-224o236-264i293-311o323-350i362-385o391-409i | CytoplasmicMembrane | 10 | 19 | ||||||
| YCIC_ECOLI | P21365 | yciC | b1255 JW1247 | integral IM protein (SEC in IM), UPF0259 YciC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.196 | TMH | 0 | 6.50025 | - | 6 | 6 | N | i20-41o77-104i116-136o142-166i187-212o218-239i | CytoplasmicMembrane | 10 | |||||||
| NMPC_ECOLI | P21420 | nmpC phmA | phmA | b0553 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative porin NmpC | Outer Membrane b-barrel protein | PMID: 337109 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ss-barrel protein(experimental) | SEC | BAM | pseudogene (Uniprot) | yes | no | Y | 24 | 0.879 | SpI | 23 | 25.1335 | - | 0 | 0 | Y | n4-15c23/24o | OuterMembrane | 10 | 11 | ||||||
| YCAD_ECOLI | P21503 | ycaD | b0898 JW0881 | integral IM protein (SEC in IM), MFS-type transporter YcaD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.154 | TMH | 0 | 14.4924 | - | 12 | 11 | Y | n10-18c23/24o47-65i74-92o98-119i131-149o161-181i202-223o235-253i265-283o289-311i323-345o351-369i | CytoplasmicMembrane | 10 | |||||||
| KDPD_ECOLI | P21865 | kdpD | b0695 JW0683 | integral IM protein (SEC in IM), Sensor KdpD | Integral Inner Membrane | PMID: 1532388 PMID: 15919996 PMID: 21605551 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 46 | 0.149 | CYT | 0 | -0.200913 | - | 4 | 4 | N | i399-419o425-443i448-465o477-498i | CytoplasmicMembrane | 10 | 22 | ||||||
| YCBB_ECOLI | P22525 | ycbB | b0925 JW0908 | periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YcbB | Peripheral outer membrane protein facing the periplasm | YcbB forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan. | PMID: 23832002 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Membrane | Periplasmic | SEC | yes | yes | Y | 31 | 0.448 | SpI | 30 | 10.8337 | - | 0 | 0 | Y | n11-22c30/31o | Periplasmic | 9 | 63 | ||||||||
| FLIO_ECOLI | P22586 | fliO flaP flbD | flaP flbD | b1947 JW5316 | Flagellar integral IM protein (SEC in IM), FliO | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell membrane | Membrane anchored | flagellum | SRP | SEC | no | yes | N | 27 | 0.161 | TMH | 0 | 0.0866025 | - | 1 | 1 | N | o18-39i | CytoplasmicMembrane | 9 | 14 | ||||||
| LIVM_ECOLI | P22729 | livM | b3456 JW3421 | integral IM protein (SEC in IM), High-affinity branched-chain amino acid transport system permease LivM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.39 | SpI | 20 | 11.5293 | - | 10 | 10 | Y | n9-20c25/26o44-61i91-108o114-132i137-156o162-184i191-209o262-283i313-336o348-373i385-403o | CytoplasmicMembrane | 10 | |||||||
| TNAB_ECOLI | P23173 | tnaB trpP | trpP | b3709 JW5619/JW5622 | integral IM protein (SEC in IM), Low affinity tryptophan permease TnaB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 25 | 0.14 | TMH | 0 | 16.6914 | - | 11 | 11 | N | i12-32o38-61i82-105o125-143i155-174o194-219i226-246o282-310i322-341o347-369i381-406o | CytoplasmicMembrane | 10 | 5 | |||||
| MGLC_ECOLI | P23200 | mglC | b2148 JW2135 | integral IM protein (SEC in IM), Galactoside transport system permease MglC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.106 | TMH | 0 | 5.37465 | - | 9 | 8 | N | i12-31o43-64i105-129o135-155i175-201o227-248i269-299o311-330i | CytoplasmicMembrane | 10 | |||||||
| HYFB_ECOLI | P23482 | hyfB yffF | yffF | b2482 JW2467 | integral IM protein (SEC in IM), Hydrogenase-4 component B HyfB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 57 | 0.166 | TMH | 0 | 7.57984 | - | 16 | 16 | N | o6-27i39-62o82-103i110-129o135-154i166-185o205-224i245-267o273-296i303-326o332-363i383-405o425-452i473-496o532-551i652-671o | CytoplasmicMembrane | 10 | ||||||
| FECR_ECOLI | P23485 | fecR | b4292 JW4252 | integral IM protein (SEC in IM), FecR | Integral Inner Membrane | The protein is oriented such that residues 1 to 85 are in the cytoplasm, residues 86 to 100 form a transmembrane segment, and residues 101 to 317 are in the periplasm where the C-terminus can interact with the N-domain of the outer membrane protein FecA. | PMID: 12057967 PMID: 9573190 | Integral Inner Membrane | B | - | IM (predicted-detected) | Periplasm | Integral Membrane Protein | SRP | SEC | no | yes | N | 35 | 0.136 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 10 | |||||||
| ECOT_ECOLI | P23827 | eco eti | eti | b2209 JW2197 | periplasmic protein (SEC through IM), Eco | Periplasmic | Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bridge (70 107) Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 21 | 0.889 | SpI | 20 | 16.5012 | - | 0 | 0 | Y | n4-15c20/21o | Periplasmic | 10 | 85 | |||||||
| PHOQ_ECOLI | P23837 | phoQ | b1129 JW1115 | integral IM protein (SEC in IM), Sensor PhoQ | Integral Inner Membrane | PMID: 15919996 PMID: 23359663 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.287 | TMH | 0 | 6.14229 | - | 2 | 1 | Y | n17-28c33/34o194-216i | CytoplasmicMembrane | 10 | 20 | ||||||
| PDEA_ECOLI | P23842 | pdeA yfeA | yfeA | b2395 JW5391 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 45 | 0.113 | TMH | 0 | 9.46751 | - | 8 | 9 | N | o12-31i43-61o81-104i125-143o163-186i214-232o238-255i262-279o291-312i | CytoplasmicMembrane | 10 | ||||||
| OPPA_ECOLI | P23843 | oppA | b1243 JW1235 | periplasmic protein (SEC through IM), oligopeptide-binding protein OppA | Periplasmic | SecB substrate. Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (297 443) Disulfide bond-containing protein PMID: 25664544 | PMID: 16352602 PMID: 19953543 PMID: 22030350 PMID: 25664544 PMID: 9298646 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SECB | SEC | yes | yes | Y | 27 | 0.825 | SpI | 26 | 18.3169 | - | 1 | 0 | Y | n8-18c26/27o | Periplasmic | 10 | 73 | |||||||
| DPPA_ECOLI | P23847 | dppA | b3544 JW3513 | periplasmic protein (SEC through IM), dipeptide transport DppA | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (34 262;450 463) Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 15911532 PMID: 19953543 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA,SKP | yes | yes | Y | 29 | 0.638 | SpI | 28 | 16.4393 | - | 0 | 0 | Y | n13-23c28/29o | Periplasmic | 10 | 85 | |||||||
| TRKG_ECOLI | P23849 | trkG | b1363 JW1358 | integral IM protein (SEC in IM), Trk system potassium uptake TrkG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | yes | no | N | 32 | 0.135 | TMH | 0 | 11.2875 | - | 11 | 11 | N | i12-34o40-60i72-93o139-164i185-206o239-263i275-296o336-356i399-418o424-446i458-483o | CytoplasmicMembrane | 10 | ||||||
| PSPE_ECOLI | P23857 | pspE | b1308 JW1301 | periplasmic protein (SEC through IM), Thiosulfate sulfurtransferase PspE | Periplasmic | Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 9868784 Disulfide bond-containing protein PMID: 25664544 | PMID: 1712397 PMID: 25664544 PMID: 9868784 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | Prophage Transposase | yes | no | Y | 20 | 0.9 | SpI | 19 | 20.0627 | - | 0 | 0 | Y | n5-15c19/20o | Unknown | 2 | ||||||||
| PRC_ECOLI | P23865 | prc tsp | tsp | b1830 JW1819 | periplasmic peripheral IM protein (SEC through IM), Tail-specific protease Prc | Peripheral inner membrane protein facing the periplasm | Fractionation of the maxicells producing the product or prc gene suggested that the product was associated with the periplasmic side of the cytoplasmic membrane. The prc gene, which is involved in cleavage of the C-terminal peptide from the precursor form of penicillin-binding protein 3 (PBP 3) of Escherichia coli. PMID: 1856173 PMID: 1729701 | PMID: 1729701 PMID: 1856173 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cell inner membrane; Peripheral membrane protein; Periplasmic side | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.786 | SpI | 22 | 11.2952 | - | 0 | 0 | Y | n7-17c22/23o | CytoplasmicMembrane | 10 | ||||||||
| FEPD_ECOLI | P23876 | fepD | b0590 JW0582 | integral IM protein (SEC in IM), Ferric enterobactin transport system permease FepD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.205 | TMH | 0 | 1.30983 | - | 9 | 9 | N | o6-30i64-81o93-114i121-139o151-172i193-213o239-264i284-304o310-326i | CytoplasmicMembrane | 10 | |||||||
| FEPG_ECOLI | P23877 | fepG | b0589 JW0581 | integral IM protein (SEC in IM), Ferric enterobactin transport system permease FepG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.416 | TMH | 0 | 10.9363 | - | 8 | 8 | Y | n8-23c41/42o65-83i95-112o118-138i145-167o187-211i236-262o274-296i303-324o | CytoplasmicMembrane | 10 | |||||||
| CYDC_ECOLI | P23886 | cydC mdrA mdrH surB | mdrA mdrH surB | b0886 JW0869 | integral IM protein (SEC in IM), ATP-binding/permease CydC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 50 | 0.199 | TMH | 0 | 16.2776 | - | 6 | 6 | N | i16-35o41-61i133-155o161-182i243-266o278-301i | CytoplasmicMembrane | 10 | 10 | |||||
| CADC_ECOLI | P23890 | cadC | b4133 JW4094 | nucleoid & integral IM protein (SEC in IM), Transcriptional activator CadC | Integral Inner Membrane, Nucleoid | Membrane-integrated pH sensor. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP. | PMID: 18086202 PMID: 21890895 PMID: 23138451 PMID: 24056175 | Integral Inner Membrane, Nucleoid | B, N | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 50 | 0.131 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o159-181i | CytoplasmicMembrane | 9 | ||||||||
| HTPX_ECOLI | P23894 | htpX | b1829 JW1818 | integral IM protein (SEC in IM), Protease HtpX | Integral Inner Membrane | PMID: 12081643 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.141 | TMH | 0 | 12.8648 | - | 4 | 3 | Y | n4-18c23/24o33-53i158-178o193-217i | CytoplasmicMembrane | 10 | 8 | ||||||
| EMRE_ECOLI | P23895 | emrE eb mvrC | eb mvrC | b0543 JW0531 | integral IM protein (SEC-YidC in IM), Multidrug transporter EmrE | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996 | PMID: 15919996 PMID: 16429150 PMID: 20508091 PMID: 22108384 PMID: 22178925 PMID: 22444835 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | in/out, out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | Prophage Integrase (EcoGene), pseudogene (Ochman & Davalos, 2006) | no | no | N | 62 | 0.162 | TMH | 0 | 6.32256 | - | 4 | 3 | N | o30-48i60-79o85-104i | CytoplasmicMembrane | 10 | 7 | |||
| NLPC_ECOLI | P23898 | nlpC | b1708 JW1698 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Probable endopeptidase NlpC | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 21 | 0.325 | SpII | 15 | 16.0698 | Pos+2=S | 0 | 0 | Y | n3-13c17/18o | Unknown | 2 | 34 | |||||||
| ARAJ_ECOLI | P23910 | araJ | b0396 JW0386 | integral IM protein (SEC in IM), Putative transporter AraJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.21 | TMH | 0 | 4.92502 | - | 12 | 11 | Y | n4-15c20/21o44-63i70-96o102-120i127-150o156-178i199-219o225-251i263-284o290-310i331-350o356-375i | CytoplasmicMembrane | 10 | |||||||
| LNT_ECOLI | P23930 | lnt cutE | cutE | b0657 JW0654 | integral IM protein (SEC in IM), ApoN-acyltransferase Lnt | Integral Inner Membrane | PMID: 15919996 PMID: 2032623 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.184 | TMH | 0 | 13.3696 | - | 6 | 8 | N | i12-28o34-50i57-79o91-112i124-142o162-188i195-214o489-507i | CytoplasmicMembrane | 10 | 2 | |||||
| ENTS_ECOLI | P24077 | entS ybdA | ybdA | b0591 JW0583 | integral IM protein (SEC in IM), Enterobactin exporter EntS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.337 | TMH | 0 | 10.2914 | - | 11 | 12 | N | i21-42o54-74i86-105o111-135i147-170o176-199i219-246o258-276i288-305o311-336i357-374o380-399i | CytoplasmicMembrane | 10 | ||||||
| ACRD_ECOLI | P24177 | acrD yffA | yffA | b2470 JW2454 | integral IM protein (SEC-YidC in IM), Probable aminoglycoside efflux pump AcrD | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 35 | 0.15 | SpI | 34 | 5.86063 | - | 11 | 11 | Y | n10-21c26/27o340-359i366-387o393-413i438-458o470-497i538-558o873-890i897-917o923-944i972-992o1004-1026i | CytoplasmicMembrane | 10 | |||||
| ACRE_ECOLI | P24180 | acrE envC | envC | b3265 JW3233 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug export AcrE | Inner Membrane Lipoprotein | Proven pignal peptidase II substrate. | PMID: 15174130 PMID: 8472900 | Inner Membrane Lipoprotein | E | N/A | Cell inner membrane | Inner membrane lipoprotein | SEC | LOL | yes | yes | Y | 23 | 0.241 | SpII | 23 | 10.9032 | Pos+2=N | 0 | 0 | Y | n7-18c23/24o | CytoplasmicMembrane | 9 | 70 | ||||||
| ACRF_ECOLI | P24181 | acrF envD | envD | b3266 JW3234 | integral IM protein (SEC in IM), Multidrug export AcrF | Integral Inner Membrane | PMID: 11274125 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.286 | SpI | 26 | 12.2125 | - | 12 | 11 | Y | n10-21c26/27o340-359i366-390o396-416i437-458o470-497i541-558o872-891i898-918o924-948i969-990o1002-1028i | CytoplasmicMembrane | 10 | ||||||
| FDNG_ECOLI | P24183 | fdnG | b1474 JW1470 | periplasmic peripheral IM protein (TAT through IM), Formate dehydrogenase, nitrate-inducible, major subunit FdnG | Peripheral inner membrane protein facing the periplasm | TAT secretion system; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit forms the active site. FdnG is the catalytic subunit of formate dehydrogenase-N (FdnGHI). FdnG was found in the periplasmic fraction of a mutant lacking the membrane anchor subunit FdnI, confirming that FdnG is located at the periplasmic face of the cytoplasmic membrane. PMID: 11929547 PMID: 11884747 PMID: 12923080 PMID: 11884747 PMID: 16858726 | PMID: 11884747 PMID: 11929547 PMID: 12923080 PMID: 15342602 PMID: 16858726 PMID: 17218314 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasm | Membrane associated (Experimental) | TAT | no | yes | N | 34 | 0.342 | SpI | 33 | 6.74593 | - | 0 | 0 | Y | n11-24c33/34o | Periplasmic | 10 | |||||||||
| LPXM_ECOLI | P24205 | lpxM msbB | msbB | b1855 JW1844 | integral IM protein (SEC in IM), Lipid A biosynthesis myristoyltransferase LpxM | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 45 | 0.121 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o24-43i | CytoplasmicMembrane | 10 | 16 | |||||||
| PHEP_ECOLI | P24207 | pheP | b0576 JW0565 | integral IM protein (SEC in IM), Phenylalanine-specific permease PheP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 53 | 0.106 | TMH | 0 | 1.83401 | - | 12 | 12 | N | i30-49o55-71i107-130o136-156i163-184o204-228i249-271o291-308i340-361o367-387i408-428o434-452i | CytoplasmicMembrane | 10 | |||||||
| FLID_ECOLI | P24216 | fliD flaV flbC | flaV flbC | b1924 JW1909 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), hook-associated 2 FliD | Peripheral outer membrane protein facing the extra-cellular space | Filament capping protein. PMID: 7551038 PMID: 1527488 PMID: 6305924 | PMID: 1527488 PMID: 6305924 PMID: 7551038 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Secreted Bacterial flagellum | Cell surface appendage (Experimental) | flagellum | Flagellum | Fla | no | yes | N | 25 | 0.12 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 93 | |||||
| DACB_ECOLI | P24228 | dacB | b3182 JW3149 | periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacB | Peripheral inner membrane protein facing the periplasm | Exported from cytosol and signal peptide is cleaved. Anchored via C terminal the rest of the protein protudes into periplasm. Involved in peptidoglycan biosynthesis and is Penicillin-binding. PMID: 16411754 PMID: 15576782 DacB(PBP-4) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. PMID: 9371419 | PMID: 12444970 PMID: 15576782 PMID: 15911532 PMID: 16411754 PMID: 9371419 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasm | Membrane anchored (Experimental) | SEC | yes | yes | Y | 21 | 0.58 | SpI | 20 | 13.4163 | - | 0 | 0 | Y | n6-16c20/21o | Periplasmic | 9 | 34 | ||||||||
| PTIBC_ECOLI | P24241 | ascF | b2715 JW5435 | integral IM protein (SEC-YidC in IM), PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component AscF | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 25 | 0.128 | CYT | 0 | -0.200913 | - | 8 | 10 | N | i104-127o147-167i179-197o217-234i254-282o288-309i330-350o362-382i389-413o433-456i | CytoplasmicMembrane | 10 | 7 | |||||
| APPX_ECOLI | P24244 | appX yccB | yccB | b4592 JW0961.1 b0979.1 | integral IM protein (SEC in IM), Putative cytochrome bd-II ubiquinol oxidase subunit AppX | Integral Inner Membrane | Experimentally verified orientation: N(out)-C(in). | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | out/in | N/A | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.107 | TMH | 0 | 2.07613 | - | 1 | 1 | N | o6-24i | CytoplasmicMembrane | 9 | |||||
| TEHA_ECOLI | P25396 | tehA | b1429 JW1425 | integral IM protein (SEC in IM), Tellurite resistance TehA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.119 | TMH | 0 | 12.0389 | - | 8 | 10 | N | i12-31o43-64i76-97o103-121i141-160o166-184i196-218o230-249i256-274o286-310i | CytoplasmicMembrane | 10 | |||||||
| GABP_ECOLI | P25527 | gabP | b2663 JW2638 | integral IM protein (SEC in IM), GABA permease GabP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.302 | TMH | 0 | 8.50646 | - | 12 | 12 | N | i21-40o46-66i97-118o124-144i156-180o200-220i241-264o284-308i335-354o360-380i401-423o429-449i | CytoplasmicMembrane | 10 | |||||||
| ASLA_ECOLI | P25549 | aslA atsA | atsA | b3801 JW3773 | periplasmic protein (SEC through IM), Arylsulfatase AslA | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 25 | 0.743 | SpI | 24 | 17.5099 | - | 0 | 0 | Y | n10-20c24/25o | Unknown | 6 | 25 | ||||||||||
| YIDC_ECOLI | P25714 | yidC | b3705 JW3683 | integral IM protein (SEC in IM), insertase YidC | Integral Inner Membrane | YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. The first periplasmic region of YidC include residues 24???346. Residues 215???265 of YidC are sufficient for SecF binding. The interaction of YidC with SecF is though not critical for cell viability as YidC, lacking residues 24-264, was fully functional to support the growth of <i>E. coli</i>. The integration of YidC into the cytoplasmic membrane requires the signal recognition particle, SecA and SecYEG. | PMID: 10675323 PMID: 11777926 PMID: 11821429 PMID: 15919657 PMID: 16079137 PMID: 17073462 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 25 | 0.321 | SpI | 24 | 12.0898 | - | 4 | 4 | Y | n7-17c24/25o354-373i417-440o464-482i494-519o | CytoplasmicMembrane | 10 | 26 | |||||
| AMY1_ECOLI | P25718 | malS | b3571 JW3543 | periplasmic protein (SEC through IM), alpha-amylase MalS | Periplasmic | Disulfide bridge (57 75;121 537) PMID: 9268356 Disulfide bond-containing protein PMID: 25664544 | PMID: 1544897 PMID: 25664544 PMID: 9268356 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 18 | 0.764 | SpI | 17 | 14.5348 | - | 0 | 0 | Y | n3-11c17/18o | Periplasmic | 10 | 25 | ||||||||
| END1_ECOLI | P25736 | endA | b2945 JW2912 | periplasmic protein (SEC through IM), Endonuclease-1 EndA | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 7867949 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 4955462 PMID: 7867949 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | no | yes | Y | 23 | 0.883 | SpI | 22 | 22.5344 | - | 0 | 0 | Y | n5-16c22/23o | Unknown | 5 | 99 | |||||||
| LYSP_ECOLI | P25737 | lysP cadR | cadR | b2156 JW2143 | integral IM protein (SEC in IM), Lysine-specific permease LysP | Integral Inner Membrane | Lysine-specific permease LysP and the membrane-integrated pH sensor CadC induce lysine-dependent adaptation of E. coli under acidic stress. In absence of lysine or high low pH LysP and CadC form stable complex. Probably CadC is inhibited by LysP via intramembrane and periplasmic contacts under non-inducing conditions. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP. | PMID: 15919996 PMID: 18086202 PMID: 24056175 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.175 | TMH | 0 | 10.7386 | - | 12 | 12 | N | i21-43o49-66i103-125o131-149i161-182o202-224i245-267o287-312i348-365o371-394i415-435o447-467i | CytoplasmicMembrane | 10 | |||||
| YCHE_ECOLI | P25743 | ychE | b1242 JW1229 | integral IM protein (SEC in IM), UPF0056 YchE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.169 | TMH | 0 | 10.9574 | - | 6 | 6 | N | o12-32i52-72o78-97i118-141o147-168i189-210o | CytoplasmicMembrane | 10 | 13 | ||||||
| MDTG_ECOLI | P25744 | mdtG yceE | yceE | b1053 JW1040 | integral IM protein (SEC in IM), Multidrug resistance MdtG | Integral Inner Membrane | PMID: 11566977 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein(experimental) | SRP | SEC | no | yes | N | 32 | 0.145 | TMH | 0 | 16.0858 | - | 10 | 10 | N | i16-40o52-74i86-104o110-130i142-162o174-193i220-245o257-278i290-308o374-393i | CytoplasmicMembrane | 10 | ||||||
| YEIB_ECOLI | P25747 | yeiB | b2152 JW2139 | integral IM protein (SEC in IM), YeiB | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.167 | TMH | 0 | 9.38597 | - | 10 | 10 | N | i9-28o48-71i83-101o107-122i134-153o201-221i233-254o274-292i312-332o338-359i | CytoplasmicMembrane | 10 | |||||||||
| FLIF_ECOLI | P25798 | fliF fla AII.1 fla BI | fla AII.1 fla BI | b1938 JW1922 | Flagellar integral IM protein (SEC in IM), M-ring protein FliF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | flagellum | SRP | SEC | no | yes | N | 46 | 0.141 | SpI | 43 | 3.78777 | - | 2 | 2 | N | i23-43o451-468i | CytoplasmicMembrane | 10 | 54 | ||||
| LOIP_ECOLI | P25894 | loiP yggG | yggG | b2936 JW2903 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Metalloprotease LoiP | Outer Membrane Lipoprotein | Disulfide bridge (53 108) PMID: 22491786 | PMID: 17909889 PMID: 20932056 PMID: 22491786 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | N | 35 | 0.146 | SpII | 18 | 25.8287 | Pos+2=Q | 0 | 0 | Y | n5-16c34/35o | Unknown | 2 | 60 | ||||||
| YDBD_ECOLI | P25907 | ydbD | b1407 JW5221 | periplasmic protein (SEC through IM), YdbD | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 25 | 0.744 | SpI | 24 | 7.29978 | - | 0 | 0 | Y | n12-20c24/25o | CytoplasmicMembrane | 9 | 28 | ||||||||||||
| LEP4_ECOLI | P25960 | gspO hofD hopD hopO yheC | hofD hopD hopO yheC | b3335 JW3297 | integral IM protein (SEC in IM), Type 4 prepilin-like proteins leader peptide-processing enzyme GspO | Integral Inner Membrane | Part of gsp locus. PMID: 15919996 | PMID: 11118204 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 24 | 0.153 | TMH | 0 | 0.982152 | - | 7 | 5 | Y | n4-15c21/22o55-84i104-122o128-149i161-191o203-222i | CytoplasmicMembrane | 10 | |||||
| BGLH_ECOLI | P26218 | bglH yieC | yieC | b3720 JW3698 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Cryptic porin BglH | Outer Membrane b-barrel protein | Reconstitution experiments with lipid bilayer membranes defined BglH as a channel-forming component, i.e. it is an outer membrane porin. Can be easily removed from the outer membrane by treatment with detergent. PMID: 10027967 PMID: 10027967 | PMID: 10027967 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | no | yes | Y | 26 | 0.64 | SpI | 25 | 13.3498 | - | 0 | 0 | Y | n6-17c25/26o | OuterMembrane | 10 | 8 | ||||||
| FEPE_ECOLI | P26266 | fepE | b0587 JW0579 | integral IM protein (SEC in IM), Ferric enterobactin transport FepE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 46 | 0.11 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i42-61o339-362i | CytoplasmicMembrane | 10 | 33 | ||||||
| AMIB_ECOLI | P26365 | amiB yjeD | yjeD | b4169 JW4127 | periplasmic protein (SEC through IM), N-acetylmuramoyl-L-alanine amidase AmiB | Periplasmic | PMID: 12787347 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.861 | SpI | 22 | 13.4392 | - | 0 | 0 | Y | n9-17c22/23o | Unknown | 2 | 30 | ||||||||
| APPB_ECOLI | P26458 | appB cbdB cyxB | cbdB cyxB | b0979 JW0961 | integral IM protein (SEC in IM), Cytochrome bd-II ubiquinol oxidase subunit 2 AppB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.107 | TMH | 0 | 10.1949 | - | 8 | 9 | N | o12-40i61-79o85-103i123-148o168-188i209-233o263-283i290-314o334-356i | CytoplasmicMembrane | 10 | ||||||
| APPC_ECOLI | P26459 | appC cbdA cyxA | cbdA cyxA | b0978 JW0960 | integral IM protein (SEC-YidC in IM), Cytochrome bd-II ubiquinol oxidase subunit 1 AppC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 37 | 0.11 | TMH | 0 | 11.9815 | - | 9 | 9 | N | o20-42i54-71o91-116i128-145o184-208i215-235o386-409i421-442o471-492i | CytoplasmicMembrane | 10 | |||||
| PLSC_ECOLI | P26647 | plsC parF | parF | b3018 JW2986 | integral IM protein (SEC in IM), 1-acyl-sn-glycerol-3-phosphate acyltransferase PlsC | Integral Inner Membrane | PMID: 1557036 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored (Experimental) | SEC | yes | yes | N | 36 | 0.111 | TMH | 0 | 1.55803 | - | 1 | 1 | N | o6-27i | CytoplasmicMembrane | 10 | 28 | ||||||
| FTSP_ECOLI | P26648 | ftsP sufI | sufI | b3017 JW2985 | periplasmic protein (TAT-SEC through IM), Cell division FtsP | Periplasmic | TAT secretion system. PMID: 9298646 | PMID: 10593889 PMID: 17218314 PMID: 19135451 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | no | yes | Y | 28 | 0.494 | SpI | 27 | 10.6124 | - | 0 | 0 | Y | n8-19c27/28o | Periplasmic | 10 | 8 | |||||||
| RHAT_ECOLI | P27125 | rhaT | b3907 JW3878 | integral IM protein (SEC in IM), L-rhamnose-proton symporter RhaT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) , Soluble IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 20 | 0.227 | TMH | 0 | 12.7916 | - | 10 | 10 | N | o6-26i38-58o64-85i97-121o133-154i175-194o214-234i255-277o289-310i322-343o | CytoplasmicMembrane | 10 | |||||||
| RFAL_ECOLI | P27243 | rfaL waaL | waaL | b3622 JW3597 | integral IM protein (SEC in IM), O-antigen ligase RfaL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.114 | TMH | 0 | 0.404949 | - | 12 | 12 | N | i20-38o44-60i72-91o103-122i134-152o172-189i196-212o218-233i240-258o349-368i375-393o399-415i | CytoplasmicMembrane | 10 | ||||||
| LPXK_ECOLI | P27300 | lpxK ycaH | ycaH | b0915 JW0898 | integral IM protein (SEC in IM), Tetraacyldisaccharide 4'-kinase LpxK | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | no | yes | N | 44 | 0.107 | TMH | 0 | 1.00613 | - | 1 | 1 | N | o12-34i | Unknown | 2 | 30 | ||||||||
| EMRA_ECOLI | P27303 | emrA | b2685 JW2660 | integral IM protein (SEC in IM), Multidrug export EmrA | Integral Inner Membrane | PMID: 12482849 PMID: 1409590 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 38 | 0.157 | TMH | 0 | 6.79297 | - | 1 | 1 | N | i23-44o | CytoplasmicMembrane | 10 | 25 | ||||||
| RODZ_ECOLI | P27434 | rodZ yfgA | yfgA | b2516 JW2500 | nucleoid & integral IM protein (SEC in IM), Cytoskeleton RodZ | Integral Inner Membrane, Nucleoid | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Quantitative immunoblotting agaist RodZ purified protein indicate that RodZ is present at ~650 copies per average exponentially growing cell in LB medium and M9. The hth domain of RodZ is not required for transcription but for interaction with MreB. The protein, RodZ, is required for assembly of the actin cytoskeleton MreB that controls cell wall synthesis and cell shape. PMID: 19194484 | PMID: 15919657 PMID: 19008860 PMID: 19078962 PMID: 19194484 PMID: 21890895 PMID: 23138451 PMID: 9008159 PMCID: PMC2637328 | Integral Inner Membrane, Nucleoid | B, N | IM (predicted) | Cell inner membrane | Membrane anchored | SEC | yes | yes | N | 35 | 0.243 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i112-133o | Unknown | 2 | ||||||||
| WZYE_ECOLI | P27835 | wzyE wzy | wzy | b3793 JW3769 | integral IM protein (SEC in IM), Probable ECA polymerase WzyE | Integral Inner Membrane | PMID: 16816184 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.116 | TMH | 0 | 14.4283 | - | 11 | 11 | N | o6-26i38-58o70-88i115-137o157-175i182-199o205-220i227-245o337-361i381-398o410-430i | CytoplasmicMembrane | 10 | ||||||
| YIFK_ECOLI | P27837 | yifK | b3795 JW5595 | integral IM protein (SEC in IM), Probable transport YifK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.143 | TMH | 0 | 8.10925 | - | 12 | 12 | N | i12-34o40-60i94-119o125-146i158-177o197-219i240-259o271-299i333-353o359-380i401-423o429-448i | CytoplasmicMembrane | 10 | 31 | ||||||
| YIGE_ECOLI | P27840 | yigE | b4482 JW5591 | periplasmic protein (SEC through IM), YigE | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | pseudogene (Ochman & Davalos, 2006) | no | no | Y | 33 | 0.615 | SpI | 32 | 10.2626 | - | 0 | 0 | Y | n19-29c33/34o | Unknown | 2 | ||||||||
| YIGF_ECOLI | P27842 | yigF | b3817 JW3790 | integral IM protein (SEC in IM), YigF | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | no | yes | N | 40 | 0.108 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i52-72o78-107i | CytoplasmicMembrane | 9 | 25 | |||||||||
| YIGG_ECOLI | P27843 | yigG | b3818 JW5590 | integral IM protein (SEC in IM), YigG | Integral Inner Membrane | PMID: 11867724 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 42 | 0.121 | TMH | 0 | 5.14332 | - | 4 | 4 | N | i18-35o41-57i69-91o103-121i | CytoplasmicMembrane | 10 | |||||||
| RARD_ECOLI | P27844 | rarD | b3819 JW5589 | integral IM protein (SEC in IM), RarD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.239 | TMH | 0 | 9.7991 | - | 10 | 10 | N | i12-31o43-61i73-92o104-121i128-145o151-167i179-198o210-230i242-261o273-290i | CytoplasmicMembrane | 10 | |||||||
| NARQ_ECOLI | P27896 | narQ | b2469 JW2453 | integral IM protein (SEC in IM), Nitrate/nitrite sensor NarQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.145 | TMH | 0 | 1.10259 | - | 2 | 2 | N | o14-34i147-169o | CytoplasmicMembrane | 10 | 7 | ||||||
| MLIC_ECOLI | P28224 | mliC ydhA | ydhA | b1639 JW1631 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lysozyme inhibitor of C-type lysozyme MliC | Outer Membrane Lipoprotein | Disulfide bridge (37 102) PMID: 16937244 | PMID: 16937244 PMID: 18369469 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 23 | 0.288 | SpII | 17 | 7.61087 | Pos+2=S | 0 | 0 | Y | n6-15c20/21o | Unknown | 2 | 53 | ||||||
| BCR_ECOLI | P28246 | bcr bicA bicR sur suxA | bicA bicR sur suxA | b2182 JW5363 | integral IM protein (SEC-YidC in IM), Bicyclomycin resistance Bcr | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 33 | 0.128 | TMH | 0 | 13.9575 | - | 12 | 12 | N | i7-26o46-65i77-96o102-123i135-159o165-185i215-241o253-273i285-307o313-332i344-366o372-391i | CytoplasmicMembrane | 10 | |||||
| ASMA_ECOLI | P28249 | asmA yegA | yegA | b2064 JW2049 | integral IM protein (SEC in IM), AsmA | Integral Inner Membrane | Involved in outer memebrane protein assembly and has an apparent signal peptide. It has been predicted to be periplasmic or outer membrane protein but detailed sub-fractionation studies revealed that it is localized to the inner membranePMID: 8866482. Reduced LPS levels in asmA mutants indicate a possible role of AsmA in LPS biogenesis. | PMID: 19346309 PMID: 7476172 PMID: 8866482 PMCID: PMC178309 | Integral Inner Membrane | B | Bout | in/out | N/A | Periplasm | Membrane anchored | SRP | SEC | yes | yes | N | 26 | 0.141 | TMH | 0 | 10.2137 | - | 1 | 0 | Y | n4-16c21/22o | Unknown | 2 | 69 | ||||
| DINF_ECOLI | P28303 | dinF | b4044 JW4004 | integral IM protein (SEC in IM), DNA damage-inducible F DinF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.258 | TMH | 0 | 3.41253 | - | 13 | 13 | N | o6-22i29-49o61-83i103-124o152-173i180-199o205-227i259-278o284-302i338-359o371-393i405-422o428-446i | CytoplasmicMembrane | 10 | 10 | ||||||
| MLTG_ECOLI | P28306 | mltG yceG | yceG | b1097 JW1083 | integral IM protein (SEC in IM), Endolytic murein transglycosylase MltG | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 20 | 0.198 | SpI | 18 | 0.538854 | - | 1 | 0 | Y | n4-15c20/21o | Unknown | 6 | 16 | |||||||
| CSGA_ECOLI | P28307 | csgA | b1042 JW1025 | Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Major curlin subunit CsgA | Peripheral outer membrane protein facing the extra-cellular space | Curli component. CsgA, is secreted from the cell in an unpolymerized form PMID: 11823641 The secretion and stability of CsgA and CsgB are dependent on the outer membrane lipoprotein CsgG. PMID: 21645131 Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041 During a process called interbacterial complementation, a csgB mutant cell secretes soluble CsgA that can be assembled on the surface of a cell expressing only csgB PMID: 8817489 High levels of both IbsC and ShoB lead to changes in membrane potential suggesting that both act at the membrane, consistent with the hydrophobic nature of the proteins. | PMID: 11823641 PMID: 16704339 PMID: 18710431 PMID: 19131513 PMID: 21645131 PMID: 8817489 PMID: 9312041 PMID: 9383186 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Cell surface appendage (Experimental) | Curli | SEC | Curli | yes | yes | Y | 21 | 0.854 | SpI | 20 | 20.7833 | - | 0 | 0 | Y | n3-14c20/21o | Extracellular | 9 | 66 | ||||||
| METQ_ECOLI | P28635 | metQ yaeC | yaeC | b0197 JW0193 | IM lipoprotein (SEC through IM), inserted in OM by LOL), D-methionine-binding MetQ | Inner Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 12218041 | PMID: 12218041 PMID: 15174130 | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Cell membrane | Inner membrane lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 25 | 0.18 | SpII | 22 | 19.6725 | Pos+2=G | 0 | 0 | Y | n7-18c23/24o | CytoplasmicMembrane | 9 | 85 | ||||||
| YAAI_ECOLI | P28696 | yaaI | b0013 JW0012 | periplasmic protein (SEC through IM), UPF0412 YaaI | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 24 | 0.727 | SpI | 23 | 9.88216 | - | 0 | 0 | Y | n4-15c23/24o | Unknown | 2 | 59 | ||||||||||||
| GLTF_ECOLI | P28721 | gltF | b3214 JW3181 | Fimbrial periplasmic protein (SEC through IM), GltF | Periplasmic | Putative chaperone???usher fimbrial operon (class ??). Fimbrial Subunit. PMID: 10481090 | PMID: 10481090 PMID: 20345943 PMID: 21890895 | Periplasmic | G | N/A | Cell membrane | Periplasmic (Experimental) | fimbriae | SEC | no | yes | Y | 26 | 0.754 | SpI | 25 | 26.3964 | - | 0 | 0 | Y | n7-18c25/26o | Unknown | 2 | 95 | |||||||
| YHCA_ECOLI | P28722 | yhcA | b3215 JW3182 | Fimbrial periplasmic protein (SEC through IM), Chaperone YhcA | Periplasmic | Potential fimbrial yhc operon (class ??); Usher. | PMID: 20345943 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | no | yes | N | 20 | 0.315 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n5-13c21/22o | Cytoplasmic | 8 | 26 | |||||||
| YHHH_ECOLI | P28911 | yhhH | b3483 JW3449 | integral IM protein (SEC in IM), YhhH | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 32 | 0.366 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i12-30o | Unknown | 2 | 52 | |||||||||
| YBFC_ECOLI | P28915 | ybfC | b0704 JW0693 | periplasmic protein (SEC through IM), YbfC | Prediction of three weak transmembrane helixes (one with 0.6 probability) in Phobius. | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.787 | SpI | 19 | 3.48234 | - | 0 | 0 | Y | n4-15c19/20o | Unknown | 2 | 48 | |||||||||||
| CYDD_ECOLI | P29018 | cydD htrD | htrD | b0887 JW0870 | integral IM protein (SEC-YidC in IM), ATP-binding/permease CydD | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919657 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 43 | 0.111 | TMH | 0 | 0.800558 | - | 5 | 6 | N | i29-49o61-82i140-159o165-188i245-272o278-297i | CytoplasmicMembrane | 10 | |||||
| FTSN_ECOLI | P29131 | ftsN msgA | msgA | b3933 JW3904 | integral IM protein (SEC in IM), Cell division FtsN | Integral Inner Membrane | Localizes to potential division sites in filamentous cells. FtsN interacts directly with itself, FtsW, FtsI and ZapA. | PMID: 11703663 PMID: 20497333 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 41 | 0.126 | SpI | 40 | 0.332384 | - | 1 | 1 | N | i29-54o | CytoplasmicMembrane | 10 | 23 | ||||
| FLGL_ECOLI | P29744 | flgL flaT flaU | flaT flaU | b1083 JW1070 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), hook-associated 3 FlgL | Peripheral outer membrane protein facing the extra-cellular space | Second hook-filament junction protein. PMID: 12730325 | PMID: 12631703 PMID: 12730325 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Secreted Bacterial flagellum | Cell surface appendage (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 58 | 0.149 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 35 | |||||
| FIMD_ECOLI | P30130 | fimD | b4317 JW5780 | Fimbrial OM b-barrel protein (SEC through IM, chaperone usher export system in OM), FimD | Outer Membrane b-barrel protein | Fim operon (class ??1); Usher. ??uter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in the outer membrane by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 12842468 Disulfide bridge (855 877) | PMID: 12488465 PMID: 12624733 PMID: 12842468 PMID: 15911532 PMID: 16372265 PMID: 20345943 PMID: 24140205 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | fimbriae | SEC | CU | yes | yes | Y | 38 | 0.415 | SpI | 37 | 1.20154 | - | 1 | 0 | Y | n23-38c45/46o | OuterMembrane | 10 | |||||||
| THIF_ECOLI | P30138 | thiF | b3992 JW3956 | integral IM protein (SEC in IM), Sulfur carrier ThiS adenylyltransferase ThiF | Integral Inner Membrane | Very strong TMHMM and Phobius and Kyte/Doolittle predictions for at least one TM region. Proteins that have activities as nucleoside-triphosphatase and hydrolysis of thiamin triphosphate in Escherichia coli have been shown to be membrane-bound but there is no experimental evidence for ThiF PMID: 3026493. | PMID: 3026493 | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | yes | yes | N | 59 | 0.161 | CYT | 0 | -0.200913 | - | 1 | 0 | N | i | Cytoplasmic | 9 | 45 | ||||||
| YAAJ_ECOLI | P30143 | yaaJ | b0007 JW0006 | integral IM protein (SEC in IM), transporter YaaJ | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.113 | TMH | 0 | 10.2038 | - | 9 | 9 | N | o12-30i68-87o93-116i137-156o176-194i206-228o297-321i342-370o414-438i | CytoplasmicMembrane | 10 | |||||||||
| YABI_ECOLI | P30149 | yabI | b0065 JW5005 | integral IM protein (SEC in IM) of DedA family, YabI | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996 | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 43 | 0.146 | TMH | 0 | 11.6076 | - | 5 | 5 | N | i12-36o56-79i145-165o177-196i217-236o | CytoplasmicMembrane | 10 | 17 | |||||
| BASS_ECOLI | P30844 | basS pmrB | pmrB | b4112 JW4073 | integral IM protein (SEC-YidC in IM), Sensor BasS | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 35 | 0.113 | TMH | 0 | 3.38744 | - | 2 | 2 | N | i14-34o65-85i | CytoplasmicMembrane | 10 | 20 | ||||
| EPTA_ECOLI | P30845 | eptA pmrC yjdB | pmrC yjdB | b4114 JW5730 | integral IM protein (SEC in IM), Phosphoethanolamine transferase EptA | Integral Inner Membrane | YjdB co-localizes with the ZipA protein and is involved in cell division. Has been purified as a complex with ZipA-EptA. | PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.157 | TMH | 0 | 13.2858 | - | 5 | 5 | N | i12-33o45-66i78-100o120-142i154-176o | CytoplasmicMembrane | 10 | |||||
| BAES_ECOLI | P30847 | baeS | b2078 JW2063 | integral IM protein (SEC-YidC in IM), Signal transduction histidine-kinase BaeS | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 31 | 0.161 | TMH | 0 | 6.32525 | - | 2 | 2 | N | i12-31o168-186i | CytoplasmicMembrane | 10 | 31 | |||||
| EVGS_ECOLI | P30855 | evgS | b2370 JW2367 | integral IM protein (SEC in IM), Sensor EvgS | Integral Inner Membrane | Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 25403562 | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | YfgM | no | yes | Y | 22 | 0.874 | SpI | 21 | 7.57923 | - | 0 | 1 | Y | n3-14c21/22o536-558i | CytoplasmicMembrane | 9 | |||||
| ARTI_ECOLI | P30859 | artI | b0863 JW0847 | periplasmic protein (SEC through IM), Putative ABC transporter arginine-binding 2 ArtI | Periplasmic | Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 8801422 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 22030350 PMID: 25664544 PMID: 8801422 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 20 | 0.883 | SpI | 19 | 18.5986 | - | 0 | 0 | Y | n4-15c19/20o | Periplasmic | 10 | 76 | ||||||||
| ARTJ_ECOLI | P30860 | artJ | b0860 JW0844 | periplasmic protein (SEC through IM), ABC transporter arginine-binding 1 ArtJ | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 8801423 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 | PMID: 19953543 PMID: 22030350 PMID: 8801422 PMID: 8801423 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 20 | 0.849 | SpI | 19 | 18.9337 | - | 0 | 0 | Y | n4-15c19/20o | Periplasmic | 10 | 73 | |||||||
| YADC_ECOLI | P31058 | yadC | b0135 JW0131 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), YadC | Peripheral outer membrane protein facing the extra-cellular space | Potential fimbrial yad operon (class ??4); Potential tip-adhesin. | PMID: 19820722 PMID: 20345943 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 23 | 0.677 | SpI | 22 | 12.8917 | - | 1 | 0 | Y | n8-17c22/23o | Extracellular | 9 | 14 | ||||||
| YEDD_ECOLI | P31063 | yedD | b1928 JW1913 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YedD | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bond-containing protein PMID: 25664544 | PMID: 12488465 PMID: 15174130 PMID: 15911532 PMID: 19953543 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | DSBA | LOL | no | yes | Y | 20 | 0.338 | SpII | 15 | 12.6143 | Pos+2=A | 0 | 0 | Y | n4-12c16/17o | Unknown | 2 | 130 | ||||||
| YEDE_ECOLI | P31064 | yedE | b1929 JW1914 | integral IM protein (SEC in IM), UPF0394 YedE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.167 | TMH | 0 | 16.7358 | - | 10 | 10 | N | i12-32o81-100i112-136o148-171i197-215o221-240i260-280o292-314i321-341o361-382i | CytoplasmicMembrane | 10 | |||||||
| KCH_ECOLI | P31069 | kch | b1250 JW1242 | integral IM protein (SEC in IM), Voltage-gated potassium channel Kch | Integral Inner Membrane | PMID: 15919996 PMID: 8824224 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.106 | TMH | 0 | 2.91162 | - | 7 | 6 | N | i21-39o59-80i87-104o110-127i139-161o200-225i | CytoplasmicMembrane | 10 | |||||||
| AAS_ECOLI | P31119 | aas | b2836 JW2804 | integral IM protein (SEC-YidC in IM), Bifunctional Aas Aas | Integral Inner Membrane | Integral membrane protein (experimental; from GenProtEC) Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/out | Soluble IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 57 | 0.217 | CYT | 0 | -0.200913 | - | 0 | 2 | N | o258-277i415-438o | CytoplasmicMembrane | 10 | 7 | |||||
| MARB_ECOLI | P31121 | marB | b1532 JW1525 | periplasmic protein (SEC through IM), Multiple antibiotic resistance MarB | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 22 | 0.602 | SpI | 21 | 18.3001 | - | 0 | 0 | Y | n4-15c21/22o | Unknown | 2 | 60 | ||||||||||||
| SOTB_ECOLI | P31122 | sotB ydeA | ydeA | b1528 JW1521 | integral IM protein (SEC in IM), Sugar efflux transporter SotB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.15 | TMH | 0 | 12.9623 | - | 12 | 12 | N | i12-36o48-68i80-99o105-126i138-156o168-189i210-232o244-265i272-293o299-321i333-352o364-384i | CytoplasmicMembrane | 10 | ||||||
| EAMA_ECOLI | P31125 | eamA ydeD | ydeD | b1533 JW5250 | integral IM protein (SEC-YidC in IM), Probable amino-acid metabolite efflux pump EamA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 37 | 0.113 | TMH | 0 | 10.8414 | - | 10 | 10 | N | i7-27o33-52i61-82o88-108i117-135o141-161i173-196o216-237i244-263o269-289i | CytoplasmicMembrane | 10 | 4 | ||||
| YDEE_ECOLI | P31126 | ydeE ydeF | ydeF | b1534 JW1527 | integral IM protein (SEC in IM), MFS-type transporter YdeE | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.123 | TMH | 0 | 10.3798 | - | 12 | 11 | Y | n8-19c24/25o44-63i75-93o99-121i133-156o162-182i207-233o245-263i275-293o299-323i335-357o363-381i | CytoplasmicMembrane | 10 | 94 | |||||||
| YDEI_ECOLI | P31130 | ydeI | b1536 JW1529 | periplasmic protein (SEC through IM), YdeI | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.882 | SpI | 19 | 13.7979 | - | 0 | 0 | Y | n3-14c19/20o | Unknown | 2 | 100 | ||||||||||||
| POTF_ECOLI | P31133 | potF | b0854 JW0838 | periplasmic protein (SEC through IM), Putrescine-binding periplasmic protein PotF | Periplasmic | Disulfide bridge (175 239) PMID: 9651355 Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 PMID: 9298646 PMID: 9651355 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.731 | SpI | 26 | 15.245 | - | 0 | 0 | Y | n9-20c26/27o | Periplasmic | 10 | 61 | ||||||||
| POTH_ECOLI | P31135 | potH | b0856 JW0840 | integral IM protein (SEC in IM), Putrescine transport system permease PotH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 58 | 0.132 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i31-52o103-122i134-155o185-208i229-253o284-305i | CytoplasmicMembrane | 10 | |||||||
| ACRB_ECOLI | P31224 | acrB acrE | acrE | b0462 JW0451 | integral IM protein (SEC-YidC in IM), Multidrug efflux pump subunit AcrB | Integral Inner Membrane | AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC (AcrAB-TolC multidrug efflux system) PMID: 15228545. Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. Crystal structure of AcrB shows three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. In the transmembrane region, each protomer has twelve transmembrane alpha-helicesPMID: 12374972. | PMID: 11266632 PMID: 12374972 PMID: 15228545 PMID: 15919996 PMID: 16079137 PMID: 22108384 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC-YidC | yes | yes | N | 55 | 0.156 | TMH | 0 | 4.86972 | - | 11 | 12 | N | i12-32o340-359i366-390o396-416i437-458o470-493i541-557o875-892i899-919o925-946i975-995o1007-1029i | CytoplasmicMembrane | 10 | |||||
| YICH_ECOLI | P31433 | yicH | b3655 JW3630 | integral IM protein (SEC in IM), YicH | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Membrane anchored | SRP | SEC | yes | yes | N | 33 | 0.134 | TMH | 0 | 7.0277 | - | 1 | 1 | N | i7-26o | Unknown | 2 | 7 | |||||||||
| YICJ_ECOLI | P31435 | yicJ | b3657 JW5939 | integral IM protein (SEC in IM), symporter YicJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 57 | 0.115 | TMH | 0 | 2.46347 | - | 11 | 12 | N | i12-34o40-58i79-98o110-132i152-174o180-202i232-258o264-283i295-313o319-342i363-390o402-424i | CytoplasmicMembrane | 10 | |||||||
| SETC_ECOLI | P31436 | setC yicK | yicK | b3659 JW3633 | integral IM protein (SEC in IM), Sugar efflux transporter C SetC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.244 | TMH | 0 | 9.2462 | - | 12 | 11 | Y | n14-25c33/34o49-70i82-100o106-129i141-161o173-193i221-238o258-277i284-308o314-331i352-368o374-391i | CytoplasmicMembrane | 10 | ||||||
| YICL_ECOLI | P31437 | yicL | b3660 JW3634 | integral IM protein (SEC in IM), transporter YicL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.389 | TMH | 0 | 7.96611 | - | 10 | 9 | Y | n11-18c25/26o41-60i72-94o100-120i127-146o152-172i184-205o217-237i249-270o276-293i | CytoplasmicMembrane | 10 | |||||||
| ADEQ_ECOLI | P31440 | adeQ yicO | yicO | b3664 JW5636 | integral IM protein (SEC in IM), Adenine permease AdeQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 57 | 0.125 | CYT | 0 | -0.200913 | - | 13 | 12 | N | o33-51i63-86o98-131i143-161o181-199i206-227o247-267i296-318o330-350i357-377o389-413i425-443o | CytoplasmicMembrane | 10 | ||||||
| EMRD_ECOLI | P31442 | emrD yicQ | yicQ | b3673 JW5634 | integral IM protein (SEC-YidC in IM), Multidrug resistance D EmrD | Integral Inner Membrane | EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Crystal structure of EmrD reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane.PMID: 16675700. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. | PMID: 11266632 PMID: 15919996 PMID: 16675700 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 24 | 0.319 | SpI | 23 | 9.69754 | - | 12 | 11 | Y | n9-20c25/26o44-63i75-92o98-116i136-159o165-183i203-226o232-261i273-291o297-318i330-353o365-383i | CytoplasmicMembrane | 10 | |||||
| YIDI_ECOLI | P31446 | yidI | b3677 JW3653 | integral IM protein (SEC in IM), YidI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 36 | 0.149 | TMH | 0 | 0.964289 | - | 3 | 3 | N | i12-30o78-98i110-143o | CytoplasmicMembrane | 10 | 27 | ||||||
| YIDK_ECOLI | P31448 | yidK | b3679 JW3655 | integral IM protein (SEC in IM), symporter YidK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 23 | 0.12 | CYT | 0 | -0.200913 | - | 15 | 15 | N | o6-22i34-56o76-98i119-141o161-180i192-212o242-261i282-307o327-349i381-397o409-427i434-454o460-481i506-526o532-550i | CytoplasmicMembrane | 10 | |||||||
| PTXC_ECOLI | P31452 | glvC | b3683 JW3660 | integral IM protein (SEC in IM), Phosphotransferase IIC component GlvC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 51 | 0.159 | TMH | 0 | 11.5504 | - | 9 | 10 | N | i12-32o63-80i87-109o129-153i174-194o206-222i234-255o275-298i305-323o329-356i | CytoplasmicMembrane | 10 | ||||||
| MDTL_ECOLI | P31462 | mdtL yidY | yidY | b3710 JW3688 | integral IM protein (SEC in IM), Multidrug resistance MdtL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.157 | TMH | 0 | 2.89051 | - | 11 | 11 | Y | n4-12c16/17o40-58i70-89o95-116i128-152o158-178i199-222o242-262i269-287o293-312i324-345o351-376i | CytoplasmicMembrane | 10 | ||||||
| ADEP_ECOLI | P31466 | adeP purP yieG | purP yieG | b3714 JW3692 | integral IM protein (SEC in IM), Adenine permease AdeP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 12 | 0.099 | TMH | 0 | 0.786304 | - | 13 | 13 | N | i32-56o62-81i88-106o112-130i142-161o181-199i206-226o246-266i295-317o329-349i356-376o388-412i424-442o | CytoplasmicMembrane | 10 | ||||||
| CBRB_ECOLI | P31468 | cbrB yieI | yieI | b3716 JW3694 | integral IM protein (SEC in IM), CbrB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 34 | 0.114 | TMH | 0 | 14.4652 | - | 4 | 4 | N | i12-32o38-69i81-100o120-138i | CytoplasmicMembrane | 10 | 25 | |||||
| YIEL_ECOLI | P31471 | yieL | b3719 JW5612 | periplasmic protein (SEC through IM), YieL | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 24 | 0.659 | SpI | 23 | 16.8534 | - | 0 | 0 | Y | n5-16c23/24o | Unknown | 2 | |||||||||||||
| HSRA_ECOLI | P31474 | hsrA yieO | yieO | b3754 JW3733 | integral IM protein (SEC in IM), Probable transport HsrA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.237 | TMH | 0 | 8.54455 | - | 14 | 13 | Y | n10-21c27/28o51-71i78-97o103-124i136-158o164-182i194-211o223-244i264-287o293-314i326-347o353-374i394-417o429-450i | CytoplasmicMembrane | 10 | ||||||
| EFEB_ECOLI | P31545 | efeB ycdB | ycdB | b1019 JW1004 | periplasmic protein (TAT-SEC through IM), Deferrochelatase/peroxidase EfeB | Periplasmic | TAT secretion system. | PMID: 16551627 PMID: 17218314 | Periplasmic | G | N/A | Periplasm | Periplasmic | TAT,SEC | yes | yes | Y | 36 | 0.748 | SpI | 35 | 5.64598 | - | 0 | 0 | Y | n20-30c35/36o | Periplasmic | 10 | 33 | |||||||
| METI_ECOLI | P31547 | metI yaeE | yaeE | b0198 JW0194 | integral IM protein (SEC in IM), D-methionine transport system permease MetI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.111 | TMH | 0 | 18.923 | - | 5 | 5 | N | o20-40i52-76o82-105i142-162o182-203i | CytoplasmicMembrane | 10 | ||||||
| THIP_ECOLI | P31549 | thiP yabK | yabK | b0067 JW0066 | integral IM protein (SEC in IM), Thiamine transport system permease ThiP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.209 | TMH | 0 | 18.9215 | - | 12 | 12 | N | i12-38o58-78i90-114o134-151i199-220o240-260i289-311o331-354i375-394o406-424i465-484o504-525i | CytoplasmicMembrane | 10 | 11 | |||||
| THIB_ECOLI | P31550 | thiB tbpA yabL | tbpA yabL | b0068 JW0067 | periplasmic protein (SEC through IM), Thiamine-binding periplasmic protein ThiB | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544 | PMID: 18498364 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | SURA | no | yes | Y | 19 | 0.685 | SpI | 18 | 10.962 | - | 0 | 0 | Y | n5-13c18/19o | Periplasmic | 10 | 22 | ||||||
| CAIT_ECOLI | P31553 | caiT yaaP | yaaP | b0040 JW0039 | integral IM protein (SEC-YidC in IM), L-carnitine/gamma-butyrobetaine antiporter CaiT | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 36 | 0.144 | TMH | 0 | 16.018 | - | 12 | 12 | N | i12-30o50-71i91-116o145-163i195-216o228-251i263-286o318-335i347-366o406-425i446-466o472-495i | CytoplasmicMembrane | 10 | |||||
| LPTD_ECOLI | P31554 | lptD imp ostA yabG | imp ostA yabG | b0054 JW0053 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), LPS-assembly LptD | Outer Membrane b-barrel protein | The Protein-disulfide Isomerase DsbC Cooperates with SurA and DsbA in the Assembly of LptD. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (31 724;173 725) | PMID: 12724388 PMID: 15911532 PMID: 16079137 PMID: 19343722 PMID: 19953543 PMID: 20615876 PMID: 20932056 PMID: 22901060 PMID: 9298646 | Outer Membrane b-barrel protein | H | Soluble IM Fraction | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | DSBA,DSBC,SURA,SKP | BAM | yes | yes | Y | 25 | 0.626 | SpI | 24 | 18.6702 | - | 0 | 0 | Y | n7-17c24/25o | OuterMembrane | 10 | ||||||
| NFRA_ECOLI | P31600 | nfrA | b0568 JW0557 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Bacteriophage adsorption A NfrA | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) | PMID: 12624733 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | BAM | no | yes | Y | 28 | 0.836 | SpI | 27 | 8.97469 | - | 0 | 0 | Y | n10-21c27/28o | OuterMembrane | 10 | 4 | |||||||
| YADE_ECOLI | P31666 | yadE | b0130 JW0126 | periplasmic peripheral IM protein (SEC through IM), YadE | Homolog to C-terminus of DnaA which is a peripherally accossiated proteins with a C-terminal anchor. | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasmic | SEC | yes | yes | Y | 20 | 0.838 | SpI | 19 | 12.5161 | - | 1 | 0 | Y | n5-15c19/20o | Unknown | 2 | 12 | |||||||||||
| SETA_ECOLI | P31675 | setA yabM | yabM | b0070 JW0069 | integral IM protein (SEC in IM), Sugar efflux transporter A SetA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.202 | TMH | 0 | 15.307 | - | 12 | 11 | Y | n13-24c32/33o48-70i82-99o105-127i148-166o172-196i217-236o256-275i282-301o307-329i341-363o369-387i | CytoplasmicMembrane | 10 | ||||||
| YAAU_ECOLI | P31679 | yaaU yabE | yabE | b0045 JW0044 | integral IM protein (SEC in IM), Putative metabolite transport YaaU | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.102 | TMH | 0 | 7.08001 | - | 12 | 12 | N | i20-42o54-74i86-104o110-132i144-166o172-193i242-263o283-303i310-329o335-358i370-390o402-421i | CytoplasmicMembrane | 10 | ||||||
| DJLA_ECOLI | P31680 | djlA yabH | yabH | b0055 JW0054 | integral IM protein (SEC in IM), Co-chaperone DjlA | Integral Inner Membrane | PMID: 11106641 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 22 | 0.135 | TMH | 0 | 10.4559 | - | 1 | 1 | N | o6-30i | CytoplasmicMembrane | 10 | 11 | |||||
| FIMC_ECOLI | P31697 | fimC | b4316 JW4279 | Fimbrial periplasmic protein (SEC through IM), Chaperone FimC | Periplasmic | Fim operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 1363735 | PMID: 1363735 PMID: 18498364 PMID: 20345943 PMID: 24140205 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | fimbriae | SEC | SURA | yes | yes | N | 37 | 0.473 | SpI | 36 | 11.9808 | - | 1 | 0 | Y | n14-23c41/42o | Periplasmic | 10 | |||||||
| CHAA_ECOLI | P31801 | chaA | b1216 JW1207 | integral IM protein (SEC in IM), Sodium-potassium/proton antiporter ChaA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 62 | 0.229 | TMH | 0 | 1.59472 | - | 11 | 11 | N | i15-32o38-60i72-94o106-131i143-164o170-188i221-240o252-269i290-313o319-340i347-365o | CytoplasmicMembrane | 10 | |||||||
| YDDA_ECOLI | P31826 | yddA | b1496 JW5242 | integral IM protein (SEC in IM), ABC transporter ATP-binding YddA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.12 | CYT | 0 | -0.200913 | - | 5 | 5 | N | o6-24i31-51o71-90i152-173o193-210i | CytoplasmicMembrane | 10 | |||||||
| YDDB_ECOLI | P31827 | yddB | b1495 JW1490 | OM b-barrel protein (SEC through IM), YddB | Outer Membrane b-barrel protein | H | N/A | Periplasmic | SEC | no | yes | N | 20 | 0.536 | SpI | 19 | 4.63803 | - | 0 | 0 | Y | n4-14c19/20o | OuterMembrane | 9 | 3 | ||||||||||||
| PQQL_ECOLI | P31828 | pqqL yddC | yddC | b1494 JW1489 | periplasmic protein (SEC through IM), Probable zinc protease PqqL | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | Soluble IM Fraction | Cytoplasmic | SEC | SURA | no | yes | N | 27 | 0.318 | SpI | 26 | 5.54177 | - | 1 | 0 | Y | n8-20c26/27o | CytoplasmicMembrane | 9 | 37 | |||||||
| YDCD_ECOLI | P31991 | ydcD | b1457 JW1452 | integral IM protein (SEC in IM), YdcD | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 32 | 0.142 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-25o | Unknown | 2 | 9 | |||||||||
| YDEK_ECOLI | P32051 | ydeK orfT | orfT | b1510 JW1503 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YdeK | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein | SEC | LOL | pseudogene (Uniprot) | no | no | N | 62 | 0.164 | SpII | 18 | 0.949979 | Pos+2=S | 0 | 0 | N | i | OuterMembrane | 9 | |||||||||
| YIBG_ECOLI | P32106 | yibG | b3596 JW3570 | periplasmic protein (SEC through IM), YibG | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.567 | SpI | 19 | 0.904394 | - | 0 | 0 | Y | n3-14c19/20o | Unknown | 2 | 18 | ||||||||||||
| YIBI_ECOLI | P32108 | yibI | b3598 JW3572 | integral IM protein (SEC in IM), YibI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.12 | TMH | 0 | 12.0249 | - | 2 | 2 | N | o6-25i46-66o | CytoplasmicMembrane | 10 | 33 | |||||||
| YIHF_ECOLI | P32128 | yihF | b3861 JW5574 | integral IM protein (SEC in IM), YihF | Integral Inner Membrane | Potential Signal Peptide. It appears to have aminotemrinal TM. It is homologous to YDGA_ECOLI. | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | no | yes | N | 25 | 0.128 | SpI | 23 | 2.38596 | - | 1 | 0 | Y | n5-13c18/19o | CytoplasmicMembrane | 9 | 82 | |||||||
| YIHG_ECOLI | P32129 | yihG | b3862 JW3834 | integral IM protein (SEC in IM), Probable acyltransferase YihG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | N/A | Cell inner membrane; Multi-pass membrane protein | Cytoplasmic | SRP | SEC | no | yes | N | 41 | 0.134 | TMH | 0 | 9.85797 | - | 1 | 3 | N | o14-47i59-77o97-116i | CytoplasmicMembrane | 10 | 15 | ||||||
| YIHN_ECOLI | P32135 | yihN | b3874 JW3845 | integral IM protein (SEC in IM), YihN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Membrane Lipoprotein | SRP | SEC | no | yes | N | 23 | 0.116 | SpII | 15 | 5.95413 | Pos+2=G | 12 | 11 | Y | n7-17c22/23o46-67i74-90o96-122i143-165o171-189i221-242o248-268i289-308o314-339i351-374o386-406i | CytoplasmicMembrane | 10 | |||||||
| YIHO_ECOLI | P32136 | yihO | b3876 JW5852 | integral IM protein (SEC in IM), Putative sulfoquinovose importer YihO | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.104 | TMH | 0 | 5.69819 | - | 11 | 12 | N | i17-38o50-74i86-106o118-139i160-179o185-206i238-258o270-291i303-322o328-350i381-402o414-436i | CytoplasmicMembrane | 10 | |||||||||
| YIHP_ECOLI | P32137 | yihP | b3877 JW3848 | integral IM protein (SEC in IM), Putative 2,3-dihydroxypropane-1-sulfonate exporter YihP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 68 | 0.101 | CYT | 0 | -0.200913 | - | 11 | 11 | N | i20-41o53-77i89-109o121-143i164-183o189-210i244-264o276-297i309-328o334-356i421-442o | CytoplasmicMembrane | 10 | |||||||
| YIIG_ECOLI | P32151 | yiiG | b3896 JW3867 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YiiG | Inner Membrane Lipoprotein | Proven pignal peptidase II substrate. | PMID: 15174130 | Inner Membrane Lipoprotein | E | N/A | Inner membrane lipoprotein | SEC | LOL | no | yes | N | 22 | 0.152 | SpII | 21 | 26.248 | Pos+2=D | 0 | 0 | Y | n5-17c22/23o | Unknown | 4 | 106 | ||||||||
| PTFLB_ECOLI | P32154 | frvB yiiJ | yiiJ | b3899 JW5562 | integral IM protein (SEC in IM), Fructose-like PTS system EIIBC component FrvB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.166 | CYT | 0 | -0.200913 | - | 9 | 10 | N | i139-159o179-198i205-222o228-247i259-281o301-321i342-363o375-396i403-422o442-463i | CytoplasmicMembrane | 10 | ||||||
| YIIQ_ECOLI | P32160 | yiiQ | b3920 JW3891 | periplasmic protein (SEC through IM), YiiQ | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 24 | 0.736 | SpI | 23 | 14.7775 | - | 0 | 0 | Y | n4-15c23/24o | Unknown | 2 | |||||||||||||
| MENA_ECOLI | P32166 | menA yiiW | yiiW | b3930 JW3901 | integral IM protein (SEC in IM), 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 36 | 0.309 | TMH | 0 | 4.61773 | - | 9 | 9 | N | i21-38o44-63i98-118o124-143i150-172o178-199i228-246o252-270i290-307o | CytoplasmicMembrane | 10 | 14 | |||||
| YIIX_ECOLI | P32167 | yiiX | b3937 JW3908 | periplasmic protein (SEC through IM), YiiX | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 19 | 0.818 | SpI | 18 | 14.7441 | - | 0 | 0 | Y | n5-13c18/19o | Unknown | 2 | 27 | ||||||||||||
| FDOG_ECOLI | P32176 | fdoG | b3894 JW3865 | periplasmic protein (TAT through IM), Formate dehydrogenase-O major subunit FdoG | Periplasmic | TAT secretion system. PMID: 12923080 | PMID: 12923080 PMID: 17218314 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | TAT | no | yes | N | 34 | 0.487 | SpI | 33 | 14.6779 | - | 0 | 0 | Y | n11-24c33/34o | Periplasmic | 10 | |||||||||
| YIJF_ECOLI | P32668 | yijF | b3944 JW3916 | periplasmic protein (SEC through IM), YijF | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 19 | 0.257 | SpI | 20 | 11.5911 | - | 0 | 0 | Y | n3-14c18/19o | Unknown | 2 | 14 | ||||||||||||
| PTFC2_ECOLI | P32672 | frwC yijJ | yijJ | b3949 JW3921 | integral IM protein (SEC in IM), Fructose-like permease IIC component 2 FrwC | Integral Inner Membrane | Multiphosphoryl transfer protein 2 | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.192 | TMH | 0 | 4.57594 | - | 8 | 9 | N | o22-45i57-78o98-120i132-152o172-190i202-229o249-269i281-301o313-334i | CytoplasmicMembrane | 10 | |||||
| YJAH_ECOLI | P32681 | yjaH | b4001 JW3965 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YjaH | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | yes | yes | N | 36 | 0.151 | SpII | 30 | 6.9142 | Pos+2=S | 0 | 0 | Y | n20-28c46/47o | Unknown | 2 | 25 | |||||||||||
| YJBF_ECOLI | P32687 | yjbF | b4027 JW5711 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YjbF | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 21 | 0.427 | SpII | 15 | 13.4041 | Pos+2=S | 0 | 0 | Y | n5-13c18/19o | Unknown | 2 | ||||||||
| YJBG_ECOLI | P32688 | yjbG | b4028 JW3988 | periplasmic protein (SEC through IM), YjbG | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 21 | 0.827 | SpI | 20 | 17.0485 | - | 0 | 0 | Y | n5-15c20/21o | CytoplasmicMembrane | 9 | |||||||||||||
| YJBH_ECOLI | P32689 | yjbH | b4029 JW3989 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YjbH | Inner Membrane Lipoprotein | E | N/A | Cell membrane | Membrane Lipoprotein | SEC | LOL | yes | yes | Y | 21 | 0.41 | SpII | 17 | 12.8674 | Pos+2=Y | 0 | 0 | Y | n6-14c20/21o | OuterMembrane | 9 | |||||||||||
| PSPG_ECOLI | P32696 | pspG yjbO | yjbO | b4050 JW5716 | integral IM protein (SEC in IM), Phage shock G PspG | Integral Inner Membrane | PMID: 19555453 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | Prophage Transposase | no | no | N | 32 | 0.133 | TMH | 0 | 16.1628 | - | 2 | 2 | N | i7-37o43-64i | CytoplasmicMembrane | 9 | |||||
| YJCB_ECOLI | P32700 | yjcB | b4060 JW5718 | integral IM protein (SEC in IM), YjcB | Integral Inner Membrane | PMID: 19555453 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 65 | 0.12 | TMH | 0 | 9.92398 | - | 2 | 2 | N | o12-29i36-56o | CytoplasmicMembrane | 9 | 45 | |||||||
| PDEC_ECOLI | P32701 | pdeC yjcC | yjcC | b4061 JW4022 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 35 | 0.165 | TMH | 0 | 3.89399 | - | 2 | 2 | N | i12-34o243-264i | CytoplasmicMembrane | 10 | ||||||
| YJCE_ECOLI | P32703 | yjcE | b4065 JW4026 | integral IM protein (SEC in IM), YjcE | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 69 | 0.131 | TMH | 0 | 7.97851 | - | 11 | 13 | N | o6-25i32-50o56-73i85-108o114-136i157-179o185-204i216-235o241-259i280-298o313-337i361-385o397-420i | CytoplasmicMembrane | 10 | |||||||||
| ACTP_ECOLI | P32705 | actP yjcG | yjcG | b4067 JW4028 | integral IM protein (SEC in IM), Cation/acetate symporter ActP | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | Y | 19 | 0.597 | SpI | 18 | 16.2988 | - | 13 | 13 | Y | n4-14c18/19o34-54i75-97o103-122i148-167o179-197i209-227o262-286i298-323o355-383i404-423o429-453i465-486o498-517i | CytoplasmicMembrane | 10 | ||||||
| NRFD_ECOLI | P32709 | nrfD yjcK | yjcK | b4073 JW4034 | integral IM protein (SEC in IM), NrfD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.148 | TMH | 0 | 10.9164 | - | 8 | 8 | N | o18-39i51-73o93-113i150-168o180-203i224-241o261-278i290-312o | CytoplasmicMembrane | 10 | ||||||
| NRFE_ECOLI | P32710 | nrfE yjcL | yjcL | b4074 JW4035 | integral IM protein (SEC in IM), Probable cytochrome c-type biogenesis NrfE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 10 | 0.193 | TMH | 0 | 7.53708 | - | 12 | 12 | N | i21-54o79-97i104-126o158-178i190-212o232-248i260-288o294-312i333-357o377-394i401-422o528-545i | CytoplasmicMembrane | 10 | ||||||
| NRFF_ECOLI | P32711 | nrfF yjcM | yjcM | b4075 JW4036 | integral IM protein (SEC in IM), Formate-dependent nitrite reductase complex subunit NrfF | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Periplasm | Membrane anchored | SRP | SEC | no | yes | Y | 19 | 0.845 | SpI | 18 | 16.61 | - | 1 | 1 | Y | n4-14c18/19o103-121i | CytoplasmicMembrane | 10 | 20 | |||||||
| NRFG_ECOLI | P32712 | nrfG yjcN | yjcN | b4076 JW4037 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Formate-dependent nitrite reductase complex subunit NrfG | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | yes | yes | N | 35 | 0.209 | SpII | 21 | 6.47674 | Pos+2=V | 1 | 0 | Y | n11-22c30/31o | Unknown | 2 | 64 | ||||||||||
| MDTP_ECOLI | P32714 | mdtP yjcP | yjcP | b4080 JW4041 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug resistance MdtP | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | N | 23 | 0.147 | SpII | 23 | 4.25545 | Pos+2=A | 0 | 0 | Y | n9-21c29/30o | OuterMembrane | 9 | 12 | |||||||||
| MDTO_ECOLI | P32715 | mdtO yjcQ | yjcQ | b4081 JW4042 | integral IM protein (SEC in IM), Multidrug resistance MdtO | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.102 | CYT | 0 | -0.200913 | - | 9 | 9 | N | o36-63i75-97o103-120i127-146o152-178i399-420o426-445i457-477o483-502i | CytoplasmicMembrane | 10 | ||||||||
| MDTN_ECOLI | P32716 | mdtN yjcR | yjcR | b4082 JW4043 | integral IM protein (SEC in IM), Multidrug resistance MdtN | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 47 | 0.139 | SpI | 35 | 7.86193 | - | 1 | 0 | Y | n15-30c35/36o | CytoplasmicMembrane | 9 | ||||||||
| YJCS_ECOLI | P32717 | yjcS | b4083 JW5721 | periplasmic protein (SEC through IM), Putative alkyl/aryl-sulfatase YjcS | Periplasmic | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 30 | 0.725 | SpI | 29 | 16.7747 | - | 0 | 0 | Y | n12-20c29/30o | Unknown | 4 | 27 | |||||||||||
| ALSC_ECOLI | P32720 | alsC yjcV | yjcV | b4086 JW4047 | integral IM protein (SEC-YidC in IM), D-allose transport system permease AlsC | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | N | 49 | 0.11 | TMH | 0 | 4.98579 | - | 9 | 8 | N | i21-42o71-93i105-129o168-193i222-246o252-272i279-298o304-324i | CytoplasmicMembrane | 10 | |||||
| YEEA_ECOLI | P33011 | yeeA | b2008 JW1990 | integral IM protein (SEC in IM), YeeA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.114 | TMH | 0 | 6.9225 | - | 5 | 6 | N | i20-40o46-66i73-89o95-113i120-136o148-168i | CytoplasmicMembrane | 10 | 32 | ||||||
| DACD_ECOLI | P33013 | dacD phsE yeeC | phsE yeeC | b2010 JW5329 | periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacD | Peripheral inner membrane protein facing the periplasm | Penicillin-binding protein 5 (PBP 5); membrane-bound cell wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane. PMID: 8955390 | PMID: 20192190 PMID: 8955390 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cell inner membrane | Membrane anchored (Experimental) | SEC | yes | yes | Y | 22 | 0.485 | SpI | 21 | 12.6922 | - | 0 | 0 | Y | n5-16c21/22o | CytoplasmicMembrane | 9 | 12 | |||||||
| YEEE_ECOLI | P33015 | yeeE | b2013 JW1995 | integral IM protein (SEC in IM), UPF0394 YeeE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 59 | 0.121 | TMH | 0 | 4.74224 | - | 9 | 9 | Y | n6-17c25/26o41-60i72-100o106-123i144-169o198-217i224-241o247-266i287-310o316-337i | CytoplasmicMembrane | 10 | |||||||
| NUPX_ECOLI | P33021 | nupX yeiJ | yeiJ | b2161 JW2148 | integral IM protein (SEC in IM), Putative nucleoside permease NupX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein(experimental) | SRP | SEC | yes | yes | N | 57 | 0.114 | TMH | 0 | 3.09344 | - | 8 | 10 | N | o6-22i29-49o61-82i89-108o114-132i173-195o201-220i258-280o353-380i392-415o | CytoplasmicMembrane | 10 | ||||||
| PSUT_ECOLI | P33024 | psuT pscT yeiM | pscT yeiM | b2164 JW2151 | integral IM protein (SEC in IM), Putative pseudouridine transporter PsuT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 25 | 0.143 | TMH | 0 | 2.44494 | - | 8 | 10 | N | o6-22i29-49o95-118i173-195o201-220i258-280o286-310i322-341o353-378i390-413o | CytoplasmicMembrane | 10 | ||||||
| SETB_ECOLI | P33026 | setB yeiO | yeiO | b2170 JW2157 | integral IM protein (SEC in IM), Sugar efflux transporter B SetB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.175 | TMH | 0 | 8.14886 | - | 12 | 12 | N | i12-33o53-72i84-101o107-129i141-158o164-194i219-244o256-276i283-301o307-330i351-367o373-390i | CytoplasmicMembrane | 10 | ||||||
| YADV_ECOLI | P33128 | yadV ecpD | ecpD | b0140 JW0136 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone YadV | Periplasmic | Putative chaperone???usher fimbrial operon (class ??4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 PMID: 20345943 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | no | yes | Y | 26 | 0.667 | SpI | 25 | 16.6944 | - | 0 | 0 | Y | n8-19c25/26o | Periplasmic | 10 | ||||||
| HTRE_ECOLI | P33129 | htrE | b0139 JW0135 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), HtrE | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon (class ??4); Usher. Disulfide bridge (838 862) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | Y | 30 | 0.677 | SpI | 29 | 6.72527 | - | 0 | 0 | N | i | OuterMembrane | 10 | 8 | ||||||
| FLIR_ECOLI | P33135 | fliR flaP | flaP | b1950 JW1934 | Flagellar integral IM protein (SEC in IM), biosynthetic FliR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | flagellum | SRP | SEC | no | yes | N | 61 | 0.121 | TMH | 0 | 5.44162 | - | 6 | 6 | N | o15-33i42-59o65-86i131-151o179-201i213-237o | CytoplasmicMembrane | 10 | |||||
| OPGG_ECOLI | P33136 | mdoG opgG | opgG | b1048 JW1035 | periplasmic protein (SEC through IM), Glucans biosynthesis G MdoG | Periplasmic | Copurifies with trigger factor in pull down assays. Potential Skp substrate PMID: 19953543 PMID: 9298646 | PMID: 19737520 PMID: 19953543 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TF | SEC | SKP | yes | yes | Y | 23 | 0.708 | SpI | 22 | 16.361 | - | 0 | 0 | Y | n6-17c22/23o | Periplasmic | 10 | 23 | |||||
| YEBE_ECOLI | P33218 | yebE | b1846 JW1835 | integral IM protein (SEC in IM), YebE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | N/A | Cell inner membrane; Single-pass membrane protein | Membrane anchored | SRP | SEC | no | yes | N | 24 | 0.329 | SpI | 23 | 0.790424 | - | 2 | 2 | N | o26-44i56-74o | CytoplasmicMembrane | 10 | 88 | ||||||
| YEBF_ECOLI | P33219 | yebF | b1847 JW1836 | extra-cellular protein (SEC through IM, secreted in OMV), YebF | Extra-cellular | Outer membrane proteins OmpF, OmpC, and OmpX are central to the YebF export mechanism. Identified DsbA substrate PMID: 19953543 PMID: 16369539 Disulfide bond-containing protein PMID: 25664544 | PMID: 16369539 PMID: 19953543 PMID: 22658749 PMID: 25664544 | Extra-cellular | X | N/A | Secreted | Secreted and released (Experimental) | SEC | OMV | no | yes | Y | 22 | 0.777 | SpI | 21 | 20.4773 | - | 0 | 0 | Y | n5-16c21/22o | Extracellular | 10 | 108 | |||||||
| TORA_ECOLI | P33225 | torA | b0997 JW0982 | periplasmic protein (TAT through IM), Trimethylamine-N-oxide reductase 1 TorA | Periplasmic | TAT secretion system. Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Interaction studies showed that, when immature, TorC can no longer bind TorA efficiently but can bind the periplasmic detector region of sensor TorS. Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase TorD, a cytoplasmic chaperone that interacts with the unfolded trimethylamine N-oxide reductase enzyme (TorA). The absence of TorD protein leads to a two times decrease of the final amount of TorA enzyme. PMID: 15073303 | PMID: 11056172 PMID: 15073303 PMID: 17218314 PMID: 2512991 PMID: 9632735 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT | yes | yes | N | 40 | 0.294 | SpI | 39 | 1.32729 | - | 0 | 0 | Y | n14-24c42/43o | Periplasmic | 10 | 8 | ||||||||
| TORC_ECOLI | P33226 | torC | b0996 JW0981 | integral IM protein (SEC in IM), Cytochrome c-type TorC | Integral Inner Membrane | TAT secretion system. Binds 5 heme groups per subunit ; Belongs to the torC/torY family. Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region. Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase PMID: 11056172 | PMID: 11056172 PMID: 11562502 PMID: 17218314 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane; Single-pass type II membrane protein | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 20 | 0.12 | TMH | 0 | 6.50112 | - | 1 | 1 | N | i12-34o | CytoplasmicMembrane | 9 | 43 | |||||
| LLDP_ECOLI | P33231 | lldP lctP | lctP | b3603 JW3578 | integral IM protein (SEC in IM), L-lactate permease LldP | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. | PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 66 | 0.171 | TMH | 0 | 11.5559 | - | 12 | 12 | N | o12-33i40-58o70-95i116-149o155-179i199-217o223-240i252-269o368-387i407-425o431-456i529-550o | CytoplasmicMembrane | 10 | |||||
| FLGK_ECOLI | P33235 | flgK flaS flaW | flaS flaW | b1082 JW1069 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), hook-associated 1 FlgK | Peripheral outer membrane protein facing the extra-cellular space | Part of FlgN-FlgK-FliJ-FlhA complex. First hook-filament junction protein. Flagella proteins contribute to the production of outer membrane vesicles. Analysis of E. coli W3110 OMVs revealed that they contain abundant levels of FliC. Compared to the parental strain expressing wild-type flgK, an E. coli strain with a flgK-null mutation produced reduced amounts of OMVs. PMID: 12730325 | PMID: 12631703 PMID: 12730325 PMID: 22233518 PMID: 24134841 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Secreted | Cell surface appendage (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 18 | 0.238 | SpI | 17 | 2.83622 | - | 0 | 0 | N | i | Extracellular | 9 | 43 | |||||
| MOKC_ECOLI | P33236 | mokC gefL | gefL | b0018 JW5879 | integral IM protein (SEC in IM), Regulatory MokC | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Periplasmic | SRP | SEC | no | yes | N | 41 | 0.287 | SpI | 40 | 1.37208 | - | 1 | 1 | N | i25-44o | Periplasmic | 9 | ||||||||
| YEHA_ECOLI | P33340 | yehA | b2108 JW2095 | Fimbrial periplasmic protein (SEC through IM), YehA | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??4); Unkown function. | PMID: 16372265 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | Y | 21 | 0.622 | SpI | 20 | 7.58765 | - | 0 | 0 | Y | n7-15c20/21o | Unknown | 2 | 48 | ||||||||
| YEHB_ECOLI | P33341 | yehB | b2109 JW2096 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YehB | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon yeh (class ??4); Usher. Disulfide bridge (809 825) | PMID: 16372265 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | Y | 23 | 0.679 | SpI | 22 | 11.7505 | - | 0 | 0 | Y | n7-18c22/23o | OuterMembrane | 10 | 5 | ||||||
| YEHC_ECOLI | P33342 | yehC | b2110 JW2097 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone YehC | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | no | yes | N | 34 | 0.721 | SpI | 33 | 9.53077 | - | 1 | 0 | Y | n18-29c33/34o | Periplasmic | 10 | 43 | ||||||
| YEHD_ECOLI | P33343 | yehD | b2111 JW2098 | Fimbrial periplasmic protein (SEC through IM), YehD | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??4); Fimbrial Subunit. Disulfide bond-containing protein PMID: 25664544 | PMID: 19820722 PMID: 20345943 PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | Y | 23 | 0.891 | SpI | 22 | 24.5442 | - | 1 | 0 | Y | n4-15c22/23o | Unknown | 2 | 95 | ||||||||
| YEHE_ECOLI | P33344 | yehE | b2112 JW2099 | periplasmic protein (SEC through IM), YehE | Periplasmic | Yeh operon is homolog to fim operon (yehd is fimI homolog). | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 23 | 0.529 | SpI | 22 | 11.8793 | - | 0 | 0 | Y | n6-17c22/23o | CytoplasmicMembrane | 9 | 49 | |||||||||
| YEHR_ECOLI | P33354 | yehR | b2123 JW5351 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YehR | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 22 | 0.219 | SpII | 22 | 22.3044 | Pos+2=G | 0 | 0 | Y | n7-18c23/24o | Unknown | 2 | 81 | |||||||
| YEHW_ECOLI | P33359 | yehW | b2128 JW2116 | integral IM protein (SEC in IM), Glycine betaine uptake system permease YehW | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.403 | TMH | 0 | 15.5124 | - | 6 | 5 | Y | n8-22c30/31o46-74i86-111o117-144i164-189o201-226i | CytoplasmicMembrane | 10 | 15 | ||||||
| YEHY_ECOLI | P33361 | yehY | b2130 JW2118 | integral IM protein (SEC in IM), Glycine betaine uptake system permease YehY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.257 | TMH | 0 | 13.4216 | - | 10 | 9 | Y | n9-16c20/21o44-65i72-90o102-123i135-153o183-204i225-246o258-278i324-347o353-379i | CytoplasmicMembrane | 10 | |||||||
| YEHZ_ECOLI | P33362 | yehZ osmF | osmF | b2131 JW2119 | periplasmic protein (SEC through IM), Glycine betaine-binding YehZ | Periplasmic | PMID: 15911532 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 24 | 0.77 | SpI | 23 | 13.9464 | - | 0 | 0 | Y | n6-17c23/24o | CytoplasmicMembrane | 9 | 72 | |||||||
| BGLX_ECOLI | P33363 | bglX yohA | yohA | b2132 JW2120 | periplasmic protein (SEC through IM), beta-glucosidase BglX | Periplasmic | PMID: 8757730 | Periplasmic | G | Soluble IM Fraction | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 21 | 0.824 | SpI | 20 | 6.29436 | - | 0 | 0 | Y | n4-15c20/21o | Periplasmic | 10 | 31 | ||||||||
| YOHD_ECOLI | P33366 | yohD | b2136 JW2124 | integral IM protein (SEC in IM) of DedA family, YohD | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 22 | 0.131 | CYT | 0 | -0.200913 | - | 4 | 4 | N | i12-35o41-63i122-143o163-180i | CytoplasmicMembrane | 10 | 65 | |||||
| MDTQ_ECOLI | P33369 | mdtQ yohG yohH | yohG yohH | b2139 JW5838/JW5358 b2138 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative multidrug resistance MdtQ | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Cytoplasmic | SEC | LOL | pseudogene (Ochman & Davalos, 2006) | no | yes | Y | 24 | 0.204 | SpII | 21 | 10.0112 | Pos+2=A | 0 | 0 | Y | n9-20c38/39o | OuterMembrane | 10 | 2 | ||||||||
| PPDA_ECOLI | P33554 | ppdA | b2826 JW2794 | periplasmic protein (SEC through IM), Prepilin peptidase-dependent A PpdA | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | N | 27 | 0.172 | TMH | 0 | 7.10154 | - | 1 | 1 | N | i12-33o | CytoplasmicMembrane | 9 | 10 | ||||||||||||
| NIKA_ECOLI | P33590 | nikA | b3476 JW3441 | periplasmic protein (SEC through IM), Nickel-binding periplasmic protein NikA | Periplasmic | Might be is co-translationally translocated through Sec translocon. PMID: 7867647 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 15838024 PMID: 7867647 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SRP (exp) | SEC | yes | yes | Y | 23 | 0.82 | SpI | 22 | 20.282 | - | 0 | 0 | Y | n8-18c22/23o | Periplasmic | 10 | ||||||||
| NIKB_ECOLI | P33591 | nikB | b3477 JW3442 | integral IM protein (SEC in IM), Nickel transport system permease NikB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.197 | TMH | 0 | 11.5427 | - | 6 | 6 | N | i9-29o104-125i137-164o176-195i232-255o275-298i | CytoplasmicMembrane | 10 | |||||||
| NUOL_ECOLI | P33607 | nuoL | b2278 JW2273 | integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit L NuoL | Integral Inner Membrane | PMID: 15919996 PMID: 20732298 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 27 | 0.186 | TMH | 0 | 9.92034 | - | 16 | 17 | Y | n4-15c19/20o29-52i64-81o87-104i116-133o139-158i170-189o209-228i249-267o279-300i307-325o331-354i374-392o412-434i455-475o495-513i534-560o593-612i | CytoplasmicMembrane | 10 | |||||||
| FEOB_ECOLI | P33650 | feoB | b3409 JW3372 | integral IM protein (SEC in IM), FeoB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.107 | CYT | 0 | -0.200913 | - | 10 | 9 | N | o282-302i309-327o347-367i421-447o453-473i511-529o664-685i697-715o721-742i | CytoplasmicMembrane | 10 | 8 | ||||||
| YDBA_ECOLI | P33666 | ydbA | b4492 JW5802/JW1402 b1401/b1405 | OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative exported YdbA | Outer Membrane b-barrel protein | Ag43 homologue; known autotransporter protein. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> | PMID: 15590781 | Outer Membrane b-barrel protein | H | IM (predicted) | Secreted | Cytoplasmic | SEC | Autotransporter(T5S) | pseudogene (Uniprot) | no | yes | Y | 22 | 0.75 | SpI | 20 | 0 | 21 | 0 | 0 | Y | n5-16c21/22o | Unknown | 6 | 28 | ||||||
| YBBC_ECOLI | P33668 | ybbC | b0498 JW0487 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YbbC | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 18 | 0.367 | SpII | 17 | 8.97285 | Pos+2=N | 0 | 0 | Y | n6-17c25/26o | Unknown | 2 | 48 | |||||||||||
| YBBD_ECOLI | P33669 | ybbD | b0501 JW0489 | integral IM protein (SEC in IM), Putative YbbD | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Membrane | Membrane anchored | SRP | SEC | pseudogene (Uniprot) | no | no | N | 35 | 0.114 | TMH | 0 | 9.05171 | - | 1 | 1 | N | o12-32i | CytoplasmicMembrane | 9 | 46 | |||||||
| YEJA_ECOLI | P33913 | yejA | b2177 JW2165 | periplasmic protein (SEC through IM), YejA | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | Soluble IM Fraction | Periplasmic | SEC | SURA | no | yes | Y | 20 | 0.634 | SpI | 19 | 9.78276 | - | 1 | 0 | Y | n5-15c19/20o | Periplasmic | 10 | 19 | ||||||||
| YEJE_ECOLI | P33915 | yejE | b2179 JW2167 | integral IM protein (SEC in IM), ABC transporter permease YejE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 43 | 0.206 | TMH | 0 | 6.40686 | - | 6 | 6 | N | i21-42o142-167i179-197o203-222i259-286o306-327i | CytoplasmicMembrane | 10 | |||||||
| YEJO_ECOLI | P33924 | yejO | b2190 JW5839 | OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative YejO | Outer Membrane b-barrel protein | Ag43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> | PMID: 15590781 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | cytoplasmic | SEC | Autotransporter(T5S) | Insertion Sequence, Insertion Element, pseudogene (Uniprot) | no | no | Y | 30 | 0.756 | SpI | 29 | 7.15031 | - | 0 | 0 | Y | n12-22c29/30o | Unknown | 7 | 29 | ||||||
| CCMF_ECOLI | P33927 | ccmF yejR | yejR | b2196 JW2184 | integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 54 | 0.151 | TMH | 0 | 12.9934 | - | 15 | 15 | N | o6-29i41-62o96-114i121-142o178-198i210-230o250-267i274-294o314-332i353-374o394-412i424-444o450-472i484-503o609-629i | CytoplasmicMembrane | 10 | ||||||
| NAPH_ECOLI | P33934 | napH yejZ | yejZ | b2204 JW2192 | integral IM protein (SEC in IM), Ferredoxin-type NapH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.13 | TMH | 0 | 7.44595 | - | 4 | 4 | N | i30-50o78-98i139-160o172-192i | CytoplasmicMembrane | 10 | 6 | |||||
| NAPA_ECOLI | P33937 | napA yojC yojD yojE | yojC yojD yojE | b2206 JW2194 | periplasmic protein (TAT through IM), nitrate reductase NapA | Periplasmic | TAT secretion system. Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 PMID: 10234835 Disulfide bond-containing protein PMID: 25664544 | PMID: 10234835 PMID: 11844760 PMID: 17218314 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT | yes | yes | Y | 32 | 0.617 | SpI | 31 | 20.6365 | - | 0 | 0 | Y | n13-23c31/32o | Periplasmic | 10 | ||||||||
| YOJI_ECOLI | P33941 | yojI yojJ | yojJ | b2211 JW2199 | integral IM protein (SEC in IM), ABC transporter ATP-binding/permease YojI | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.136 | TMH | 0 | 12.5457 | - | 6 | 6 | N | i12-36o56-80i125-144o150-169i231-253o273-296i | CytoplasmicMembrane | 10 | 18 | |||||||
| HOFQ_ECOLI | P34749 | hofQ hopQ | hopQ | b3391 JW3354 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), DNA utilization HofQ | Outer Membrane b-barrel protein | Secretin family, homologous to the secretin of T2S (P45758 (GSPD_ECOLI)); homologus to ComE of H.influenza involved in DNA uptake | PMID: 16707682 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Periplasmic | SEC | BAM | yes | yes | Y | 19 | 0.736 | SpI | 19 | 10.1451 | - | 0 | 0 | Y | n5-13c18/19o | OuterMembrane | 10 | 63 | ||||||
| AMIA_ECOLI | P36548 | amiA yfeE | yfeE | b2435 JW2428 | periplasmic protein (TAT-SEC through IM), N-acetylmuramoyl-L-alanine amidase AmiA | Periplasmic | The Escherichia coli amidase AmiC is a periplasmic septal ring component exported via the twin-arginine transport pathwayPMID: 17218314PMID: 12787347. PMID: 12787347 | PMID: 12787347 PMID: 17218314 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | Y | 35 | 0.684 | SpI | 34 | 15.9519 | - | 0 | 0 | Y | n16-26c34/35o | Unknown | 2 | 36 | |||||||
| MDTD_ECOLI | P36554 | mdtD yegB | yegB | b2077 JW2062 | integral IM protein (SEC in IM), Putative multidrug resistance MdtD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.206 | TMH | 0 | 7.65965 | - | 13 | 13 | N | i12-33o45-64i76-96o102-123i135-157o163-185i197-214o226-243i263-280o286-308i329-355o396-418i430-451o | CytoplasmicMembrane | 10 | ||||||
| ASR_ECOLI | P36560 | asr | b1597 JW5826 | periplasmic protein (SEC through IM), Acid shock protein Asr | Periplasmic | PMID: 12670971 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.907 | SpI | 21 | 28.9272 | - | 0 | 0 | Y | n4-15c21/22o | Periplasmic | 10 | ||||||||||
| COBS_ECOLI | P36561 | cobS | b1992 JW1970 | integral IM protein (SEC in IM), Adenosylcobinamide-GDP ribazoletransferase CobS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 58 | 0.15 | TMH | 0 | 3.98364 | - | 4 | 6 | N | i34-58o64-88i109-132o138-158i178-196o202-219i | CytoplasmicMembrane | 10 | 2 | ||||||
| HOFC_ECOLI | P36646 | hofC hopC yacD | hopC yacD | b0106 JW0102 | integral IM protein (SEC in IM), transport homolog HofC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 19 | 0.132 | CYT | 0 | -0.200913 | - | 3 | 4 | N | i162-185o216-234i263-281o369-389i | CytoplasmicMembrane | 10 | ||||||
| PPDD_ECOLI | P36647 | ppdD | b0108 JW0104 | integral IM protein (SEC in IM), Prepilin peptidase-dependent D PpdD | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Fimbrium | Membrane anchored | SRP | SEC | no | yes | N | 53 | 0.143 | TMH | 0 | 4.07217 | - | 1 | 1 | N | i12-30o | Extracellular | 9 | 9 | ||||||||
| CUEO_ECOLI | P36649 | cueO yacK | yacK | b0123 JW0119 | periplasmic protein (TAT-SEC through IM), Blue copper oxidase CueO | Periplasmic | TAT secretion system. PMID: 9298646 | PMID: 17218314 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | Y | 29 | 0.821 | SpI | 28 | 16.1248 | - | 0 | 0 | Y | n11-22c28/29o | Periplasmic | 10 | 6 | |||||||
| DSBD_ECOLI | P36655 | dsbD cutA2 cycZ dipZ | cutA2 cycZ dipZ | b4136 JW5734 | integral IM protein (SEC in IM), Thiol:disulfide interchange DsbD | Integral Inner Membrane | DsbD is an inner membrane protein that is recognised and targeted to the Sec pathway by short, cleavable, N-terminal signal sequence. PMID: 15919996 Disulfide bridge (122 128;182 304;480 483) | PMID: 15919996 PMID: 18406599 PMID: 7628442 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | Y | 20 | 0.853 | SpI | 19 | 10.1575 | - | 8 | 7 | Y | n5-13c19/20o168-195i207-231o243-267i288-317o329-351i363-381o387-406i | CytoplasmicMembrane | 10 | |||||
| PTTBC_ECOLI | P36672 | treB | b4240 JW4199 | integral IM protein (SEC in IM), PTS system trehalose-specific EIIBC component TreB | Integral Inner Membrane | Trigger factor-sensitive aggregation. | PMID: 15919657 PMID: 15919996 PMID: 19737520 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP,TF | SEC | no | yes | N | 44 | 0.348 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i107-131o159-180i187-208o228-245i257-281o301-321i341-361o373-392i399-418o438-461i | CytoplasmicMembrane | 10 | 4 | |||||
| GSPM_ECOLI | P36678 | gspM hopZ pshM | hopZ pshM | b3334 JW5704 | integral IM protein (SEC in IM), Putative type II secretion system M GspM | Integral Inner Membrane | Potential component of type II secretion system. | PMID: 11118204 PMID: 14966662 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 30 | 0.121 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o16-34i | Unknown | 2 | |||||
| YACH_ECOLI | P36682 | yacH | b0117 JW0113 | periplasmic protein (SEC through IM), YacH | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.224 | SpI | 29 | 9.50022 | - | 0 | 0 | Y | n11-21c26/27o | Extracellular | 9 | 13 | ||||||||||||
| DTPB_ECOLI | P36837 | dtpB yhiP | yhiP | b3496 JW3463 | integral IM protein (SEC in IM), Dipeptide and tripeptide permease B DtpB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 61 | 0.154 | TMH | 0 | 6.34727 | - | 14 | 14 | N | i28-46o52-72i84-101o107-124i145-167o173-193i214-232o238-256i268-285o320-337i349-371o383-408i415-437o457-479i | CytoplasmicMembrane | 10 | ||||||
| RSMB_ECOLI | P36929 | rsmB fmu/fmv rrmB sun yhdB | fmu/fmv rrmB sun yhdB | b3289 JW3250 | integral IM protein (SEC in IM), Ribosomal RNA small subunit methyltransferase B RsmB | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cytoplasm | Cytoplasmic | SRP | SEC | yes | yes | N | 68 | 0.106 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i76-93o | Cytoplasmic | 9 | 50 | |||||||
| EAEH_ECOLI | P36943 | eaeH | b0297 JW0291 | periplasmic protein (SEC through IM), Putative attaching and effacing homolog EaeH | Periplasmic | Uniprot gives portential signal peptide (1-25) although it is not predicted by any tool. Intimin homologue but missing the C-terminus. Intimin is in the OM. Could be periplasmic. The signal peptide could be long autotransporter-like signal peptide. Intimin does not have a classical signal peptide either. | Periplasmic | G | N/A | Membrane anchored | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 45 | 0.383 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i21-44o | OuterMembrane | 9 | 5 | |||||||||
| PAGP_ECOLI | P37001 | pagP crcA ybeG | crcA ybeG | b0622 JW0617 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Lipid A palmitoyltransferase PagP | Outer Membrane b-barrel protein | PMID: 11013210 PMID: 11266632 PMID: 12357033 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | no | yes | N | 26 | 0.361 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n7-18c25/26o | OuterMembrane | 10 | 9 | |||||||
| CRCB_ECOLI | P37002 | crcB ybeI | ybeI | b0624 JW0619 | integral IM protein (SEC-YidC in IM), Putative fluoride ion transporter CrcB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996 | PMID: 15919996 PMID: 16429150 PMID: 22108384 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | in/out, out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | yes | yes | N | 33 | 0.138 | TMH | 0 | 7.1142 | - | 4 | 3 | Y | n2-10c15/16o31-55i67-91o97-121i | CytoplasmicMembrane | 10 | 19 | ||||
| YADK_ECOLI | P37016 | yadK | b0136 JW0132 | Fimbrial periplasmic protein (SEC through IM), YadK | Periplasmic | Putative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | yes | yes | Y | 29 | 0.766 | SpI | 28 | 16.7043 | - | 1 | 0 | Y | n12-23c28/29o | Unknown | 2 | 41 | |||||||
| YADL_ECOLI | P37017 | yadL | b0137 JW0133 | Fimbrial periplasmic protein (SEC through IM), YadL | Periplasmic | Putative chaperone???usher fimbrial operon (class ??4); Unkown function. | PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | no | yes | Y | 29 | 0.815 | SpI | 28 | 19.3349 | - | 1 | 0 | Y | n11-22c28/29o | Unknown | 2 | 23 | |||||||
| YADM_ECOLI | P37018 | yadM | b0138 JW0134 | Fimbrial periplasmic protein (SEC through IM), YadM | Periplasmic | Putative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | no | yes | Y | 24 | 0.878 | SpI | 23 | 14.8521 | - | 0 | 0 | Y | n9-17c23/24o | Unknown | 2 | 25 | |||||||
| CLCA_ECOLI | P37019 | clcA eriC yadQ | eriC yadQ | b0155 JW5012 | integral IM protein (SEC in IM), H(+)/Cl(-) exchange transporter ClcA | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Alpha-helcal transmembrane protein (experimental). The transmembrane segments are all helical and buried within the protein and the membranePMID: 11796999. C-terminal tagging with the alkaline phosphatase and green fluorescent protein in order to define the periplasmic or cytoplasmic locations of the C terminiPMID: 15919996. | PMID: 11266632 PMID: 11796999 PMID: 15919996 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 50 | 0.115 | CYT | 0 | -0.200913 | - | 11 | 10 | N | o33-53i74-97o177-201i213-232o252-270i291-308o328-348i355-376o388-413i420-439o | CytoplasmicMembrane | 10 | 38 | ||||
| BTUF_ECOLI | P37028 | btuF yadT | yadT | b0158 JW0154 | periplasmic protein (SEC through IM), Vitamin B12-binding protein BtuF | Periplasmic | Disulfide bridge (183 259) Disulfide bond-containing protein PMID: 25664544 | PMID: 11790740 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.751 | SpI | 22 | 10.8439 | - | 0 | 0 | Y | n8-18c22/23o | Periplasmic | 10 | ||||||||
| YAEI_ECOLI | P37049 | yaeI | b0164 JW5014 | periplasmic protein (SEC through IM), Phosphodiesterase YaeI | Periplasmic | G | N/A | Membrane anchored | SEC | no | yes | N | 47 | 0.129 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n7-17c22/23o | Unknown | 2 | 6 | ||||||||||||
| YADN_ECOLI | P37050 | yadN | b0141 JW0137 | Fimbrial periplasmic protein (SEC through IM), YadN | Periplasmic | Putative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit. Disulfide bridge (41 86) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 24 | 0.713 | SpI | 23 | 17.9817 | - | 0 | 0 | Y | n5-15c23/24o | Extracellular | 9 | 77 | ||||||
| YAEF_ECOLI | P37056 | yaeF yaeK | yaeK | b0193 JW5016 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Probable peptidase YaeF | Outer Membrane Lipoprotein | I | N/A | Cell inner membrane | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 26 | 0.176 | SpII | 20 | 9.80359 | Pos+2=T | 0 | 0 | Y | n10-21c26/27o | Unknown | 2 | 50 | |||||||||
| RIR4_ECOLI | P37146 | nrdF ygaD | ygaD | b2676 JW2651 | integral IM protein (SEC in IM), Ribonucleoside-diphosphate reductase 2 subunit beta NrdF | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cytoplasmic | SRP | SEC | yes | yes | N | 62 | 0.104 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i152-172o | Unknown | 2 | 31 | ||||||||
| FXSA_ECOLI | P37147 | fxsA yjeG | yjeG | b4140 JW4100 | integral IM protein (SEC in IM), UPF0716 FxsA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 64 | 0.114 | TMH | 0 | 5.51241 | - | 3 | 3 | N | o6-24i29-47o78-101i | CytoplasmicMembrane | 10 | 25 | |||||
| HYBB_ECOLI | P37180 | hybB | b2995 JW5494 | integral IM protein (SEC in IM), Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit HybB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 69 | 0.111 | TMH | 0 | 13.5768 | - | 10 | 10 | N | i12-31o51-79i91-110o130-154i166-184o211-234i246-264o284-302i314-332o352-373i | CytoplasmicMembrane | 10 | |||||||
| SLP_ECOLI | P37194 | slp | b3506 JW3474 | OM lipoprotein (SEC through IM, inserted in OM by LOL), Slp | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 PMID: 9298646 | PMID: 10806384 PMID: 15174130 PMID: 15911532 PMID: 16079137 PMID: 20932056 PMID: 21541338 PMID: 9298646 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 18 | 0.153 | SpII | 18 | 21.4364 | Pos+2=S | 0 | 0 | Y | n6-16c21/22o | OuterMembrane | 10 | ||||||||
| YHJA_ECOLI | P37197 | yhjA | b3518 JW3486 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Probable cytochrome c peroxidase YhjA | Inner Membrane Lipoprotein | By virtue of its homology to the Neisseria protein (Q5F5Z9_neigo1) | PMID: 12720546 | Inner Membrane Lipoprotein | E | N/A | Membrane anchored | SEC | LOL | no | yes | N | 29 | 0.287 | SpI | 28 | 4.74738 | - | 1 | 1 | N | i7-28o | Periplasmic | 9 | 21 | ||||||||
| HOKA_ECOLI | P37305 | hokA yiaZ | yiaZ | b4455 JW3526 | integral IM protein (SEC in IM), HokA | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 25 | 0.11 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-24o | Periplasmic | 9 | 110 | ||||
| YBCH_ECOLI | P37325 | ybcH | b0567 JW0556 | periplasmic protein (SEC through IM), YbcH | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 21 | 0.6 | SpI | 20 | 14.6445 | - | 1 | 0 | Y | n4-15c20/21o | CytoplasmicMembrane | 9 | 26 | ||||||||||||
| YFDC_ECOLI | P37327 | yfdC | b2347 JW2344 | integral IM protein (SEC in IM), YfdC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.112 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i58-76o96-114i135-158o187-206i213-233o253-275i | CytoplasmicMembrane | 10 | 38 | ||||||
| MODA_ECOLI | P37329 | modA | b0763 JW0746 | periplasmic protein (SEC through IM), Molybdate-binding ModA | Periplasmic | PMID: 8576221 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 25 | 0.754 | SpI | 24 | 18.4352 | - | 0 | 0 | Y | n8-19c24/25o | Periplasmic | 10 | 99 | |||||||||
| MDTK_ECOLI | P37340 | mdtK norE norM ydhE | norE norM ydhE | b1663 JW1655 | integral IM protein (SEC in IM), Multidrug resistance MdtK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 37 | 0.255 | TMH | 0 | 9.01951 | - | 12 | 11 | Y | n10-21c29/30o53-72i92-113o133-149i161-183o189-212i245-268o280-301i313-336o348-366i387-407o419-438i | CytoplasmicMembrane | 10 | ||||||
| XYLF_ECOLI | P37387 | xylF xylT | xylT | b3566 JW3538 | periplasmic protein (SEC through IM), D-xylose-binding periplasmic protein XylF | Periplasmic | PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.78 | SpI | 23 | 14.4657 | - | 0 | 0 | Y | n6-17c23/24o | Periplasmic | 10 | |||||||||
| YCAI_ECOLI | P37443 | ycaI | b0913 JW5120 | integral IM protein (SEC in IM), YcaI | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.135 | TMH | 0 | 10.6181 | - | 7 | 12 | N | o23-42i49-69o222-243i255-274o280-297i304-322o328-346i358-383o389-411i423-439o445-467i474-491o | CytoplasmicMembrane | 10 | |||||||||
| YDHC_ECOLI | P37597 | ydhC | b1660 JW1652 | integral IM protein (SEC in IM), transport YdhC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.384 | TMH | 0 | 10.7821 | - | 12 | 11 | Y | n7-22c30/31o40-61i73-91o97-119i131-155o161-180i209-229o235-258i270-293o299-322i334-355o361-381i | CytoplasmicMembrane | 10 | |||||||
| YHHL_ECOLI | P37614 | yhhL | b3466 JW5683 | integral IM protein (SEC in IM), YhhL | Integral Inner Membrane | B | Binout | out/out | IM (predicted) | Integral Membrane Protein | SRP | SEC | no | yes | N | 25 | 0.114 | TMH | 0 | 1.98334 | - | 2 | 1 | Y | n8-19c24/25o34-51i | CytoplasmicMembrane | 9 | 47 | |||||||||
| YHHM_ECOLI | P37615 | yhhM | b3467 JW3432 | integral IM protein (SEC in IM), YhhM | Single transmembrane helice predicted which would be removed upon signal peptide cleavage IM-cter inside. | Integral Inner Membrane | B | Bin | out/in | N/A | Membrane anchored | SRP | SEC | yes | yes | N | 32 | 0.135 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-24i | Unknown | 2 | 75 | ||||||||
| ZNTA_ECOLI | P37617 | zntA yhhO | yhhO | b3469 JW3434 | integral IM protein (SEC in IM), Zinc/cadmium/lead-transporting P-type ATPase ZntA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.185 | CYT | 0 | -0.200913 | - | 5 | 8 | N | i128-144o150-168i180-197o203-222i353-374o380-404i686-702o708-729i | CytoplasmicMembrane | 10 | 26 | |||||
| QPTR_ECOLI | P37619 | yhhQ | b3471 JW3436 | integral IM protein (SEC in IM), Queuosine precursor transporter YhhQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.133 | TMH | 0 | 11.3075 | - | 6 | 6 | N | i12-31o43-64i71-92o104-127i139-165o185-206i | CytoplasmicMembrane | 10 | |||||||
| YHHS_ECOLI | P37621 | yhhS | b3473 JW5945 | integral IM protein (SEC in IM), MFS-type transporter YhhS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.135 | TMH | 0 | 8.30657 | - | 12 | 12 | N | i19-41o47-65i85-103o109-131i152-175o181-199i220-241o253-271i283-303o309-330i342-364o370-388i | CytoplasmicMembrane | 10 | |||||||
| RBBA_ECOLI | P37624 | rbbA yhiG yhiH | yhiG yhiH | b3486 JW5676 | integral IM protein (SEC in IM), Ribosome-associated ATPase RbbA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 24 | 0.13 | CYT | 0 | -0.200913 | - | 5 | 6 | N | i558-579o716-739i766-789o795-817i824-845o884-906i | CytoplasmicMembrane | 10 | 17 | |||||
| YHII_ECOLI | P37626 | yhiI | b3487 JW3454 | integral IM protein (SEC in IM), YhiI | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Membrane anchored | SRP | SEC | no | yes | N | 31 | 0.132 | TMH | 0 | 4.13485 | - | 1 | 1 | N | i7-27o | CytoplasmicMembrane | 7 | ||||||||||
| YHIM_ECOLI | P37630 | yhiM | b3491 JW5944 | integral IM protein (SEC in IM), YhiM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.131 | TMH | 0 | 11.4226 | - | 10 | 10 | N | i7-28o40-62i74-95o107-133i154-175o187-211i223-246o258-281i293-313o325-343i | CytoplasmicMembrane | 10 | |||||||
| YHIN_ECOLI | P37631 | yhiN | b3492 JW3459 | integral IM protein (SEC in IM), YhiN | Integral Inner Membrane | B | Bout | in/out | N/A | Cytoplasmic | SRP | SEC | yes | yes | N | 23 | 0.367 | SpI | 22 | 3.94669 | - | 1 | 0 | Y | n6-17c22/23o | Unknown | 4 | 20 | |||||||||
| MDTE_ECOLI | P37636 | mdtE yhiU | yhiU | b3513 JW3481 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug resistance MdtE | Outer Membrane Lipoprotein | Outer membrane protein related to resistance to ampicillin and tetracycline Proven pignal peptidase II substrate. | PMID: 15174130 PMID: 16372265 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell inner membrane | Inner membrane lipoprotein | SEC | LOL | yes | yes | Y | 26 | 0.181 | SpII | 20 | 22.544 | Pos+2=D | 0 | 0 | Y | n7-15c20/21o | CytoplasmicMembrane | 9 | 89 | ||||||
| MDTF_ECOLI | P37637 | mdtF yhiV | yhiV | b3514 JW3482 | integral IM protein (SEC in IM), Multidrug resistance MdtF | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 55 | 0.14 | TMH | 0 | 7.6049 | - | 11 | 12 | N | i12-32o340-359i366-390o396-416i437-458o470-497i539-555o873-890i897-917o923-948i969-989o1009-1031i | CytoplasmicMembrane | 10 | ||||||
| YHJD_ECOLI | P37642 | yhjD | b3522 JW3490 | integral IM protein (SEC in IM), YhjD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.105 | CYT | 0 | -0.200913 | - | 6 | 5 | N | o72-97i186-209o229-250i262-282o294-321i | CytoplasmicMembrane | 10 | 13 | ||||||
| YHJE_ECOLI | P37643 | yhjE | b3523 JW3491 | integral IM protein (SEC in IM), metabolite transport YhjE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 45 | 0.121 | CYT | 0 | -0.200913 | - | 11 | 11 | N | o38-54i66-85o97-130i168-188o200-217i249-270o290-312i321-340o346-370i382-403o409-431i | CytoplasmicMembrane | 10 | |||||||
| YHJG_ECOLI | P37645 | yhjG yhjF | yhjF | b3524 JW3492 | integral IM protein (SEC in IM), YhjG | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | yes | yes | N | 33 | 0.12 | TMH | 0 | 1.70796 | - | 1 | 1 | N | i7-29o | Unknown | 2 | 10 | |||||||
| YHJJ_ECOLI | P37648 | yhjJ | b3527 JW3495 | periplasmic protein (SEC through IM), YhjJ | Periplasmic | Potential Skp substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SKP | yes | yes | Y | 25 | 0.722 | SpI | 24 | 14.0569 | - | 0 | 0 | Y | n8-19c24/25o | Unknown | 2 | 83 | |||||||
| PDEK_ECOLI | P37649 | pdeK yhjK | yhjK | b3529 JW5943 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.106 | TMH | 0 | 5.39989 | - | 2 | 2 | N | o12-35i151-176o | CytoplasmicMembrane | 10 | ||||||
| BCSC_ECOLI | P37650 | bcsC yhjL | yhjL | b3530 JW5942 | periplasmic protein (SEC through IM), Cellulose synthase operon C BcsC | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 24 | 0.51 | SpI | 23 | 6.58448 | - | 0 | 0 | Y | n8-18c23/24o | Unknown | 4 | ||||||||||||
| GUN_ECOLI | P37651 | bcsZ bcsC yhjM | bcsC yhjM | b3531 JW3499 | periplasmic protein (SEC through IM), Endoglucanase BcsZ | Periplasmic | PMID: 10102357 PMID: 11260463 PMID: 21454578 PMID: 24097954 | Periplasmic | G | N/A | Secreted | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.88 | SpII | 22 | 12.5942 | Pos+2=T | 0 | 0 | Y | n6-17c21/22o | Extracellular | 10 | 6 | ||||||||
| BCSB_ECOLI | P37652 | bcsB yhjN | yhjN | b3532 JW3500 | integral IM protein (SEC-YidC in IM), Cyclic di-GMP-binding BcsB | Integral Inner Membrane | BscC is involved in biosynthesis of cellulose, which is a significant constituent of the extracellular matrix. Encodes the catalytic subunit of cellulose synthase. Exhibites aberrant localization by microscopy in the absence of YidC. BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 24097954 | 24127606 PMID: 15919996 PMID: 2030672 PMID: 22108384 PMID: 24097954 | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cell inner membrane; Single-pass type I membrane protein | Integral Membrane Protein | SRP | SEC-YidC | no | yes | Y | 26 | 0.342 | SpI | 25 | 20.4203 | - | 2 | 1 | Y | n5-13c25/26o745-766i | CytoplasmicMembrane | 10 | 82 | ||||
| BCSA_ECOLI | P37653 | bcsA yhjO yhjP | yhjO yhjP | b3533 JW5665 | integral IM protein (SEC in IM), Cellulose synthase catalytic subunit BcsA | Integral Inner Membrane | BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 24097954 | 24127606 PMID: 24097954 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 16 | 0.123 | CYT | 0 | -0.200913 | - | 10 | 9 | Y | n3-10c15/16o31-50i150-168o174-190i197-216o228-252i524-547o553-575i639-659o665-690i | CytoplasmicMembrane | 10 | |||||
| BCSG_ECOLI | P37659 | bcsG yhjU | yhjU | b3538 JW3506 | integral IM protein (SEC in IM), Cellulose biosynthesis BcsG | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 52 | 0.108 | TMH | 0 | 9.60827 | - | 4 | 4 | N | o34-56i68-85o113-132i139-162o | CytoplasmicMembrane | 10 | 10 | |||||||
| YHJV_ECOLI | P37660 | yhjV | b3539 JW3508 | integral IM protein (SEC in IM), transport YhjV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 34 | 0.111 | TMH | 0 | 10.9997 | - | 11 | 11 | N | i20-40o46-64i95-118o138-155i167-185o205-227i247-267o294-318i339-362o368-389i401-422o | CytoplasmicMembrane | 10 | |||||||
| EPTB_ECOLI | P37661 | eptB yhjW | yhjW | b3546 JW5660 | integral IM protein (SEC in IM), EptB | Integral Inner Membrane | Disulfide bond-containing protein PMID: 25664544 | PMID: 15795227 PMID: 15919996 PMID: 25664544 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 38 | 0.136 | TMH | 0 | 11.408 | - | 5 | 5 | N | i12-30o42-65i77-103o123-140i161-178o | CytoplasmicMembrane | 10 | |||||
| YHJX_ECOLI | P37662 | yhjX | b3547 JW3516 | integral IM protein (SEC in IM), MFS-type transporter YhjX | Integral Inner Membrane | PMID: 15919996 PMID: 23222720 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.124 | TMH | 0 | 10.8343 | - | 12 | 12 | N | i12-33o45-66i78-95o101-122i134-154o166-186i216-237o249-270i282-301o307-329i341-360o366-387i | CytoplasmicMembrane | 10 | |||||||
| YHJY_ECOLI | P37663 | yhjY | b3548 JW5659 | OM b-barrel protein (SEC through IM, T5S secreted through OM), YhjY | Outer Membrane b-barrel protein | Ag43 homologue ; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> | PMID: 15590781 | Outer Membrane b-barrel protein | H | N/A | Periplasmic | SEC | Autotransporter(T5S) | no | yes | N | 31 | 0.371 | SpI | 30 | 11.8549 | - | 1 | 0 | Y | n14-25c30/31o | Unknown | 7 | 9 | ||||||||
| YIAD_ECOLI | P37665 | yiaD | b3552 JW5657 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Probable YiaD | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 15919996 PMID: 20932056 | Outer Membrane Lipoprotein | I | out/out | N/A | Cell inner membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 18 | 0.162 | SpII | 20 | 21.9879 | Pos+2=T | 3 | 2 | Y | n5-16c20/21o36-55i62-81o | OuterMembrane | 10 | 63 | ||||||
| WECH_ECOLI | P37669 | wecH yiaH | yiaH | b3561 JW3533 | integral IM protein (SEC in IM), O-acetyltransferase WecH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 33 | 0.129 | TMH | 0 | 7.27964 | - | 10 | 10 | N | i12-29o49-67i79-102o114-131i143-160o172-190i202-224o236-255i267-288o300-321i | CytoplasmicMembrane | 10 | ||||||
| YIAM_ECOLI | P37674 | yiaM | b3577 JW3549 | integral IM protein (SEC in IM), 2,3-diketo-L-gulonate TRAP transporter small permease YiaM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 23 | 0.132 | TMH | 0 | 6.97669 | - | 4 | 4 | N | i7-28o40-59i80-101o113-137i | CytoplasmicMembrane | 10 | 13 | ||||||
| YIAN_ECOLI | P37675 | yiaN | b3578 JW5651 | integral IM protein (SEC in IM), 2,3-diketo-L-gulonate TRAP transporter large permease YiaN | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 66 | 0.188 | TMH | 0 | 16.4337 | - | 11 | 11 | N | o12-35i56-75o95-124i136-158o170-191i212-234o240-256i277-295o315-343i355-375o395-419i | CytoplasmicMembrane | 10 | |||||||||
| YIAO_ECOLI | P37676 | yiaO | b3579 JW3551 | periplasmic protein (SEC through IM), 2,3-diketo-L-gulonate-binding periplasmic YiaO | Periplasmic | PMID: 16385129 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 25 | 0.815 | SpI | 24 | 15.7433 | - | 0 | 0 | Y | n6-17c24/25o | Periplasmic | 10 | 20 | |||||||||
| YIAT_ECOLI | P37681 | yiaT | b3584 JW3556 | OM b-barrel protein (SEC through IM), Putative YiaT | Outer Membrane b-barrel protein | PMID: 20639525 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | no | yes | Y | 22 | 0.602 | SpI | 21 | 11.315 | - | 0 | 0 | Y | n7-17c21/22o | OuterMembrane | 10 | 22 | |||||||||
| YIAV_ECOLI | P37683 | yiaV | b3586 JW3558 | integral IM protein (SEC in IM), YiaV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 16 | 0.116 | TMH | 0 | 1.11111 | - | 2 | 1 | Y | n3-13c17/18o27-49i | CytoplasmicMembrane | 10 | 22 | ||||||
| ENVC_ECOLI | P37690 | envC yibP | yibP | b3613 JW5646 | periplasmic protein (SEC through IM), Murein hydrolase activator EnvC | Periplasmic | PMID: 12113939 PMID: 15165230 PMID: 19525345 PMID: 8472900 | Periplasmic | G | Soluble IM Fraction | Periplasm | Inner Membrane Lipoprotein (Experimental) | SEC | yes | yes | Y | 35 | 0.862 | SpI | 34 | 13.522 | - | 1 | 0 | Y | n18-29c34/35o | OuterMembrane | 9 | 10 | ||||||||
| YIBQ_ECOLI | P37691 | yibQ | b3614 JW5645 | periplasmic protein (SEC through IM), YibQ | Periplasmic | PMID: 19953543 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 24 | 0.782 | SpI | 23 | 13.9145 | - | 1 | 0 | Y | n8-18c23/24o | Unknown | 2 | 14 | ||||||||||
| RMLA1_ECOLI | P37744 | rfbA rmlA rmlA1 | rmlA rmlA1 | b2039 JW2024 | periplasmic protein (SEC through IM), Glucose-1-phosphate thymidylyltransferase 1 RfbA | Periplasmic | PMID: 23138692 PMID: 7537247 | Periplasmic | G | IM (predicted-detected) | Cytoplasmic | SEC | yes | yes | N | 24 | 0.125 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n7-18c23/24o | Cytoplasmic | 9 | 63 | |||||||||
| RFBX_ECOLI | P37746 | rfbX wzx | wzx | b2037 JW2022 | integral IM protein (SEC in IM), Putative O-antigen transporter RfbX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 51 | 0.11 | TMH | 0 | 8.627 | - | 10 | 12 | N | i12-30o42-63i84-106o118-139i146-166o172-196i217-243o263-282i294-316o328-349i361-380o386-407i | CytoplasmicMembrane | 10 | ||||||
| RFC_ECOLI | P37748 | rfc yefF | yefF | b2035 JW2020 | integral IM protein (SEC in IM), O-antigen polymerase Rfc | Integral Inner Membrane | Phobius prediction for a very very weak aminoterminal TM | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 50 | 0.134 | TMH | 0 | 0.878412 | - | 12 | 12 | N | i23-43o55-78i99-117o144-161i173-188o194-209i214-233o239-258i270-289o309-332i339-357o363-382i | CytoplasmicMembrane | 10 | |||||
| NARU_ECOLI | P37758 | narU yddF | yddF | b1469 JW1464 | integral IM protein (SEC in IM), Nitrate/nitrite transporter NarU | Integral Inner Membrane | PMID: 15919996 PMID: 18691156 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.118 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i36-60o72-90i102-122o128-150i171-194o214-232i252-276o288-306i318-340o346-374i401-422o434-454i | CytoplasmicMembrane | 10 | ||||||
| YJFF_ECOLI | P37772 | yjfF | b4231 JW5754 | integral IM protein (SEC in IM), ABC transporter permease YjfF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.156 | TMH | 0 | 9.53051 | - | 8 | 8 | N | o6-23i44-77o89-109i116-134o162-180i211-231o251-274i295-315o | CytoplasmicMembrane | 10 | |||||||
| GLTI_ECOLI | P37902 | gltI ybeJ yzzK | ybeJ yzzK | b0655 JW5092 | periplasmic protein (SEC through IM), Glutamate/aspartate import solute-binding protein GltI | Periplasmic | Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 8740179 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544 | PMID: 14726535 PMID: 19953543 PMID: 22030350 PMID: 25664544 PMID: 8740179 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 23 | 0.775 | SpI | 22 | 21.5903 | - | 0 | 0 | Y | n7-17c22/23o | Periplasmic | 10 | 93 | ||||||
| YFJD_ECOLI | P37908 | yfjD ypjE | ypjE | b4461 JW5415 b2612/b2613 | integral IM protein (SEC in IM), UPF0053 YfjD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | no | yes | N | 24 | 0.142 | CYT | 0 | -0.200913 | - | 4 | 4 | N | o6-25i62-86o92-112i124-146o | CytoplasmicMembrane | 10 | 11 | ||||
| YBGD_ECOLI | P37909 | ybgD | b0719 JW0709 | Fimbrial periplasmic protein (SEC through IM), YbgD | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??); Fimbrial Subunit. Disulfide bridge (42 81) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 24 | 0.878 | SpI | 23 | 15.4399 | - | 0 | 0 | Y | n7-18c23/24o | Extracellular | 9 | |||||||
| SFMF_ECOLI | P38052 | sfmF ybcG | ybcG | b0534 JW5072 | Fimbrial periplasmic protein (SEC through IM), SfmF | Periplasmic | Potential fimbrial sfm operon (class ??1); Fimbrial Subunit. Disulfide bridge (40 80) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 21 | 0.763 | SpI | 20 | 16.3129 | - | 0 | 0 | Y | n4-15c20/21o | Extracellular | 9 | 64 | |||||
| CUSA_ECOLI | P38054 | cusA ybdE | ybdE | b0575 JW0564 | integral IM protein (SEC-YidC in IM), Cation efflux system CusA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 39 | 0.202 | TMH | 0 | 6.2187 | - | 12 | 12 | N | i12-32o338-357i364-384o390-411i442-464o484-505i538-554o874-891i898-918o924-948i985-1006o1012-1037i | CytoplasmicMembrane | 10 | |||||
| YDJE_ECOLI | P38055 | ydjE | b1769 JW1758 | integral IM protein (SEC in IM), metabolite transport YdjE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.167 | TMH | 0 | 6.79423 | - | 12 | 12 | N | i21-40o60-80i92-112o118-139i151-173o179-198i264-287o299-320i327-346o352-375i387-410o416-438i | CytoplasmicMembrane | 10 | |||||||
| DGCE_ECOLI | P38097 | dgcE yegE | yegE | b2067 JW2052 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 62 | 0.16 | TMH | 0 | 12.1449 | - | 11 | 10 | N | i12-33o39-58i65-85o91-112i124-144o156-177i189-206o212-228i235-258o270-290i | CytoplasmicMembrane | 10 | ||||||
| EAMB_ECOLI | P38101 | eamB yfiK | yfiK | b2578 JW2562 | integral IM protein (SEC in IM), Cysteine/O-acetylserine efflux protein EamB | Integral Inner Membrane | PMID: 12562784 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 45 | 0.172 | TMH | 0 | 7.57291 | - | 6 | 5 | Y | n4-15c27/28o43-67i74-91o111-133i140-163o175-194i | CytoplasmicMembrane | 10 | ||||||
| ETK_ECOLI | P38134 | etk yccC | yccC | b0981 JW0964 | integral IM protein (SEC in IM), Tyrosine-kinase Etk | Integral Inner Membrane | PMID: 10369665 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein(experimental) | SRP | SEC | no | yes | N | 59 | 0.28 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i33-51o425-445i | CytoplasmicMembrane | 10 | 41 | |||||
| SIEB_ECOLI | P38392 | sieB | b1353 JW5209 | integral IM protein (SEC in IM), Superinfection exclusion B SieB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 42 | 0.105 | TMH | 0 | 3.43476 | - | 2 | 2 | N | i20-38o50-70i | CytoplasmicMembrane | 10 | 13 | |||||
| TORT_ECOLI | P38683 | torT yccH | yccH | b0994 JW0979 | periplasmic protein (SEC through IM), Periplasmic TorT | Periplasmic | Might be is co-translationally translocated through Sec translocon. PMID: 8576063 The precursor of TorT harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 Disulfide bond-containing protein PMID: 25664544 | PMID: 15838024 PMID: 24717922 PMID: 25664544 PMID: 8576063 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SRP (exp) | SEC | yes | yes | Y | 19 | 0.789 | SpI | 18 | 12.9296 | - | 0 | 0 | Y | n3-14c18/19o | Periplasmic | 10 | 12 | ||||||
| DEGQ_ECOLI | P39099 | degQ hhoA | hhoA | b3234 JW3203 | periplasmic protein (SEC through IM), pH-dependent serine endoprotease DegQ | Periplasmic | PMID: 8576051 PMID: 8576052 PMID: 9740056 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 28 | 0.555 | SpI | 27 | 17.6659 | - | 1 | 0 | Y | n7-19c27/28o | Periplasmic | 10 | 66 | ||||||||
| YCHO_ECOLI | P39165 | ychO ychP | ychP | b1220 JW1211 | periplasmic protein (SEC through IM), YchO | Homologous to intimin / invasin family (yeej_coli). | Periplasmic | G | N/A | Periplasm | Cytoplasmic | SEC | yes | yes | Y | 25 | 0.55 | SpI | 24 | 8.3661 | - | 0 | 0 | Y | n8-19c24/25o | OuterMembrane | 10 | 7 | |||||||||
| ZNUA_ECOLI | P39172 | znuA yebL yzzP | yebL yzzP | b1857 JW5831 | periplasmic protein (SEC through IM), High-affinity zinc uptake system ZnuA | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 27 | 0.573 | SpI | 23 | 18.3411 | - | 0 | 0 | Y | n6-17c26/27o | Periplasmic | 10 | 84 | |||||||
| ERFK_ECOLI | P39176 | erfK yeeG yzzT | yeeG yzzT | b1990 JW1968 | periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase ErfK | Peripheral outer membrane protein facing the periplasm | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. ErfK has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646 | PMID: 18498364 PMID: 23832002 PMID: 9298646 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 22 | 0.658 | SpI | 21 | 17.0042 | - | 0 | 0 | Y | n6-16c21/22o | Unknown | 2 | 11 | ||||||
| AG43_ECOLI | P39180 | flu yeeQ yzzX | yeeQ yzzX | b2000 JW1982 | OM b-barrel protein (SEC through IM), T5S and TAM secreted in OM), Antigen 43 Flu | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (PMID: 15911532, PMID: 12624733, PMID: 10806384). Potential substrate of TAM secretion systemPMID: 22466966. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> PMID: 9298646 | PMID: 10806384 PMID: 12624733 PMID: 15590781 PMID: 15911532 PMID: 22466966 PMID: 22905239 PMID: 9298646 | Outer Membrane b-barrel protein | H | N/A | Antigen 43: Periplasm | Outer Membrane ??-barrel protein (Experimental) | SEC | Autotransporter(T5S), TAM | Prophage Integrase (EcoGene) | no | no | N | 53 | 0.646 | SpI | 52 | 5.41594 | - | 1 | 0 | Y | n34-45c52/53o | OuterMembrane | 10 | 32 | |||||
| YTFJ_ECOLI | P39187 | ytfJ | b4216 JW4175 | periplasmic protein (SEC through IM), YtfJ | Periplasmic | PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic(experimental) | SEC | yes | yes | Y | 21 | 0.734 | SpI | 20 | 13.6826 | - | 0 | 0 | Y | n6-14c22/23o | Unknown | 2 | 18 | |||||||||
| LPLT_ECOLI | P39196 | lplT ygeD | ygeD | b2835 JW2803 | integral IM protein (SEC in IM), Lysophospholipid transporter LplT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.127 | TMH | 0 | 8.05882 | - | 10 | 11 | N | o20-41i53-73o93-117i138-158o164-184i220-245o257-278i285-302o308-329i349-369o375-393i | CytoplasmicMembrane | 10 | ||||||
| YFCC_ECOLI | P39263 | yfcC | b2298 JW2295 | integral IM protein (SEC in IM), Putative basic amino acid antiporter YfcC | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 49 | 0.144 | TMH | 0 | 3.89092 | - | 11 | 13 | N | i20-41o106-127i148-165o171-187i194-221o233-252i287-308o314-332i353-371o383-403i410-432o452-471i483-503o | CytoplasmicMembrane | 10 | |||||||||
| FIMI_ECOLI | P39264 | fimI | b4315 JW5779 | Fimbrial periplasmic protein (SEC through IM), Fimbrin-like FimI | Periplasmic | Fim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. Disulfide bridge (43 83) | PMID: 19820722 PMID: 20345943 PMID: 2890081 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 20 | 0.716 | SpI | 19 | 16.0857 | - | 0 | 0 | Y | n6-13c19/20o | Extracellular | 9 | 37 | ||||||
| ALSB_ECOLI | P39265 | alsB yjcX | yjcX | b4088 JW4049 | periplasmic protein (SEC through IM), D-allose-binding periplasmic AlsB | Periplasmic | PMID: 14499611 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 24 | 0.81 | SpI | 23 | 18.079 | - | 1 | 0 | Y | n8-18c23/24o | Periplasmic | 10 | 53 | ||||||||
| YJDF_ECOLI | P39270 | yjdF | b4121 JW4082 | integral IM protein (SEC in IM), YjdF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 29 | 0.268 | TMH | 0 | 4.29363 | - | 6 | 6 | N | i7-26o32-49i61-83o103-120i132-155o175-194i | CytoplasmicMembrane | 10 | 3 | ||||||
| DTPC_ECOLI | P39276 | dtpC yjdL | yjdL | b4130 JW4091 | integral IM protein (SEC in IM), Dipeptide and tripeptide permease C DtpC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.104 | TMH | 0 | 2.87637 | - | 14 | 14 | N | i12-35o47-68i75-94o100-116i137-161o167-186i207-228o234-251i263-281o308-329i341-361o373-395i407-428o454-473i | CytoplasmicMembrane | 10 | ||||||
| YJEH_ECOLI | P39277 | yjeH | b4141 JW4101 | integral IM protein (SEC in IM), L-methionine/branched-chain amino acid exporter YjeH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.297 | TMH | 0 | 10.0553 | - | 11 | 10 | Y | n8-21c33/34o43-66i87-108o120-137i149-166o186-208i220-242o262-287i318-336o342-360i372-405o | CytoplasmicMembrane | 10 | |||||||
| YJEM_ECOLI | P39282 | yjeM | b4156 JW5739 | integral IM protein (SEC in IM), transporter YjeM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.324 | TMH | 0 | 13.0295 | - | 12 | 11 | Y | n10-18c23/24o39-62i83-110o130-149i161-183o203-223i244-264o311-336i357-381o393-412i432-454o466-484i | CytoplasmicMembrane | 10 | |||||||
| YJEO_ECOLI | P39284 | yjeO | b4158 JW4119 | integral IM protein (SEC in IM), YjeO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.227 | TMH | 0 | 7.24951 | - | 3 | 2 | Y | n6-17c25/26o55-72i79-98o | CytoplasmicMembrane | 10 | 56 | ||||||
| MSCM_ECOLI | P39285 | mscM yjeP | yjeP | b4159 JW4120 | integral IM protein (SEC in IM), Miniconductance mechanosensitive channel MscM | Integral Inner Membrane | PMID: 22874652 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | Y | 20 | 0.667 | SpI | 19 | 8.61826 | - | 11 | 11 | Y | n3-14c19/20o476-496i517-539o551-576i597-617o629-649i670-691o697-718i785-808o828-848i879-897o903-930i | CytoplasmicMembrane | 10 | 15 | |||||
| BSMA_ECOLI | P39297 | bsmA yjfO | yjfO | b4189 JW5743 | OM lipoprotein (SEC through IM, inserted in OM by LOL), BsmA | Outer Membrane Lipoprotein | PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 30 | 0.447 | SpII | 24 | 20.0908 | Pos+2=S | 1 | 0 | Y | n13-22c27/28o | Unknown | 2 | 46 | |||||||
| ULAA_ECOLI | P39301 | ulaA sgaT yjfS | sgaT yjfS | b4193 JW5744 | integral IM protein (SEC in IM), Ascorbate-specific PTS system EIIC component UlaA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.105 | TMH | 0 | 3.53199 | - | 10 | 10 | N | o15-34i46-66o100-121i142-170o233-253i265-285o305-331i338-359o379-402i423-445o | CytoplasmicMembrane | 10 | ||||||
| YTFB_ECOLI | P39310 | ytfB | b4206 JW5745 | integral IM protein (SEC in IM), Cell division YtfB | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | no | yes | N | 57 | 0.108 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i30-48o | Extracellular | 9 | 57 | ||||||||
| YTFF_ECOLI | P39314 | ytfF | b4210 JW4168 | integral IM protein (SEC in IM), YtfF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.128 | TMH | 0 | 8.9392 | - | 10 | 10 | N | i5-25o31-52i64-86o92-113i125-142o154-175i195-216o231-255i262-281o287-306i | CytoplasmicMembrane | 10 | |||||||
| TAMB_ECOLI | P39321 | tamB ytfN ytfO | ytfN ytfO | b4221 JW4180 | integral IM protein (SEC in IM), Translocation and assembly module subunit TamB | Integral Inner Membrane | Part of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria. | PMID: 22466966 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 24 | 0.143 | SpI | 25 | 7.57895 | - | 1 | 0 | Y | n8-19c23/24o | Unknown | 4 | 31 | ||||
| YTFQ_ECOLI | P39325 | ytfQ | b4227 JW4186 | periplasmic protein (SEC through IM), ABC transporter periplasmic-binding YtfQ | Periplasmic | Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544 | PMID: 19953543 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | DSBA | yes | yes | Y | 22 | 0.849 | SpI | 21 | 21.6548 | - | 1 | 0 | Y | n5-13c21/22o | Periplasmic | 10 | 90 | |||||||
| YTFT_ECOLI | P39328 | ytfT | b4230 JW5753 | integral IM protein (SEC in IM), ABC transporter permease YtfT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 44 | 0.117 | TMH | 0 | 7.85185 | - | 10 | 10 | N | i21-39o59-77i84-103o109-130i137-155o175-195i224-246o258-275i282-304o310-329i | CytoplasmicMembrane | 10 | |||||||
| YJGN_ECOLI | P39338 | yjgN | b4257 JW5759 | integral IM protein (SEC in IM), YjgN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 57 | 0.116 | TMH | 0 | 3.32963 | - | 8 | 8 | N | o24-45i65-90o96-116i142-164o176-208i229-249o280-299i327-349o | CytoplasmicMembrane | 10 | |||||||
| IDNT_ECOLI | P39344 | idnT gntW yjgT | gntW yjgT | b4265 JW4222 | integral IM protein (SEC in IM), Gnt-II system L-idonate transporter IdnT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 46 | 0.134 | TMH | 0 | 10.8686 | - | 12 | 12 | N | i12-38o58-76i97-130o136-154i175-194o222-242i254-275o295-312i324-344o350-369i376-393o413-438i | CytoplasmicMembrane | 10 | ||||||
| YJGX_ECOLI | P39349 | yjgX | b4575 b4275/b4276/b4560 | integral IM protein (SEC in IM), Putative phosphoethanolamine transferase YjgX | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 31 | 0.126 | TMH | 0 | 4.71526 | - | 1 | 1 | N | o6-25i | CytoplasmicMembrane | 10 | 49 | |||||||
| YJHB_ECOLI | P39352 | yjhB | b4279 JW5768 | integral IM protein (SEC in IM), Putative metabolite transport YjhB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 17 | 0.101 | TMH | 0 | 7.56655 | - | 11 | 12 | N | i21-41o53-73i85-105o111-129i141-160o166-185i215-235o247-271i283-302o308-327i339-362o368-392i | CytoplasmicMembrane | 10 | |||||||
| YJHE_ECOLI | P39355 | yjhE | b4282 | integral IM protein (SEC in IM), Putative YjhE | Integral Inner Membrane | B | - | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | no | no | N | 38 | 0.334 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i22-49o55-76i | CytoplasmicMembrane | 10 | 15 | ||||||||
| YJHF_ECOLI | P39357 | yjhF | b4296 JW4258 | integral IM protein (SEC in IM), permease YjhF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.161 | TMH | 0 | 4.20538 | - | 12 | 11 | Y | n3-13c17/18o27-44i56-76o99-129i136-154o174-193i228-249o261-285i305-327o347-380i387-405o425-448i | CytoplasmicMembrane | 10 | |||||||
| SGCC_ECOLI | P39365 | sgcC yjhN | yjhN | b4304 JW4266 | integral IM protein (SEC in IM), Putative permease IIC component SgcC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.12 | TMH | 0 | 10.5542 | - | 11 | 11 | N | o6-25i32-54o85-109i130-152o172-194i214-235o247-268i289-319o325-344i353-374o408-430i | CytoplasmicMembrane | 10 | ||||||
| NANM_ECOLI | P39371 | nanM yjhT | yjhT | b4310 JW5777 | periplasmic protein (SEC through IM), N-acetylneuraminate epimerase NanM | Periplasmic | PMID: 18063573 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 20 | 0.747 | SpI | 19 | 18.4486 | - | 0 | 0 | Y | n4-15c19/20o | Unknown | 2 | 75 | ||||||||
| YJIH_ECOLI | P39379 | yjiH | b4330 JW5783 | integral IM protein (SEC in IM), YjiH | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 38 | 0.143 | TMH | 0 | 5.26808 | - | 4 | 4 | N | i21-39o86-104i116-135o176-201i | CytoplasmicMembrane | 9 | 16 | ||||||||
| YJIJ_ECOLI | P39381 | yjiJ | b4332 JW4295 | integral IM protein (SEC in IM), YjiJ | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 43 | 0.129 | TMH | 0 | 16.3295 | - | 12 | 12 | N | i12-34o54-72i84-103o109-131i138-159o171-191i212-235o247-267i274-293o299-321i333-355o361-385i | CytoplasmicMembrane | 10 | |||||||||
| YJIK_ECOLI | P39382 | yjiK | b4333 JW5869 | integral IM protein (SEC in IM), YjiK | Belongs to the yjiK family. | Integral Inner Membrane | B | Bout | in/out | N/A | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 39 | 0.139 | SpI | 30 | 8.5892 | - | 1 | 1 | N | i12-28o | Unknown | 2 | 31 | |||||||
| YJIN_ECOLI | P39385 | yjiN | b4336 JW4299 | integral IM protein (SEC in IM), YjiN | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.127 | TMH | 0 | 11.0197 | - | 3 | 3 | N | i12-31o43-62i401-421o | CytoplasmicMembrane | 9 | |||||||||
| MDTM_ECOLI | P39386 | mdtM yjiO | yjiO | b4337 JW4300 | integral IM protein (SEC in IM), Multidrug resistance MdtM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.289 | TMH | 0 | 7.71747 | - | 12 | 11 | Y | n9-20c24/25o48-68i80-99o105-126i138-162o168-187i216-241o253-271i283-304o310-335i347-368o374-395i | CytoplasmicMembrane | 10 | ||||||
| BTST_ECOLI | P39396 | btsT yjiY | yjiY | b4354 JW5791 | integral IM protein (SEC in IM), Pyruvate/proton symporter BtsT | Integral Inner Membrane | PMID: 15919996 PMID: 22685278 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.119 | TMH | 0 | 7.29235 | - | 16 | 16 | N | i12-28o34-54i95-115o121-141i162-185o191-211i223-243o258-278i283-303o323-343i364-387o488-505i533-552o564-589i596-616o669-689i | CytoplasmicMembrane | 10 | ||||||
| LGOT_ECOLI | P39398 | lgoT yjiZ yjjL | yjiZ yjjL | b4356 JW4319 | integral IM protein (SEC in IM), Probable L-galactonate transporter LgoT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.161 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i39-56o108-127i170-192o198-217i260-279o299-321i333-352o358-385i397-415o421-442i | CytoplasmicMembrane | 10 | ||||||
| OPGB_ECOLI | P39401 | mdoB opgB yjjO | opgB yjjO | b4359 JW5794 | integral IM protein (SEC in IM), Phosphoglycerol transferase I MdoB | Integral Inner Membrane | Disulfide bond-containing protein PMID: 25664544 | PMID: 15919996 PMID: 25664544 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.198 | TMH | 0 | 5.71979 | - | 4 | 4 | Y | n4-14c18/19o28-47i59-74o80-98i110-128o | CytoplasmicMembrane | 10 | 7 | ||||
| TTDT_ECOLI | P39414 | ttdT ygjC ygjE | ygjC ygjE | b3063 JW3035 | integral IM protein (SEC in IM), L-tartrate/succinate antiporter TtdT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 30 | 0.161 | TMH | 0 | 15.2878 | - | 12 | 14 | N | i7-27o33-49i56-73o93-116i137-154o192-214i235-258o289-307i312-328o340-364i371-391o397-415i422-442o462-486i | CytoplasmicMembrane | 10 | ||||||
| TORS_ECOLI | P39453 | torS yccI | yccI | b0993 JW5135 | integral IM protein (SEC in IM), Sensor TorS | Integral Inner Membrane | Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Interaction studies showed that, when immature, TorC can no longer bind TorA efficiently but can bind the periplasmic detector region of sensor TorS. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region. | PMID: 11562502 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.124 | TMH | 0 | 8.89656 | - | 2 | 2 | N | o12-31i331-352o | CytoplasmicMembrane | 10 | 13 | ||||
| YBAL_ECOLI | P39830 | ybaL ylaA | ylaA | b0478 JW0467 | integral IM protein (SEC in IM), Putative cation/proton antiporter YbaL | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.134 | TMH | 0 | 5.87955 | - | 12 | 12 | N | o6-26i33-51o57-76i88-112o118-136i148-168o180-206i227-260o280-299i306-328o334-361i368-387o | CytoplasmicMembrane | 10 | 36 | |||||
| ZNUB_ECOLI | P39832 | znuB yebI | yebI | b1859 JW1848 | integral IM protein (SEC in IM), High-affinity zinc uptake system ZnuB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.205 | TMH | 0 | 13.4596 | - | 7 | 9 | N | o6-28i33-51o57-74i86-107o127-145i166-183o189-207i214-233o239-256i | CytoplasmicMembrane | 10 | ||||||
| YGIL_ECOLI | P39834 | ygiL | b3043 JW3011 | Fimbrial periplasmic protein (SEC through IM), YgiL | Periplasmic | Putative chaperone???usher fimbrial operon (class ??); Unknown function. Disulfide bridge (41 80) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 24 | 0.867 | SpI | 23 | 15.5994 | - | 0 | 0 | Y | n7-18c23/24o | Extracellular | 9 | 92 | ||||||
| GNTT_ECOLI | P39835 | gntT gntM usgA yhgC | gntM usgA yhgC | b3415 JW5690 | integral IM protein (SEC in IM), High-affinity gluconate transporter GntT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.124 | TMH | 0 | 9.75395 | - | 11 | 9 | Y | n3-16c34/35o58-76i97-130o136-154i175-194o224-246i258-278o298-316i337-370o416-437i | CytoplasmicMembrane | 10 | 14 | |||||
| YFEH_ECOLI | P39836 | yfeH | b2410 JW5876 | integral IM protein (SEC in IM), Putative symporter YfeH | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.211 | TMH | 0 | 6.99994 | - | 8 | 10 | N | i7-24o30-48i69-89o101-119i126-152o164-181i202-221o227-250i262-283o289-311i | CytoplasmicMembrane | 10 | ||||||||||
| RCSD_ECOLI | P39838 | rcsD yojN yojP yojQ | yojN yojP yojQ | b2216 JW2204 | integral IM protein (SEC in IM), Phosphotransferase RcsD | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 45 | 0.148 | SpI | 40 | 6.36777 | - | 1 | 2 | N | o22-46i309-330o | CytoplasmicMembrane | 10 | 24 | |||||||
| OPGD_ECOLI | P40120 | mdoD opgD ydcG yzzZ | opgD ydcG yzzZ | b1424 JW1420 | periplasmic protein (TAT-SEC through IM), Glucans biosynthesis D MdoD | Periplasmic | TAT secretion system. PMID: 9298646 Disulfide bond-containing protein PMID: 25664544 | PMID: 17218314 PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | no | yes | Y | 33 | 0.683 | SpI | 32 | 18.7932 | - | 0 | 0 | Y | n14-25c32/33o | Periplasmic | 10 | 61 | |||||||
| NLPE_ECOLI | P40710 | nlpE cutF | cutF | b0192 JW0188 | OM lipoprotein (SEC through IM, inserted in OM by LOL), NlpE | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 7635807 | PMID: 15174130 PMID: 20932056 PMID: 7635807 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein(experimental) | SEC | LOL | yes | yes | Y | 36 | 0.226 | SpII | 20 | 12.8918 | Pos+2=N | 0 | 0 | Y | n6-17c35/36o | OuterMembrane | 10 | 112 | ||||||
| QSEC_ECOLI | P40719 | qseC ygiY | ygiY | b3026 JW2994 | integral IM protein (SEC in IM), Sensor QseC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.271 | SpI | 34 | 9.27705 | - | 2 | 2 | N | i12-33o155-182i | CytoplasmicMembrane | 10 | 22 | |||||
| YCBF_ECOLI | P40876 | ycbF | b0944 JW5124 | Fimbrial periplasmic protein (SEC through IM), Chaperone YcbF | Periplasmic | Potential fimbrial ycb operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | no | yes | N | 27 | 0.646 | SpI | 26 | 9.39817 | - | 1 | 0 | Y | n8-19c26/27o | Periplasmic | 9 | 19 | ||||||
| NANT_ECOLI | P41036 | nanT | b3224 JW3193 | integral IM protein (SEC in IM), Sialic acid transporter NanT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 58 | 0.109 | TMH | 0 | 3.96571 | - | 12 | 14 | N | i21-43o55-74i86-106o112-134i146-165o171-190i224-242o248-267i274-292o312-334i343-361o367-391i403-425o431-452i | CytoplasmicMembrane | 10 | |||||||
| MLTB_ECOLI | P41052 | mltB | b2701 JW2671 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase B MltB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane; Lipid-anchor; Periplasmic side | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.231 | SpII | 18 | 24.349 | Pos+2=S | 0 | 0 | Y | n7-17c21/22o | CytoplasmicMembrane | 9 | 27 | |||||||
| GSPF_ECOLI | P41441 | gspF hofF hopF | hofF hopF | b3327 JW3289 | integral IM protein (SEC in IM), Putative type II secretion system F GspF | Integral Inner Membrane | Part of gsp locus. Homolog to type two secretion system proteins PulF. | PMID: 11118204 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 67 | 0.101 | CYT | 0 | -0.200913 | - | 3 | 4 | N | i164-186o217-236i248-268o370-391i | CytoplasmicMembrane | 10 | 16 | ||||
| GSPG_ECOLI | P41442 | gspG hofG hopG | hofG hopG | b3328 JW3290 | integral IM protein (SEC in IM), Putative type II secretion system G GspG | Integral Inner Membrane | Homolog to major pilin PulG (T2SS). Potential component of type II secretion system. GspG is the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve secretion. Toget | PMID: 11118204 PMID: 14966662 PMID: 18241884 PMID: 20616068 PMID: 23006128 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 36 | 0.127 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i12-34o | CytoplasmicMembrane | 9 | 46 | |||||
| GSPH_ECOLI | P41443 | gspH hofH hopH | hofH hopH | b3329 JW3291 | integral IM protein (SEC in IM), Putative type II secretion system H GspH | Integral Inner Membrane | GspH is one of four low abundance pseudopillins together with GspI, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve se | PMID: 11118204 PMID: 17172336 PMID: 18241884 PMID: 18461043 PMID: 21890895 PMID: 23006128 | Integral Inner Membrane | B | - | N/A | Membrane anchored | SEC | T2S | no | yes | N | 29 | 0.113 | TMH | 0 | 4.86781 | - | 1 | 1 | N | o12-31i | CytoplasmicMembrane | 9 | 72 | ||||||
| YGJI_ECOLI | P42590 | ygjI | b3078 JW5512 | nucleoid & integral IM protein (SEC in IM), transporter YgjI | Integral Inner Membrane, Nucleoid | PMID: 15919996 PMID: 23138451 | Integral Inner Membrane, Nucleoid | B, N | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.124 | TMH | 0 | 5.79735 | - | 12 | 12 | N | i12-29o41-63i84-108o120-140i152-176o196-220i232-255o287-312i332-353o365-385i406-426o432-452i | CytoplasmicMembrane | 10 | ||||||||
| YGJJ_ECOLI | P42591 | ygjJ | b3079 JW3050 | periplasmic protein (SEC through IM), YgjJ | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | yes | yes | Y | 22 | 0.252 | SpI | 24 | 7.25386 | - | 0 | 0 | Y | n3-14c19/20o | Unknown | 2 | 31 | ||||||||
| YGJK_ECOLI | P42592 | ygjK | b3080 JW3051 | periplasmic protein (SEC through IM), Glucosidase YgjK | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 23 | 0.898 | SpI | 22 | 21.1996 | - | 0 | 0 | Y | n5-16c25/26o | Periplasmic | 9 | 22 | ||||||||||||
| YGJQ_ECOLI | P42598 | ygjQ | b3086 JW3057 | integral IM protein (SEC in IM), YgjQ | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane | Periplasmic | SRP | SEC | no | yes | N | 37 | 0.199 | SpI | 36 | 6.02153 | - | 1 | 0 | Y | n21-31c36/37o | CytoplasmicMembrane | 9 | |||||||||
| ALX_ECOLI | P42601 | alx ygjT | ygjT | b3088 JW5515 | integral IM protein (SEC in IM), Putative membrane-bound redox modulator Alx | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.24 | TMH | 0 | 11.5369 | - | 9 | 9 | N | o6-29i41-63o83-102i114-136o142-161i205-229o235-255i267-286o292-311i | CytoplasmicMembrane | 10 | ||||||
| YGJV_ECOLI | P42603 | ygjV | b3090 JW3061 | integral IM protein (SEC in IM), YgjV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 56 | 0.156 | TMH | 0 | 4.26984 | - | 5 | 5 | N | o6-24i36-59o71-89i101-124o136-157i | CytoplasmicMembrane | 10 | |||||||
| MZRA_ECOLI | P42615 | mzrA ecfM yqjB | ecfM yqjB | b3096 JW3067 | integral IM protein (SEC in IM), Modulator of the activity of the EnvZ/OmpR two-component regulatory system MzrA | Integral Inner Membrane | PMID: 19432797 PMID: 20889743 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 30 | 0.154 | SpI | 29 | 4.521 | - | 1 | 0 | Y | n11-22c27/28o | Unknown | 2 | 14 | |||||
| YQJC_ECOLI | P42616 | yqjC | b3097 JW5516 | periplasmic protein (SEC through IM), YqjC | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 21 | 0.508 | SpI | 20 | 9.52426 | - | 0 | 0 | Y | n5-15c20/21o | Unknown | 2 | 79 | ||||||||||||
| YQJF_ECOLI | P42619 | yqjF | b3101 JW5850 | integral IM protein (SEC in IM), YqjF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 35 | 0.118 | TMH | 0 | 8.80873 | - | 4 | 4 | N | i7-26o46-66i73-91o103-122i | CytoplasmicMembrane | 10 | |||||||
| YHAM_ECOLI | P42626 | yhaM yhaN | yhaN | b4470 JW5518 | integral IM protein (SEC in IM), UPF0597 YhaM | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cytoplasmic | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | no | N | 43 | 0.167 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o319-340i | Cytoplasmic | 9 | 83 | |||||||
| DLST_ECOLI | P42628 | dlsT yhaO | yhaO | b3110 JW5519 | integral IM protein (SEC in IM), Probable serine transporter DlsT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 20 | 0.128 | TMH | 0 | 0.623427 | - | 11 | 11 | N | i38-58o64-82i111-135o155-173i185-206o221-243i264-285o318-339i360-381o387-411i423-442o | CytoplasmicMembrane | 10 | ||||||
| YHBX_ECOLI | P42640 | yhbX | b3173 JW5534 | integral IM protein (SEC in IM), Putative phosphoethanolamine transferase YhbX | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 32 | 0.175 | TMH | 0 | 13.1458 | - | 5 | 6 | N | i15-31o37-54i61-82o112-131i143-163o175-195i | CytoplasmicMembrane | 10 | |||||||
| PTPC2_ECOLI | P42905 | agaW | b3134 | integral IM protein (SEC in IM), Putative N-acetylgalactosamine permease IIC component 2 AgaW | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot) | no | yes | N | 70 | 0.132 | TMH | 0 | 6.59862 | - | 3 | 3 | N | o6-26i33-56o94-116i | CytoplasmicMembrane | 10 | 9 | |||||
| PTPC1_ECOLI | P42910 | agaC yraE | yraE | b3139 JW3108 | integral IM protein (SEC in IM), N-acetylgalactosamine permease IIC component 1 AgaC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 28 | 0.124 | TMH | 0 | 4.72274 | - | 6 | 4 | Y | n4-15c20/21o97-121i142-164o184-202i209-238o | CytoplasmicMembrane | 10 | 2 | |||||
| PTPD_ECOLI | P42911 | agaD yraF | yraF | b3140 JW3109 | integral IM protein (SEC in IM), N-acetylgalactosamine permease IID component AgaD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.125 | CYT | 0 | -0.200913 | - | 5 | 5 | N | i96-119o131-151i172-195o215-236i243-262o | CytoplasmicMembrane | 10 | 5 | |||||
| YRAH_ECOLI | P42913 | yraH | b3142 JW3111 | Fimbrial periplasmic protein (SEC through IM), YraH | Periplasmic | Potential fimbrial yra operon (class ??1); Fimbrial Subunit. Disulfide bridge (38 78) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 23 | 0.673 | SpI | 22 | 11.7644 | - | 0 | 0 | Y | n7-17c22/23o | Extracellular | 9 | |||||||
| YRAI_ECOLI | P42914 | yraI | b3143 JW3112 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone YraI | Periplasmic | Potential fimbrial yra operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 15838024 PMID: 18498364 PMID: 20345943 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SRP (exp) | SEC | SURA | no | yes | Y | 24 | 0.709 | SpI | 23 | 14.1781 | - | 1 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 56 | |||||
| YRAJ_ECOLI | P42915 | yraJ | b3144 JW3113 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YraJ | Outer Membrane b-barrel protein | Potential fimbrial yra operon (class ??1); Usher. Disulfide bridge (815 837) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | N | 41 | 0.51 | SpI | 40 | 9.33083 | - | 0 | 0 | N | i | OuterMembrane | 10 | 6 | ||||||
| YRAK_ECOLI | P43319 | yraK | b3145 JW3114 | Fimbrial periplasmic protein (SEC through IM), YraK | Periplasmic | Potential fimbrial yra operon (class ??1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | SURA | CU | no | yes | Y | 21 | 0.726 | SpI | 20 | 18.7753 | - | 0 | 0 | Y | n4-15c20/21o | Unknown | 2 | 78 | |||||
| YNFM_ECOLI | P43531 | ynfM yzyC | yzyC | b1596 JW1588 | integral IM protein (SEC in IM), transport YnfM | Integral Inner Membrane | Phobius weak prediction of a hydrophobic TMIn the middle of sequence/Kyte-Doolittle predicts several hydrophobic patches. | PMID: 15919996 PMID: 19275539 PMID: 20608695 PMID: 3905795 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 53 | 0.119 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i37-59o71-91i103-122o128-149i156-175o187-208i240-261o267-285i306-323o329-352i364-386o392-411i | CytoplasmicMembrane | 10 | |||||
| YGAH_ECOLI | P43667 | ygaH | b2683 JW2658 | integral IM protein (SEC in IM), YgaH | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 18 | 0.142 | CYT | 0 | -0.200913 | - | 3 | 3 | Y | n5-15c20/21o36-57i69-85o91-109i | CytoplasmicMembrane | 10 | ||||||||||
| PQIB_ECOLI | P43671 | pqiB pqi5B | pqi5B | b0951 JW0934 | integral IM protein (SEC in IM), Intertransport PqiB | Integral Inner Membrane | PMID: 15919657 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 42 | 0.124 | TMH | 0 | 6.02674 | - | 1 | 1 | N | i20-38o | Unknown | 2 | ||||||
| YCAL_ECOLI | P43674 | ycaL | b0909 JW0892 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Metalloprotease YcaL | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 26 | 0.214 | SpII | 19 | 26.2238 | Pos+2=Q | 0 | 0 | Y | n6-17c25/26o | Unknown | 2 | 24 | ||||||||
| PITB_ECOLI | P43676 | pitB | b2987 JW2955 | integral IM protein (SEC in IM), Probable low-affinity inorganic phosphate transporter 2 PitB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.141 | TMH | 0 | 10.6201 | - | 10 | 11 | N | o6-26i52-76o96-116i123-143o155-177i208-227o233-255i343-361o381-402i423-442o474-495i | CytoplasmicMembrane | 10 | 6 | ||||||
| YRBG_ECOLI | P45394 | yrbG | b3196 JW3163 | integral IM protein (SEC in IM), YrbG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 26 | 0.208 | CYT | 0 | -0.200913 | - | 9 | 9 | Y | n2-17c25/26o35-56i68-90o105-122i129-150o170-188i200-219o239-264i276-294o300-319i | CytoplasmicMembrane | 10 | |||||||
| YHCD_ECOLI | P45420 | yhcD | b3216 JW3183 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YhcD | Outer Membrane b-barrel protein | Potential fimbrial yhc operon (class ??); Uknown function. Disulfide bridge (769 792) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | Y | 22 | 0.809 | SpI | 21 | 10.0887 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | |||||||
| YHCE_ECOLI | P45421 | yhcE | b4569 b3217 | Fimbrial periplasmic protein (SEC through IM), Putative YhcE | Periplasmic | Potential fimbrial yhc operon (class ??); Uknown function. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | pseudogene (Uniprot) | no | no | Y | 20 | 0.69 | SpI | 19 | 4.02903 | - | 0 | 0 | Y | n4-11c16/17o | Unknown | 2 | 20 | |||||||
| YHCF_ECOLI | P45422 | yhcF | b3219 JW3188 | Fimbrial periplasmic protein (SEC through IM), YhcF | Periplasmic | Potential fimbrial yhc operon (class ??); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | Y | 21 | 0.835 | SpI | 20 | 16.471 | - | 0 | 0 | Y | n6-16c20/21o | Unknown | 2 | 7 | ||||||||
| DCUD_ECOLI | P45428 | dcuD yhcL | yhcL | b3227 JW3196 | integral IM protein (SEC in IM), Putative cryptic C4-dicarboxylate transporter DcuD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 30 | 0.172 | TMH | 0 | 2.68784 | - | 13 | 12 | N | i26-48o68-89i109-128o134-150i157-174o194-215i242-265o271-290i348-369o375-397i409-430o436-454i | CytoplasmicMembrane | 10 | ||||||
| LPOA_ECOLI | P45464 | lpoA yraM | yraM | b3147 JW3116 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Penicillin-binding activator LpoA | Outer Membrane Lipoprotein | The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 20932056 PMID: 21183073 PMID: 21183074 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Membrane Lipoprotein | SEC | LOL | no | yes | Y | 26 | 0.162 | SpII | 26 | 12.6937 | Pos+2=G | 0 | 0 | Y | n14-27c45/46o | CytoplasmicMembrane | 9 | 105 | ||||||
| YRAQ_ECOLI | P45468 | yraQ | b3151 JW3120 | integral IM protein (SEC in IM), UPF0718 YraQ | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 10 | 0.146 | TMH | 0 | 3.98221 | - | 9 | 9 | N | o15-32i72-95o115-134i146-167o173-191i227-249o261-280i287-305o325-345i | CytoplasmicMembrane | 10 | |||||||||
| YFAL_ECOLI | P45508 | yfaL yfaF yfaJ yfaK | yfaF yfaJ yfaK | b2233 JW2227 | OM b-barrel protein (SEC through IM), T5S secreted through OM), Probable autotransporter YfaL | Outer Membrane b-barrel protein | Ag43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> | PMID: 15590781 | Outer Membrane b-barrel protein | H | N/A | Probable autotransporter YfaL: Periplasm; Probable secreted autotransporter protein YfaL: Secreted Cell surface; Probable autotransporter YfaL translocator: Cell outer membrane | Periplasmic | SEC | Autotransporter(T5S) | yes | yes | Y | 29 | 0.358 | SpI | 28 | 13.6585 | - | 0 | 0 | Y | n11-22c29/30o | OuterMembrane | 9 | 52 | ||||||
| KEFB_ECOLI | P45522 | kefB trkB | trkB | b3350 JW3313 | integral IM protein (SEC in IM), Glutathione-regulated potassium-efflux system KefB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.23 | TMH | 0 | 10.3228 | - | 13 | 13 | N | o6-25i32-50o56-75i87-107o113-135i147-171o183-201i213-231o237-255i267-285o291-312i324-343o355-373i | CytoplasmicMembrane | 10 | ||||||
| FKBA_ECOLI | P45523 | fkpA yzzS | yzzS | b3347 JW3309 | periplasmic protein (SEC through IM), FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | Periplasmic | SecB substrate. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 | PMID: 16352602 PMID: 22030350 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SECB | SEC | yes | yes | Y | 26 | 0.701 | SpI | 25 | 14.7593 | - | 0 | 0 | Y | n7-18c25/26o | Periplasmic | 10 | |||||||
| YHFK_ECOLI | P45537 | yhfK | b3358 JW5701 | integral IM protein (SEC in IM), YhfK | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 54 | 0.107 | TMH | 0 | 0.537733 | - | 9 | 11 | N | o38-55i67-85o91-108i115-133o139-160i371-388o394-411i418-435o441-457i464-481o487-509i | CytoplasmicMembrane | 10 | 6 | ||||||||
| FRLA_ECOLI | P45539 | frlA yhfM | yhfM | b3370 JW3333 | integral IM protein (SEC in IM), Probable fructoselysine/psicoselysine transporter FrlA | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 20 | 0.117 | TMH | 0 | 13.0134 | - | 11 | 12 | N | i12-32o44-66i87-113o125-143i155-175o195-219i231-256o276-302i327-347o353-375i387-406o412-434i | CytoplasmicMembrane | 10 | ||||||||
| YHFT_ECOLI | P45546 | yhfT | b3377 JW3340 | integral IM protein (SEC in IM), YhfT | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 22 | 0.311 | TMH | 0 | 0.362704 | - | 11 | 11 | N | o6-28i49-70o90-113i133-153o159-176i183-200o229-249i289-314o320-339i369-397o409-432i | CytoplasmicMembrane | 10 | |||||||||
| XAPB_ECOLI | P45562 | xapB | b2406 JW2397 | nucleoid & integral IM protein (SEC in IM), Xanthosine permease XapB | Integral Inner Membrane, Nucleoid | PMID: 15919996 | Integral Inner Membrane, Nucleoid | B, N | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 51 | 0.121 | TMH | 0 | 9.53241 | - | 12 | 12 | N | i12-30o42-62i71-88o94-114i135-154o160-178i212-235o255-275i282-301o307-327i348-369o381-402i | CytoplasmicMembrane | 10 | |||||||
| YFEN_ECOLI | P45564 | yfeN | b2408 JW2399 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), YfeN | Outer Membrane b-barrel protein | H | N/A | Outer Membrane ??-barrel protein | SEC | BAM | no | yes | Y | 23 | 0.452 | SpI | 22 | 12.5667 | - | 0 | 0 | Y | n5-16c22/23o | Unknown | 2 | 6 | |||||||||||
| AIS_ECOLI | P45565 | ais pmrG | pmrG | b2252 JW2246 | periplasmic protein (SEC through IM), polysaccharide core heptose Ais | Periplasmic | Periplasmic protein by virtue of its homology with the well characterized Salmonella homologue PmrGPMID: 16803591. Disulfide bond-containing protein PMID: 25664544 | PMID: 16803591 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Membrane anchored | SEC | yes | yes | N | 32 | 0.351 | SpI | 31 | 9.81523 | - | 1 | 0 | Y | n16-27c31/32o | Unknown | 2 | 50 | |||||||
| YHDT_ECOLI | P45566 | yhdT | b3257 JW3225 | integral IM protein (SEC in IM), YhdT | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.15 | TMH | 0 | 15.9222 | - | 2 | 2 | N | i12-33o45-65i | CytoplasmicMembrane | 9 | 43 | ||||||||
| YBCI_ECOLI | P45570 | ybcI | b0527 JW0516 | integral IM protein (SEC in IM), YbcI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.121 | TMH | 0 | 4.35035 | - | 4 | 4 | N | i27-47o59-78i85-103o149-170i | CytoplasmicMembrane | 10 | 4 | ||||||
| HOFP_ECOLI | P45750 | hofP yrfA | yrfA | b3392 JW5694 | periplasmic protein, DNA utilization HofP | No transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius. | Periplasmic | G | IM (predicted-detected) | Cytoplasmic | no | yes | N | 21 | 0.138 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n6-16c20/21o | Unknown | 2 | ||||||||||||
| HOFO_ECOLI | P45751 | hofO yrfB | yrfB | b3393 JW3356 | integral IM protein (SEC in IM), DNA utilization HofO | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 40 | 0.213 | TMH | 0 | 6.9432 | - | 1 | 1 | N | o20-38i | Unknown | 2 | 19 | |||||||
| GSPA_ECOLI | P45756 | gspA yheD | yheD | b3323 JW3285 | integral IM protein (SEC in IM), Putative general secretion pathway A GspA | Integral Inner Membrane | C-terminus of GspA is in the periplasm. The protein fractionates with the inner membrane. Part of gsp locus. | PMID: 11118204 PMID: 21378198 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 37 | 0.16 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i237-257o | Cytoplasmic | 9 | 75 | ||||
| GSPC_ECOLI | P45757 | gspC yheE | yheE | b3324 JW3286 | integral IM protein (SEC in IM), Putative type II secretion system C GspC | Integral Inner Membrane | Homolog to type two secretion system proteins PulC. Potential component of type II secretion system. A representative PulC-PhoA hybrid protein fractionated mainly with the inner membrane upon isopycnic sucrose gradient centrifugation of membrane vesicles. PMID: 2677007 GspC is the inner membrane component of type II secretion system (T2SS). GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548 | PMID: 11118204 PMID: 14966662 PMID: 21931548 PMID: 2677007 | Integral Inner Membrane | B | Bin | out/in | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 18 | 0.127 | TMH | 0 | -0.020813 | - | 1 | 1 | N | o17-38i | Unknown | 2 | 27 | ||||
| GSPD_ECOLI | P45758 | gspD yheF | yheF | b3325 JW5707 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative type II secretion system D GspD | Outer Membrane b-barrel protein | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Homolog to type two secretion system proteins PulD. Potential outer membrane b-barel protein since it is homolog to pulD major component of type two secretion system. GspD is the outer membrane secretin of type II secretion system (T2SS) which forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548 PMID: 11266368 | PMID: 11118204 PMID: 11266368 PMID: 14966662 PMID: 18498364 PMID: 21931548 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Periplasmic (Experimental) | SEC | SURA | BAM | no | yes | Y | 24 | 0.553 | SpI | 23 | 14.273 | - | 0 | 0 | Y | n7-16c23/24o | OuterMembrane | 10 | 34 | |||||
| GSPI_ECOLI | P45760 | gspI yheH | yheH | b3330 JW5706 | integral IM protein (SEC in IM), Putative type II secretion system I GspI | Integral Inner Membrane | Potential component of type II secretion system. GspI is one of four low abundance pseudopillins together with GspH, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368 | PMID: 11118204 PMID: 11266368 PMID: 14966662 PMID: 18241884 PMID: 21890895 PMID: 23006128 | Integral Inner Membrane | B | Bin | out/in | N/A | Periplasmic (Experimental) | SEC | T2S | no | yes | N | 24 | 0.233 | SpI | 23 | 3.86957 | - | 1 | 1 | N | o12-30i | CytoplasmicMembrane | 9 | 60 | |||||
| GSPJ_ECOLI | P45761 | gspJ yheI | yheI | b3331 JW3293 | periplasmic protein (SEC through IM), Putative type II secretion system J GspJ | Periplasmic | Potential component of type II secretion system. GspJ is one of four low abundance pseudopillins together with GspI, H and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368 | PMID: 11118204 PMID: 11266368 PMID: 14966662 PMID: 18241884 PMID: 21890895 PMID: 23006128 | Periplasmic | G | N/A | Periplasmic (Experimental) | SEC | T2S | no | yes | N | 28 | 0.304 | SpI | 34 | 2.3055 | - | 1 | 1 | N | i7-31o | CytoplasmicMembrane | 9 | ||||||||
| GSPK_ECOLI | P45762 | gspK yheJ | yheJ | b3332 JW3294 | periplasmic protein (SEC through IM), Putative type II secretion system K GspK | Periplasmic | Potential component of type II secretion system. GspK is one of four low abundance pseudopillins together with GspI, J and H. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368 | PMID: 11118204 PMID: 11266368 PMID: 14966662 PMID: 18241884 PMID: 21890895 PMID: 23006128 | Periplasmic | G | N/A | Cell inner membrane | Periplasmic (Experimental) | SEC | T2S | no | yes | N | 25 | 0.537 | SpI | 24 | 8.69449 | - | 1 | 0 | Y | n8-19c24/25o | CytoplasmicMembrane | 9 | 30 | ||||||
| GSPL_ECOLI | P45763 | gspL yheK | yheK | b3333 JW5705 | integral IM protein (SEC in IM), Putative type II secretion system L GspL | Integral Inner Membrane | Potential component of type II secretion system. EspL (GspL homolog) protein interacts through its N-terminal cytoplasmic domain with EspL (GspL homolog) protein | PMID: 11118204 PMID: 14966662 PMCID: PMC398259 | Integral Inner Membrane | B | Binout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Cytoplasmic | SRP | SEC | no | yes | N | 45 | 0.133 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i242-260o | Unknown | 2 | 17 | ||||
| YHDW_ECOLI | P45766 | yhdW | b3268 JW3236 | periplasmic protein (SEC through IM), Putative amino-acid ABC transporter-binding YhdW | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | Soluble IM Fraction | Periplasm | Cytoplasmic | SEC | pseudogene (Uniprot) | no | no | Y | 25 | 0.628 | SpI | 24 | 20.0416 | - | 0 | 0 | Y | n6-17c24/25o | Periplasmic | 10 | 89 | |||||||
| YHDX_ECOLI | P45767 | yhdX | b3269 JW5544 | integral IM protein (SEC in IM), Putative amino-acid ABC transporter permease YhdX | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 22 | 0.16 | TMH | 0 | 9.39948 | - | 8 | 8 | N | i21-40o92-114i126-146o181-200i220-241o261-280i335-353o359-384i | CytoplasmicMembrane | 10 | |||||||||
| YHDY_ECOLI | P45768 | yhdY | b3270 JW5545 | integral IM protein (SEC in IM), amino-acid ABC transporter permease YhdY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.123 | TMH | 0 | 1.0833 | - | 8 | 8 | N | i28-46o98-119i126-148o160-182i194-219o231-250i292-315o335-352i | CytoplasmicMembrane | 10 | |||||||
| IGAA_ECOLI | P45800 | yrfF | b3398 JW3361 | integral IM protein (SEC in IM), Putative IgaA homolog YrfF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.26 | SpI | 18 | 4.58634 | - | 5 | 5 | N | o6-22i206-223o229-247i337-358o652-674i | CytoplasmicMembrane | 10 | 26 | ||||||
| YHGE_ECOLI | P45804 | yhgE | b3402 JW3365 | integral IM protein (SEC in IM), YhgE | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.113 | TMH | 0 | 10.0663 | - | 11 | 11 | N | i12-33o39-59i66-84o99-118i138-163o183-201i213-236o248-268i289-308o320-341i353-373o | CytoplasmicMembrane | 10 | |||||||||
| YCIQ_ECOLI | P45848 | yciQ yciP | yciP | b1268 JW5197 | integral IM protein (SEC in IM), YciQ | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | no | yes | Y | 24 | 0.803 | SpI | 23 | 8.83165 | - | 5 | 5 | Y | n7-18c23/24o249-266i398-423o429-448i460-480o486-513i | CytoplasmicMembrane | 10 | |||||||||
| CPOB_ECOLI | P45955 | cpoB ybgF | ybgF | b0742 JW0732 | periplasmic protein (SEC through IM), Cell division coordinator CpoB | Periplasmic | SecB substrate. The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF.The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 11703658 | PMID: 11703658 PMID: 16352602 PMID: 20816983 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SECB | SEC | yes | yes | Y | 27 | 0.495 | SpI | 26 | 13.974 | - | 0 | 0 | Y | n9-20c26/27o | Periplasmic | 9 | 19 | ||||||
| MTGA_ECOLI | P46022 | mtgA mgt yrbM | mgt yrbM | b3208 JW3175 | integral IM protein (SEC in IM), Biosynthetic PG transglycosylase MtgA | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 25 | 0.133 | TMH | 0 | 13.1588 | - | 1 | 1 | N | i21-41o | CytoplasmicMembrane | 10 | 11 | |||||||
| YBJC_ECOLI | P46119 | ybjC | b0850 JW0834 | integral IM protein (SEC in IM), YbjC | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.131 | TMH | 0 | 6.40394 | - | 2 | 2 | N | i12-29o44-68i | CytoplasmicMembrane | 9 | 45 | |||||||||
| YAJI_ECOLI | P46122 | yajI | b0412 JW5056 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YajI | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 24 | 0.215 | SpII | 19 | 18.9902 | Pos+2=V | 0 | 0 | Y | n8-18c23/24o | Unknown | 2 | 88 | ||||||||||
| YEDI_ECOLI | P46125 | yedI | b1958 JW1941 | integral IM protein (SEC in IM), YedI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.143 | CYT | 0 | -0.200913 | - | 5 | 5 | Y | n2-12c30/31o73-102i152-171o177-199i220-249o269-294i | CytoplasmicMembrane | 10 | 4 | ||||||
| YFIM_ECOLI | P46126 | yfiM | b2586 JW2570 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YfiM | Contains the following signature IPR018736 Protein of unknown function DUF2279,Periplasmic lipoprotein | Inner Membrane Lipoprotein | E | N/A | Cytoplasmic | SEC | LOL | yes | yes | Y | 20 | 0.599 | SpII | 14 | 15.2395 | Pos+2=S | 0 | 0 | Y | n3-13c18/19o | CytoplasmicMembrane | 9 | 12 | ||||||||||
| YBHC_ECOLI | P46130 | ybhC | b0772 JW0755 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative acyl-CoA thioester hydrolase YbhC | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) PMID: 10806384 Disulfide bridge (185 197) PMID: 19452549 | PMID: 10806384 PMID: 15174130 PMID: 15911532 PMID: 19452549 PMID: 20932056 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.274 | SpII | 21 | 24.9976 | Pos+2=S | 0 | 0 | Y | n9-19c24/25o | OuterMembrane | 9 | 71 | |||||||
| ABGT_ECOLI | P46133 | abgT ydaH | ydaH | b1336 JW5822 ECK1332 | integral IM protein (SEC in IM), p-aminobenzoyl-glutamate transport AbgT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 55 | 0.352 | TMH | 0 | 3.72666 | - | 13 | 13 | N | i30-52o85-104i125-147o153-175i182-202o214-232i260-281o301-322i343-362o382-403i415-434o440-458i470-495o | CytoplasmicMembrane | 10 | ||||||
| YDDG_ECOLI | P46136 | yddG | b1473 JW1469 | integral IM protein (SEC in IM), Aromatic amino acid exporter YddG | Integral Inner Membrane | PMID: 15919996 PMID: 21042032 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.109 | TMH | 0 | 7.54403 | - | 10 | 9 | Y | n6-17c26/27o36-57i64-86o92-113i120-138o158-175i182-203o215-235i242-264o270-290i | CytoplasmicMembrane | 10 | |||||||
| DGCN_ECOLI | P46139 | dgcN yfiN | yfiN | b2604 JW2585 | integral IM protein (SEC in IM), Diguanylate cyclase DgcN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 67 | 0.12 | TMH | 0 | 11.5458 | - | 2 | 2 | N | i21-43o155-177i | CytoplasmicMembrane | 10 | ||||||
| YGBE_ECOLI | P46141 | ygbE | b2749 JW2719 | integral IM protein (SEC in IM), YgbE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.233 | TMH | 0 | 10.6872 | - | 3 | 3 | N | o23-46i53-79o85-106i | CytoplasmicMembrane | 10 | |||||||
| YGGM_ECOLI | P46142 | yggM | b2956 JW2923 | periplasmic protein (SEC through IM), YggM | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.874 | SpI | 21 | 16.8631 | - | 0 | 0 | Y | n5-16c21/22o | Periplasmic | 9 | 32 | ||||||||||||
| RSEC_ECOLI | P46187 | rseC | b2570 JW2554 | integral IM protein (SEC in IM), RseC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.187 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i79-98o104-121i | CytoplasmicMembrane | 10 | 27 | ||||||
| YHDP_ECOLI | P46474 | yhdP yhdQ yhdR | yhdQ yhdR | b4472 JW5542 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), YhdP | Outer Membrane b-barrel protein | H | N/A | Cytoplasmic | SEC | BAM | pseudogene (Ochman & Davalos, 2006) | yes | yes | N | 30 | 0.25 | SpI | 29 | 5.14802 | - | 1 | 0 | Y | n7-22c29/30o | CytoplasmicMembrane | 9 | ||||||||||
| AAEX_ECOLI | P46478 | aaeX yhcR | yhcR | b3242 JW5541 | integral IM protein (SEC in IM), AaeX | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.106 | TMH | 0 | 10.7464 | - | 2 | 2 | N | o6-31i43-62o | CytoplasmicMembrane | 9 | 34 | |||||||
| AAEB_ECOLI | P46481 | aaeB yhcP | yhcP | b3240 JW3209 | integral IM protein (SEC in IM), p-hydroxybenzoic acid efflux pump subunit AaeB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 54 | 0.637 | TMH | 0 | 6.80417 | - | 10 | 10 | N | i13-32o38-56i68-87o93-112i119-135o371-395i407-426o432-449i461-480o486-503i | CytoplasmicMembrane | 10 | ||||||
| AAEA_ECOLI | P46482 | aaeA yhcQ | yhcQ | b3241 JW3210 | integral IM protein (SEC in IM), p-hydroxybenzoic acid efflux pump subunit AaeA | Integral Inner Membrane | PET family proteins are believed to be membrane localized, having 12 predicted transmembrane segments in gram-negative bacteria PMID: 10939244 PMID: 15489430 | PMID: 10939244 PMID: 15489430 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Periplasmic (Experimental) | SRP | SEC | yes | yes | N | 31 | 0.144 | SpI | 28 | 8.87913 | - | 1 | 1 | N | i12-32o | CytoplasmicMembrane | 9 | |||||
| YQGD_ECOLI | P46879 | yqgD | b2941 JW2908 | integral IM protein (SEC in IM), YqgD | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | pseudogene (Ecogene), pseudogene (Uniprot) | no | no | N | 62 | 0.118 | TMH | 0 | 1.01241 | - | 2 | 1 | N | o27-50i | CytoplasmicMembrane | 9 | |||||||||
| AMO_ECOLI | P46883 | tynA maoA | maoA | b1386 JW1381 | periplasmic protein (SEC through IM), Primary amine oxidase TynA | Periplasmic | Potential Skp substrate PMID: 19953543 PMID: 8631685 | PMID: 19953543 PMID: 8631685 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SKP | no | yes | Y | 31 | 0.714 | SpI | 30 | 12.7601 | - | 0 | 0 | Y | n13-24c30/31o | Periplasmic | 10 | 97 | ||||||
| FTSK_ECOLI | P46889 | ftsK | b0890 JW0873 | nucleoid & integral IM protein (SEC in IM), DNA translocase FtsK | Integral Inner Membrane, Nucleoid | PMID: 11703663 PMID: 11948172 PMID: 15919996 PMID: 9723913 | Integral Inner Membrane, Nucleoid | B, N | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 53 | 0.169 | TMH | 0 | 6.50875 | - | 5 | 5 | N | i25-44o75-98i110-131o137-158i165-184o | CytoplasmicMembrane | 10 | 14 | ||||||
| TORZ_ECOLI | P46923 | torZ bisZ | bisZ | b1872 JW1861 | periplasmic protein (TAT-SEC through IM), Trimethylamine-N-oxide reductase 2 TorZ | Periplasmic | TAT secretion system. PMID: 11004177 | PMID: 11004177 PMID: 17218314 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | N | 32 | 0.688 | SpI | 31 | 17.7989 | - | 0 | 0 | Y | n12-23c31/32o | Periplasmic | 10 | 33 | |||||||
| AER_ECOLI | P50466 | aer air yqjJ | air yqjJ | b3072 JW3043 | integral IM protein (SEC-YidC in IM), Aerotaxis receptor Aer | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 PMID: 22380631 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC-YidC | yes | yes | N | 34 | 0.205 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i171-200o | CytoplasmicMembrane | 10 | 31 | ||||
| TORY_ECOLI | P52005 | torY yecK | yecK | b1873 JW1862 | integral IM protein (SEC in IM), Cytochrome c-type TorY | Integral Inner Membrane | Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme. PMID: 11004177 | PMID: 11004177 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 32 | 0.123 | SpI | 26 | 7.35562 | - | 1 | 0 | Y | n7-18c26/27o | Unknown | 4 | 44 | ||||
| FSR_ECOLI | P52067 | fsr | b0479 JW0468 | integral IM protein (SEC in IM), Fosmidomycin resistance protein Fsr | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 29 | 0.107 | TMH | 0 | 4.87385 | - | 10 | 11 | N | o26-50i62-84o104-130i151-175o181-202i223-242o262-282i294-313o319-340i352-375o381-399i | CytoplasmicMembrane | 10 | |||||||
| HISQ_ECOLI | P52094 | hisQ | b2308 JW2305 | integral IM protein (SEC in IM), Histidine transport system permease HisQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.408 | TMH | 0 | 6.17401 | - | 5 | 5 | N | o12-35i47-70o90-108i149-171o191-215i | CytoplasmicMembrane | 10 | 8 | ||||||
| GLRK_ECOLI | P52101 | glrK yfhK | yfhK | b2556 JW5407 | integral IM protein (SEC in IM), Sensor histidine kinase GlrK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.258 | SpI | 30 | 8.61403 | - | 2 | 1 | Y | n14-24c30/31o174-198i | CytoplasmicMembrane | 10 | 18 | |||||
| CSGC_ECOLI | P52107 | csgC | b1043 JW1026 | periplasmic protein (SEC through IM), Curli assembly CsgC | Periplasmic | Uniprot mentions an 8aa signal peptide but Signal P prediction is for a "typical" 22 residue peptide Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544 | PMID: 19131513 PMID: 21645131 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | N | 22 | 0.179 | SpI | 22 | 2.07115 | - | 0 | 0 | Y | n4-16c21/22o | Unknown | 2 | 68 | ||||||||
| YPJK_ECOLI | P52134 | ypjK | b2635 JW5888 | integral IM protein (SEC in IM), YpjK | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 46 | 0.265 | TMH | 0 | 5.94794 | - | 3 | 1 | Y | n3-14c22/23o46-68i | CytoplasmicMembrane | 10 | |||||||||
| YFJT_ECOLI | P52135 | yfjT | b2637 JW2618 | periplasmic protein (SEC through IM), YfjT | Periplasmic | G | N/A | Periplasmic | SEC | Prophage Integrase (EcoGene) | no | no | Y | 24 | 0.673 | SpI | 23 | 19.2157 | - | 0 | 0 | Y | n9-19c23/24o | Unknown | 2 | 22 | |||||||||||
| YFJW_ECOLI | P52138 | yfjW | b2642 JW2623 | integral IM protein (SEC in IM), YfjW | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 47 | 0.122 | TMH | 0 | 6.6613 | - | 5 | 6 | N | i20-46o66-89i96-118o130-151i163-188o536-557i | CytoplasmicMembrane | 10 | ||||||||
| YPJA_ECOLI | P52143 | ypjA | b2647 JW5422 | OM b-barrel protein (SEC through IM, T5S secreted through OM), YpjA | Outer Membrane b-barrel protein | Ag43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>. Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner. | PMID: 12466262 PMID: 15590781 PMID: 22905239 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SRP | SEC | Autotransporter(T5S) | no | yes | Y | 30 | 0.688 | SpI | 29 | 11.7048 | - | 1 | 0 | Y | n13-24c29/30o | Unknown | 5 | |||||||
| EMRK_ECOLI | P52599 | emrK | b2368 JW2365 | periplasmic protein (SEC through IM), Probable multidrug resistance EmrK | Periplasmic | PMID: 11914367 | Periplasmic | G | N/A | Cell inner membrane | Periplasmic (Experimental) | SEC | yes | yes | N | 34 | 0.579 | SpI | 33 | 15.7518 | - | 1 | 0 | Y | n17-28c33/34o | CytoplasmicMembrane | 9 | 38 | |||||||||
| EMRY_ECOLI | P52600 | emrY | b2367 JW2364 | integral IM protein (SEC-YidC in IM), Probable multidrug resistance EmrY | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 40 | 0.184 | TMH | 0 | 10.5527 | - | 13 | 13 | N | i12-32o55-73i85-104o110-132i144-165o171-193i205-224o236-255i276-295o307-325i337-355o375-394i484-502o | CytoplasmicMembrane | 10 | ||||||
| FLIK_ECOLI | P52614 | fliK flaE flaR | flaE flaR | b1943 JW1927 | Flagellar cytoplasmic & extra-cellular protein (Flagellum secreted), hook-length control protein FliK | Cytoplasmic, Extra-cellular | Hook-length control protein. Protein FliK detects the point where the flagellar hook substructure has reached its optimal length. Then it terminates hook export and assembly and transmits a signal to begin filament export. | PMID: 17456739 | Cytoplasmic, Extra-cellular | A, X | N/A | Cytoplasmic | flagellum | Flagellum | Fla | no | yes | N | 47 | 0.186 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 97 | ||||||
| YCCM_ECOLI | P52636 | yccM | b0992 JW0977 | integral IM protein (SEC in IM), Putative electron transport YccM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 48 | 0.107 | CYT | 0 | -0.200913 | - | 5 | 5 | N | i37-54o96-114i159-180o200-218i307-332o | CytoplasmicMembrane | 10 | 12 | ||||||
| HSLJ_ECOLI | P52644 | hslJ ydbI | ydbI | b1379 JW1374 | OM lipoprotein (SEC through IM, inserted in OM by LOL), HslJ | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 25 | 0.238 | SpII | 16 | 16.4623 | Pos+2=V | 0 | 0 | Y | n4-15c20/21o | Unknown | 2 | 106 | |||||||
| YDBH_ECOLI | P52645 | ydbH | b1381 JW1376 | integral IM protein (SEC in IM), YdbH | Uncharacterized, echolocation Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold). BOMP reliability scores are below 2 and so this is unlikely to be an OMP. | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | no | yes | N | 35 | 0.163 | TMH | 0 | 6.49797 | - | 1 | 0 | Y | n7-26c34/35o | CytoplasmicMembrane | 9 | 12 | ||||||||
| YBHD_ECOLI | P52696 | ybhD | b0768 JW5896 | nucleoid & integral IM protein (SEC in IM), HTH-type transcriptional regulator YbhD | Integral Inner Membrane, Nucleoid | Uncharacterized HTH-type transcriptional regulator | Integral Inner Membrane, Nucleoid | B, N | N/A | Membrane anchored | SRP | SEC | no | yes | N | 24 | 0.184 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i94-112o | Cytoplasmic | 9 | ||||||||||
| MNGA_ECOLI | P54745 | mngA hrsA | hrsA | b0731 JW0720 | integral IM protein (SEC in IM), PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component MngA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.104 | CYT | 0 | -0.200913 | - | 9 | 8 | N | i310-337o357-376i388-414o434-454i466-486o498-518i574-596o616-641i | CytoplasmicMembrane | 10 | 37 | |||||
| YGCG_ECOLI | P55140 | ygcG | b2778 JW5445 | integral IM protein (SEC in IM), UPF0603 YgcG | Integral Inner Membrane | B | Bpoly | - | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | Y | 18 | 0.242 | SpI | 17 | 4.90841 | - | 2 | 3 | Y | n4-12c17/18o176-194i206-222o228-249i | CytoplasmicMembrane | 10 | |||||||||
| YGAP_ECOLI | P55734 | ygaP | b2668 JW2643 | integral IM protein (SEC in IM), YgaP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 12 | 0.121 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i117-135o141-165i | CytoplasmicMembrane | 10 | 28 | ||||||
| YJJZ_ECOLI | P55914 | yjjZ | b4567 JW5797 | integral IM protein (SEC in IM), YjjZ | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.223 | TMH | 0 | 9.90172 | - | 3 | 3 | N | i7-25o31-48i55-75o | CytoplasmicMembrane | 9 | 19 | |||||||||
| CYDX_ECOLI | P56100 | cydX ybgT | ybgT | b4515 JW0724 | integral IM protein (SEC-YidC in IM), Cytochrome bd-I ubiquinol oxidase subunit X CydX | Integral Inner Membrane | Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. | PMID: 19121005 PMID: 21778229 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | Cytoplasmic | SRP | SEC-YidC | no | yes | N | 24 | 0.168 | SpI | 23 | 3.08714 | - | 1 | 0 | Y | n4-15c23/24o | Unknown | 2 | |||||
| PTHC_ECOLI | P56579 | srlA gutA sbl | gutA sbl | b2702 JW5429 | integral IM protein (SEC in IM), PTS system glucitol/sorbitol-specific EIIC component SrlA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 46 | 0.112 | CYT | 0 | -0.200913 | - | 3 | 3 | N | o22-48i69-91o122-149i | CytoplasmicMembrane | 10 | 17 | |||||
| PTHB_ECOLI | P56580 | srlE gutA gutE | gutA gutE | b2703 JW5430 | integral IM protein (SEC in IM), PTS system glucitol/sorbitol-specific EIIB component SrlE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 22 | 0.109 | CYT | 0 | -0.200913 | - | 4 | 6 | N | i147-165o177-197i204-226o232-250i257-280o300-318i | CytoplasmicMembrane | 10 | 17 | |||||
| BLR_ECOLI | P56976 | blr | b4409 JW5963 | integral IM protein (SEC in IM), Divisome-associated Blr | Integral Inner Membrane | Small membrane protein detected experimentally. | PMID: 10931331 PMID: 19121005 PMID: 22885295 | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.106 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-26o | CytoplasmicMembrane | 10 | ||||||
| YMGF_ECOLI | P58034 | ymgF | b4520 JW1156 | integral IM protein (SEC in IM), YmgF | Integral Inner Membrane | PMID: 18978050 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.129 | TMH | 0 | 0.559611 | - | 2 | 2 | N | i12-31o37-59i | CytoplasmicMembrane | 9 | 24 | ||||||
| RZOD_ECOLI | P58041 | rzoD | b4510 JW5080 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage RzoD (o-spanin) | Outer Membrane Lipoprotein | Disulfide bridge (29 29) | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | Prophage Integrase (EcoGene) | no | no | Y | 20 | 0.187 | SpII | 19 | 19.9508 | Pos+2=T | 0 | 0 | Y | n8-18c22/23o | Unknown | 2 | 147 | |||||||
| RZOR_ECOLI | P58042 | rzoR | b4528 JW5213 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage RzoR (o-spanin) | Outer Membrane Lipoprotein | Disulfide bridge (29 29) | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | Prophage Integrase (EcoGene) | no | no | Y | 20 | 0.189 | SpII | 19 | 20.8844 | Pos+2=T | 0 | 0 | Y | n8-18c22/23o | Unknown | 2 | 88 | |||||||
| ADIC_ECOLI | P60061 | adiC aniC yjdD yjdE | aniC yjdD yjdE | b4115 JW4076 | integral IM protein (SEC in IM), Arginine/agmatine antiporter AdiC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 62 | 0.127 | TMH | 0 | 8.65108 | - | 12 | 12 | N | i12-35o41-61i91-116o122-141i153-173o193-217i229-254o274-296i317-340o352-374i386-404o410-428i | CytoplasmicMembrane | 10 | ||||||
| YOHJ_ECOLI | P60632 | yohJ | b2141 JW2129 | integral IM protein (SEC in IM), UPF0299 YohJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 30 | 0.138 | TMH | 0 | 13.9988 | - | 4 | 4 | N | i12-32o38-55i67-86o92-113i | CytoplasmicMembrane | 10 | 15 | ||||||
| MSBA_ECOLI | P60752 | msbA | b0914 JW0897 | integral IM protein (SEC in IM), Lipid A export ATP-binding/permease MsbA | Integral Inner Membrane | PMID: 15919996 PMID: 8809774 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 39 | 0.127 | TMH | 0 | 7.05231 | - | 5 | 6 | N | i21-45o65-93i142-163o169-186i244-269o275-295i | CytoplasmicMembrane | 10 | 11 | ||||||
| TSGA_ECOLI | P60778 | tsgA gutS yhfC yhfH | gutS yhfC yhfH | b3364 JW3327 | integral IM protein (SEC in IM), TsgA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.126 | TMH | 0 | 17.4563 | - | 12 | 12 | N | i12-35o47-66i78-97o103-122i134-157o163-183i204-229o249-268i273-289o295-317i329-352o358-381i | CytoplasmicMembrane | 10 | ||||||
| PLSY_ECOLI | P60782 | plsY ygiH | ygiH | b3059 JW3031 | integral IM protein (SEC in IM), Probable glycerol-3-phosphate acyltransferase PlsY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.12 | TMH | 0 | 1.31378 | - | 5 | 5 | N | o6-28i49-68o80-102i109-132o138-158i | CytoplasmicMembrane | 10 | 17 | |||||
| AQPZ_ECOLI | P60844 | aqpZ bniP | bniP | b0875 JW0859 | integral IM protein (SEC-YidC in IM), Aquaporin Z AqpZ | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. AqpZ forms tetramer in the inner membranePMID: 14691544. Sucrose gradient sedimentation analysis showed that the native, solubilized AqpZ protein is a trypsin-resistant tetramerPMID: 10518952. Upon reconstitution into proteoliposomes, AqpZ displays very high osmotic water permeability. No permeation by glycerol, urea or sorbitol was detectedPMID: 10518952. Electron crystallography has shown monomers to consist of six membrane spanning alpha-helices confirming sequence based predictionsPMID: 10487750. | PMID: 10487750 PMID: 10518952 PMID: 11266632 PMID: 14691544 PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 43 | 0.268 | TMH | 0 | 14.8231 | - | 6 | 5 | Y | n5-17c26/27o36-60i81-103o129-149i161-180o206-226i | CytoplasmicMembrane | 10 | |||||
| YBJL_ECOLI | P60869 | ybjL | b0847 JW0831 | integral IM protein (SEC in IM), Putative transport YbjL | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 23 | 0.115 | TMH | 0 | 4.04335 | - | 9 | 10 | N | o12-30i37-55o61-85i92-114o161-181i383-403o409-426i447-464o476-498i532-557o | CytoplasmicMembrane | 10 | |||||||||
| YIDE_ECOLI | P60872 | yidE yibE | yibE | b3685 JW3662 | integral IM protein (SEC in IM), Putative transport YidE | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.131 | TMH | 0 | 7.15912 | - | 10 | 11 | N | o6-22i29-47o67-86i93-115o162-182i371-391o397-417i429-446o466-485i492-513o533-552i | CytoplasmicMembrane | 10 | ||||||||
| UPPP_ECOLI | P60932 | uppP bacA upk | bacA upk | b3057 JW3029 | integral IM protein (SEC in IM), Undecaprenyl-diphosphatase UppP | Integral Inner Membrane | PMID: 15138271 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.112 | TMH | 0 | 2.62176 | - | 7 | 7 | Y | n6-13c18/19o50-69i90-110o116-136i157-175o195-213i225-246o252-272i | CytoplasmicMembrane | 10 | ||||||
| LGT_ECOLI | P60955 | lgt umpA | umpA | b2828 JW2796 | integral IM protein (SEC in IM), Prodiacylglyceryl transferase Lgt | Integral Inner Membrane | PMID: 15919996 PMID: 8051048 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.128 | TMH | 0 | 9.00412 | - | 5 | 7 | N | o14-40i60-80o100-118i130-148o200-218i225-242o262-282i | CytoplasmicMembrane | 10 | 10 | |||||
| LOLA_ECOLI | P61316 | lolA lplA yzzV | lplA yzzV | b0891 JW0874 | periplasmic protein (SEC through IM), Outer-carrier LolA | Periplasmic | PMID: 15276320 PMID: 7628437 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 22 | 0.602 | SpI | 21 | 20.5659 | - | 0 | 0 | Y | n4-15c21/22o | Periplasmic | 10 | 70 | ||||||||
| LOLB_ECOLI | P61320 | lolB hemM ychC | hemM ychC | b1209 JW1200 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Outer-LolB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 16091355 | PMID: 12488465 PMID: 12624733 PMID: 15174130 PMID: 15276320 PMID: 15911532 PMID: 16091355 PMID: 20932056 PMID: 21541338 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane; Lipid-anchor | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 24 | 0.169 | SpII | 21 | 13.4863 | Pos+2=S | 0 | 0 | Y | n11-22c27/28o | Periplasmic | 9 | 85 | ||||||
| SECM_ECOLI | P62395 | secM srrA yacA | srrA yacA | b0097 JW5007 | cytoplasmic & periplasmic protein (SEC through IM), Secretion monitor SecM | Cytoplasmic, Periplasmic | SecM regulates secA expression by translational coupling of the secM secA operon. Fusion of SecM with alkaline phosphatase activity exhibits substantial activity in the periplasm. SecM periplasmic form is rapidly degraded. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 11597451 | PMID: 11597451 PMID: 1834634 PMID: 18498364 | Cytoplasmic, Periplasmic | A, G | N/A | Cytoplasm; cytosol | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 38 | 0.527 | SpI | 37 | 11.5151 | - | 1 | 0 | Y | n20-31c37/38o | Cytoplasmic | 10 | |||||||
| OPGH_ECOLI | P62517 | mdoH opgH | opgH | b1049 JW1037 | integral IM protein (SEC in IM), Glucans biosynthesis glucosyltransferase H MdoH | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. OpgH localizes to the nascent septal site, where it antagonizes assembly of the tubulin-like cell division protein FtsZ, delaying division and increasing cell size. | PMID: 15919657 PMID: 15919996 PMID: 9008159 PMCID: PMC3723540 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP (exp) | SEC | yes | yes | N | 35 | 0.119 | CYT | 0 | -0.200913 | - | 6 | 8 | N | i139-156o188-221i512-533o566-590i599-617o623-640i660-676o682-706i | CytoplasmicMembrane | 10 | 3 | ||||
| YEIH_ECOLI | P62723 | yeiH | b2158 JW2145 | integral IM protein (SEC in IM), UPF0324 YeiH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 41 | 0.241 | TMH | 0 | 13.02 | - | 8 | 11 | N | i12-32o38-58i79-98o104-122i134-151o163-185i197-219o225-246i266-284o290-311i323-344o | CytoplasmicMembrane | 10 | |||||||
| KUP_ECOLI | P63183 | kup trkD | trkD | b3747 JW5609 | integral IM protein (SEC in IM), Low affinity potassium transport system kup | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | yes | N | 23 | 0.142 | TMH | 0 | 5.56396 | - | 12 | 11 | Y | n9-17c22/23o48-69i102-129o141-157i169-190o210-233i245-267o287-316i337-357o363-383i395-413o419-440i | CytoplasmicMembrane | 10 | |||||
| GADC_ECOLI | P63235 | gadC acsA xasA | acsA xasA | b1492 JW1487 | integral IM protein (SEC in IM), Probable glutamate/gamma-aminobutyrate antiporter GadC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.285 | TMH | 0 | 15.6618 | - | 12 | 12 | N | i12-30o42-66i87-108o128-146i158-178o198-217i238-260o288-310i337-356o368-392i413-432o444-466i | CytoplasmicMembrane | 10 | ||||||
| YQEG_ECOLI | P63340 | yqeG | b2845 JW2813 | integral IM protein (SEC in IM), transport YqeG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 23 | 0.142 | TMH | 0 | 9.79347 | - | 10 | 11 | N | i12-30o36-53i92-112o124-145i152-173o193-216i236-261o281-302i334-355o361-381i390-408o | CytoplasmicMembrane | 10 | |||||||
| AMIC_ECOLI | P63883 | amiC ygdN | ygdN | b2817 JW5449 | periplasmic protein (TAT-SEC through IM), N-acetylmuramoyl-L-alanine amidase AmiC | Periplasmic | TAT secretion system. PMID: 12787347 | PMID: 12787347 PMID: 17218314 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | TAT,SEC | yes | yes | N | 32 | 0.61 | SpI | 31 | 9.65072 | - | 0 | 0 | Y | n13-23c31/32o | Unknown | 2 | 33 | |||||||
| ZNTB_ECOLI | P64423 | zntB ydaN | ydaN | b1342 JW1336 | integral IM protein (SEC in IM), Zinc transport ZntB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.108 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i268-289o301-321i | CytoplasmicMembrane | 10 | 82 | |||||
| YDDW_ECOLI | P64426 | yddW | b1491 JW1486 | OM lipoprotein (SEC through IM), inserted in OM by LOL), UPF0748 YddW | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 36 | 0.168 | SpII | 27 | 12.5186 | Pos+2=K | 0 | 0 | Y | n16-26c30/31o | Unknown | 2 | 62 | |||||||
| YPFJ_ECOLI | P64429 | ypfJ | b2475 JW2460 | integral IM protein (SEC in IM), YpfJ | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Membrane | Membrane anchored | SRP | SEC | yes | yes | N | 33 | 0.101 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i38-58o | Unknown | 2 | |||||||||
| YPJD_ECOLI | P64432 | ypjD | b2611 JW2592 | integral IM protein (SEC in IM), YpjD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 18 | 0.156 | CYT | 0 | -0.200913 | - | 8 | 7 | Y | n3-12c17/18o33-51i63-84o90-112i124-146o176-198i210-226o238-258i | CytoplasmicMembrane | 10 | |||||||
| YBJM_ECOLI | P64439 | ybjM | b0848 JW0832 | integral IM protein (SEC in IM), YbjM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.187 | TMH | 0 | 12.0012 | - | 4 | 4 | N | i7-28o40-57i64-83o95-117i | CytoplasmicMembrane | 10 | 52 | ||||||
| YCEO_ECOLI | P64442 | yceO | b1058 JW1045 | integral IM protein (SEC in IM), YceO | Integral Inner Membrane | Small membrane protein detected experimentally. | PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 16 | 0.097 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i25-45o | CytoplasmicMembrane | 9 | |||||||
| YNAJ_ECOLI | P64445 | ynaJ | b1332 JW1326 | integral IM protein (SEC in IM), YnaJ | Integral Inner Membrane | B | Bout | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.241 | TMH | 0 | 15.6597 | - | 2 | 1 | Y | n15-26c31/32o55-80i | CytoplasmicMembrane | 9 | 29 | ||||||||
| YNBE_ECOLI | P64448 | ynbE | b1382 JW1377 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YnbE | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 25 | 0.214 | SpII | 16 | 4.04646 | Pos+2=T | 0 | 0 | Y | n4-15c24/25o | Unknown | 2 | |||||||||
| YDCL_ECOLI | P64451 | ydcL | b1431 JW1427 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YdcL | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 25 | 0.223 | SpII | 20 | 19.8371 | Pos+2=A | 0 | 0 | Y | n9-18c23/24o | Unknown | 2 | ||||||||
| ORTT_ECOLI | P64453 | ortT ydcX | ydcX | b1445 JW5232 | integral IM protein (SEC in IM), Orphan toxin OrtT | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 19 | 0.119 | TMH | 0 | 10.662 | - | 2 | 2 | N | o6-25i37-56o | CytoplasmicMembrane | 9 | ||||||||
| YNCJ_ECOLI | P64459 | yncJ | b1436 JW1432 | periplasmic protein (SEC through IM), YncJ | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 23 | 0.752 | SpI | 22 | 8.63896 | - | 0 | 0 | Y | n5-16c22/23o | Unknown | 2 | 38 | ||||||||||||
| YDHI_ECOLI | P64471 | ydhI | b1643 JW1635 | integral IM protein (SEC in IM), YdhI | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.128 | TMH | 0 | 10.2168 | - | 2 | 2 | N | o20-44i56-77o | CytoplasmicMembrane | 9 | 43 | ||||||||
| YDJM_ECOLI | P64481 | ydjM | b1728 JW5281 | integral IM protein (SEC in IM), YdjM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 28 | 0.333 | CYT | 0 | -0.200913 | - | 0 | 4 | Y | n7-17c22/23o32-48i69-90o110-128i149-166o | CytoplasmicMembrane | 10 | 15 | ||||||
| YEAQ_ECOLI | P64485 | yeaQ | b1795 JW1784 | integral IM protein (SEC in IM), UPF0410 YeaQ | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 18 | 0.108 | TMH | 0 | 15.2932 | - | 3 | 3 | N | o6-21i28-52o58-77i | CytoplasmicMembrane | 10 | |||||||||
| YOAF_ECOLI | P64493 | yoaF | b1793 JW1782 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YoaF | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 24 | 0.245 | SpII | 16 | 20.7594 | Pos+2=S | 0 | 0 | Y | n4-15c23/24o | Unknown | 2 | 90 | ||||||||
| YEBO_ECOLI | P64499 | yebO | b1825 JW1814 | integral IM protein (SEC in IM), YebO | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell membrane | Membrane anchored | SRP | SEC | yes | yes | N | 36 | 0.143 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o12-32i | Unknown | 2 | 46 | ||||||||
| YEBY_ECOLI | P64506 | yebY | b1839 JW1828 | periplasmic protein (SEC through IM), YebY | Periplasmic | Identified DsbA substrate PMID: 19953543 | PMID: 19953543 | Periplasmic | G | N/A | Periplasmic | SEC | DSBA | yes | yes | Y | 21 | 0.862 | SpI | 20 | 19.6801 | - | 1 | 0 | Y | n5-12c20/21o | Unknown | 2 | 35 | ||||||||
| MGRB_ECOLI | P64512 | mgrB yobG | yobG | b1826 JW1815 | integral IM protein (SEC in IM), PhoP/PhoQ regulator MgrB | Integral Inner Membrane | Small membrane protein detected experimentally. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. | PMID: 19121005 PMID: 20041203 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | Periplasmic | SEC | no | yes | N | 22 | 0.24 | SpI | 21 | 10.2239 | - | 1 | 0 | Y | n6-17c21/22o | CytoplasmicMembrane | 9 | 53 | |||||
| YECN_ECOLI | P64515 | yecN | b1869 JW5308 | integral IM protein (SEC in IM), YecN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Single-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 21 | 0.119 | CYT | 0 | -0.200913 | - | 3 | 2 | Y | n4-14c18/19o72-92i104-122o | CytoplasmicMembrane | 10 | 50 | ||||||
| RCNB_ECOLI | P64534 | rcnB yohN | yohN | b2107 JW5346 | periplasmic protein (SEC through IM), Nickel/cobalt homeostasis RcnB | Periplasmic | PMID: 21665978 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 22 | 0.81 | SpI | 21 | 23.7077 | - | 1 | 0 | Y | n8-16c21/22o | Unknown | 2 | 79 | ||||||||
| YEIS_ECOLI | P64536 | yeiS | b2145 JW5359 | integral IM protein (SEC in IM), YeiS | Integral Inner Membrane | B | - | IM (predicted) | Membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.124 | TMH | 0 | 2.78571 | - | 2 | 2 | N | o6-24i54-77o | CytoplasmicMembrane | 9 | 57 | |||||||||
| YPEC_ECOLI | P64542 | ypeC | b2390 JW2387 | periplasmic protein (SEC through IM), YpeC | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 22 | 0.729 | SpI | 21 | 14.9819 | - | 0 | 0 | Y | n4-15c21/22o | Unknown | 2 | 14 | ||||||||||||
| YFGG_ECOLI | P64545 | yfgG | b2504 JW5399 | integral IM protein (SEC in IM), YfgG | Integral Inner Membrane | B | Binout | in/out | N/A | Membrane | Membrane anchored | SRP | SEC | no | yes | N | 41 | 0.141 | TMH | 0 | 3.8997 | - | 1 | 0 | Y | n20-31c39/40o | CytoplasmicMembrane | 9 | |||||||||
| YFIR_ECOLI | P64548 | yfiR | b2603 JW2584 | periplasmic protein (SEC through IM), YfiR | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 23 | 0.684 | SpI | 22 | 13.4131 | - | 0 | 0 | Y | n7-17c22/23o | Unknown | 6 | 21 | ||||||||
| AlaE_ECOLI | P64550 | alaE ygaW | ygaW | b2670 JW2645 | integral IM protein (SEC in IM), L-alanine exporter AlaE | Integral Inner Membrane | PMID: 21531828 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 49 | 0.117 | TMH | 0 | 6.24909 | - | 4 | 4 | N | i12-36o42-62i82-104o110-131i | CytoplasmicMembrane | 10 | 12 | |||||
| YGGT_ECOLI | P64564 | yggT | b2952 JW2919 | integral IM protein (SEC in IM), YggT | Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | YfgM | yes | yes | N | 31 | 0.194 | TMH | 0 | 0.565687 | - | 4 | 4 | N | o6-25i67-91o97-119i144-165o | CytoplasmicMembrane | 10 | 5 | ||||||
| YQJD_ECOLI | P64581 | yqjD | b3098 JW3069 | integral IM protein (SEC in IM), YqjD | Integral Inner Membrane | YqJD is expressed during the stationary growth phase. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. Expressed during the stationary growth phase, and expression is regulated by stress response sigma factor RpoS. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. PMID: 22661687 YqjD is an inner membrane protein associated with stationary-phase ribosomes. PMID: 22661687 | PMID: 22380631 PMID: 22661687 | Integral Inner Membrane | B | Bout | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 33 | 0.103 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o81-99i | Unknown | 2 | |||||||
| YQJE_ECOLI | P64585 | yqjE | b3099 JW3070 | integral IM protein (SEC in IM), YqjE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 62 | 0.126 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i50-76o82-104i | CytoplasmicMembrane | 10 | |||||||
| YHAH_ECOLI | P64590 | yhaH | b3103 JW3074 | integral IM protein (SEC in IM), YhaH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.122 | TMH | 0 | 8.08221 | - | 3 | 3 | N | o23-40i52-70o82-103i | CytoplasmicMembrane | 10 | 8 | ||||||
| YHAI_ECOLI | P64592 | yhaI | b3104 JW3075 | integral IM protein (SEC in IM), YhaI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.264 | TMH | 0 | 0.961473 | - | 3 | 3 | N | i23-44o50-68i80-98o | CytoplasmicMembrane | 10 | 28 | ||||||
| YRAP_ECOLI | P64596 | yraP | b3150 JW3119 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YraP | Outer Membrane Lipoprotein | Contains 2 BON domains <a target="_blank" href="http://www.ebi.ac.uk/interpro/entry/IPR007055">IPR007055</a>. BON domains are putative membrane-binding domains PMID: 12878000.The BON domain is typically ~60 residues long and has an alpha/beta predicted fold. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane. These are found in a family of osmotic shock protection proteins (e.g. P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. Is homologous to the OsmY_Ecoli protein. There is a conserved glycine residue and several hydrophobic regions. This pattern of conservation is more suggestive of a binding or structural function rather than a catalytic function. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins. Outside of this group the distribution is more disparate. OsmY protein is a 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions. In particular, helping to provide protection against osmotic shock. One hypothesis is that OsmYPrevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. Proven pignal peptidase II substrate PMID: 15174130. Detected in the outer membrane fraction, with mass spectrometric analysis coupled by SDS gel electrophoresisPMID: 20932056. Outer membrane protein determined by LC-MS PMID: 12488465. DacB, DcrB, HybA, and YraP were assigned to either the inner or outer membrane. These apparent differences could be reasonably accommodated if these proteins were peripherally associated with the side of either the inner or outer membrane that faces the periplasmic space PMID: 15911532. PMID: 15174130 | PMID: 12488465 PMID: 12878000 PMID: 15174130 PMID: 15911532 PMID: 15968066 PMID: 17904518 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Periplasm | Outer membrane Lipoprotein(experimental) | SEC | LOL | yes | yes | Y | 23 | 0.327 | SpII | 18 | 13.0401 | Pos+2=V | 1 | 0 | Y | n3-16c21/22o | Periplasmic | 9 | 95 | |||||||
| MLAD_ECOLI | P64604 | mlaD yrbD | yrbD | b3193 JW3160 | periplasmic protein (SEC through IM), Interphospholipid transport system binding MlaD | Periplasmic | G | Soluble IM Fraction | Cell inner membrane | Periplasmic | SEC | yes | yes | N | 29 | 0.187 | SpI | 28 | 7.17952 | - | 1 | 0 | Y | n8-23c28/29o | Unknown | 2 | 60 | ||||||||||
| MLAE_ECOLI | P64606 | mlaE yrbE | yrbE | b3194 JW3161 | integral IM protein (SEC in IM), Interphospholipid transport system permease MlaE | Integral Inner Membrane | PMID: 15919996 PMID: 19383799 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 67 | 0.105 | CYT | 0 | -0.200913 | - | 5 | 6 | N | i48-69o75-96i103-125o148-177i198-219o239-258i | CytoplasmicMembrane | 10 | ||||||
| YHCN_ECOLI | P64614 | yhcN | b3238 JW5540 | periplasmic protein (SEC through IM), YhcN | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 23 | 0.834 | SpI | 22 | 22.7033 | - | 0 | 0 | Y | n7-18c22/23o | Unknown | 2 | ||||||||||||
| YHDU_ECOLI | P64619 | yhdU | b3263 JW3231 | integral IM protein (SEC in IM), YhdU | Potential Signal Peptide | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 31 | 0.117 | TMH | 0 | 0.197917 | - | 1 | 0 | Y | n7-18c30/31o | CytoplasmicMembrane | 9 | 82 | |||||||
| YHDV_ECOLI | P64622 | yhdV | b3267 JW3235 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YhdV | Outer Membrane Lipoprotein | Proven signal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | IM (predicted) | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 21 | 0.268 | SpII | 16 | 14.2179 | Pos+2=A | 1 | 1 | Y | n4-15c20/21o50-71i | Unknown | 2 | 30 | |||||||
| YHFL_ECOLI | P64627 | yhfL | b3369 JW3332 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YhfL | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 21890895 | Outer Membrane Lipoprotein | I | N/A | Membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 22 | 0.162 | SpII | 19 | 15.9797 | Pos+2=T | 0 | 0 | Y | n7-17c22/23o | Unknown | 2 | ||||||||
| YHFU_ECOLI | P64631 | yhfU | b3378 JW5697 | integral IM protein (SEC in IM), YhfU | Integral Inner Membrane | B | Binout | out/in | N/A | Membrane anchored | SRP | SEC | no | yes | N | 37 | 0.114 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o47-69i | Unknown | 2 | 90 | |||||||||
| HOFN_ECOLI | P64634 | hofN yrfC | yrfC | b3394 JW3357 | integral IM protein (SEC in IM), DNA utilization HofN | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 49 | 0.175 | TMH | 0 | 3.72613 | - | 1 | 1 | N | i21-40o | CytoplasmicMembrane | 9 | 22 | |||||||
| GHOT_ECOLI | P64646 | ghoT yjdO | yjdO | b4559 JW5732 | integral IM protein (SEC in IM), Toxin GhoT | Integral Inner Membrane | Toxin-antitoxin system Ghot-GhoS.In vitro RNA degradation studies, quantitative real-time reverse-transcription PCR and whole-transcriptome studies revealed that GhoS masks GhoT toxicity by cleaving specifically yjdO (ghoT) mRNA. | PMID: 22941047 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 33 | 0.1 | TMH | 0 | 9.94204 | - | 2 | 2 | N | i7-26o32-56i | CytoplasmicMembrane | 9 | |||||
| YFGH_ECOLI | P65290 | yfgH | b2505 JW5400 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YfgH | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 27 | 0.349 | SpII | 21 | 24.716 | Pos+2=Q | 0 | 0 | Y | n7-17c22/23o | Unknown | 2 | 73 | |||||||
| YGDI_ECOLI | P65292 | ygdI | b2809 JW5448 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YgdI | Outer Membrane Lipoprotein | Outer membrane protein determined by LC-MS (Gevaert et al 2002) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130 | PMID: 12488465 PMID: 15174130 PMID: 21541338 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 22 | 0.339 | SpII | 19 | 21.6734 | Pos+2=S | 1 | 0 | Y | n6-17c22/23o | Unknown | 2 | 119 | |||||||
| YGDR_ECOLI | P65294 | ygdR | b2833 JW2801 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YgdR | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 28 | 0.252 | SpII | 19 | 15.677 | Pos+2=S | 1 | 0 | Y | n6-17c22/23o | Unknown | 2 | ||||||||
| YQHH_ECOLI | P65298 | yqhH | b3014 JW2982 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YqhH | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 24 | 0.242 | SpII | 19 | 15.1531 | Pos+2=V | 1 | 0 | Y | n4-17c22/23o | OuterMembrane | 9 | 17 | |||||||
| BEPA_ECOLI | P66948 | bepA yfgC | yfgC | b2494 JW2479 | periplasmic protein (SEC through IM), Beta-barrel assembly-enhancing protease BepA | Periplasmic | BepA maintains the integrity of OM both by promoting assembly of OMPs and by proteolytically eliminating OMPs when their correct assembly was compromised. BepA is a metalloprotease that cleaves its targets preferentially between Phe-Phe residues. Potential Skp substrate PMID: 19953543 | PMID: 19953543 PMID: 22491786 PMID: 22901060 PMID: 24003122 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | SKP | yes | yes | Y | 28 | 0.636 | SpI | 27 | 15.2429 | - | 0 | 0 | Y | n9-19c27/28o | Unknown | 2 | 10 | ||||||
| YGDQ_ECOLI | P67127 | ygdQ | b2832 JW2800 | integral IM protein (SEC in IM), UPF0053 YgdQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 49 | 0.35 | TMH | 0 | 3.66789 | - | 7 | 7 | N | o12-38i50-71o77-101i122-141o153-172i184-201o213-230i | CytoplasmicMembrane | 10 | 17 | ||||||
| YHGN_ECOLI | P67143 | yhgN | b3434 JW3397 | integral IM protein (SEC in IM), UPF0056 YhgN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 26 | 0.114 | CYT | 0 | -0.200913 | - | 6 | 6 | N | o6-27i39-57o63-85i106-127o139-162i174-195o | CytoplasmicMembrane | 10 | 37 | ||||||
| YQFA_ECOLI | P67153 | yqfA | b2899 JW2867 | integral IM protein (SEC in IM), UPF0073 YqfA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 49 | 0.173 | TMH | 0 | 3.45027 | - | 7 | 7 | N | i21-42o54-74i86-105o111-132i139-157o163-186i195-216o | CytoplasmicMembrane | 10 | |||||||
| YQHA_ECOLI | P67244 | yqhA | b3002 JW2971 | integral IM protein (SEC in IM), UPF0114 YqhA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 32 | 0.15 | TMH | 0 | 6.53453 | - | 3 | 4 | N | o12-32i53-75o109-126i138-156o | CytoplasmicMembrane | 10 | 15 | ||||||
| XANQ_ECOLI | P67444 | xanQ ygfO | ygfO | b2882 JW2850 | integral IM protein (SEC in IM), Xanthine permease XanQ | Integral Inner Membrane | PMID: 15919996 PMID: 16096267 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 59 | 0.123 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i24-50o56-74i81-104o116-142i154-175o187-204i211-231o251-275i338-360o366-388i395-412o424-446i | CytoplasmicMembrane | 10 | ||||||
| YNFC_ECOLI | P67553 | ynfC | b1585 JW5258 | IM lipoprotein (SEC through IM), inserted in OM by LOL), UPF0257 YnfC | Inner Membrane Lipoprotein | Proven pignal peptidase II substrate. | PMID: 15174130 | Inner Membrane Lipoprotein | E | N/A | Cell membrane | Inner membrane lipoprotein | SEC | LOL | yes | yes | N | 21 | 0.178 | SpII | 16 | 14.4125 | Pos+2=D | 0 | 0 | Y | n5-14c19/20o | Cytoplasmic | 8 | ||||||||
| YOBD_ECOLI | P67601 | yobD | b1820 JW1809 | integral IM protein (SEC in IM), UPF0266 YobD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.285 | TMH | 0 | 3.32601 | - | 2 | 3 | N | o6-24i45-62o68-87i | CytoplasmicMembrane | 10 | |||||||
| AAER_ECOLI | P67662 | aaeR yhcS | yhcS | b3243 JW3212 | nucleoid & integral IM protein (SEC in IM), HTH-type transcriptional activator AaeR | Integral Inner Membrane, Nucleoid | PMID: 23138451 | Integral Inner Membrane, Nucleoid | B, N | IM (predicted) | Cytoplasmic | SRP | SEC | yes | yes | N | 24 | 0.199 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i226-245o | Cytoplasmic | 9 | |||||||||
| YFEO_ECOLI | P67729 | yfeO | b2389 JW2386 | integral IM protein (SEC in IM), Putative ion-transport YfeO | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.188 | TMH | 0 | 12.9661 | - | 11 | 11 | N | i12-37o57-77i98-117o147-170i182-203o223-245i257-281o301-318i325-340o346-364i371-398o | CytoplasmicMembrane | 10 | |||||||||
| MALG_ECOLI | P68183 | malG | b4032 JW3992 | integral IM protein (SEC in IM), Maltose/maltodextrin transport system permease MalG | Integral Inner Membrane | Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289 | PMID: 15919996 PMID: 18033289 PMID: 18456666 PMID: 2233678 PMID: 9008159 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP (exp) | SEC | no | yes | N | 37 | 0.136 | TMH | 0 | 14.3943 | - | 6 | 6 | N | i12-39o91-110i122-143o163-181i202-227o258-281i | CytoplasmicMembrane | 10 | ||||||
| ATPL_ECOLI | P68699 | atpE papH uncE | papH uncE | b3737 JW3715 | integral IM protein (YidC in IM), ATP synthase subunit c AtpE | Integral Inner Membrane | Experimentally verified gene-productPMID: 9868784. Methionine start codon is cleavedPMID: 9868784. Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreasedPMID: 15263011PMID: 21778229. PMID: 9237612 | PMID: 15263011 PMID: 15919996 PMID: 21778229 PMID: 9237612 PMID: 9868784 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | YidC | no | yes | N | 28 | 0.117 | TMH | 0 | 7.95599 | - | 2 | 2 | N | o12-32i53-76o | CytoplasmicMembrane | 10 | 56 | ||||
| DHSC_ECOLI | P69054 | sdhC cybA | cybA | b0721 JW0711 | integral IM protein (SEC in IM), Succinate dehydrogenase cytochrome b556 subunit SdhC | Integral Inner Membrane | Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 12560550. | PMID: 11266632 PMID: 12560550 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.129 | TMH | 0 | 1.73943 | - | 3 | 3 | N | i20-48o68-89i110-128o | CytoplasmicMembrane | 10 | 42 | ||||
| MDTI_ECOLI | P69210 | mdtI ydgE | ydgE | b1599 JW1591 | integral IM protein (SEC in IM), Spermidine export MdtI | Integral Inner Membrane | PMID: 15919996 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 56 | 0.185 | TMH | 0 | 3.45748 | - | 4 | 4 | N | o6-25i37-56o62-84i91-108o | CytoplasmicMembrane | 10 | 14 | |||||
| MDTJ_ECOLI | P69212 | mdtJ ydgF | ydgF | b1600 JW1592 | integral IM protein (SEC in IM), Spermidine export MdtJ | Integral Inner Membrane | PMID: 15919996 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.125 | TMH | 0 | 7.68505 | - | 4 | 3 | Y | n3-13c21/22o31-52i59-80o86-102i | CytoplasmicMembrane | 10 | 36 | |||||
| MDTH_ECOLI | P69367 | mdtH yceL | yceL | b1065 JW1052 | integral IM protein (SEC in IM), Multidrug resistance MdtH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 8 | 0.11 | TMH | 0 | 12.8944 | - | 10 | 12 | N | i12-35o41-58i78-94o100-116i136-157o163-185i210-235o247-264i276-294o300-317i337-357o369-388i | CytoplasmicMembrane | 10 | ||||||
| FIEF_ECOLI | P69380 | fieF yiiP | yiiP | b3915 JW3886 | integral IM protein (SEC in IM), Ferrous-iron efflux pump FieF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.141 | TMH | 0 | 3.82255 | - | 6 | 6 | N | i12-33o39-60i81-106o118-138i158-175o181-199i | CytoplasmicMembrane | 10 | ||||||
| RCSF_ECOLI | P69411 | rcsF | b0196 JW0192 | OM lipoprotein (SEC through IM, inserted in OM by LOL), RcsF | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bridge (74 118;109 124) Disulfide bond-containing protein PMID: 25664544 | PMID: 15174130 PMID: 16740933 PMID: 19953543 PMID: 20932056 PMID: 23813676 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | DSBA | LOL | yes | yes | Y | 23 | 0.182 | SpII | 15 | 13.2891 | Pos+2=S | 0 | 0 | Y | n3-13c21/22o | OuterMembrane | 10 | 81 | ||||||
| TATC_ECOLI | P69423 | tatC mttB yigU yigV | mttB yigU yigV | b3839 JW3815 | integral IM protein (SEC-YidC in IM), Sec-independent translocase TatC | Integral Inner Membrane | PMID: 11591389 PMID: 15225613 PMID: 15919996 PMID: 20169075 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 39 | 0.339 | TMH | 0 | 4.27208 | - | 6 | 6 | N | i20-38o74-95i116-137o157-183i195-212o218-237i | CytoplasmicMembrane | 10 | 65 | |||||
| TATB_ECOLI | P69425 | tatB mttA2 ysgB | mttA2 ysgB | b3838 JW5580 | integral IM protein (SEC in IM), Sec-independent translocase TatB | Integral Inner Membrane | PMID: 11591389 PMID: 14580344 PMID: 15225613 PMID: 20169075 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 44 | 0.115 | CYT | 0 | -0.200913 | - | 1 | 0 | Y | n9-20c28/29o | CytoplasmicMembrane | 10 | ||||||
| TATA_ECOLI | P69428 | tatA mttA1 yigT | mttA1 yigT | b3836 JW3813 | integral IM protein (SEC in IM), Sec-independent translocase TatA | Integral Inner Membrane | TatA-GFP was distributed in the membrane, often with higher abundance at the poles. PMID: 14580344 | PMID: 11591389 PMID: 14580344 PMID: 15225613 PMID: 20169075 | Integral Inner Membrane | B | Bin | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.112 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-22i | CytoplasmicMembrane | 10 | |||||
| PGAD_ECOLI | P69432 | pgaD ycdP | ycdP | b1021 JW1006 | integral IM protein (SEC in IM), Biofilm PGA synthesis PgaD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 38 | 0.135 | TMH | 0 | 10.5144 | - | 2 | 2 | N | i16-36o56-74i | CytoplasmicMembrane | 10 | 9 | |||||
| PGAA_ECOLI | P69434 | pgaA ycdS | ycdS | b1024 JW1010 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Poly-beta-1,6-N-acetyl-D-glucosamine export PgaA | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | BAM | no | yes | Y | 33 | 0.331 | SpI | 32 | 12.415 | - | 0 | 0 | Y | n18-26c32/33o | Unknown | 2 | 6 | |||||||||
| CCME_ECOLI | P69490 | ccmE yejS | yejS | b2197 JW2185 | integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmE | Integral Inner Membrane | CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983 PMID: 9770295 PMID: 16364305 | PMID: 11384983 PMID: 16364305 PMID: 9770295 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 29 | 0.181 | TMH | 0 | 8.60358 | - | 1 | 1 | N | i9-30o | Cytoplasmic | 8 | 66 | ||||
| AMTB_ECOLI | P69681 | amtB ybaG | ybaG | b0451 JW0441 | integral IM protein (SEC-YidC in IM), Ammonia channel AmtB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 9720863 PMID: 10231487 PMID: 11847102 PMID: 14668330 | PMID: 10231487 PMID: 11266632 PMID: 11847102 PMID: 14668330 PMID: 15361618 PMID: 15919996 PMID: 22108384 PMID: 9720863 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | yes | yes | Y | 23 | 0.645 | SpI | 22 | 12.8449 | - | 12 | 11 | Y | n3-14c22/23o32-54i66-86o120-142i149-171o183-205i217-236o248-268i280-297o303-324i336-356o376-396i | CytoplasmicMembrane | 10 | |||||
| MBHS_ECOLI | P69739 | hyaA | b0972 JW0954 | integral IM protein (TAT in IM), Hydrogenase-1 small chain HyaA | Integral Inner Membrane | Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. PMID: 2180913 PMID: 1856178 PMID: 9738917 | PMID: 15919996 PMID: 17218314 PMID: 1856178 PMID: 2180913 PMID: 9738917 | Integral Inner Membrane | B | Bout | out/in | N/A | Cell inner membrane; Single-pass type I membrane protein; Periplasmic side | Integral Membrane Protein (Experimental) | TAT | yes | yes | N | 46 | 0.373 | SpI | 45 | 1.06961 | - | 2 | 1 | Y | n25-36c45/46o327-348i | CytoplasmicMembrane | 10 | 38 | ||||||
| MBHT_ECOLI | P69741 | hybO yghV | yghV | b2997 JW2965 | periplasmic peripheral IM protein (TAT-SEC through IM), Hydrogenase-2 small chain HybO | Peripheral inner membrane protein facing the periplasm | Copurifies with trigger factor in pull down assays. Exported by the Tat system. Experimentally proven signal peptide cleavage site. Under anaerobic conditions Escherichia coli synthesizes three membrane-associated [NiFe]-hydrogenases (Hyd). Hyd-1 and Hyd-2 are respiratory hydrogenases with their active sites facing the periplasm. PMID: 22769583 PMID: 9738917 | PMID: 17218314 PMID: 19737520 PMID: 22769583 PMID: 9738917 | Peripheral inner membrane protein facing the periplasm | F2 | IM (predicted) | Cell membrane; Peripheral membrane protein; Periplasmic side Periplasm | Membrane anchored (Experimental) | TF | TAT,SEC | yes | yes | N | 38 | 0.248 | SpI | 37 | 7.00921 | - | 1 | 1 | Y | n21-32c37/38o332-355i | CytoplasmicMembrane | 10 | |||||||
| LPP_ECOLI | P69776 | lpp mlpA mulI | mlpA mulI | b1677 JW1667 | OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM, inserted in OM by LOL), Lpp | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | Trigger factor-sensitive aggregation. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Covalently attached to the peptidoglycan cell wall by the ??-amino group of its C-terminal Lys residue; stabilizes the bacterial envelope. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 4575979 | PMID: 15174130 PMID: 15911532 PMID: 16079137 PMID: 19737520 PMID: 21219470 PMID: 21541338 PMID: 3013869 PMID: 4575979 | Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular space | I, F4 | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | TF | SEC | LOL | yes | yes | Y | 26 | 0.325 | SpII | 20 | 26.7873 | Pos+2=S | 0 | 0 | Y | n6-17c25/26o | OuterMembrane | 10 | 58 | |||||
| PTGCB_ECOLI | P69786 | ptsG glcA umg | glcA umg | b1101 JW1087 | integral IM protein (SEC in IM), PTS system glucose-specific EIICB component PtsG | Integral Inner Membrane | PMID: 12717030 PMID: 15650111 PMID: 15919657 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.133 | TMH | 0 | 12.5578 | - | 10 | 9 | N | o16-39i51-71o77-101i113-132o152-172i254-272o278-297i304-331o354-376i | CytoplasmicMembrane | 10 | 3 | |||||
| PTXB_ECOLI | P69789 | glvB glvC | glvC | b3682 JW3659 | integral IM protein (SEC in IM), Phosphotransferase enzyme IIB component GlvB | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | no | N | 45 | 0.17 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o12-31i | CytoplasmicMembrane | 9 | 33 | ||||||
| PTNC_ECOLI | P69801 | manY pel ptsP | pel ptsP | b1818 JW1807 | integral IM protein (SEC in IM), PTS system mannose-specific EIIC component ManY | Integral Inner Membrane | PTS transport system component and membrane localized in complexomics study by (Stenberg et al., 2005) | PMID: 15911532 PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 26 | 0.11 | TMH | 0 | 6.083 | - | 7 | 7 | N | o6-24i33-56o62-86i98-124o144-165i177-197o209-239i | CytoplasmicMembrane | 10 | |||||
| PTND_ECOLI | P69805 | manZ gptB ptsM | gptB ptsM | b1819 JW1808 | integral IM protein (SEC in IM), PTS system mannose-specific EIID component ManZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.108 | CYT | 0 | -0.200913 | - | 3 | 3 | N | i130-154o238-255i262-282o | CytoplasmicMembrane | 10 | 29 | |||||
| PTMCB_ECOLI | P69826 | cmtA | b2933 JW2900 | integral IM protein (SEC-YidC in IM), PTS system mannitol-specific cryptic EIICB component CmtA | Integral Inner Membrane | Mannitol-specific cryptic phosphotransferase enzyme IIA component. Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 12558186 PMID: 15919996 PMID: 22108384 PMID: 9260961 PMID: 9525892 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 51 | 0.119 | TMH | 0 | 14.5212 | - | 8 | 8 | N | i12-40o52-74i86-114o134-158i214-235o247-266i287-307o313-335i | CytoplasmicMembrane | 10 | ||||||
| PTKC_ECOLI | P69831 | gatC | b2092 JW2076 | integral IM protein (SEC in IM), PTS system galactitol-specific EIIC component GatC | Integral Inner Membrane | PTS system galactitol-specific EIIC component.The galactitol phosphotransferase system transporter (EIIGat) is also composed of three subunits, GatA (IIAGat), GatB (IIBGat), and GatC (IICGat). These three subunits assemble in a 1:1:2 stoichiometry to form a complex with a predicted molecular mass of ???122 kDa | PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | no | yes | N | 34 | 0.145 | TMH | 0 | 0.817461 | - | 11 | 11 | N | o12-29i41-58o91-113i134-158o178-198i218-239o245-264i298-322o328-346i353-371o417-435i | CytoplasmicMembrane | 10 | |||||
| NANC_ECOLI | P69856 | nanC yjhA | yjhA | b4311 JW5778 | periplasmic protein (SEC through IM), Probable N-acetylneuraminic acid channel NanC | Periplasmic | G | N/A | Cell outer membrane | Periplasmic | SEC | no | yes | Y | 24 | 0.708 | SpI | 23 | 19.1942 | - | 0 | 0 | Y | n6-15c23/24o | OuterMembrane | 10 | 8 | ||||||||||
| SUGE_ECOLI | P69937 | sugE | b4148 JW5738 | integral IM protein (SEC in IM), Quaternary ammonium compound-resistance SugE | Integral Inner Membrane | Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996 | PMID: 14728684 PMID: 15919996 PMID: 16429150 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | in/out, out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 61 | 0.195 | TMH | 0 | 10.6118 | - | 4 | 3 | Y | n4-12c17/18o33-50i57-79o85-103i | CytoplasmicMembrane | 10 | ||||||
| WCAD_ECOLI | P71238 | wcaD | b2056 JW2041 | integral IM protein (SEC in IM), Putative colanic acid polymerase WcaD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 26 | 0.141 | TMH | 0 | 2.50534 | - | 11 | 11 | N | i7-25o31-48i55-73o85-105i117-138o172-191i203-226o246-266i278-296o328-347i368-397o | CytoplasmicMembrane | 10 | |||||||
| WCAJ_ECOLI | P71241 | wcaJ | b2047 JW2032 | integral IM protein (SEC in IM), UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase WcaJ | Integral Inner Membrane | PMID: 15919996 PMID: 22408159 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.107 | TMH | 0 | 4.26813 | - | 5 | 5 | N | i12-34o46-69i81-101o113-137i279-300o | CytoplasmicMembrane | 10 | |||||||
| WCAM_ECOLI | P71244 | wcaM yefK | yefK | b2043 JW2028 | periplasmic protein (TAT through IM), Colanic acid biosynthesis WcaM | Periplasmic | TAT secretion system. | PMID: 17218314 | Periplasmic | G | N/A | Periplasmic | TAT | no | yes | Y | 29 | 0.421 | SpI | 28 | 15.7954 | - | 0 | 0 | Y | n10-21c28/29o | Unknown | 2 | |||||||||
| YAAX_ECOLI | P75616 | yaaX | b0005 JW0004 | periplasmic protein (SEC through IM), YaaX | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 24 | 0.841 | SpI | 23 | 19.693 | - | 1 | 0 | Y | n6-17c23/24o | Unknown | 2 | 77 | ||||||||||||
| AFUB_ECOLI | P75681 | afuB fbpB | fbpB | b0263 JW0255 | integral IM protein (SEC in IM), Putative ferric transport system permease-like AfuB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 46 | 0.154 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i33-56o76-101i | CytoplasmicMembrane | 9 | 30 | ||||
| YAGG_ECOLI | P75683 | yagG | b0270 JW0263 | integral IM protein (SEC in IM), Putative glycoside/cation symporter YagG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | yes | no | N | 58 | 0.129 | TMH | 0 | 4.66722 | - | 12 | 12 | N | i12-34o40-59i80-101o107-130i150-172o178-199i233-255o267-287i294-311o317-340i360-384o404-426i | CytoplasmicMembrane | 10 | ||||||
| RCLC_ECOLI | P75685 | rclC ykgB | ykgB | b0301 JW5038 | integral IM protein (SEC in IM), RclC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.117 | TMH | 0 | 0.0510112 | - | 3 | 4 | N | i12-32o87-105i112-133o153-175i | CytoplasmicMembrane | 10 | ||||||
| RCLB_ECOLI | P75687 | rclB ykgI | ykgI | b0303 JW5039 | periplasmic protein (SEC through IM), RclB | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 23 | 0.662 | SpI | 22 | 16.2846 | - | 0 | 0 | Y | n6-17c22/23o | Unknown | 2 | |||||||||||
| YAHN_ECOLI | P75693 | yahN | b0328 JW0320 | integral IM protein (SEC in IM), YahN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 20 | 0.167 | TMH | 0 | 6.85455 | - | 6 | 6 | N | o20-42i54-79o85-103i136-153o159-179i199-217o | CytoplasmicMembrane | 10 | 45 | ||||||
| YAHO_ECOLI | P75694 | yahO | b0329 JW0321 | periplasmic protein (SEC through IM), YahO | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | no | yes | Y | 22 | 0.85 | SpI | 21 | 13.1005 | - | 0 | 0 | Y | n8-16c21/22o | Unknown | 2 | 85 | |||||||||||
| YBBV_ECOLI | P75711 | ybbV | b0510 JW0498 | integral IM protein (SEC in IM), YbbV | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 61 | 0.11 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o15-33i | Unknown | 2 | ||||||||||
| ALLP_ECOLI | P75712 | ybbW glxB2 | glxB2 | b0511 JW0499 | integral IM protein (SEC in IM), Putative allantoin permease YbbW | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 43 | 0.107 | TMH | 0 | 1.55234 | - | 12 | 12 | N | i46-79o91-110i117-139o151-174i186-212o224-245i266-288o308-328i349-367o373-397i417-439o451-468i | CytoplasmicMembrane | 10 | ||||||
| SFMH_ECOLI | P75715 | sfmH | b0533 JW5071 | Fimbrial periplasmic protein (SEC through IM), SfmH | Periplasmic | Potential fimbrial sfm operon (class ??1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Cytoplasmic | fimbriae | SEC | SURA | CU | no | yes | Y | 19 | 0.186 | SpI | 24 | 6.26896 | - | 0 | 0 | Y | n2-9c14/15o | Unknown | 2 | 17 | |||||
| RZPD_ECOLI | P75719 | rzpD ybcT | ybcT | b0556 JW5079 | integral IM protein (SEC in IM), Prophage Rz endopeptidase RzpD | Integral Inner Membrane | Required for normal curli ex<x>pression and biofilm development. | PMID: 23378572 | Integral Inner Membrane | B | - | N/A | Periplasmic | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 23 | 0.233 | SpI | 22 | 3.631 | - | 1 | 0 | Y | n6-17c22/23o | Unknown | 2 | 28 | |||||
| CHIP_ECOLI | P75733 | chiP ybfM | ybfM | b0681 JW0667 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Chitoporin ChiP | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | BAM | no | yes | Y | 33 | 0.272 | SpI | 32 | 12.9387 | - | 0 | 0 | Y | n10-20c32/33o | Unknown | 2 | 1 | |||||||||
| CHIQ_ECOLI | P75734 | chiQ ybfN | ybfN | b0682 JW0668 | OM lipoprotein (SEC through IM, inserted in OM by LOL), ChiQ | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 19 | 0.487 | SpII | 16 | 19.5262 | Pos+2=A | 0 | 0 | Y | n4-14c18/19o | Unknown | 2 | 77 | ||||||
| YBFP_ECOLI | P75737 | ybfP | b0689 JW0676 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YbfP | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 25 | 0.444 | SpII | 22 | 15.3591 | Pos+2=A | 1 | 0 | Y | n7-20c24/25o | Unknown | 2 | 51 | |||||||
| DTPD_ECOLI | P75742 | dtpD ybgH | ybgH | b0709 JW0699 | integral IM protein (SEC in IM), Dipeptide permease D DtpD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.16 | TMH | 0 | 1.28832 | - | 14 | 14 | N | i12-36o48-69i78-96o102-121i142-162o168-187i208-231o237-255i267-284o304-332i344-365o377-398i410-430o462-479i | CytoplasmicMembrane | 10 | ||||||
| ABRB_ECOLI | P75747 | abrB ybgN | ybgN | b0715 JW5097 ECK0704 | integral IM protein (SEC in IM), Putative regulator AbrB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 23 | 0.182 | TMH | 0 | 11.997 | - | 7 | 9 | N | o6-32i53-75o81-103i144-162o174-200i207-224o230-247i259-280o323-343i | CytoplasmicMembrane | 10 | ||||||
| YBGO_ECOLI | P75748 | ybgO | b0716 JW5098 | Fimbrial periplasmic protein (SEC through IM), YbgO | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??); Unkown function. Disulfide bond-containing protein PMID: 25664544 | PMID: 20345943 PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | N | 24 | 0.359 | SpI | 23 | 7.76951 | - | 0 | 0 | Y | n7-18c23/24o | Cytoplasmic | 8 | 53 | ||||||||
| YBGP_ECOLI | P75749 | ybgP | b0717 JW0707 | Fimbrial periplasmic protein (SEC through IM), Chaperone YbgP | Periplasmic | Putative chaperone???usher fimbrial operon yeh (class ??); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 PMID: 20345943 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | no | yes | Y | 21 | 0.795 | SpI | 20 | 5.41341 | - | 0 | 0 | Y | n6-16c20/21o | Periplasmic | 10 | 19 | ||||||
| YBGQ_ECOLI | P75750 | ybgQ | b0718 JW5099 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YbgQ | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon yeh (class ??); Usher. Disulfide bridge (795 814) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | Y | 22 | 0.84 | SpI | 21 | 8.29107 | - | 0 | 0 | Y | n6-16c21/22o | OuterMembrane | 10 | 10 | ||||||
| ZITB_ECOLI | P75757 | zitB ybgR | ybgR | b0752 JW0735 | integral IM protein (SEC in IM), Zinc transporter ZitB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 52 | 0.121 | TMH | 0 | 5.6947 | - | 5 | 6 | N | i21-41o47-68i89-110o122-143i155-182o188-205i | CytoplasmicMembrane | 10 | ||||||
| YBHI_ECOLI | P75763 | ybhI | b0770 JW0753 | integral IM protein (SEC in IM), YbhI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 27 | 0.378 | TMH | 0 | 13.1359 | - | 15 | 14 | N | i7-25o31-48i55-71o91-108i120-141o147-166i178-198o218-244i273-291o297-315i327-345o365-381i388-415o445-468i | CytoplasmicMembrane | 10 | |||||||
| YBHM_ECOLI | P75769 | ybhM | b0787 JW0770 | integral IM protein (SEC in IM), YbhM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 41 | 0.18 | TMH | 0 | 4.77792 | - | 7 | 7 | N | i21-41o53-70i77-98o104-129i136-155o161-179i209-229o | CytoplasmicMembrane | 10 | 67 | ||||||
| YBHN_ECOLI | P75770 | ybhN | b0788 JW0771 | integral IM protein (SEC in IM), YbhN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.118 | TMH | 0 | 10.4723 | - | 8 | 7 | Y | n14-27c31/32o47-65i85-106o126-151i163-186o206-227i234-266o286-303i | CytoplasmicMembrane | 10 | |||||||
| YBHG_ECOLI | P75777 | ybhG | b0795 JW0779 | integral IM protein (SEC in IM), UPF0194 YbhG | Integral Inner Membrane | PMID: 17446557 | Integral Inner Membrane | B | 0 | Soluble IM Fraction | Periplasm | Membrane anchored | SRP | SEC | yes | yes | N | 26 | 0.132 | SpI | 20 | 6.65671 | - | 1 | 0 | Y | n6-16c20/21o | CytoplasmicMembrane | 9 | 31 | |||||||
| FIU_ECOLI | P75780 | fiu ybiL | ybiL | b0805 JW0790 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Catecholate siderophore receptor Fiu | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 19953543 PMID: 20932056 PMID: 25664544 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP | BAM | yes | yes | Y | 34 | 0.525 | SpI | 33 | 11.8291 | - | 1 | 0 | Y | n14-25c33/34o | OuterMembrane | 10 | 10 | |||||
| YBIO_ECOLI | P75783 | ybiO | b0808 JW5108 | integral IM protein (SEC in IM), Moderate conductance mechanosensitive channel YbiO | Integral Inner Membrane | PMID: 15919996 PMID: 22874652 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | Y | 19 | 0.624 | SpI | 18 | 12.9319 | - | 11 | 11 | Y | n3-13c18/19o141-163i183-205o225-244i268-286o292-315i335-361o381-399i419-446o466-488i509-531o537-559i | CytoplasmicMembrane | 10 | 22 | ||||||
| OPGE_ECOLI | P75785 | opgE ybiP | ybiP | b0815 JW0800 | integral IM protein (SEC in IM), Phosphoethanolamine transferase OpgE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 22 | 0.112 | TMH | 0 | 6.83717 | - | 4 | 4 | N | o34-54i63-84o104-127i139-158o | CytoplasmicMembrane | 10 | 6 | |||||
| YBIR_ECOLI | P75788 | ybiR | b0818 JW0802 | integral IM protein (SEC in IM), YbiR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 39 | 0.126 | TMH | 0 | 6.01785 | - | 9 | 10 | N | o14-32i44-64o84-108i120-140o160-182i202-217o223-241i248-268o312-335i347-369o | CytoplasmicMembrane | 10 | |||||||
| GSIB_ECOLI | P75797 | gsiB yliB | yliB | b0830 JW5111 | periplasmic protein (SEC through IM), Glutathione-binding GsiB | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15911532 | PMID: 15911532 PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic(experimental) | SEC | SURA | yes | yes | Y | 27 | 0.582 | SpI | 26 | 15.0769 | - | 0 | 0 | Y | n10-21c26/27o | Periplasmic | 10 | 40 | ||||||
| GSIC_ECOLI | P75798 | gsiC yliC | yliC | b0831 JW0815 | integral IM protein (SEC in IM), Glutathione transport system permease GsiC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.137 | TMH | 0 | 6.79337 | - | 6 | 6 | N | i9-30o99-123i135-155o170-191i227-249o278-299i | CytoplasmicMembrane | 10 | 2 | |||||
| GSID_ECOLI | P75799 | gsiD yliD | yliD | b0832 JW0816 | integral IM protein (SEC in IM), Glutathione transport system permease GsiD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 66 | 0.123 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i40-61o103-129i136-158o164-183i222-247o267-290i | CytoplasmicMembrane | 10 | 10 | |||||
| PDEI_ECOLI | P75800 | pdeI yliE | yliE | b0833 JW0817 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 28 | 0.121 | TMH | 0 | 1.46888 | - | 2 | 2 | N | i12-32o286-304i | CytoplasmicMembrane | 7 | 4 | |||||
| DGCI_ECOLI | P75801 | dgcI yliF | yliF | b0834 JW0818 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.568 | SpI | 23 | 7.00044 | - | 2 | 1 | Y | n7-17c25/26o231-251i | CytoplasmicMembrane | 10 | 10 | |||||
| YLII_ECOLI | P75804 | yliI | b0837 JW0821 | periplasmic protein (SEC through IM), Aldose sugar dehydrogenase YliI | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Cell outer membrane | Periplasmic | SEC | SURA | no | yes | Y | 21 | 0.629 | SpI | 20 | 9.24571 | - | 0 | 0 | Y | n5-15c20/21o | CytoplasmicMembrane | 9 | 21 | |||||||
| YBJG_ECOLI | P75806 | ybjG | b0841 JW5112 | integral IM protein (SEC in IM), Putative undecaprenyl-diphosphatase YbjG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.216 | TMH | 0 | 2.64993 | - | 4 | 5 | N | o20-48i60-80o100-119i126-144o150-168i | CytoplasmicMembrane | 10 | 9 | ||||||
| YBJJ_ECOLI | P75810 | ybjJ | b0845 JW0829 | integral IM protein (SEC in IM), YbjJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.184 | TMH | 0 | 16.9774 | - | 12 | 12 | N | i15-32o52-71i78-98o104-124i145-164o170-187i217-234o254-275i282-301o307-328i340-358o370-389i | CytoplasmicMembrane | 10 | |||||||
| YBJP_ECOLI | P75818 | ybjP | b0865 JW0849 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YbjP | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Identified DsbA substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544 | PMID: 10806384 PMID: 15174130 PMID: 15911532 PMID: 19953543 PMID: 20932056 PMID: 21541338 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | DSBA | LOL | no | yes | Y | 28 | 0.445 | SpII | 18 | 10.6734 | Pos+2=T | 0 | 0 | Y | n9-19c24/25o | Unknown | 2 | 69 | ||||||
| AMID_ECOLI | P75820 | amiD ybjR | ybjR | b0867 JW0851 | OM lipoprotein (SEC through IM), inserted in OM by LOL), N-acetylmuramoyl-L-alanine amidase AmiD | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 21 | 0.182 | SpII | 16 | 18.0923 | Pos+2=A | 0 | 0 | Y | n4-14c19/20o | Unknown | 6 | 18 | ||||||
| YBJT_ECOLI | P75822 | ybjT | b0869 JW5116 | integral IM protein (SEC in IM), Putative NAD(P)-binding YbjT | Integral Inner Membrane | B | Bout | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 20 | 0.113 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o446-464i | CytoplasmicMembrane | 9 | 18 | ||||||||
| LYSO_ECOLI | P75826 | lysO ybjE | ybjE | b0874 JW0858 | integral IM protein (SEC in IM), Lysine exporter LysO | No TMH predictions | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 25 | 0.234 | TMH | 0 | 5.36895 | - | 8 | 9 | N | o6-23i35-55o61-83i104-129o135-155i167-188o208-228i249-267o279-297i | CytoplasmicMembrane | 10 | |||||||
| MACA_ECOLI | P75830 | macA ybjY | ybjY | b0878 JW0862 | integral IM protein (SEC in IM), Macrolide export MacA | Integral Inner Membrane | The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. PMID: 11544226 PMID: 17214741 | PMID: 11544226 PMID: 17214741 PMID: 19254725 PMID: 21325274 PMID: 21890895 | Integral Inner Membrane | B | N/A | Cell inner membrane | Membrane anchored | SEC | yes | yes | N | 32 | 0.134 | SpI | 31 | 3.90027 | - | 1 | 1 | N | i12-29o | CytoplasmicMembrane | 7 | 45 | |||||||
| MACB_ECOLI | P75831 | macB ybjZ | ybjZ | b0879 JW0863 | integral IM protein (SEC in IM), Macrolide export ATP-binding/permease MacB | Integral Inner Membrane | The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. | PMID: 11544226 PMID: 17214741 PMID: 19254725 PMID: 21325274 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.136 | CYT | 0 | -0.200913 | - | 4 | 4 | N | i273-293o523-548i572-602o608-631i | CytoplasmicMembrane | 10 | 17 | ||||
| YCAM_ECOLI | P75835 | ycaM | b0899 JW5119 | integral IM protein (SEC in IM), transporter YcaM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 35 | 0.133 | TMH | 0 | 12.317 | - | 12 | 12 | N | i12-30o42-63i84-102o126-146i153-176o196-218i239-261o293-312i344-364o384-402i414-435o447-470i | CytoplasmicMembrane | 10 | |||||||
| YCAP_ECOLI | P75839 | ycaP | b0906 JW0889 | integral IM protein (SEC in IM), UPF0702 transYcaP | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 64 | 0.104 | TMH | 0 | 0.694512 | - | 3 | 3 | N | o18-37i49-69o75-96i | Cytoplasmic | 8 | 26 | ||||||||
| SSUC_ECOLI | P75851 | ssuC ycbM | ycbM | b0934 JW5121 | integral IM protein (SEC in IM), Putative aliphatic sulfonates transport permease SsuC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.119 | TMH | 12 | 0 | 0 | 7 | 7 | N | i12-34o69-92i104-122o128-147i168-185o191-211i223-245o | CytoplasmicMembrane | 10 | 6 | |||||
| SSUA_ECOLI | P75853 | ssuA ycbO | ycbO | b0936 JW0919 | periplasmic protein (SEC through IM), Putative aliphatic sulfonates-binding protein SsuA | Periplasmic | PMID: 10781534 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.876 | SpI | 21 | 14.9607 | - | 0 | 0 | Y | n7-18c22/23o | Unknown | 2 | 76 | ||||||||
| ELFA_ECOLI | P75855 | elfA ycbQ | ycbQ | b0938 JW5122 | Fimbrial periplasmic protein (SEC through IM), subunit ElfA | Periplasmic | Potential fimbrial ycb operon (class ??1); Fimbrial Subunit. | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 22 | 0.807 | SpI | 21 | 23.0184 | - | 0 | 0 | Y | n5-16c21/22o | Extracellular | 10 | 85 | |||||
| ELFD_ECOLI | P75856 | elfD ycbR | ycbR | b0939 JW0922 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone ElfD | Periplasmic | Potential fimbrial ycb operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | yes | yes | Y | 27 | 0.835 | SpI | 26 | 18.1825 | - | 0 | 0 | Y | n10-21c26/27o | Unknown | 6 | 29 | |||||
| ELFC_ECOLI | P75857 | elfC ycbS | ycbS | b0940 JW0923 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Probable usher ElfC | Outer Membrane b-barrel protein | Potential fimbrial ycb operon (class ??1); Usher. | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | yes | yes | N | 36 | 0.312 | SpI | 35 | 6.8393 | - | 1 | 0 | Y | n19-30c35/36o | OuterMembrane | 10 | 7 | |||||
| ELFG_ECOLI | P75858 | elfG ycbT | ycbT | b0941 JW0924 | Fimbrial periplasmic protein (SEC through IM), ElfG | Periplasmic | Potential fimbrial ycb operon (class ??1); Potential tip-adhesin. | PMID: 19820722 PMID: 20345943 PMID: 21890895 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 31 | 0.334 | SpI | 30 | 5.91464 | - | 1 | 0 | Y | n15-25c30/31o | Extracellular | 9 | 32 | |||||
| YCBU_ECOLI | P75859 | ycbU | b0942 JW0925 | Fimbrial periplasmic protein (SEC through IM), YcbU | Periplasmic | Potential fimbrial ycb operon (class ??1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog). | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 25 | 0.653 | SpI | 24 | 5.70567 | - | 1 | 0 | Y | n6-17c24/25o | Extracellular | 9 | 41 | |||||||
| YCBV_ECOLI | P75860 | ycbV | b0943 JW5123 | Fimbrial periplasmic protein (SEC through IM), YcbV | Periplasmic | Potential fimbrial ycb operon (class ??1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog). | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | CU | no | yes | N | 23 | 0.301 | SpI | 22 | 5.04607 | - | 0 | 0 | Y | n6-17c22/23o | Unknown | 2 | 47 | |||||||
| YCCS_ECOLI | P75870 | yccS | b0960 JW5128 | integral IM protein (SEC in IM), YccS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.115 | TMH | 0 | 6.42867 | - | 9 | 12 | N | i15-34o40-57i64-81o87-105i112-133o139-161i389-410o416-433i440-459o465-482i487-503o509-531i | CytoplasmicMembrane | 10 | |||||||
| GFCD_ECOLI | P75882 | gfcD ymcA | ymcA | b0984 JW0967 | periplasmic protein (SEC through IM), GfcD | Periplasmic | G | N/A | Cell membrane | Periplasmic | SEC | yes | yes | Y | 22 | 0.783 | SpI | 21 | 17.8352 | - | 0 | 0 | Y | n7-15c21/22o | OuterMembrane | 9 | |||||||||||
| GFCC_ECOLI | P75883 | gfcC ymcB | ymcB | b0985 JW0968 | periplasmic protein (SEC through IM), GfcC | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.723 | SpI | 22 | 8.45245 | - | 0 | 0 | Y | n4-15c22/23o | Unknown | 2 | 41 | |||||||||||
| GFCB_ECOLI | P75884 | gfcB ymcC | ymcC | b0986 JW0969 | OM lipoprotein (SEC through IM, inserted in OM by LOL), GfcB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 20 | 0.315 | SpII | 15 | 11.1657 | Pos+2=T | 0 | 0 | Y | n4-14c19/20o | CytoplasmicMembrane | 9 | 37 | ||||||
| GFCA_ECOLI | P75885 | gfcA ymcD | ymcD | b0987 JW5133 | integral IM protein (SEC in IM), Threonine-rich GfcA | Integral Inner Membrane | When the protein is over-expressed protein is located on the Inner Membrane. | PMID: 15919996 | Integral Inner Membrane | B | out/out | IM (predicted) | Cell inner membrane; Single-pass membrane protein | Membrane anchored | SRP | SEC | no | yes | Y | 22 | 0.858 | SpI | 21 | 31.9353 | - | 2 | 0 | Y | n5-16c21/22o | CytoplasmicMembrane | 10 | 113 | |||||
| RUTG_ECOLI | P75892 | rutG ycdG | ycdG | b1006 JW5137 | integral IM protein (SEC in IM), Putative pyrimidine permease RutG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 43 | 0.115 | CYT | 0 | -0.200913 | - | 11 | 12 | N | i33-54o60-76i83-103o109-129i141-161o173-190i197-219o239-261i281-299o319-338i350-373o385-418i | CytoplasmicMembrane | 10 | ||||||
| EFEU_ECOLI | P75901 | efeU ycdN | ycdN | b4490 JW5141/JW1002 b1016/b1017 | integral IM protein (SEC in IM), Putative inactive ferrous iron permease EfeU | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 16 | 0.112 | CYT | 0 | -0.200913 | - | 6 | 7 | N | o6-26i38-58o70-90i117-142o148-171i183-203o248-265i | CytoplasmicMembrane | 10 | |||||||
| PGAC_ECOLI | P75905 | pgaC ycdQ | ycdQ | b1022 JW1007 | integral IM protein (SEC in IM), Poly-beta-1,6-N-acetyl-D-glucosamine synthase PgaC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 23 | 0.19 | TMH | 0 | 17.09 | - | 5 | 4 | Y | n6-17c22/23o32-54i323-345o365-383i395-417o | CytoplasmicMembrane | 10 | 17 | |||||
| PGAB_ECOLI | P75906 | pgaB ycdR | ycdR | b1023 JW5142 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 26 | 0.161 | SpII | 20 | 14.5441 | Pos+2=I | 0 | 0 | Y | n9-20c25/26o | Periplasmic | 9 | 15 | ||||||
| DGCT_ECOLI | P75908 | dgcT ycdT | ycdT | b1025 JW5143 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.126 | TMH | 0 | 10.4982 | - | 8 | 8 | N | i12-29o41-67i79-99o114-131i151-169o189-213i220-241o261-278i | CytoplasmicMembrane | 10 | ||||||
| YCDU_ECOLI | P75910 | ycdU | b1029 JW1015 | integral IM protein (SEC in IM), YcdU | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 36 | 0.12 | TMH | 0 | 7.11263 | - | 8 | 8 | N | i16-32o44-68i89-114o120-141i162-182o202-222i255-277o289-309i | CytoplasmicMembrane | 10 | |||||||||
| YCDZ_ECOLI | P75916 | ycdZ | b1036 JW5147 | integral IM protein (SEC in IM), YcdZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 65 | 0.232 | TMH | 0 | 14.4904 | - | 5 | 5 | N | o20-42i49-70o76-94i99-117o123-147i | CytoplasmicMembrane | 10 | |||||||
| YMDA_ECOLI | P75917 | ymdA | b1044 JW1031 | periplasmic protein (SEC through IM), YmdA | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 23 | 0.463 | SpI | 22 | 13.2508 | - | 1 | 0 | Y | n11-22c28/29o | Extracellular | 9 | 36 | ||||||||||||
| OPGC_ECOLI | P75920 | mdoC opgC ymdD | opgC ymdD | b1047 JW1034 | integral IM protein (SEC in IM), Glucans biosynthesis C MdoC | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.12 | TMH | 0 | 12.3178 | - | 10 | 10 | N | i17-38o58-80i92-113o133-157i177-201o213-234i246-264o276-295i307-330o336-356i | CytoplasmicMembrane | 10 | ||||||||
| C56I_ECOLI | P75925 | yceJ | b1057 JW1044 | integral IM protein (SEC in IM), Cytochrome b561 homolog 2 YceJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 31 | 0.121 | TMH | 0 | 13.644 | - | 4 | 4 | N | i12-35o55-72i92-111o144-164i | CytoplasmicMembrane | 10 | 10 | ||||||
| FLGA_ECOLI | P75933 | flgA | b1072 JW1059 | periplasmic protein (SEC through IM), Flagella basal body P-ring formation FlgA | Periplasmic | Periplasmic chaperone for P ring protein. PMID: 12730325 | PMID: 12631703 PMID: 12730325 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | Fla | yes | yes | Y | 22 | 0.722 | SpI | 21 | 5.00523 | - | 0 | 0 | Y | n8-16c21/22o | Periplasmic | 9 | 12 | |||||||
| FLGD_ECOLI | P75936 | flgD fla FIV flaV | fla FIV flaV | b1075 JW1062 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), Basal-body rod modification FlgD | Peripheral outer membrane protein facing the extra-cellular space | Hook-capping protein. The hook cap FlgD is displaced by FlgK, allowing filament growth PMID: 12631703 Using the hook scaffolding protein FlgD of Escherichia coli as a model substrate, it is demonstrated that the export signal is contained within the N-terminal 71 amino acids of FlgD. PMID: 16897036 PMID: 16897036 | PMID: 12631703 PMID: 16897036 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Cell surface appendage (Experimental) | Flagellum | Fla | pseudogene (Ochman & Davalos, 2006) | yes | no | N | 29 | 0.171 | SpI | 28 | 2.5996 | - | 0 | 0 | N | i | Extracellular | 10 | 106 | ||||||
| FLGE_ECOLI | P75937 | flgE fla FV flaK | fla FV flaK | b1076 JW1063 | Flagellar extra-cellular peripheral OM protein (Flagellum secreted), hook FlgE | Peripheral outer membrane protein facing the extra-cellular space | Hook protein. PMID: 12730325 | PMID: 12631703 PMID: 12730325 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Bacterial flagellum basal body | Cell surface appendage (Experimental) | flagellum | Flagellum | Fla | pseudogene (Ochman & Davalos, 2006) | no | yes | N | 28 | 0.186 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Extracellular | 10 | 106 | ||||
| FLGF_ECOLI | P75938 | flgF fla FVI flaX | fla FVI flaX | b1077 JW1064 | Flagellar periplasmic protein (Flagellum secreted through IM), basal body rod FlgF | Periplasmic | Homolog to flgG. Proximal rod protein. PMID: 12730325 FlgB, FlgC, FlgF, and FlgG are four proteins that comprise the rod section of the basal-body assembly of the flagellar motor. The rod is a rotational component which is situated transverse to the outer membrane and peptidoglycan layers and is circumscribed by a set of four rings which lie in a horizontal plane within the inner and outer membranes of the cell envelope. PMID: 2181149 FlgG is a distal component of the basal body rod. While FlgF was highly soluble, FlgB, FlgC, FlgG and FliE tended to self or cross-aggregate into fibrils in solutions at neutral pH or below, at high ionic strength, or at high protein concentration. PMID: 15136044 | PMID: 12631703 PMID: 12730325 PMID: 15136044 PMID: 2181149 | Periplasmic | G | N/A | Bacterial flagellum basal body | Periplasmic (Experimental) | flagellum | Flagellum | Fla | yes | yes | N | 30 | 0.199 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Periplasmic | 9 | 101 | |||||
| YCFL_ECOLI | P75946 | ycfL | b1104 JW1090 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YcfL | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 24 | 0.214 | SpII | 18 | 19.4253 | Pos+2=R | 0 | 0 | Y | n5-16c21/22o | Unknown | 2 | 70 | |||||||||||
| YCFS_ECOLI | P75954 | ycfS | b1113 JW5820 | periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YcfS | Peripheral outer membrane protein facing the periplasm | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YcfS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. | PMID: 18498364 PMID: 23832002 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Periplasm | Periplasmic | SEC | SURA | yes | yes | Y | 29 | 0.319 | SpI | 28 | 14.2493 | - | 1 | 0 | Y | n11-24c28/29o | Unknown | 2 | 63 | |||||||
| YCFT_ECOLI | P75955 | ycfT | b1115 JW1101 | integral IM protein (SEC in IM), YcfT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 33 | 0.109 | TMH | 0 | 11.9971 | - | 8 | 8 | N | i12-32o52-70i90-113o133-156i163-183o195-212i224-256o310-331i | CytoplasmicMembrane | 10 | |||||||
| LOLE_ECOLI | P75958 | lolE ycfW | ycfW | b1118 JW1104 | integral IM protein (SEC in IM), Lipoprotein-releasing system TM protein LolE | Integral Inner Membrane | PMID: 10783239 PMID: 15276320 PMID: 17498646 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 36 | 0.113 | TMH | 0 | 6.76692 | - | 4 | 4 | N | i21-48o270-293i314-341o380-399i | CytoplasmicMembrane | 10 | 20 | |||||
| YCFZ_ECOLI | P75961 | ycfZ | b1121 JW1107 | integral IM protein (SEC in IM), YcfZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 19 | 0.268 | SpI | 20 | 7.80323 | - | 4 | 3 | Y | n4-14c19/20o183-201i208-230o242-259i | CytoplasmicMembrane | 10 | |||||||
| YMFA_ECOLI | P75962 | ymfA | b1122 JW5164 | integral IM protein (SEC in IM), YmfA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 29 | 0.212 | TMH | 0 | 6.47267 | - | 2 | 2 | N | i7-28o117-139i | CytoplasmicMembrane | 10 | |||||||
| YMFE_ECOLI | P75968 | ymfE | b1138 JW5166 | integral IM protein (SEC in IM), YmfE | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 37 | 0.102 | TMH | 0 | 1.7441 | - | 4 | 4 | N | i21-39o59-79i151-173o185-208i | CytoplasmicMembrane | 10 | 7 | |||||||
| Y1142_ECOLI | P75971 | b1142 | b1142 JW1128 | integral IM protein (SEC in IM), Putative b1142 B114 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot), pseudogene (Ecogene), pseudogene (Ochman & Davalos, 2006) | no | no | N | 63 | 0.119 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i41-62o74-92i | Unknown | 2 | 54 | |||||||
| YMFR_ECOLI | P75979 | ymfR | b1150 JW1136 | integral IM protein (SEC in IM), YmfR | Integral Inner Membrane | B | Binout | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 22 | 0.153 | TMH | 0 | 11.0494 | - | 2 | 1 | Y | n4-17c21/22o31-49i | CytoplasmicMembrane | 9 | 16 | |||||||
| PDEG_ECOLI | P75995 | pdeG ycgG | ycgG | b1168 JW5174 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SEC | no | yes | N | 33 | 0.194 | CYT | 0 | -0.200913 | - | 2 | 2 | N | o6-28i221-239o | CytoplasmicMembrane | 7 | |||||||
| YCGI_ECOLI | P76000 | ycgI ymgH | ymgH | b4521 JW1162/JW5179 b1173 | OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative YcgI | Contains a predicted autotransporter domain. Potential outer membrane b-barrel protein though it does not have prediction for a signal peptide. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> | Outer Membrane b-barrel protein | H | N/A | Cytoplasmic | SEC | Autotransporter(T5S) | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 25 | 0.12 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 7 | 12 | ||||||||
| YCGJ_ECOLI | P76001 | ycgJ | b1177 JW1166 | periplasmic protein (SEC through IM), YcgJ | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.404 | SpI | 22 | 8.58297 | - | 0 | 0 | Y | n6-16c24/25o | Unknown | 2 | 77 | |||||||||
| PLIG_ECOLI | P76002 | pliG ycgK | ycgK | b1178 JW1167 | periplasmic protein (SEC through IM), Inhibitor of g-type lysozyme PliG | Periplasmic | SecB substrate. Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 16352602 PMID: 20734102 PMID: 25403562 | Periplasmic | G | N/A | Periplasm | Periplasmic | SECB | SEC | no | yes | Y | 23 | 0.798 | SpI | 22 | 19.6754 | - | 0 | 0 | Y | n9-17c22/23o | Unknown | 2 | 72 | ||||||
| NHAP2_ECOLI | P76007 | cvrA nhaP2 ycgO | nhaP2 ycgO | b1191 JW5184 | integral IM protein (SEC in IM), K(+)/H(+) antiporter NhaP2 CvrA | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.165 | TMH | 0 | 9.70846 | - | 11 | 13 | N | o6-23i30-47o59-76i88-113o119-141i162-179o191-210i217-237o243-261i273-292o298-323i335-357o363-381i | CytoplasmicMembrane | 10 | ||||||||
| YMGE_ECOLI | P76011 | ymgE tag | tag | b1195 JW1184 | integral IM protein (SEC in IM), UPF0410 YmgE | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.106 | TMH | 0 | 11.3901 | - | 3 | 3 | N | o6-21i28-47o59-81i | CytoplasmicMembrane | 10 | 16 | |||||||
| YCGV_ECOLI | P76017 | ycgV | b1202 JW1193 | OM b-barrel protein (SEC through IM, T5S secreted through OM), YcgV | Outer Membrane b-barrel protein | Ag43 homologue; known autotransporter protein. Signal peptide 1-56 (by clustalW). Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>. Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner. | PMID: 12466262 PMID: 15590781 | Outer Membrane b-barrel protein | H | IM (predicted) | Cytoplasmic | SRP | SEC | Autotransporter(T5S) | no | yes | N | 47 | 0.309 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i27-47o | Extracellular | 9 | 17 | |||||||
| PUUP_ECOLI | P76037 | puuP ycjJ | ycjJ | b1296 JW1289 | integral IM protein (SEC in IM), Putrescine importer PuuP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 43 | 0.116 | TMH | 0 | 2.35137 | - | 12 | 12 | N | i24-47o59-77i98-120o132-150i162-182o202-221i241-264o291-319i340-359o365-386i398-417o423-442i | CytoplasmicMembrane | 10 | ||||||
| YCJN_ECOLI | P76042 | ycjN | b1310 JW1303 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative ABC transporter periplasmic-binding YcjN | Outer Membrane Lipoprotein | Phobius prediction hydrophobic region around residue 400 with transmembrane probability equal to 0.8. Minor prediction of weak transmembrane region in the same region by TMHMM . Otherwise no obvious signals. Homologous to P28904 (TREC_ECOLI) Trehalose-6-phosphate hydrolase that is totally soluble and cytoplasmic Wikipedia classifies Categories: Transferases | EC 2.4.1 | Peripheral membrane proteins. In Streptococcus Jaecalis it is not found associated with the membrane. Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 13859056 PMID: 15174130 PMID: 15660210 | Outer Membrane Lipoprotein | I | N/A | Periplasm | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 20 | 0.189 | SpII | 20 | 13.8019 | Pos+2=K | 0 | 0 | Y | n6-17c21/22o | Unknown | 2 | 66 | |||||||
| OMPG_ECOLI | P76045 | ompG | b1319 JW1312 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpG | Outer Membrane b-barrel protein | Proteoliposome swelling assays showed that OmpG channels were much larger than those of the OmpF and OmpC porins, with an estimated limited diameter of about 2 nm. PMID: 9721282 Potential Skp substrate PMID: 19953543 PMID: 9721282 | PMID: 19953543 PMID: 9721282 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SEC | SKP | BAM | no | yes | Y | 20 | 0.465 | SpI | 21 | 14.867 | - | 0 | 0 | Y | n4-14c19/20o | OuterMembrane | 10 | 54 | ||||||
| YDBL_ECOLI | P76076 | ydbL | b1383 JW5216 | periplasmic protein (SEC through IM), YdbL | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.838 | SpI | 21 | 15.5115 | - | 1 | 0 | Y | n4-15c21/22o | Unknown | 2 | 51 | ||||||||||||
| YNBA_ECOLI | P76090 | ynbA | b1408 JW1405 | integral IM protein (SEC in IM), YnbA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 50 | 0.126 | TMH | 0 | -0.193337 | - | 5 | 5 | N | o31-64i85-107o113-132i152-168o174-191i | CytoplasmicMembrane | 10 | 11 | ||||||
| YNBB_ECOLI | P76091 | ynbB | b1409 JW1406 | integral IM protein (SEC in IM), YnbB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 60 | 0.122 | TMH | 0 | 8.47225 | - | 9 | 7 | Y | n6-16c21/22o37-54i61-83o95-119i131-154o166-187i208-227o233-253i | CytoplasmicMembrane | 10 | |||||||
| YNBD_ECOLI | P76093 | ynbD | b1411 JW1408 | integral IM protein (SEC in IM), YnbD | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.123 | TMH | 0 | 13.3648 | - | 8 | 8 | Y | n4-15c33/34o49-72i84-105o125-141i153-170o176-193i213-236o242-261i273-292o | CytoplasmicMembrane | 10 | |||||||||
| YDCO_ECOLI | P76103 | ydcO | b1433 JW5229 | integral IM protein (SEC in IM), YdcO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 27 | 0.198 | TMH | 0 | 15.9189 | - | 10 | 12 | Y | n10-20c25/26o41-63i70-88o94-114i119-138o144-161i168-187o207-224i236-254o260-276i288-313o319-337i349-382o | CytoplasmicMembrane | 10 | |||||||
| YDCS_ECOLI | P76108 | ydcS | b1440 JW1435 | periplasmic protein (SEC through IM), Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding YdcS | Periplasmic | Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 22030350 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 23 | 0.836 | SpI | 22 | 17.8592 | - | 0 | 0 | Y | n10-18c22/23o | Periplasmic | 10 | 16 | ||||||||
| YDCZ_ECOLI | P76111 | ydcZ | b1447 JW1442 | integral IM protein (SEC in IM), YdcZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 61 | 0.165 | TMH | 0 | 8.79151 | - | 5 | 4 | Y | n4-19c24/25o34-55i67-88o94-114i126-145o | CytoplasmicMembrane | 10 | 14 | ||||||
| YNCD_ECOLI | P76115 | yncD | b1451 JW1446 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Probable TonB-dependent receptor YncD | Outer Membrane b-barrel protein | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 | PMID: 12624733 PMID: 19953543 PMID: 20932056 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | SKP | BAM | no | yes | Y | 24 | 0.888 | SpI | 23 | 12.8703 | - | 0 | 0 | Y | n10-18c23/24o | OuterMembrane | 10 | 2 | ||||||
| YNCE_ECOLI | P76116 | yncE | b1452 JW1447 | periplasmic protein (SEC through IM), YncE | Periplasmic | SecB substrate. | PMID: 16352602 | Periplasmic | G | N/A | Periplasmic | SECB | SEC | no | yes | Y | 31 | 0.794 | SpI | 30 | 16.4204 | - | 0 | 0 | Y | n15-26c30/31o | Unknown | 2 | 64 | ||||||||
| YNCH_ECOLI | P76118 | yncH | b1455 JW5235 | periplasmic protein (SEC through IM), YncH | Periplasmic | G | IM (predicted) | Cytoplasmic | SEC | no | yes | N | 40 | 0.113 | CYT | 0 | -0.200913 | - | 0 | 0 | Y | n2-13c18/19o | Unknown | 2 | 35 | ||||||||||||
| DDPA_ECOLI | P76128 | ddpA yddS | yddS | b1487 JW5240 | periplasmic protein (SEC through IM), Probable D,D-dipeptide-binding periplasmic DdpA | Periplasmic | PMID: 11121068 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 26 | 0.839 | SpI | 25 | 19.0002 | - | 0 | 0 | Y | n10-17c25/26o | Periplasmic | 10 | 61 | ||||||||
| SAFA_ECOLI | P76136 | safA yneN | yneN | b1500 JW1494.1 | integral IM protein (SEC in IM), Two-component-system connector SafA | Integral Inner Membrane | PMID: 17998538 | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell inner membrane | - | SRP | SEC | no | yes | N | 40 | 0.109 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o19-40i | CytoplasmicMembrane | 9 | ||||||
| LSRB_ECOLI | P76142 | lsrB yneA | yneA | b1516 JW1509 | periplasmic protein (SEC through IM), Autoinducer 2-binding LsrB | Periplasmic | PMID: 15601708 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 27 | 0.845 | SpI | 26 | 21.9126 | - | 0 | 0 | Y | n9-20c26/27o | Periplasmic | 10 | 75 | ||||||||
| YNEE_ECOLI | P76146 | yneE | b1520 JW5245 | integral IM protein (SEC in IM), UPF0187 YneE | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 38 | 0.113 | TMH | 0 | 13.5444 | - | 3 | 4 | N | i28-46o52-70i208-229o235-255i | CytoplasmicMembrane | 9 | |||||||||
| DGCF_ECOLI | P76147 | dgcF yneF | yneF | b1522 JW5825 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | no | no | N | 34 | 0.118 | TMH | 0 | 9.08181 | - | 4 | 4 | N | o12-29i41-68o80-102i114-135o | CytoplasmicMembrane | 10 | 31 | ||||
| RZPQ_ECOLI | P76158 | rzpQ ydfP | ydfP | b1553 JW1545 | periplasmic protein (SEC through IM), RzpQ | Periplasmic | G | N/A | Periplasmic | SEC | Prophage Integrase (EcoGene) | no | no | N | 23 | 0.245 | SpI | 22 | 0.491707 | - | 1 | 0 | Y | n7-17c22/23o | Unknown | 2 | 19 | ||||||||||
| YNFA_ECOLI | P76169 | ynfA | b1582 JW1574 | integral IM protein (SEC in IM), UPF0060 YnfA | Integral Inner Membrane | Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996 | PMID: 11867724 PMID: 15919996 PMID: 16429150 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | out/out, in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 62 | 0.224 | TMH | 0 | 10.6101 | - | 4 | 4 | N | o6-26i33-54o60-78i85-105o | CytoplasmicMembrane | 10 | ||||||
| YNFB_ECOLI | P76170 | ynfB | b1583 JW1575 | periplasmic peripheral OM protein (SEC through IM), UPF0482 YnfB | Peripheral outer membrane protein facing the periplasm | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544 | PMID: 15911532 PMID: 25664544 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Periplasmic | SEC | yes | yes | Y | 29 | 0.87 | SpI | 28 | 19.5483 | - | 0 | 0 | Y | n9-20c28/29o | Unknown | 2 | 49 | |||||||||
| YNFD_ECOLI | P76172 | ynfD | b1586 JW5259 | periplasmic protein (SEC through IM), YnfD | Periplasmic | Experimentally verified gene-product. PMID: 9868784 | PMID: 9868784 | Periplasmic | G | Soluble IM Fraction | Periplasmic (Experimental) | SEC | no | yes | Y | 22 | 0.874 | SpI | 21 | 22.7125 | - | 0 | 0 | Y | n3-14c21/22o | Extracellular | 9 | 79 | |||||||||
| YNFH_ECOLI | P76173 | ynfH | b1590 JW5261 | integral IM protein (SEC in IM), Anaerobic dimethyl sulfoxide reductase chain YnfH | Integral Inner Membrane | The physiological substrate and relevance of the YnfFGH S- and N-oxide reductase is unknown. DmsC paralog. So far, hydroxy pyridine N-oxide is the best substrate for YnfFGH. ynfFGH are expressed anaerobically. YnfH can function with DmsAB, replacing DMSC a The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. PMID: 14522592 | PMID: 14522592 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.15 | TMH | 0 | 13.2137 | - | 8 | 8 | N | o12-34i46-67o87-104i116-138o150-169i181-204o224-243i250-271o | CytoplasmicMembrane | 10 | ||||||
| CLCB_ECOLI | P76175 | clcB mriT ynfJ | mriT ynfJ | b1592 JW5263 | nucleoid & integral IM protein (SEC in IM), Voltage-gated ClC-type chloride channel ClcB | Integral Inner Membrane, Nucleoid | PMID: 15919996 PMID: 23138451 | Integral Inner Membrane, Nucleoid | B, N | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 21 | 0.254 | TMH | 0 | 10.4168 | - | 10 | 9 | Y | n5-16c21/22o54-71i144-162o174-200i221-241o261-282i294-313o319-338i350-372o384-404i | CytoplasmicMembrane | 10 | 39 | ||||||
| YDGD_ECOLI | P76176 | ydgD | b1598 JW1590 | periplasmic (SEC through IM) serine protease YdgD | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.691 | SpI | 21 | 15.015 | - | 0 | 0 | Y | n3-14c21/22o | Unknown | 2 | 28 | ||||||||||||
| YDGH_ECOLI | P76177 | ydgH | b1604 JW1596 | periplasmic protein (SEC through IM), YdgH | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 23 | 0.805 | SpI | 22 | 22.3224 | - | 0 | 0 | Y | n7-18c22/23o | Unknown | 2 | 13 | ||||||||||||
| YDGK_ECOLI | P76180 | ydgK | b1626 JW1618 | integral IM protein (SEC in IM), YdgK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 40 | 0.147 | TMH | 0 | 19.3259 | - | 4 | 4 | N | i12-36o56-78i90-108o114-133i | CytoplasmicMembrane | 10 | |||||||
| RSXD_ECOLI | P76182 | rsxD rnfD ydgO | rnfD ydgO | b1630 JW1622 | integral IM protein (SEC in IM), Ion-translocating oxidoreductase complex subunit D RsxD | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.191 | TMH | 0 | 5.44392 | - | 10 | 10 | N | i20-38o44-62i69-89o95-113i125-143o210-235i242-262o268-287i299-318o324-342i | CytoplasmicMembrane | 10 | ||||||||
| YDHJ_ECOLI | P76185 | ydhJ | b1644 JW1636 | integral IM protein (SEC in IM), YdhJ | Integral Inner Membrane | B | Bin | out/in | N/A | Membrane | Membrane anchored | SRP | SEC | yes | yes | N | 69 | 0.119 | TMH | 0 | 4.39451 | - | 1 | 1 | N | o6-26i | CytoplasmicMembrane | 9 | 26 | ||||||||
| YDHK_ECOLI | P76186 | ydhK | b1645 JW1637 | integral IM protein (SEC in IM), transporter YdhK | EchoLOCATION Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold) | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.119 | TMH | 0 | 4.68512 | - | 10 | 12 | N | i21-41o47-65i72-88o94-112i119-137o149-170i359-379o385-404i411-431o437-454i461-481o493-510i | CytoplasmicMembrane | 10 | ||||||||
| MEPH_ECOLI | P76190 | mepH ydhO | ydhO | b1655 JW5270 | periplasmic protein (SEC through IM), Murein DD-endopeptidase MepH | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 28 | 0.421 | SpI | 27 | 15.3587 | - | 0 | 0 | Y | n8-19c27/28o | Unknown | 6 | ||||||||||||
| YNHG_ECOLI | P76193 | ynhG | b1678 JW1668 | periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YnhG | Peripheral outer membrane protein facing the periplasm | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YnhG forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan. | PMID: 18498364 PMID: 23832002 | Peripheral outer membrane protein facing the periplasm | F3 | N/A | Periplasm | Periplasmic | SEC | SURA | yes | yes | Y | 24 | 0.48 | SpI | 23 | 15.3547 | - | 0 | 0 | Y | n4-15c23/24o | Periplasmic | 9 | 22 | |||||||
| YDIM_ECOLI | P76197 | ydiM | b1690 JW1680 | integral IM protein (SEC in IM), transport YdiM | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 42 | 0.151 | TMH | 0 | 9.7669 | - | 12 | 12 | N | i12-30o42-62i74-90o96-112i133-156o162-183i204-227o247-268i275-292o298-325i337-359o365-385i | CytoplasmicMembrane | 10 | |||||||
| YDIN_ECOLI | P76198 | ydiN | b1691 JW5274 | integral IM protein (SEC in IM), transport YdiN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.235 | TMH | 0 | 11.6576 | - | 12 | 12 | N | i12-30o50-72i79-97o103-126i133-152o164-185i210-235o255-273i280-301o307-329i341-363o369-390i | CytoplasmicMembrane | 10 | |||||||
| YDIY_ECOLI | P76206 | ydiY | b1722 JW1711 | periplasmic protein (SEC through IM), YdiY | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 26 | 0.481 | SpI | 25 | 20.5374 | - | 0 | 0 | Y | n7-18c23/24o | Unknown | 2 | 15 | ||||||||||||
| YNIB_ECOLI | P76208 | yniB | b1726 JW1715 | integral IM protein (SEC in IM), YniB | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 44 | 0.107 | TMH | 0 | 5.0431 | - | 3 | 4 | N | o15-33i45-63o83-101i150-172o | CytoplasmicMembrane | 10 | 40 | ||||||||
| YDJX_ECOLI | P76219 | ydjX | b1750 JW1739 | integral IM protein (SEC in IM), of TVP38/TMEM64 family and DedA family, YdjX | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.175 | TMH | 0 | 13.2473 | - | 5 | 6 | N | i7-30o50-76i83-104o124-146i158-180o192-214i | CytoplasmicMembrane | 10 | ||||||
| YDJY_ECOLI | P76220 | ydjY | b1751 JW5283 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YdjY | Inner Membrane Lipoprotein | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Inner membrane lipoprotein | SEC | LOL | no | yes | N | 34 | 0.346 | SpII | 26 | 15.9526 | Pos+2=D | 0 | 0 | Y | n13-24c29/30o | Unknown | 2 | 96 | ||||||||||
| YDJZ_ECOLI | P76221 | ydjZ | b1752 JW1741 | integral IM protein (SEC in IM), of TVP38/TMEM64 family and DedA family, YdjZ | Integral Inner Membrane | Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. | PMID: 15919996 PMID: 23086209 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.23 | TMH | 0 | 23.0428 | - | 5 | 5 | Y | n16-27c45/46o55-73i80-97o103-121i177-196o202-223i | CytoplasmicMembrane | 10 | ||||||
| YNJA_ECOLI | P76222 | ynjA | b1753 JW1742 | integral IM protein (SEC in IM), YnjA | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cytoplasmic | SRP | SEC | yes | yes | N | 26 | 0.102 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o33-51i | CytoplasmicMembrane | 9 | 41 | |||||||||
| YNJB_ECOLI | P76223 | ynjB | b1754 JW5284 | periplasmic protein (SEC through IM), YnjB | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | no | yes | Y | 21 | 0.688 | SpI | 20 | 11.9034 | - | 0 | 0 | Y | n4-16c20/21o | Unknown | 2 | 70 | ||||||||
| YNJC_ECOLI | P76224 | ynjC | b1755 JW5285 | integral IM protein (SEC in IM), ABC transporter permease YnjC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 47 | 0.204 | TMH | 0 | 14.426 | - | 12 | 12 | N | i7-33o53-80i92-111o131-156i177-202o239-260i281-303o315-337i346-370o376-395i428-449o482-503i | CytoplasmicMembrane | 10 | |||||||
| YNJF_ECOLI | P76226 | ynjF | b1758 JW1747 | integral IM protein (SEC in IM), YnjF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 43 | 0.114 | CYT | 0 | -0.200913 | - | 5 | 5 | N | o33-60i81-102o114-135i147-167o173-195i | CytoplasmicMembrane | 10 | |||||||
| YNJH_ECOLI | P76227 | ynjH | b1760 JW1749 | periplasmic protein (SEC through IM), YnjH | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 19 | 0.569 | SpI | 18 | 11.8884 | - | 0 | 0 | Y | n4-14c18/19o | CytoplasmicMembrane | 9 | 27 | |||||||||
| YNJI_ECOLI | P76228 | ynjI | b1762 JW5288 | integral IM protein (SEC in IM), YnjI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 58 | 0.169 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i42-64o70-91i | CytoplasmicMembrane | 10 | 4 | ||||||
| YDJK_ECOLI | P76230 | ydjK | b1775 JW5290 | integral IM protein (SEC in IM), Putative metabolite transport YdjK | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 43 | 0.144 | TMH | 0 | 3.8405 | - | 12 | 12 | N | i25-49o61-82i89-107o113-137i158-176o182-202i266-287o302-323i330-347o353-375i396-416o422-441i | CytoplasmicMembrane | 10 | |||||||
| CDGI_ECOLI | P76236 | cdgI yeaI | yeaI | b1785 JW1774 | integral IM protein (SEC in IM), Probable diguanylate cyclase CdgI | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 56 | 0.137 | CYT | 0 | -0.200913 | - | 8 | 8 | N | i58-76o88-110i122-143o163-182i194-215o235-257i269-287o293-318i | CytoplasmicMembrane | 10 | ||||||
| DGCJ_ECOLI | P76237 | dgcJ yeaJ | yeaJ | b1786 JW5291 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.176 | SpI | 30 | 1.61892 | - | 2 | 1 | Y | n11-26c31/32o305-327i | CytoplasmicMembrane | 9 | 15 | |||||
| YOAI_ECOLI | P76239 | yoaI | b1788 JW5885 | integral IM protein (SEC in IM), YoaI | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Membrane | - | SRP | SEC | no | yes | N | 21 | 0.164 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-30i | CytoplasmicMembrane | 9 | |||||||||
| NIMT_ECOLI | P76242 | nimT yeaN | yeaN | b1791 JW1780 | integral IM protein (SEC in IM), 2-nitroimidazole transporter NimT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.135 | TMH | 0 | 4.63339 | - | 12 | 12 | N | i12-37o49-70i82-98o104-126i138-160o166-185i212-239o251-270i279-299o305-323i335-355o367-387i | CytoplasmicMembrane | 10 | ||||||
| LEUE_ECOLI | P76249 | leuE yeaS | yeaS | b1798 JW1787 | integral IM protein (SEC in IM), Leucine efflux protein LeuE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 47 | 0.141 | TMH | 0 | 12.792 | - | 6 | 6 | N | o12-32i44-69o81-99i120-142o154-179i191-209o | CytoplasmicMembrane | 10 | ||||||
| PDED_ECOLI | P76261 | pdeD adrB yoaD | adrB yoaD | b1815 JW1804 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeD | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 29 | 0.12 | SpI | 35 | 1.97681 | - | 1 | 1 | Y | n17-27c32/33o245-265i | CytoplasmicMembrane | 7 | 13 | |||||||
| MNTP_ECOLI | P76264 | mntP yebN | yebN | b1821 JW5830 | integral IM protein (SEC in IM), Probable manganese efflux pump MntP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | Y | 20 | 0.786 | SpI | 19 | 8.81356 | - | 5 | 4 | Y | n3-11c19/20o68-86i106-127o133-154i166-186o | CytoplasmicMembrane | 10 | ||||||
| YEBQ_ECOLI | P76269 | yebQ | b1828 JW5299 | integral IM protein (SEC in IM), transporter YebQ | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 49 | 0.145 | TMH | 0 | 3.99006 | - | 12 | 14 | N | i15-34o54-74i86-107o113-133i145-167o173-191i203-225o231-249i269-295o307-328i335-357o363-379i400-420o432-451i | CytoplasmicMembrane | 10 | |||||||||
| YEBT_ECOLI | P76272 | yebT | b1834 JW1823 | integral IM protein (SEC in IM), Intertransport YebT | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 47 | 0.12 | TMH | 0 | 4.96376 | - | 1 | 1 | N | i21-39o | Unknown | 2 | 30 | ||||||||
| YEBZ_ECOLI | P76278 | yebZ | b1840 JW1829 | integral IM protein (SEC in IM), YebZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 31 | 0.14 | TMH | 0 | 12.9484 | - | 8 | 8 | N | o6-29i50-73o93-111i118-138o150-171i192-215o227-248i269-287o | CytoplasmicMembrane | 10 | |||||||
| YECT_ECOLI | P76296 | yecT | b1877 JW5310 | periplasmic protein (SEC through IM), YecT | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 19 | 0.831 | SpI | 18 | 11.1311 | - | 0 | 0 | Y | n4-14c18/19o | Unknown | 4 | 31 | ||||||||||||
| FLHE_ECOLI | P76297 | flhE | b1878 JW1867 | periplasmic protein (SEC through IM), FlhE | Periplasmic | Part of the flagellar export apparatus Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | Fla | yes | yes | Y | 17 | 0.511 | SpI | 16 | 8.24229 | - | 0 | 0 | Y | n3-14c26/27o | Unknown | 2 | 68 | ||||||||
| FLHA_ECOLI | P76298 | flhA | b1879 JW1868 | integral IM protein (SEC in IM), biosynthesis FlhA | Integral Inner Membrane | Part of FlgN-FlgK-FliJ-FlhA complex. | PMID: 15919996 PMID: 22233518 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.137 | TMH | 0 | 10.1028 | - | 7 | 8 | N | i21-40o46-65i77-97o117-140i209-231o251-273i285-305o311-327i | CytoplasmicMembrane | 10 | 14 | |||||
| FLHB_ECOLI | P76299 | flhB yecQ | yecQ | b1880 JW1869 | integral IM protein (SEC in IM), biosynthetic FlhB | Integral Inner Membrane | Regulates ordered export of flagellar components via autocleavage mechanism. | PMID: 15919996 PMID: 16246842 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 54 | 0.142 | CYT | 0 | -0.200913 | - | 4 | 4 | N | i35-53o88-115i145-168o188-213i | CytoplasmicMembrane | 10 | |||||
| YECR_ECOLI | P76308 | yecR | b1904 JW1892 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YecR | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | N | 25 | 0.325 | SpII | 15 | 8.98675 | Pos+2=T | 0 | 0 | Y | n3-14c22/23o | Unknown | 2 | 15 | ||||||||
| DGCQ_ECOLI | P76330 | dgcQ yedQ | yedQ | b1956 JW5832 | integral IM protein (SEC in IM), Probable diguanylate cyclase DgcQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 44 | 0.109 | TMH | 0 | 0.725864 | - | 2 | 2 | N | i21-42o358-380i | Cytoplasmic | 9 | 12 | |||||
| YEDR_ECOLI | P76334 | yedR | b1963 JW1946 | integral IM protein (SEC in IM), YedR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 23 | 0.118 | TMH | 0 | 0.40092 | - | 2 | 3 | N | o6-22i43-62o86-109i | CytoplasmicMembrane | 10 | 43 | ||||||
| YEDS_ECOLI | P76335 | yedS | b4496 JW5319/JW1948/JW1949 b1964/b1965/b1966 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative YedS | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Cytoplasmic | SEC | BAM | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | yes | no | Y | 22 | 0.864 | SpI | 21 | 22.1485 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | 18 | |||||||||
| YEDV_ECOLI | P76339 | yedV | b1968 JW1951 | integral IM protein (SEC in IM), Sensor histidine kinase YedV | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 24 | 0.26 | TMH | 0 | 7.43701 | - | 2 | 1 | Y | n10-18c23/24o159-180i | CytoplasmicMembrane | 10 | 12 | ||||||
| HIUH_ECOLI | P76341 | hiuH yedX | yedX | b1970 JW1953 | periplasmic protein (SEC through IM), 5-hydroxyisourate hydrolase HiuH | Periplasmic | PMID: 12542701 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 24 | 0.79 | SpI | 23 | 18.1944 | - | 0 | 0 | Y | n6-17c23/24o | Unknown | 2 | 78 | ||||||||
| MSRP_ECOLI | P76342 | msrP yedY | yedY | b1971 JW1954 | periplasmic peripheral IM protein (TAT-SEC through IM), Protein-methionine-sulfoxide reductase catalytic subunit MsrP | Peripheral inner membrane protein facing the periplasm | TAT secretion system. PMID: 15355966 | PMID: 15355966 PMID: 16042411 PMID: 17218314 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Periplasm | Membrane anchored (Experimental) | TAT,SEC | no | yes | N | 45 | 0.526 | SpI | 44 | 7.04958 | - | 0 | 0 | Y | n28-38c44/45o | Unknown | 2 | 7 | |||||||
| MSRQ_ECOLI | P76343 | msrQ yedZ | yedZ | b1972 JW1955 | integral IM protein (SEC in IM), Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ | Integral Inner Membrane | Is attached to the inner membrane when interacting with the YedZ subunit. | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.146 | TMH | 0 | 6.8144 | - | 6 | 6 | N | i9-30o50-68i80-98o118-138i150-167o173-191i | CytoplasmicMembrane | 10 | |||||
| ZINT_ECOLI | P76344 | zinT yodA | yodA | b1973 JW1956 | periplasmic protein (SEC through IM), Metal-binding ZinT | Periplasmic | After 45 min of cadmium exposure the YodA protein was primarily detected in the cytoplasmic fraction but was later (150 min) found in both the cytoplasmic and periplasmic compartments. PMID: 9579078 Disulfide bond-containing protein PMID: 25664544 | PMID: 12480884 PMID: 25664544 PMID: 9579078 | Periplasmic | G | N/A | Cytoplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.683 | SpI | 23 | 12.2997 | - | 0 | 0 | Y | n8-18c23/24o | Unknown | 2 | ||||||||
| C56H_ECOLI | P76345 | yodB | b1974 JW5323 | integral IM protein (SEC in IM), Cytochrome b561 homolog 1 YodB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 25 | 0.146 | TMH | 0 | 8.67869 | - | 4 | 4 | N | i9-26o46-63i84-108o144-162i | CytoplasmicMembrane | 10 | 15 | ||||||
| YEEJ_ECOLI | P76347 | yeeJ | b1978 JW5833 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), YeeJ | Outer Membrane b-barrel protein | Cytplasmic transciption factor that shuttles from chromosome to the membranes as a peripheral protein on the PtsG transporter. Specifically it binds to the unphosphorylated, tRNAs port-mediating form of the EIIBCGl subunit. | PMID: 15063852 | Outer Membrane b-barrel protein | H | N/A | Cytoplasmic | SEC | BAM | no | yes | N | 52 | 0.258 | SpI | 45 | 1.97486 | - | 0 | 0 | Y | n27-39c51/52o | OuterMembrane | 9 | |||||||||
| SHIA_ECOLI | P76350 | shiA yeeM | yeeM | b1981 JW1962 | integral IM protein (SEC in IM), Shikimate transporter ShiA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.125 | TMH | 0 | 0.821024 | - | 12 | 12 | N | i25-49o61-84i96-114o120-139i160-184o196-215i256-276o288-310i317-336o342-363i383-408o414-432i | CytoplasmicMembrane | 10 | 3 | |||||
| YEEO_ECOLI | P76352 | yeeO | b1985 JW1965 | integral IM protein (SEC in IM), Probable FMN/FAD exporter YeeO | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 30 | 0.152 | CYT | 0 | -0.200913 | - | 11 | 12 | N | i45-71o83-105i117-140o160-180i192-216o222-247i268-289o309-332i352-375o387-408i420-440o446-468i | CytoplasmicMembrane | 10 | |||||||
| YOEA_ECOLI | P76356 | yoeA | b4582 JW1980 b1995 b1998 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative YoeA | Outer Membrane b-barrel protein | H | N/A | Outer Membrane ??-barrel protein | SEC | BAM | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | Y | 29 | 0.402 | SpI | 28 | 8.15876 | - | 0 | 0 | Y | n12-23c28/29o | OuterMembrane | 9 | |||||||||||
| YEER_ECOLI | P76361 | yeeR | b2001 JW1983 | integral IM protein (SEC in IM), YeeR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene), pseudogene (Ochman & Davalos, 2006) | no | no | N | 34 | 0.25 | TMH | 0 | 5.74833 | - | 6 | 6 | N | i7-26o32-50i62-81o96-115i135-159o165-185i | CytoplasmicMembrane | 10 | 9 | |||||
| WZZB_ECOLI | P76372 | wzzB cld rol wzz | cld rol wzz | b2027 JW5836 | integral IM protein (SEC in IM), Chain length determinant WzzB | Integral Inner Membrane | PMID: 15919996 PMID: 16079137 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 53 | 0.174 | CYT | 0 | -0.200913 | - | 2 | 2 | N | o32-51i296-316o | CytoplasmicMembrane | 10 | 8 | |||||
| WZC_ECOLI | P76387 | wzc | b2060 JW2045 | integral IM protein (SEC in IM), Tyrosine-kinase wzc Wzc | Integral Inner Membrane | Prediction of one very weak transmembrane region. | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 58 | 0.141 | CYT | 0 | -0.200913 | - | 2 | 2 | N | o32-51i426-449o | CytoplasmicMembrane | 10 | 19 | |||||
| YEGH_ECOLI | P76389 | yegH | b2063 JW5336 | integral IM protein (SEC in IM), UPF0053 YegH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 64 | 0.117 | TMH | 0 | 2.5813 | - | 7 | 7 | N | o12-34i46-68o88-105i125-148o154-172i184-207o213-233i | CytoplasmicMembrane | 10 | 16 | ||||||
| YEGI_ECOLI | P76393 | yegI | b2070 JW2055 | integral IM protein (SEC in IM), kinase YegI | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cytoplasmic | SRP | SEC | no | yes | N | 52 | 0.148 | CYT | 0 | -0.200913 | - | 0 | 2 | N | i393-413o419-438i | Cytoplasmic | 8 | ||||||||||
| YEGJ_ECOLI | P76394 | yegJ | b2071 JW2056 | periplasmic protein (SEC through IM), YegJ | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 19 | 0.264 | SpI | 19 | 9.75379 | - | 0 | 0 | Y | n4-14c19/20o | Unknown | 2 | 79 | ||||||||||||
| MDTA_ECOLI | P76397 | mdtA yegM | yegM | b2074 JW5338 | periplasmic peripheral IM protein (SEC through IM), Multidrug resistance MdtA | Peripheral inner membrane protein facing the periplasm | Part of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. | PMID: 12107133 PMID: 12107134 PMID: 21890895 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cell inner membrane | Membrane anchored | SEC | yes | yes | N | 22 | 0.151 | TMH | 0 | 7.31567 | - | 1 | 1 | N | i9-26o | CytoplasmicMembrane | 9 | 37 | |||||||
| MDTB_ECOLI | P76398 | mdtB yegN | yegN | b2075 JW2060 | integral IM protein (SEC in IM), Multidrug resistance MdtB | Integral Inner Membrane | Part of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. References: | PMID: 12107133 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.132 | TMH | 0 | 4.88895 | - | 11 | 12 | N | i21-41o345-362i369-389o395-416i437-460o472-496i537-557o867-885i892-912o918-944i965-984o996-1022i | CytoplasmicMembrane | 10 | |||||
| MDTC_ECOLI | P76399 | mdtC yegO | yegO | b2076 JW2061 | integral IM protein (SEC in IM), Multidrug resistance MdtC | Integral Inner Membrane | Part of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. | PMID: 12107133 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 61 | 0.131 | TMH | 0 | 7.90298 | - | 10 | 12 | N | i12-32o336-353i360-384o390-410i431-451o463-490i528-545o853-871i878-895o901-917i953-970o982-1008i | CytoplasmicMembrane | 10 | |||||
| YEGR_ECOLI | P76406 | yegR | b2085 JW5837 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YegR | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 22 | 0.281 | SpII | 17 | 15.1742 | Pos+2=A | 0 | 0 | Y | n4-14c22/23o | Unknown | 2 | 54 | |||||||||||
| YEGT_ECOLI | P76417 | yegT | b2098 JW2085 | integral IM protein (SEC in IM), Putative nucleoside transporter YegT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 36 | 0.176 | TMH | 0 | 11.594 | - | 12 | 12 | N | i7-29o41-58i70-86o98-120i132-152o164-182i211-232o244-262i274-294o300-325i337-356o376-400i | CytoplasmicMembrane | 10 | |||||||
| YEGX_ECOLI | P76421 | yegX | b2102 JW5345 | integral IM protein (SEC in IM), YegX | Belongs to the glycosyl hydrolase 25 family; Glycoside hydrolase family 25 GH25 comprises enzymes with only one known activity;Lysozyme (EC:3.2.1.17). So we expect this to be acting on the peptidoglycan and therefore facing periplasm. | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | yes | yes | N | 28 | 0.118 | TMH | 0 | 7.43323 | - | 1 | 0 | Y | n11-21c25/26o | Unknown | 2 | 31 | ||||||||
| RCNA_ECOLI | P76425 | rcnA yohM | yohM | b2106 JW2093 | nucleoid & integral IM protein (SEC in IM), Nickel/cobalt efflux system RcnA | Integral Inner Membrane, Nucleoid | PMID: 15805538 PMID: 15919996 | Integral Inner Membrane, Nucleoid | B, N | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 40 | 0.135 | TMH | 0 | 8.07836 | - | 6 | 6 | N | o12-31i52-77o89-107i173-196o202-230i251-273o | CytoplasmicMembrane | 10 | ||||||
| LPXT_ECOLI | P76445 | lpxT yeiU | yeiU | b2174 JW2162 | integral IM protein (SEC in IM), Lipid A 1-diphosphate synthase LpxT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.122 | TMH | 0 | 7.40709 | - | 5 | 5 | N | i7-24o63-81i93-113o161-182i191-212o | CytoplasmicMembrane | 10 | 35 | |||||
| PDEN_ECOLI | P76446 | pdeN rtn | rtn | b2176 JW2164 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 31 | 0.108 | TMH | 0 | 2.52515 | - | 2 | 2 | N | i12-36o236-258i | CytoplasmicMembrane | 10 | 76 | |||||
| ATOE_ECOLI | P76460 | atoE | b2223 JW2217 | integral IM protein (SEC in IM), Putative short-chain fatty acid transporter AtoE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 36 | 0.138 | TMH | 0 | 16.8697 | - | 9 | 9 | N | o20-38i54-75o95-124i136-162o182-201i245-263o269-286i298-316o418-439i | CytoplasmicMembrane | 10 | |||||||
| YFAP_ECOLI | P76462 | yfaP | b2225 JW2219 | periplasmic protein (SEC through IM), YfaP | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | yes | yes | Y | 20 | 0.599 | SpI | 19 | 13.0156 | - | 0 | 0 | Y | n4-14c19/20o | Unknown | 2 | 107 | ||||||||
| YFAQ_ECOLI | P76463 | yfaQ | b2226 JW2220 | periplasmic protein (SEC through IM), YfaQ | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | no | yes | Y | 20 | 0.66 | SpI | 19 | 8.15864 | - | 0 | 0 | Y | n6-15c19/20o | Unknown | 2 | 9 | ||||||||
| YFAS_ECOLI | P76464 | yfaS yfaR | yfaR | b4500 JW2221/JW2222 b2227/b2228 | periplasmic protein (SEC through IM), Putative alpha-2-macroglobulin homolog YfaS | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | Soluble IM Fraction | Periplasmic | SEC | SURA | pseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot) | no | yes | Y | 39 | 0.71 | SpI | 38 | 14.0209 | - | 0 | 0 | Y | n20-31c38/39o | Unknown | 4 | 81 | ||||||
| YFAT_ECOLI | P76466 | yfaT | b2229 JW2223 | periplasmic protein (SEC through IM), YfaT | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.277 | SpI | 19 | 3.99575 | - | 0 | 0 | Y | n4-15c19/20o | CytoplasmicMembrane | 9 | 26 | ||||||||||||
| RHMT_ECOLI | P76470 | rhmT yfaV | yfaV | b2246 JW2240 | integral IM protein (SEC in IM), transport RhmT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 39 | 0.245 | TMH | 0 | 3.16424 | - | 12 | 11 | Y | n17-30c38/39o54-75i82-101o107-129i141-163o175-197i240-261o273-295i307-326o332-350i362-383o395-415i | CytoplasmicMembrane | 10 | ||||||
| YFAZ_ECOLI | P76471 | yfaZ | b2250 JW5371 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), YfaZ | Outer Membrane b-barrel protein | PMID: 20932056 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | SEC | BAM | no | yes | Y | 22 | 0.713 | SpI | 21 | 19.9632 | - | 0 | 0 | Y | n4-15c21/22o | Unknown | 2 | 78 | ||||||||
| ARNT_ECOLI | P76473 | arnT pmrK yfbI | pmrK yfbI | b2257 JW2251 | integral IM protein (SEC in IM), Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase ArnT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 29 | 0.116 | TMH | 0 | 5.33485 | - | 12 | 12 | N | i7-28o81-103i110-131o137-153i165-192o204-227i257-278o290-308i315-335o347-367i379-400o406-425i | CytoplasmicMembrane | 10 | ||||||
| ARNF_ECOLI | P76474 | arnF pmrM yfbJ | pmrM yfbJ | b2258 JW5373 | integral IM protein (SEC in IM), Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 24 | 0.127 | TMH | 0 | 10.9868 | - | 4 | 3 | Y | n7-18c23/24o47-65i77-97o103-121i | CytoplasmicMembrane | 10 | 9 | |||||
| YFBK_ECOLI | P76481 | yfbK | b2270 JW2265 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YfbK | Inner Membrane Lipoprotein | E | N/A | Membrane Lipoprotein | SEC | LOL | no | yes | N | 24 | 0.119 | SpII | 18 | 27.352 | Pos+2=G | 0 | 0 | Y | n6-16c21/22o | Unknown | 2 | 49 | |||||||||||
| YFBL_ECOLI | P76482 | yfbL | b2271 JW2266 | integral IM protein (SEC in IM), YfbL | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane | Membrane anchored | SRP | SEC | no | yes | N | 37 | 0.316 | TMH | 0 | 1.10045 | - | 1 | 0 | Y | n4-16c28/29o | CytoplasmicMembrane | 9 | |||||||||
| YFCO_ECOLI | P76498 | yfcO | b2332 JW2329 | Fimbrial periplasmic protein (SEC through IM), YfcO | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Unkown function | PMID: 20345943 | Periplasmic | G | Soluble IM Fraction | Periplasmic | fimbriae | SEC | no | yes | Y | 22 | 0.835 | SpI | 21 | 14.5584 | - | 0 | 0 | Y | n6-16c21/22o | Extracellular | 9 | 41 | ||||||||
| YFCP_ECOLI | P76499 | yfcP | b2333 JW2330 | Fimbrial periplasmic protein (SEC through IM), YfcP | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit. Disulfide bridge (43 83) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | yes | yes | Y | 28 | 0.79 | SpI | 27 | 14.214 | - | 1 | 0 | Y | n8-19c27/28o | Unknown | 2 | |||||||
| YFCQ_ECOLI | P76500 | yfcQ | b2334 JW2331 | Fimbrial periplasmic protein (SEC through IM), YfcQ | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | yes | yes | Y | 19 | 0.841 | SpI | 18 | 13.6429 | - | 0 | 0 | Y | n4-11c18/19o | Unknown | 2 | 96 | ||||||||
| YFCR_ECOLI | P76501 | yfcR | b2335 JW2332 | Fimbrial periplasmic protein (SEC through IM), YfcR | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | yes | yes | Y | 29 | 0.68 | SpI | 28 | 11.4125 | - | 0 | 0 | Y | n10-22c30/31o | Unknown | 2 | 49 | ||||||||
| MLAA_ECOLI | P76506 | mlaA vacJ | vacJ | b2346 JW2343 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Interphospholipid transport system MlaA | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 22 | 0.16 | SpII | 17 | 20.7085 | Pos+2=A | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 9 | 19 | ||||||
| YFDI_ECOLI | P76507 | yfdI | b2352 JW5382 | integral IM protein (SEC in IM), YfdI | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 20 | 0.145 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i7-25o71-90i97-115o121-139i146-163o169-194i206-226o354-373i380-398o410-429i | CytoplasmicMembrane | 10 | ||||||||
| YFDX_ECOLI | P76520 | yfdX | b2375 JW2372 | periplasmic protein (SEC through IM), YfdX | Periplasmic | PMID: 11157960 | Periplasmic | G | N/A | Periplasmic (Experimental) | SEC | yes | yes | Y | 22 | 0.881 | SpI | 21 | 20.5809 | - | 0 | 0 | Y | n4-15c21/22o | Unknown | 2 | 49 | ||||||||||
| YFDY_ECOLI | P76521 | yfdY | b2377 JW2374 | integral IM protein (SEC in IM), YfdY | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 28 | 0.123 | TMH | 0 | 19.5928 | - | 3 | 3 | N | o6-25i32-49o55-75i | CytoplasmicMembrane | 10 | 58 | ||||||||
| YFEY_ECOLI | P76537 | yfeY | b2432 JW2425 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YfeY | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130 Disulfide bond-containing protein PMID: 25664544 | PMID: 12488465 PMID: 15174130 PMID: 20932056 PMID: 25664544 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 29 | 0.248 | SpII | 17 | 20.3796 | Pos+2=S | 0 | 0 | Y | n8-19c27/28o | Unknown | 2 | 59 | ||||||||
| YFEZ_ECOLI | P76538 | yfeZ | b2433 JW2426 | integral IM protein (SEC in IM), YfeZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.118 | TMH | 0 | 1.95358 | - | 4 | 4 | N | i21-41o61-78i90-110o116-135i | CytoplasmicMembrane | 10 | 40 | ||||||
| YFFQ_ECOLI | P76548 | yffQ | b2448 | periplasmic protein (SEC through IM), YffQ | Periplasmic | G | N/A | Periplasmic | SEC | Prophage Integrase (EcoGene) | no | no | N | 19 | 0.652 | SpI | 18 | 3.21713 | - | 0 | 0 | Y | n3-13c18/19o | Unknown | 4 | ||||||||||||
| EUTH_ECOLI | P76552 | eutH yffU | yffU | b2452 JW2436 | integral IM protein (SEC in IM), Ethanolamine utilization EutH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 70 | 0.135 | TMH | 0 | 5.16844 | - | 10 | 9 | N | o6-24i57-84o120-146i153-178o190-215i227-250o270-294i342-364o370-392i | CytoplasmicMembrane | 10 | ||||||
| YPFG_ECOLI | P76559 | ypfG | b2466 JW2450 | periplasmic protein (SEC through IM), YpfG | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | Y | 22 | 0.804 | SpI | 21 | 15.2807 | - | 1 | 0 | Y | n5-16c21/22o | CytoplasmicMembrane | 9 | 61 | |||||||||
| YFGI_ECOLI | P76573 | yfgI | b2506 JW2490 | periplasmic protein (SEC through IM), YfgI | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.625 | SpI | 19 | 7.20342 | - | 0 | 0 | Y | n4-14c32/33o | Unknown | 2 | 11 | ||||||||||||
| YFGM_ECOLI | P76576 | yfgM | b2513 JW2497 | integral IM protein (SEC in IM), UPF0070 YfgM | Integral Inner Membrane | Periplasmic chaperone. Periplasmic chaperone which associates with PpiD and the SecYEG translocon and operates in a network that contains Skp and SurA. Potential substrates identified are nine inner membrane proteins (CusS, EvgS, MalF, OsmC, TdcB, TdcC, WrbA, YfhB, and YtfH) and seven periplasmic proteins (HdeA, HdeB, AnsB, Ggt, MalE, YcgK, and YnjE). PMID: 25403562 Periplasmic chaperone YfgM associates with PpiD and the SecYEG translocon and operates in a network that contains Skp and SurA. PMID: 25403562 | PMID: 21210718 PMID: 24855643 PMID: 25403562 | Integral Inner Membrane | B | Bout | in/out | IM (predicted), Detected in IM Fraction | Membrane | Membrane anchored | SRP | SEC | yes | yes | N | 27 | 0.142 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i24-42o | Periplasmic | 9 | 50 | |||||
| PBPC_ECOLI | P76577 | pbpC yfgN | yfgN | b2519 JW2503 | integral IM protein (SEC in IM), Penicillin-binding 1C PbpC | Integral Inner Membrane | Cell wall biogenesis. Peptidoglycan biosynthesis. PMID: 10542235 | PMID: 10542235 | Integral Inner Membrane | B | Bout | in/out | N/A | Cell inner membrane | Membrane anchored (Experimental) | SRP | SEC | no | yes | N | 28 | 0.288 | SpI | 27 | 10.5085 | - | 1 | 0 | Y | n10-23c27/28o | CytoplasmicMembrane | 10 | 8 | ||||
| YFHM_ECOLI | P76578 | yfhM | b2520 JW2504 | IM lipoprotein (SEC through IM), inserted in OM by LOL), Alpha-2-macroglobulin YfhM | Inner Membrane Lipoprotein | Identified DsbA substrate PMID: 19953543 | PMID: 19953543 | Inner Membrane Lipoprotein | E | Soluble IM Fraction | Cell inner membrane | Inner membrane lipoprotein | SEC | DSBA | LOL | yes | yes | Y | 25 | 0.18 | SpII | 17 | 28.7232 | Pos+2=D | 0 | 0 | Y | n6-13c18/19o | Unknown | 4 | |||||||
| YGAY_ECOLI | P76628 | ygaY | b2681 JW2655 b2680 | integral IM protein (SEC in IM), Putative transporter YgaY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 31 | 0.333 | TMH | 0 | 8.33787 | - | 10 | 12 | N | i12-30o42-66i78-96o102-123i135-154o166-185i217-239o245-264i276-294o300-318i339-359o365-384i | CytoplasmicMembrane | 10 | 11 | |||||
| YGAZ_ECOLI | P76630 | ygaZ | b2682 JW2657 | integral IM protein (SEC in IM), YgaZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 36 | 0.194 | TMH | 0 | 4.25735 | - | 5 | 6 | N | o22-39i51-70o76-94i140-163o175-193i205-238o | CytoplasmicMembrane | 10 | |||||||
| YQIG_ECOLI | P76655 | yqiG | b3046 JW5507 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative usher YqiG | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon (class ??); Usher. Disulfide bridge (798 817) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | pseudogene (Uniprot) | no | yes | N | 21 | 0.333 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | OuterMembrane | 10 | ||||||
| YQII_ECOLI | P76656 | yqiI | b3048 JW5509 | Fimbrial periplasmic protein (SEC through IM), YqiI | Periplasmic | Putative chaperone???usher fimbrial operon (class ??); Unknown function. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | Y | 22 | 0.868 | SpI | 21 | 14.4478 | - | 0 | 0 | Y | n4-14c21/22o | Unknown | 2 | 85 | ||||||||
| YQIJ_ECOLI | P76657 | yqiJ | b3050 JW3022 | integral IM protein (SEC in IM), YqiJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 39 | 0.125 | TMH | 0 | 3.14983 | - | 3 | 3 | N | i12-35o66-86i98-117o | CytoplasmicMembrane | 10 | 12 | ||||||
| YZGL_ECOLI | P76692 | yzgL | b3427 JW3390 | integral IM protein (SEC in IM), YzgL | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | no | no | N | 23 | 0.127 | TMH | 0 | 17.4708 | - | 2 | 2 | N | i12-40o46-69i | CytoplasmicMembrane | 10 | 29 | ||||||||
| OMPL_ECOLI | P76773 | ompL yshA | yshA | b3875 JW3846 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Porin OmpL | Outer Membrane b-barrel protein | PMID: 11080145 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | no | yes | Y | 21 | 0.672 | SpI | 20 | 13.4725 | - | 0 | 0 | Y | n6-16c20/21o | OuterMembrane | 10 | 6 | |||||||
| YQCE_ECOLI | P77031 | yqcE yqcF | yqcF | b2775 JW2746 | integral IM protein (SEC in IM), YqcE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.15 | TMH | 0 | 12.03 | - | 12 | 12 | N | i12-32o47-65i77-93o99-121i142-160o172-193i214-240o260-280i292-310o316-338i350-371o391-409i | CytoplasmicMembrane | 10 | ||||||
| HOKE_ECOLI | P77091 | hokE ybdY | ybdY | b4415 JW5084 | integral IM protein (SEC in IM), Toxic HokE | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 20 | 0.132 | SpI | 24 | 2.84692 | - | 1 | 0 | Y | n6-24c29/30o | Periplasmic | 9 | 51 | ||||
| YDCU_ECOLI | P77156 | ydcU | b1442 JW1437 | integral IM protein (SEC in IM), ABC transporter permease YdcU | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 42 | 0.107 | TMH | 0 | 17.0809 | - | 8 | 7 | N | i29-53o86-110i122-143o155-176i188-207o236-258i279-303o | CytoplasmicMembrane | 10 | |||||||
| YKFB_ECOLI | P77162 | ykfB | b0250 JW0239 | periplasmic protein (SEC through IM), YkfB | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | Prophage Integrase (EcoGene) | no | no | Y | 24 | 0.716 | SpI | 23 | 17.8556 | - | 0 | 0 | Y | n11-19c23/24o | Unknown | 2 | 59 | ||||||||
| YAGT_ECOLI | P77165 | yagT | b0286 JW0280 | periplasmic protein (TAT through IM), Aldehyde oxidoreductase iron-sulfur-binding subunit YagT | Periplasmic | TAT secretion system. YagT protein contains a 49 amino acid Tat leader peptide that allows the export of the active heterotrimer to the periplasm. Tat substrates are matured in the cytoplasm prior to their translocation. PMID: 19368556 | PMID: 17218314 PMID: 19368556 | Periplasmic | G | N/A | Periplasm | Cytoplasmic | TAT | no | yes | N | 49 | 0.297 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 4 | 89 | ||||||||
| PDEF_ECOLI | P77172 | pdeF yfgF | yfgF | b2503 JW2488 | integral IM protein (SEC in IM), Cyclic di-GMP phosphodiesterase PdeF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 64 | 0.246 | TMH | 0 | 18.0434 | - | 9 | 9 | N | o14-32i44-74o86-106i126-149o169-187i216-235o241-258i265-285o297-316i | CytoplasmicMembrane | 10 | ||||||
| ZIPA_ECOLI | P77173 | zipA | b2412 JW2404 | integral IM protein (SEC in IM), Cell division ZipA | Integral Inner Membrane | Has been purified as a complex with ZipA-EptA. PMID: 9008158 | PMID: 16079137 PMID: 9008158 | Integral Inner Membrane | B | Bout | in/out | Soluble IM Fraction | Cell inner membrane | Periplasmic with N-terminal membrane anchor (Experimental) | SRP | SEC | yes | yes | N | 25 | 0.169 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i7-26o | CytoplasmicMembrane | 10 | 96 | |||||
| RSXE_ECOLI | P77179 | rsxE rnfE ydgQ | rnfE ydgQ | b1632 JW1624 | integral IM protein (SEC in IM), Ion-translocating oxidoreductase complex subunit E RsxE | Integral Inner Membrane | PMID: 15919996 PMID: 24688744 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 38 | 0.173 | CYT | 0 | -0.200913 | - | 5 | 6 | N | i12-32o38-57i69-87o93-113i125-148o183-206i | CytoplasmicMembrane | 10 | 3 | |||||
| YKGH_ECOLI | P77180 | ykgH | b0310 JW0302 | integral IM protein (SEC in IM), YkgH | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 45 | 0.104 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i21-42o186-209i | Unknown | 2 | 25 | ||||||||
| LOMR_ECOLI | P77184 | lomR | b4570 JW5884/JW5904 b1369/b1371 | OM b-barrel protein (SEC through IM), Putative LomR | Outer Membrane b-barrel protein | H | N/A | Cytoplasmic | SEC | Insertion Sequence, pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | N | 27 | 0.169 | SpI | 26 | 0.733275 | - | 0 | 0 | N | i | OuterMembrane | 10 | ||||||||||||
| ECPB_ECOLI | P77188 | ecpB matC yagY | matC yagY | b0292 JW0286 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone EcpB | Periplasmic | Putative chaperone???usher fimbrial operon yag(class ??); Unknown function. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | no | yes | Y | 21 | 0.828 | SpI | 20 | 12.558 | - | 0 | 0 | Y | n5-15c20/21o | Unknown | 2 | 25 | |||||||
| YFCU_ECOLI | P77196 | yfcU yfcT | yfcT | b4661 JW2334/JW2335 b2337 b2338 | Fimbrial OM b-barrel protein (SEC through IM), Putative usher YfcU | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Cytoplasmic | fimbriae | SEC | pseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot) | no | yes | Y | 30 | 0.624 | SpI | 29 | 5.84101 | - | 0 | 0 | Y | n11-21c29/30o | OuterMembrane | 10 | 79 | ||||||||
| YAIT_ECOLI | P77199 | yaiT | b4580 JW0362/JW5051 b0371 b0374 | OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative YaiT | Outer Membrane b-barrel protein | Ag43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>. Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner. | PMID: 12466262 PMID: 15590781 | Outer Membrane b-barrel protein | H | N/A | Periplasmic | SRP | SEC | Autotransporter(T5S) | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | Y | 28 | 0.844 | SpI | 27 | 23.6574 | - | 0 | 0 | Y | n8-19c27/28o | Unknown | 5 | 55 | ||||||
| DSBG_ECOLI | P77202 | dsbG ybdP | ybdP | b0604 JW0597 | periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbG | Periplasmic | Disulfide bridge (126 129) PMID: 15184683 Disulfide bond-containing protein PMID: 25664544 | PMID: 15184683 PMID: 25664544 PMID: 9383195 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 18 | 0.618 | SpI | 17 | 12.1105 | - | 0 | 0 | Y | n5-12c17/18o | Periplasmic | 10 | 50 | |||||||
| CUSC_ECOLI | P77211 | cusC ibeB ylcB | ibeB ylcB | b0572 JW0561 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Cation efflux system CusC | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 PMID: 21249122 | Outer Membrane Lipoprotein | I | N/A | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 22 | 0.405 | SpII | 17 | 11.8848 | Pos+2=S | 0 | 0 | Y | n6-15c20/21o | OuterMembrane | 10 | 27 | ||||||
| CUSF_ECOLI | P77214 | cusF cusX ylcC | cusX ylcC | b0573 JW0562 | periplasmic protein (SEC through IM), Cation efflux system CusF | Periplasmic | PMID: 12813074 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.444 | SpI | 22 | 8.68332 | - | 0 | 0 | Y | n4-15c22/23o | Periplasmic | 10 | |||||||||
| YAHC_ECOLI | P77219 | yahC | b0317 JW0309 | integral IM protein (SEC in IM), YahC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 70 | 0.119 | TMH | 0 | 10.9451 | - | 4 | 5 | Y | n4-15c23/24o33-49i61-80o86-104i109-127o133-152i | CytoplasmicMembrane | 10 | |||||||
| YDFJ_ECOLI | P77228 | ydfJ | b4600 JW1536 b1543 | integral IM protein (SEC in IM), Putative transporter YdfJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | yes | no | N | 26 | 0.241 | TMH | 0 | 3.5335 | - | 9 | 11 | N | o25-49i61-79o85-105i126-152o158-180i223-242o254-273i280-301o307-328i348-368o374-394i | CytoplasmicMembrane | 10 | ||||||
| ESSQ_ECOLI | P77237 | essQ ydfS | ydfS | b1556 JW5255 | integral IM protein (SEC in IM), Prophage lysis S homolog EssQ | Integral Inner Membrane | B | Binout | in/in | IM (predicted) | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | yes | no | N | 38 | 0.166 | CYT | 0 | -0.200913 | - | 2 | 1 | Y | n7-15c20/21o36-58i | Unknown | 2 | 17 | |||||||
| CUSB_ECOLI | P77239 | cusB ylcD | ylcD | b0574 JW0563 | periplasmic peripheral IM protein (SEC through IM), Cation efflux system CusB | Peripheral inner membrane protein facing the periplasm | MFP family function as auxiliary proteins or 'adaptors', connecting a primary porter in the cytoplasmic membrane of a Gram-negative bacterium with an outer membrane factor (OMF; TC #1.B.17) protein that serves a porin or channel function in the outer membrane. | PMID: 19695261 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Membrane anchored | SEC | yes | yes | N | 29 | 0.243 | SpI | 28 | 7.5302 | - | 1 | 0 | Y | n4-16c28/29o | Unknown | 2 | 56 | ||||||||
| SFMC_ECOLI | P77249 | sfmC | b0531 JW0520 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone SfmC | Periplasmic | Potential fimbrial sfm operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 | PMID: 15838024 PMID: 18498364 PMID: 20345943 PMID: 24717922 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SRP (exp) | SEC | SURA | yes | yes | Y | 24 | 0.844 | SpI | 23 | 14.9715 | - | 1 | 0 | Y | n7-18c23/24o | Periplasmic | 10 | 28 | |||||
| ECPE_ECOLI | P77263 | ecpE matF yagV | matF yagV | b0289 JW5030 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone EcpE | Periplasmic | Putative chaperone???usher fimbrial operon yag(class ??); Unknown function. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544 | PMID: 18498364 PMID: 20345943 PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | SURA | no | yes | Y | 28 | 0.534 | SpI | 27 | 8.52618 | - | 1 | 0 | Y | n12-22c27/28o | Unknown | 2 | 17 | ||||||
| MDLA_ECOLI | P77265 | mdlA mdl | mdl | b0448 JW0438 | integral IM protein (SEC in IM), Multidrug resistance-like ATP-binding MdlA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 41 | 0.117 | TMH | 0 | 9.77173 | - | 6 | 5 | Y | n19-31c40/41o56-77i127-150o156-175i248-268o280-301i | CytoplasmicMembrane | 10 | 9 | |||||
| YPHF_ECOLI | P77269 | yphF | b2548 JW2532 | periplasmic protein (SEC through IM), ABC transporter periplasmic-binding YphF | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 PMID: 9298646 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 27 | 0.817 | SpI | 26 | 20.8859 | - | 0 | 0 | Y | n11-22c26/27o | Periplasmic | 9 | 63 | ||||||||
| PTYBC_ECOLI | P77272 | murP yfeV | yfeV | b2429 JW2422 | integral IM protein (SEC in IM), PTS system N-acetylmuramic acid-specific EIIBC component MurP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 27 | 0.108 | CYT | 0 | -0.200913 | - | 10 | 10 | N | i113-144o164-182i194-215o227-244i256-283o303-326i335-355o367-387i394-416o445-468i | CytoplasmicMembrane | 10 | ||||||
| RSXG_ECOLI | P77285 | rsxG rnfG ydgP | rnfG ydgP | b1631 JW1623 | periplasmic protein (SEC through IM), Ion-translocating oxidoreductase complex subunit G RsxG | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Cell inner membrane | Periplasmic | SEC | yes | yes | Y | 25 | 0.427 | SpI | 24 | 11.9411 | - | 0 | 0 | Y | n9-17c24/25o | Unknown | 2 | 42 | |||||||
| YDEU_ECOLI | P77286 | ydeU | b1509 JW1502 | OM b-barrel protein (SEC through IM, T5S secreted through OM), YdeU | Outer Membrane b-barrel protein | Ag43 homologue; predicted autotransporter. | PMID: 15590781 | Outer Membrane b-barrel protein | H | N/A | Cytoplasmic | SEC | Autotransporter(T5S) | pseudogene (Uniprot) | no | yes | N | 33 | 0.107 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | OuterMembrane | 9 | 3 | |||||||
| YFCV_ECOLI | P77288 | yfcV | b2339 JW2336 | Fimbrial periplasmic protein (SEC through IM), YfcV | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit. | PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | CU | yes | yes | Y | 26 | 0.533 | SpI | 25 | 14.9857 | - | 1 | 0 | Y | n7-18c25/26o | Unknown | 2 | 97 | |||||||
| GTRB_ECOLI | P77293 | yfdH | b2351 JW2347 | integral IM protein (SEC in IM), Prophage bactoprenol glucosyl transferase homolog YfdH | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene), pseudogene (Ochman & Davalos, 2006) | no | no | N | 47 | 0.115 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i228-249o261-286i | CytoplasmicMembrane | 10 | ||||||
| YDER_ECOLI | P77294 | ydeR | b1503 JW1497 | Fimbrial periplasmic protein (SEC through IM), YdeR | Periplasmic | Potential fimbrial yde operon (class ??1); Fimbrial Subunit. Disulfide bridge (39 77) | PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | CU | no | yes | Y | 24 | 0.701 | SpI | 23 | 20.0135 | - | 0 | 0 | Y | n8-18c23/24o | Unknown | 2 | 67 | ||||||
| YBET_ECOLI | P77296 | ybeT | b0647 JW0642 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Sel1-repeat-containing YbeT | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | no | yes | N | 22 | 0.112 | SpII | 18 | 5.89834 | Pos+2=I | 1 | 0 | Y | n8-17c21/22o | Unknown | 2 | 49 | |||||||||||
| DTPA_ECOLI | P77304 | dtpA tppB ydgR | tppB ydgR | b1634 JW1626 | integral IM protein (SEC in IM), Dipeptide and tripeptide permease A DtpA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 19 | 0.114 | CYT | 0 | -0.200913 | - | 14 | 14 | N | i21-40o60-81i90-107o113-131i152-173o179-199i220-239o245-264i276-295o323-341i353-371o391-411i423-444o456-477i | CytoplasmicMembrane | 10 | ||||||
| YQIK_ECOLI | P77306 | yqiK | b3051 JW3023 | integral IM protein (SEC in IM) with Band 7/SPFH domain, YqiK | Integral Inner Membrane | Fluorescent fusions of YqiK have been monitored via fluorescence microscopy. YqiK was found to be distributed diffusely throughout cytoplasm. | PMID: 15919996 PMID: 17272300 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Single-pass membrane protein | Membrane anchored | SRP | SEC | no | yes | N | 31 | 0.212 | TMH | 0 | 10.6089 | - | 2 | 2 | N | o12-32i52-72o | CytoplasmicMembrane | 10 | 101 | |||||
| FETB_ECOLI | P77307 | fetB ybbM | ybbM | b0491 JW5066 | integral IM protein (SEC in IM), Probable iron export permease FetB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.145 | CYT | 0 | -0.200913 | - | 7 | 7 | N | o6-24i36-57o63-79i91-112o118-142i191-209o215-241i | CytoplasmicMembrane | 10 | 26 | |||||
| DDPB_ECOLI | P77308 | ddpB yddR | yddR | b1486 JW1481 | integral IM protein (SEC in IM), Probable D,D-dipeptide transport system permease DdpB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 42 | 0.124 | TMH | 0 | 8.66848 | - | 7 | 7 | N | i12-32o103-124i136-158o204-223i244-267o273-294i306-330o | CytoplasmicMembrane | 10 | ||||||
| YPHD_ECOLI | P77315 | yphD | b2546 JW2530 | integral IM protein (SEC in IM), Probable ABC transporter permease YphD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 45 | 0.178 | TMH | 0 | 0.0658844 | - | 8 | 10 | N | i27-50o56-74i81-98o104-124i131-152o172-192i224-245o251-271i278-300o306-323i | CytoplasmicMembrane | 10 | 37 | ||||||
| YDEN_ECOLI | P77318 | ydeN | b1498 JW5243 | periplasmic protein (SEC through IM), sulfatase YdeN | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 30 | 0.809 | SpI | 29 | 24.3093 | - | 0 | 0 | Y | n9-20c29/30o | Unknown | 6 | 56 | ||||||||||||
| YAGS_ECOLI | P77324 | yagS | b0285 JW0279 | periplasmic protein (TAT via piggyback through IM), Aldehyde oxidoreductase FAD-binding subunit YagS | Periplasmic | TAT (piggyback) The YagT protein contains a 49 amino acid Tat leader peptide that allows the export of the active heterotrimer to the periplasm (data not shown). Tat substrates are matured in the cytoplasm prior to their translocation. The YagT protein contains a 49 amino acid Tat leader peptide that allows the export of the active heterotrimer to the periplasm (data not shown). PMID: 19368556 | PMID: 17218314 PMID: 19368556 | Periplasmic | G | N/A | Periplasm | Membrane anchored | TAT (piggyback) | no | yes | N | 16 | 0.129 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | 15 | ||||||||
| YBBY_ECOLI | P77328 | ybbY glxB4 | glxB4 | b0513 JW0501 | integral IM protein (SEC in IM), Putative purine permease YbbY | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 63 | 0.155 | TMH | 0 | 7.37862 | - | 12 | 12 | Y | n11-23c35/36o45-64i76-93o99-122i129-151o171-190i197-217o237-260i281-300o320-341i353-371o377-396i408-427o | CytoplasmicMembrane | 10 | ||||||
| BORD_ECOLI | P77330 | borD ybcU | ybcU | b0557 JW0546 | OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage Bor homolog BorD | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 Disulfide bond-containing protein PMID: 25664544 | PMID: 15174130 PMID: 25664544 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | Prophage Integrase (EcoGene) | no | no | Y | 21 | 0.303 | SpII | 16 | 21.3732 | Pos+2=A | 0 | 0 | Y | n5-14c18/19o | Unknown | 2 | 32 | |||||
| HLYE_ECOLI | P77335 | hlyE clyA hpr sheA ycgD | clyA hpr sheA ycgD | b1182 JW5181 | periplasmic & extra-cellular protein (SEC through IM), secreted in OMV), Hemolysin E, chromosomal HlyE | Periplasmic, Extra-cellular | HlyE(ClyA) forms a dodecameric transmembrane pore. The ability of ClyA to translocate to the periplasm is abolished in deletion mutants lacking the last 23 or 11 amino acid residues of the C-terminal region. Also, analysis of ClyA mutants with defined deletions and amino acid exchanges revealed that several ClyA segments which are distant of each other in the primary structure, namely, the N-terminal ??A1 region, the C-terminal region, and the hydrophobic sequence ranging from residues 89 to 101, are crucial for ClyA translocation from the E. coli cytoplasm to the periplasm. In the soluble ClyA monomer, these regions are found closely adjacent to each other in the tail domain. ClyA assembles into an oligomeric structure in solution in the absence of either bilayer membranes or detergents at physiological temperature.These oligomers can rearrange to create transmembrane pores when in contact with detergents or biological membranes. ClyA does not form transmembrane pores on E. coli lipid membranes. Recombinant E. coli overexpressing the cloned clyA gene accumulated this haemolysin in the periplasm and released only very small amounts of it into the external medium. PMID: 11902713 Disulfide bridge (87 285) PMID: 14532000 | PMID: 10027972 PMID: 11902713 PMID: 14532000 PMID: 19421192 PMID: 20511497 PMID: 24019520 PMCID: PMC2916382 | Periplasmic, Extra-cellular | G, X | N/A | Secreted Periplasm Host cell membrane | Secreted and released (Experimental) | SEC | OMV | no | yes | N | 58 | 0.117 | CYT | 0 | -0.200913 | - | 1 | 0 | N | i | Extracellular | 10 | 62 | ||||||
| MSCK_ECOLI | P77338 | mscK aefA kefA | aefA kefA | b0465 JW0454 | integral IM protein (SEC in IM), Mechanosensitive channel MscK | Integral Inner Membrane | PMID: 11985727 PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | Y | 34 | 0.323 | SpII | 26 | 9.75259 | Pos+2=Q | 12 | 11 | Y | n14-27c35/36o499-522i560-579o585-606i630-646o658-679i691-716o728-747i796-820o840-860i881-902o914-942i | CytoplasmicMembrane | 10 | ||||||
| YAFT_ECOLI | P77339 | yafT | b0217 JW0206 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YafT | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 21 | 0.197 | SpII | 18 | 23.0916 | Pos+2=A | 0 | 0 | Y | n6-16c21/22o | Unknown | 2 | 61 | |||||||
| MPPA_ECOLI | P77348 | mppA ynaH | ynaH | b1329 JW1322 | periplasmic protein (SEC through IM), murein peptide-binding protein MppA | Periplasmic | PMID: 9495761 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 23 | 0.7 | SpI | 22 | 8.93006 | - | 0 | 0 | Y | n4-14c22/23o | Periplasmic | 10 | 32 | ||||||||
| YAFU_ECOLI | P77354 | yafU | b0218 JW0207 | integral IM protein (SEC in IM), Putative YafU | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | no | no | N | 39 | 0.16 | TMH | 0 | 1.65262 | - | 2 | 2 | N | i21-38o44-64i | CytoplasmicMembrane | 10 | 73 | |||||
| DJLC_ECOLI | P77359 | djlC ybeV | ybeV | b0649 JW0644 | integral IM protein (SEC in IM), J domain-containing DjlC | Integral Inner Membrane | Hsc56 (DjlC) is a DnaJ-like protein that activates the ATPase activity of Hsc62. Hsc56 has a region that may constitute a transmembrane segment PMID: 12183460 | PMID: 12183460 | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Cytoplasmic | SRP | SEC | no | yes | N | 60 | 0.121 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o464-482i | Cytoplasmic | 8 | ||||||
| YAFY_ECOLI | P77365 | yafY | b0251 JW0240 | IM lipoprotein (SEC through IM, inserted in OM by LOL), YafY | Inner Membrane Lipoprotein | PMID: 23138451 | Inner Membrane Lipoprotein | E | N/A | Cell inner membrane | Cytoplasmic | SEC | LOL | Prophage Integrase (EcoGene) | no | no | Y | 21 | 0.302 | SpII | 20 | 17.0831 | Pos+2=D | 0 | 0 | Y | n6-17c21/22o | Unknown | 2 | 27 | |||||||
| YBCL_ECOLI | P77368 | ybcL | b0545 JW0533 | periplasmic protein (SEC through IM), UPF0098 YbcL | Periplasmic | Disulfide bridge (46 129) Disulfide bond-containing protein PMID: 25664544 | PMID: 11439028 PMID: 25664544 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | Prophage Integrase (EcoGene) | yes | no | Y | 20 | 0.717 | SpI | 19 | 19.8157 | - | 0 | 0 | Y | n4-15c19/20o | Periplasmic | 10 | 48 | |||||||
| YNFE_ECOLI | P77374 | ynfE | b1587 JW1579 | periplasmic peripheral IM protein (TAT through IM), Putative dimethyl sulfoxide reductase chain YnfE | Peripheral inner membrane protein facing the periplasm | TAT secretion system. The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. PMID: 14522592 | PMID: 14522592 PMID: 17218314 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cell membrane | Periplasmic | TAT | yes | yes | N | 28 | 0.177 | SpI | 42 | 4.96127 | - | 0 | 0 | Y | n19-37c42/43o | CytoplasmicMembrane | 9 | 21 | ||||||||
| YDHX_ECOLI | P77375 | ydhX | b1671 JW5271 | periplasmic protein (TAT-SEC through IM), Ferredoxin-like YdhX | Periplasmic | TAT secretion system. | PMID: 17218314 | Periplasmic | G | N/A | Periplasmic | TAT,SEC | yes | yes | N | 28 | 0.293 | SpI | 27 | 6.80968 | - | 1 | 0 | Y | n8-19c27/28o | Unknown | 4 | ||||||||||
| WZXC_ECOLI | P77377 | wzxC wzx | wzx | b2046 JW2031 | integral IM protein (SEC in IM), polysaccharide biosynthesis WzxC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 34 | 0.17 | TMH | 0 | 3.47452 | - | 12 | 12 | N | i12-36o42-67i79-99o111-128i149-167o173-191i289-308o320-340i361-379o385-402i414-439o445-467i | CytoplasmicMembrane | 10 | ||||||
| DJLB_ECOLI | P77381 | djlB ybeS | ybeS | b0646 JW0641 | integral IM protein (SEC in IM), J domain-containing DjlB | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Membrane anchored | SRP | SEC | no | yes | N | 32 | 0.105 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o456-474i | Cytoplasmic | 8 | 63 | ||||||||
| YDHP_ECOLI | P77389 | ydhP | b1657 JW1649 | integral IM protein (SEC in IM), transport YdhP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 53 | 0.146 | TMH | 0 | 3.82773 | - | 12 | 11 | Y | n7-16c34/35o44-64i71-89o101-122i129-152o158-180i201-224o236-257i269-287o293-311i331-349o355-374i | CytoplasmicMembrane | 10 | |||||||
| YBAT_ECOLI | P77400 | ybaT | b0486 JW0475 | integral IM protein (SEC in IM), transport YbaT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 66 | 0.222 | TMH | 0 | 20.3109 | - | 12 | 12 | N | i12-35o47-65i85-109o129-146i158-179o191-209i229-249o278-304i325-343o349-368i380-400o406-424i | CytoplasmicMembrane | 10 | |||||||
| YDHU_ECOLI | P77409 | ydhU | b1670 JW1660 | integral IM protein (SEC in IM), Putative cytochrome YdhU | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 8 | 0.115 | TMH | 0 | 1.01731 | - | 5 | 5 | N | o26-50i75-97o109-132i182-206o218-240i | CytoplasmicMembrane | 10 | 10 | ||||||||
| HYFD_ECOLI | P77416 | hyfD | b2484 JW2469 | integral IM protein (SEC in IM), Hydrogenase-4 component D HyfD | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 28 | 0.57 | SpI | 27 | 6.08873 | - | 12 | 14 | Y | n4-15c20/21o30-50i55-74o80-101i113-131o137-156i168-188o208-230i242-261o267-287i299-320o332-352i364-389o409-431i458-478o | CytoplasmicMembrane | 10 | |||||||
| HYFF_ECOLI | P77437 | hyfF | b2486 JW2471 | integral IM protein (SEC in IM), Hydrogenase-4 component F HyfF | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 24 | 0.427 | TMH | 0 | 3.63797 | - | 12 | 13 | N | o6-24i36-54o74-95i107-130o136-156i168-188o217-242i254-276o288-306i326-345o379-397i418-437o457-475i | CytoplasmicMembrane | 10 | |||||||
| DDPC_ECOLI | P77463 | ddpC yddQ | yddQ | b1485 JW1480 | integral IM protein (SEC in IM), Probable D,D-dipeptide transport system permease DdpC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 55 | 0.251 | TMH | 0 | 9.04769 | - | 5 | 6 | N | i32-54o97-121i128-150o156-174i218-240o260-282i | CytoplasmicMembrane | 10 | 15 | |||||
| SFMD_ECOLI | P77468 | sfmD | b0532 JW0521 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), SfmD | Outer Membrane b-barrel protein | Potential fimbrial sfm operon (class ??1); Usher. Disulfide bridge (840 862) | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | yes | yes | N | 36 | 0.404 | TMH | 0 | 3.9822 | - | 1 | 1 | N | i12-32o | OuterMembrane | 10 | |||||||
| PDEB_ECOLI | P77473 | pdeB ylaB | ylaB | b0457 JW5062 | integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 32 | 0.21 | CYT | 0 | -0.200913 | - | 2 | 1 | Y | n6-20c25/26o243-265i | CytoplasmicMembrane | 7 | 8 | |||||
| CUSS_ECOLI | P77485 | cusS ybcZ | ybcZ | b0570 JW5082 | integral IM protein (SEC-YidC in IM), Sensor histidine kinase CusS | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 15919996 PMID: 22108384 PMID: 25403562 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | YfgM | yes | yes | N | 27 | 0.187 | SpI | 32 | 6.24017 | - | 2 | 2 | N | i12-36o187-206i | CytoplasmicMembrane | 10 | 15 | |||
| YAGR_ECOLI | P77489 | yagR | b0284 JW0278 | periplasmic protein (TAT via piggyback through IM), Aldehyde oxidoreductase molybdenum-binding subunit YagR | Periplasmic | TAT (piggyback) The YagT protein contains a 49 amino acid Tat leader peptide that allows the export of the active heterotrimer to the periplasm. Tat substrates are matured in the cytoplasm prior to their translocation. | PMID: 19368556 | Periplasmic | G | N/A | Periplasm | Periplasmic | TAT (piggyback) | no | yes | N | 60 | 0.121 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | CytoplasmicMembrane | 9 | 27 | ||||||||
| HOKB_ECOLI | P77494 | hokB ydcB | ydcB | b4428 JW5225 | integral IM protein (SEC in IM), Toxic HokB | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Bin | out/in | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 26 | 0.105 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-24i | Periplasmic | 9 | 42 | ||||
| YBBP_ECOLI | P77504 | ybbP | b0496 JW0485 | integral IM protein (SEC in IM), ABC transporter permease YbbP | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 32 | 0.226 | TMH | 0 | 5.99165 | - | 10 | 9 | Y | n15-26c31/32o243-263i295-317o337-356i377-397o403-429i450-473o683-702i723-747o767-790i | CytoplasmicMembrane | 10 | 75 | ||||||||
| YBDJ_ECOLI | P77506 | ybdJ | b0580 JW0569 | integral IM protein (SEC in IM), YbdJ | Integral Inner Membrane | B | Binout | in/in | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 36 | 0.165 | TMH | 0 | 13.1416 | - | 2 | 1 | Y | n7-25c33/34o49-70i | CytoplasmicMembrane | 9 | |||||||||
| DPIB_ECOLI | P77510 | dpiB citA mpdB ybeP | citA mpdB ybeP | b0619 JW0611 | integral IM protein (SEC-YidC in IM), Sensor histidine kinase DpiB | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 36 | 0.245 | TMH | 0 | 4.47899 | - | 2 | 2 | N | i20-41o179-202i | CytoplasmicMembrane | 10 | |||||
| YDDL_ECOLI | P77519 | yddL | b1472 JW1468 | OM b-barrel protein (SEC through IM), YddL | Outer Membrane b-barrel protein | H | N/A | Periplasmic | SEC | pseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot) | yes | yes | Y | 22 | 0.898 | SpI | 21 | 18.2436 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 9 | 48 | |||||||||||
| YDJN_ECOLI | P77529 | ydjN | b1729 JW1718 | integral IM protein (SEC in IM), L-cystine transporter YdjN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted), Detected in IM Fraction | Cell membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 21 | 0.243 | SpI | 20 | 3.32787 | - | 9 | 11 | N | o6-22i34-51o71-92i104-126o186-205i225-245o265-284i296-313o333-358i370-389o395-415i | CytoplasmicMembrane | 10 | 9 | ||||||
| YFHR_ECOLI | P77538 | yfhR | b2534 JW2518 | integral IM protein (SEC in IM), YfhR | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Membrane | Membrane anchored | SRP | SEC | yes | yes | N | 21 | 0.132 | TMH | 0 | 7.32949 | - | 1 | 1 | N | i12-36o | CytoplasmicMembrane | 9 | 20 | ||||||||
| PRPB_ECOLI | P77541 | prpB yahQ | yahQ | b0331 JW0323 | integral IM protein (SEC in IM), 2-methylisocitrate lyase PrpB | Integral Inner Membrane | One weak transmembrane region prediction. | PMID: 12706720 | Integral Inner Membrane | B | - | IM (predicted-detected) | Cytoplasmic | SRP | SEC | no | yes | N | 51 | 0.142 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Cytoplasmic | 9 | 33 | ||||||
| YFCJ_ECOLI | P77549 | yfcJ | b2322 JW2319 | integral IM protein (SEC in IM), MFS-type transporter YfcJ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 45 | 0.121 | TMH | 0 | 9.50937 | - | 12 | 12 | N | i20-42o48-66i87-106o112-138i150-171o177-198i210-243o249-269i281-299o305-328i340-359o365-389i | CytoplasmicMembrane | 10 | |||||||
| YAHJ_ECOLI | P77554 | yahJ | b0324 JW0316 | periplasmic protein (TAT-SEC through IM), YahJ | Periplasmic | TAT secretion system. | PMID: 17218314 | Periplasmic | G | N/A | Periplasmic | TAT,SEC | no | yes | Y | 34 | 0.674 | SpI | 33 | 11.0447 | - | 0 | 0 | Y | n18-28c33/34o | Unknown | 4 | 12 | |||||||||
| YAIW_ECOLI | P77562 | yaiW | b0378 JW0369 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YaiW | Outer Membrane Lipoprotein | Disulfide bond-containing protein PMID: 25664544 | PMID: 20932056 PMID: 25664544 | Outer Membrane Lipoprotein | I | N/A | Outer membrane Lipoprotein | SEC | LOL | no | yes | Y | 26 | 0.354 | SpII | 20 | 28.9818 | Pos+2=S | 0 | 0 | Y | n7-18c23/24o | Unknown | 2 | 10 | ||||||||
| PTFC1_ECOLI | P77579 | fryC ypdG | ypdG | b2386 JW2383 | integral IM protein (SEC in IM), Fructose-like permease IIC component 1 FryC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.15 | SpI | 19 | 5.67099 | - | 10 | 9 | Y | n7-14c19/20o43-68i95-119o160-178i190-216o239-256i277-297o317-335i342-361o381-402i | CytoplasmicMembrane | 10 | ||||||
| YDEQ_ECOLI | P77588 | ydeQ | b1502 JW1496 | Fimbrial periplasmic protein (SEC through IM), YdeQ | Periplasmic | Potential fimbrial yde operon (class ??1); Potential tip-adhesin. | PMID: 18498364 PMID: 19820722 PMID: 20345943 | Periplasmic | G | N/A | Fimbrium | Periplasmic | fimbriae | SEC | SURA | CU | no | yes | N | 25 | 0.739 | SpI | 24 | 10.2575 | - | 0 | 0 | Y | n9-19c24/25o | Unknown | 2 | 61 | |||||
| MHPT_ECOLI | P77589 | mhpT yaiK | yaiK | b0353 JW5046 | integral IM protein (SEC in IM), 3-(3-hydroxy-phenyl)propionate transporter MhpT | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.177 | TMH | 0 | 11.0732 | - | 12 | 11 | Y | n15-26c44/45o54-74i81-101o107-128i140-163o169-189i209-235o255-273i280-300o306-328i340-359o371-391i | CytoplasmicMembrane | 10 | ||||||
| YFCS_ECOLI | P77599 | yfcS | b2336 JW2333 | Fimbrial periplasmic protein (SEC through IM), Probable chaperone YfcS | Periplasmic | Putative chaperone???usher fimbrial operon yfc (class ??); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasm | Periplasmic | fimbriae | SEC | SURA | yes | yes | Y | 29 | 0.747 | SpI | 28 | 11.2467 | - | 0 | 0 | Y | n10-21c28/29o | Periplasmic | 10 | 77 | ||||||
| YAGL_ECOLI | P77607 | yagL | b0278 JW0272 | integral IM protein (SEC in IM), YagL | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cytoplasmic | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 32 | 0.112 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i12-32o | Cytoplasmic | 8 | 13 | ||||||||
| ANSP_ECOLI | P77610 | ansP yncF | yncF | b1453 JW5234 | integral IM protein (SEC-YidC in IM), L-asparagine permease AnsP | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. | PMID: 15919996 PMID: 22108384 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC-YidC | yes | yes | N | 65 | 0.134 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i37-56o62-86i107-133o145-167i174-194o214-239i260-282o302-330i351-374o380-403i424-442o448-468i | CytoplasmicMembrane | 10 | |||||
| YQIH_ECOLI | P77616 | yqiH | b3047 JW5508 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Chaperone YqiH | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon (class ??); Chaperone. | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Periplasm | Outer Membrane ??-barrel protein | fimbriae | SEC | BAM | no | yes | Y | 26 | 0.426 | SpI | 25 | 12.7072 | - | 1 | 0 | Y | n9-20c25/26o | Periplasmic | 10 | 21 | ||||||
| YFEW_ECOLI | P77619 | yfeW | b2430 JW5395 | periplasmic protein (SEC through IM), UPF0214 YfeW | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.512 | SpI | 19 | 10.3062 | - | 0 | 0 | Y | n6-14c19/20o | Periplasmic | 9 | |||||||||||||
| LSRC_ECOLI | P77672 | lsrC ydeY | ydeY | b1514 JW1507 | integral IM protein (SEC in IM), Autoinducer 2 import system permease LsrC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 30 | 0.13 | TMH | 0 | 7.11134 | - | 9 | 7 | Y | n12-23c29/30o39-60i72-105o111-135i155-178o208-232i244-271o291-309i | CytoplasmicMembrane | 10 | ||||||
| GTRA_ECOLI | P77682 | yfdG | b2350 JW2346 | integral IM protein (SEC in IM), Prophage bactoprenol-linked glucose translocase homolog YfdG | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | no | no | N | 38 | 0.341 | TMH | 0 | 11.761 | - | 4 | 4 | N | i12-30o36-55i67-85o91-110i | CytoplasmicMembrane | 10 | ||||||
| ECPD_ECOLI | P77694 | ecpD matE yagW | matE yagW | b0290 JW0284 | Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Fimbria adhesin EcpD EcpD | Outer Membrane b-barrel protein | Putative chaperone???usher fimbrial operon yag(class ??); Unknown function. Putative Outer membrane protein (BOMB prediction + SignalP 98% prediction). | PMID: 20345943 | Outer Membrane b-barrel protein | H | N/A | Fimbrium | Cytoplasmic | fimbriae | SEC | BAM | no | yes | N | 32 | 0.295 | SpI | 23 | 7.3263 | - | 0 | 0 | Y | n5-16c23/24o | Unknown | 4 | 2 | |||||
| YCJP_ECOLI | P77716 | ycjP | b1312 JW1305 | integral IM protein (SEC in IM), ABC transporter permease YcjP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 40 | 0.318 | TMH | 0 | 14.4011 | - | 7 | 6 | N | i12-36o78-100i112-139o145-165i186-211o243-264i | CytoplasmicMembrane | 10 | |||||||
| YBAY_ECOLI | P77717 | ybaY | b0453 JW0443 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YbaY | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 18 | 0.379 | SpII | 18 | 21.022 | Pos+2=A | 0 | 0 | Y | n3-14c19/20o | Periplasmic | 9 | ||||||||
| YAJR_ECOLI | P77726 | yajR | b0427 JW5059 | integral IM protein (SEC in IM), transport YajR | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 37 | 0.111 | TMH | 0 | 13.9587 | - | 12 | 12 | N | i21-42o48-68i80-98o104-124i136-158o164-186i217-240o252-273i280-296o302-319i340-361o367-388i | CytoplasmicMembrane | 10 | |||||||
| FOCB_ECOLI | P77733 | focB | b2492 JW2477 | integral IM protein (SEC in IM), Probable formate transporter 2 FocB | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 46 | 0.177 | CYT | 0 | -0.200913 | - | 6 | 6 | N | i34-56o68-89i109-133o164-182i194-222o254-276i | CytoplasmicMembrane | 10 | 74 | ||||||
| OMPN_ECOLI | P77747 | ompN ynaG | ynaG | b1377 JW1371 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpN | Outer Membrane b-barrel protein | PMID: 20932056 PMID: 9642192 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane; Multi-pass membrane protein | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | yes | yes | Y | 22 | 0.895 | SpI | 21 | 24.6239 | - | 0 | 0 | Y | n5-16c21/22o | OuterMembrane | 10 | 10 | |||||||
| SPY_ECOLI | P77754 | spy | b1743 JW1732 | periplasmic protein (SEC through IM), chaperone Spy | Periplasmic | PMID: 9068658 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | yes | yes | Y | 24 | 0.817 | SpI | 23 | 20.7622 | - | 0 | 0 | Y | n4-15c23/24o | Periplasmic | 10 | 104 | |||||||||
| ARNC_ECOLI | P77757 | arnC pmrF yfbF | pmrF yfbF | b2254 JW2248 | integral IM protein (SEC in IM), Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase ArnC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 34 | 0.113 | CYT | 0 | -0.200913 | - | 2 | 2 | N | i238-259o271-295i | CytoplasmicMembrane | 10 | 13 | |||||
| BAMB_ECOLI | P77774 | bamB yfgL | yfgL | b2512 JW2496 | OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamB | Outer Membrane Lipoprotein | Part of bam complex. Interacts directry with BamA. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 15174130 | PMID: 15174130 PMID: 15851030 PMID: 15911532 PMID: 20932056 PMID: 21236263 PMID: 21370981 PMID: 21823654 | Outer Membrane Lipoprotein | I | Soluble IM Fraction | Cell outer membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | Y | 27 | 0.152 | SpII | 19 | 14.7873 | Pos+2=S | 0 | 0 | Y | n6-17c25/26o | OuterMembrane | 10 | |||||||
| YNFF_ECOLI | P77783 | ynfF | b1588 JW5260 | periplasmic peripheral IM protein (TAT-SEC through IM), Probable dimethyl sulfoxide reductase chain YnfF | Peripheral inner membrane protein facing the periplasm | Verified Tat substrate: YnfF has a Tat-only (Class II) predicted 45 aa signal peptide (Tullman-Ercek, 2007). The physiological substrate and relevance of the YnfFGH S- and N-oxide reductase is unknown.; DmsA paralog.So far, hydroxy pyridine N-oxide is the The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. PMID: 14522592 | PMID: 14522592 PMID: 17218314 PMID: 19415239 | Peripheral inner membrane protein facing the periplasm | F2 | N/A | Cell membrane | Periplasmic | TAT,SEC | yes | yes | N | 46 | 0.406 | SpI | 45 | 11.1244 | - | 0 | 0 | Y | n24-37c45/46o | CytoplasmicMembrane | 9 | 9 | ||||||||
| YDES_ECOLI | P77789 | ydeS | b1504 JW1498 | Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), YdeS | Peripheral outer membrane protein facing the extra-cellular space | Potential fimbrial yde operon (class ??1); Fimbrial Subunit. Disulfide bridge (38 78) | PMID: 19820722 PMID: 20345943 | Peripheral outer membrane protein facing the extra-cellular space | F4 | N/A | Fimbrium | Membrane anchored | fimbriae | SEC | CU | no | yes | Y | 23 | 0.426 | SpI | 22 | 11.5353 | - | 1 | 0 | Y | n6-17c22/23o | Extracellular | 10 | 79 | ||||||
| ECPC_ECOLI | P77802 | ecpC matD yagX | matD yagX | b0291 JW0285 | Fimbrial periplasmic protein (SEC through IM), Probable usher EcpC | Periplasmic | Putative chaperone???usher fimbrial operon yag(class ??); Usher. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 PMID: 20345943 | Periplasmic | G | N/A | Periplasmic | fimbriae | SEC | SURA | no | yes | Y | 30 | 0.522 | SpI | 29 | 1.61886 | - | 0 | 0 | Y | n12-23c29/30o | Unknown | 4 | |||||||
| YDGA_ECOLI | P77804 | ydgA | b1614 JW1606 | periplasmic peripheral IM protein (SEC through IM), YdgA | Peripheral inner membrane protein facing the periplasm | Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 | PMID: 16079137 PMID: 21541338 | Peripheral inner membrane protein facing the periplasm | F2 | Soluble IM Fraction | Cell inner membrane | Cytoplasmic | SEC | yes | yes | N | 25 | 0.174 | SpI | 24 | 3.81151 | - | 1 | 0 | Y | n4-14c19/20o | CytoplasmicMembrane | 10 | 25 | ||||||||
| HYFC_ECOLI | P77858 | hyfC | b2483 JW2468 | integral IM protein (SEC in IM), Hydrogenase-4 component C HyfC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 19 | 0.152 | CYT | 0 | -0.200913 | - | 8 | 8 | N | o12-32i77-99o105-127i139-161o173-195i231-249o255-278i290-311o | CytoplasmicMembrane | 10 | |||||||
| YNJE_ECOLI | P78067 | ynjE | b1757 JW5287 | periplasmic protein (SEC through IM), Thiosulfate sulfurtransferase YnjE | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 | PMID: 18498364 PMID: 25403562 | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | SURA,YfgM | yes | yes | Y | 24 | 0.698 | SpI | 23 | 21.4185 | - | 0 | 0 | Y | n8-18c23/24o | Periplasmic | 10 | 40 | |||||||
| ATOS_ECOLI | Q06067 | atoS | b2219 JW2213 | integral IM protein (SEC in IM), Signal transduction histidine-kinase AtoS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.106 | TMH | 0 | 5.06915 | - | 2 | 2 | N | o16-35i192-210o | CytoplasmicMembrane | 10 | 27 | ||||||
| YAHH_ECOLI | Q2EEQ3 | yahH | b0322 JW5893 | integral IM protein (SEC in IM), Putative YahH | Membrane anchored by EchoLOCATION | Integral Inner Membrane | B | - | N/A | Membrane anchored | SEC | pseudogene (Uniprot), pseudogene (Ecogene) | no | no | N | 42 | 0.264 | CYT | 0 | -0.200913 | - | 0 | 0 | N | i | Unknown | 2 | ||||||||||
| YNID_ECOLI | Q2EES1 | yniD | b4535 JW5911 | integral IM protein (SEC in IM), YniD | Integral Inner Membrane | Small membrane protein detected experimentally. | PMID: 19121005 | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Membrane | Membrane anchored | SRP | SEC | no | yes | N | 31 | 0.1 | TMH | 0 | 4.22082 | - | 1 | 0 | Y | n14-26c30/31o | CytoplasmicMembrane | 9 | ||||||
| YOHO_ECOLI | Q2EES6 | yohO | b4542 JW5354 | integral IM protein (SEC in IM), UPF0387 YohO | Integral Inner Membrane | Small membrane protein detected experimentally | PMID: 19121005 | Integral Inner Membrane | B | Binout | out/in | N/A | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 26 | 0.149 | TMH | 0 | 4.51604 | - | 1 | 1 | N | o6-31i | CytoplasmicMembrane | 9 | ||||||
| YPFN_ECOLI | Q2EET2 | ypfN | b4547 JW2457 | integral IM protein (SEC in IM), UPF0370 YpfN | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cell membrane | Membrane anchored | SRP | SEC | no | yes | N | 26 | 0.107 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o6-24i | Unknown | 2 | 71 | ||||||||
| YTJA_ECOLI | Q2M5U1 | ytjA | b4568 JW5891 | integral IM protein (SEC in IM), UPF0391 YtjA | Integral Inner Membrane | B | Binout | in/in | N/A | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.166 | TMH | 0 | 11.6664 | - | 2 | 1 | Y | n4-14c19/20o29-49i | CytoplasmicMembrane | 9 | |||||||||
| YSAB_ECOLI | Q2M7M3 | ysaB | b4553 JW3532 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YsaB | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein | SEC | LOL | yes | yes | Y | 27 | 0.418 | SpII | 17 | 15.6662 | Pos+2=S | 0 | 0 | Y | n5-16c26/27o | Unknown | 2 | 36 | ||||||||||
| YICS_ECOLI | Q2M7X4 | yicS | b4555 JW5965 | periplasmic protein (SEC through IM), YicS | Periplasmic | Disulfide bond-containing protein PMID: 25664544 | PMID: 25664544 | Periplasmic | G | N/A | Periplasmic | SEC | yes | yes | N | 22 | 0.681 | SpI | 21 | 10.9898 | - | 0 | 0 | Y | n4-14c21/22o | Unknown | 2 | ||||||||||
| YOBH_ECOLI | Q2MB16 | yobH | b4536 JW5298 | integral IM protein (SEC in IM), YobH | Signal peptide predicted, single transmembrane helice predicted which would be removed upon signal peptide cleavage. Putative outer membrane or exported. Taxonomy: Klebsiella pneumoniae. | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | no | yes | N | 34 | 0.169 | TMH | 0 | 5.54741 | - | 1 | 0 | Y | n10-20c24/25o | CytoplasmicMembrane | 9 | 57 | ||||||||
| SIRB2_ECOLI | Q46755 | ychQ sirB2 | sirB2 | b1213 JW1204 | integral IM protein (SEC in IM), YchQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 39 | 0.138 | TMH | 0 | 6.48818 | - | 4 | 4 | N | o6-28i40-61o73-93i105-123o | CytoplasmicMembrane | 10 | 25 | |||||
| PBL_ECOLI | Q46790 | pbl | b2854 | periplasmic protein (SEC through IM), Putative PG-binding-like protein Pbl | Periplasmic | G | N/A | Periplasm | Cytoplasmic | SEC | pseudogene (Uniprot) | no | no | Y | 25 | 0.548 | SpI | 24 | 2.39101 | - | 0 | 0 | Y | n8-19c24/25o | Periplasmic | 9 | 28 | ||||||||||
| YGEQ_ECOLI | Q46797 | ygeQ | b2863 JW5461 | periplasmic protein (SEC through IM), YgeQ | Periplasmic | G | N/A | Periplasmic | SEC | pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006) | no | no | Y | 37 | 0.449 | SpI | 36 | 11.1359 | - | 0 | 0 | Y | n20-31c36/37o | Unknown | 2 | 68 | |||||||||||
| YGER_ECOLI | Q46798 | ygeR | b2865 JW2833 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YgeR | Outer Membrane Lipoprotein | Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 PMID: 20932056 | Outer Membrane Lipoprotein | I | N/A | Cell inner membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | yes | yes | N | 33 | 0.262 | SpII | 25 | 22.1379 | Pos+2=S | 0 | 0 | Y | n11-23c28/29o | OuterMembrane | 9 | 58 | |||||||
| GHXQ_ECOLI | Q46817 | ghxQ ygfQ ygfR | ygfQ ygfR | b4464 JW5467 | integral IM protein (SEC in IM), Guanine/hypoxanthine permease GhxQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | yes | no | N | 65 | 0.11 | CYT | 0 | -0.200913 | - | 12 | 11 | N | i35-55o61-80i87-107o113-135i147-171o177-203i210-230o250-276i348-375o395-422i434-454o | CytoplasmicMembrane | 10 | |||||
| UACT_ECOLI | Q46821 | uacT ygfU | ygfU | b2888 JW5470 | integral IM protein (SEC in IM), Uric acid transporter UacT | Integral Inner Membrane | PMID: 15919996 PMID: 22437829 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.122 | CYT | 0 | -0.200913 | - | 12 | 12 | N | i30-52o64-86i93-112o118-138i145-167o179-198i205-225o255-278i332-354o360-381i393-413o419-442i | CytoplasmicMembrane | 10 | ||||||
| YGFX_ECOLI | Q46824 | ygfX cptA | cptA | b2896 JW2864 | integral IM protein (SEC in IM), YgfX | Integral Inner Membrane | PMID: 22239607 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | yes | yes | N | 39 | 0.141 | TMH | 0 | 5.61025 | - | 1 | 2 | N | i12-32o38-54i | CytoplasmicMembrane | 9 | 33 | |||||
| YQGA_ECOLI | Q46831 | yqgA | b2966 JW2934 | integral IM protein (SEC in IM), YqgA | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Cell membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 20 | 0.108 | TMH | 0 | 3.98827 | - | 6 | 8 | N | o6-23i30-50o56-75i103-123o135-157i164-181o187-206i213-233o | CytoplasmicMembrane | 10 | |||||||||
| YGHD_ECOLI | Q46832 | yghD ecfC | ecfC | b2968 JW2935 | integral IM protein (SEC in IM), Putative type II secretion system M-type YghD | Integral Inner Membrane | B | Bout | in/out | IM (predicted) | Cell inner membrane | Membrane anchored | SRP | SEC | no | yes | N | 43 | 0.102 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i38-57o | Unknown | 2 | 28 | |||||||
| YGHE_ECOLI | Q46833 | yghE | b2969 | integral IM protein (SEC in IM), Putative type II secretion system L-type YghE | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | pseudogene (Uniprot) | no | no | N | 38 | 0.296 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i136-159o | Unknown | 2 | ||||||||
| YGHF_ECOLI | Q46834 | yghF | b2970 JW5484 | periplasmic protein (SEC through IM), Putative type II secretion system C-type YghF | Periplasmic | G | N/A | Periplasm | Cytoplasmic | SEC | pseudogene (Uniprot) | no | yes | N | 43 | 0.145 | SpI | 16 | 1.1016 | - | 0 | 0 | Y | n2-9c14/15o | CytoplasmicMembrane | 9 | 36 | ||||||||||
| YGHG_ECOLI | Q46835 | yghG | b2971 JW2938 | OM lipoprotein (SEC through IM, inserted in OM by LOL), YghG | Outer Membrane Lipoprotein | Belongs to the GSP C family. Proven pignal peptidase II substrate. PMID: 15174130 | PMID: 15174130 | Outer Membrane Lipoprotein | I | N/A | Cell membrane | Outer membrane Lipoprotein (Experimental) | SEC | LOL | no | yes | Y | 29 | 0.253 | SpII | 24 | 17.6171 | Pos+2=A | 0 | 0 | Y | n10-22c27/28o | Unknown | 2 | 40 | |||||||
| PPPA_ECOLI | Q46836 | pppA yghH | yghH | b2972 JW2939 | integral IM protein (SEC in IM), Leader peptidase PppA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | no | yes | N | 18 | 0.178 | TMH | 0 | 3.73276 | - | 7 | 7 | N | o12-33i102-119o125-142i149-167o179-199i211-241o247-265i | CytoplasmicMembrane | 10 | ||||||
| GLCA_ECOLI | Q46839 | glcA yghK | yghK | b2975 JW2942 | integral IM protein (SEC in IM), Glycolate permease GlcA | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein(experimental) | SRP | SEC | yes | yes | N | 34 | 0.266 | TMH | 0 | 14.6297 | - | 13 | 13 | N | i12-35o41-58i65-91o119-147i154-179o199-217i224-246o252-269i307-326o377-399i411-433o439-464i537-559o | CytoplasmicMembrane | 10 | ||||||
| YGHQ_ECOLI | Q46841 | yghQ | b2983 JW5490 | integral IM protein (SEC in IM), YghQ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | pseudogene (Ochman & Davalos, 2006) | no | yes | N | 53 | 0.148 | TMH | 0 | 1.31655 | - | 6 | 5 | N | o30-58i101-122o187-210i261-282o311-335i | CytoplasmicMembrane | 10 | ||||||
| YGHS_ECOLI | Q46843 | yghS | b2985 JW5491 | integral IM protein (SEC in IM), ATP-binding YghS | Integral Inner Membrane | B | Binout | in/out | IM (predicted) | Cytoplasmic | SRP | SEC | no | yes | N | 33 | 0.133 | CYT | 0 | -0.200913 | - | 0 | 1 | N | i161-178o | Cytoplasmic | 8 | 35 | |||||||||
| YGHT_ECOLI | Q46844 | yghT | b2986 JW2954 | integral IM protein (SEC in IM), ATP-binding YghT | Integral Inner Membrane | B | Bin | out/in | IM (predicted) | Cytoplasmic | SRP | SEC | no | yes | N | 36 | 0.139 | CYT | 0 | -0.200913 | - | 0 | 1 | N | o77-95i | Cytoplasmic | 8 | 50 | |||||||||
| YQHG_ECOLI | Q46858 | yqhG yqhF | yqhF | b3013 JW5500 | periplasmic protein (SEC through IM), YqhG | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. | PMID: 18498364 | Periplasmic | G | N/A | Periplasmic | SEC | SURA | no | yes | Y | 19 | 0.889 | SpI | 18 | 17.8226 | - | 0 | 0 | Y | n3-14c18/19o | Unknown | 4 | 84 | |||||||
| YGIS_ECOLI | Q46863 | ygiS | b3020 JW2988 | periplasmic protein (SEC through IM), Probable deoxycholate-binding periplasmic YgiS | Periplasmic | G | N/A | Periplasm | Periplasmic | SEC | yes | yes | Y | 21 | 0.755 | SpI | 20 | 13.5931 | - | 0 | 0 | Y | n6-16c20/21o | Periplasmic | 9 | 27 | |||||||||||
| YGIZ_ECOLI | Q46867 | ygiZ | b3027 JW2995 | integral IM protein (SEC in IM), YgiZ | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 31 | 0.138 | TMH | 0 | 4.05338 | - | 3 | 3 | N | i12-29o54-72i84-103o | CytoplasmicMembrane | 10 | 27 | ||||||
| LTND_ECOLI | Q46888 | ltnD ygbJ | ygbJ | b2736 JW2706 | integral IM protein (SEC in IM), L-threonate dehydrogenase LtnD | Belongs to the 3-hydroxyisobutyrate dehydrogenase family. | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane anchored | SRP | SEC | no | yes | N | 25 | 0.132 | SpI | 24 | 0.774969 | - | 1 | 0 | N | i | Cytoplasmic | 9 | 62 | |||||||
| YGBN_ECOLI | Q46892 | ygbN | b2740 JW2710 | integral IM protein (SEC in IM), permease YgbN | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein (Experimental) | SRP | SEC | yes | yes | N | 43 | 0.315 | TMH | 0 | 8.28022 | - | 11 | 11 | N | o6-22i29-47o53-75i102-133o175-197i237-261o273-294i306-331o351-380i392-409o429-453i | CytoplasmicMembrane | 10 | |||||||
| YGCS_ECOLI | Q46909 | ygcS | b2771 JW5845 | integral IM protein (SEC in IM), metabolite transport YgcS | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | no | yes | N | 37 | 0.129 | TMH | 0 | 7.45576 | - | 12 | 12 | N | i20-42o54-74i86-104o110-132i144-167o173-194i250-270o282-303i312-333o339-358i370-395o401-421i | CytoplasmicMembrane | 10 | |||||||
| GUDP_ECOLI | Q46916 | gudP ygcZ | ygcZ | b2789 JW2760 | integral IM protein (SEC in IM), Probable glucarate transporter GudP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 48 | 0.146 | TMH | 0 | 6.1738 | - | 12 | 12 | N | i17-34o54-75i87-105o111-129i150-173o179-198i255-280o292-316i328-347o353-374i386-408o414-435i | CytoplasmicMembrane | 10 | ||||||
| TCDA_ECOLI | Q46927 | tcdA csdL, ygdL | csdL, ygdL | b2812 JW2783 | integral IM protein (SEC in IM), tRNA threonylcarbamoyladenosine dehydratase TcdA | Integral Inner Membrane | PMID: 15174130 | Integral Inner Membrane | B | Bout | out/in | IM (predicted) | Membrane | Membrane anchored | SEC | yes | yes | N | 51 | 0.13 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o238-257i | Cytoplasmic | 9 | 68 | ||||||
| YQEI_ECOLI | Q46942 | yqeI | b2847 JW2815 | nucleoid & integral IM protein (SEC in IM), YqeI | Integral Inner Membrane, Nucleoid | PMID: 23138451 | Integral Inner Membrane, Nucleoid | B, N | IM (predicted) | Cytoplasmic | SRP | SEC | no | yes | N | 51 | 0.158 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i157-174o | Cytoplasmic | 8 | 15 | |||||||||
| YQEJ_ECOLI | Q46943 | yqeJ | b2848 JW5455 | integral IM protein (SEC in IM), YqeJ | Integral Inner Membrane | B | Bout | in/out | N/A | Membrane | Periplasmic | SRP | SEC | no | yes | N | 28 | 0.216 | SpI | 27 | 6.43067 | - | 1 | 1 | N | i7-27o | Unknown | 2 | |||||||||
| HCAT_ECOLI | Q47142 | hcaT yfhS | yfhS | b2536 JW2520 | integral IM protein (SEC in IM), Probable 3-phenylpropionic acid transporter HcaT | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | yes | yes | N | 20 | 0.106 | TMH | 0 | 10.8707 | - | 12 | 12 | N | i7-29o41-60i72-89o95-113i134-152o158-176i207-229o241-257i269-286o292-316i328-350o356-373i | CytoplasmicMembrane | 10 | ||||||||
| FADE_ECOLI | Q47146 | fadE yafH | yafH | b0221 JW5020 | integral IM protein (SEC in IM), Acyl-coenzyme A dehydrogenase FadE | Integral Inner Membrane | Trigger factor-sensitive aggregation. | PMID: 19737520 | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Integral Membrane Protein | SRP,TF | SEC | yes | yes | N | 46 | 0.138 | TMH | 0 | 11.7565 | - | 2 | 2 | Y | n3-13c17/18o27-58i279-296o | CytoplasmicMembrane | 9 | ||||||
| YAFL_ECOLI | Q47151 | yafL | b0227 JW0217 | periplasmic protein (SEC through IM), Probable endopeptidase YafL | Periplasmic | G | N/A | Cell membrane | Periplasmic | SEC | yes | yes | Y | 26 | 0.582 | SpI | 27 | 11.7588 | - | 1 | 0 | Y | n8-19c37/38o | Unknown | 4 | 34 | |||||||||||
| LFHA_ECOLI | Q47153 | lfhA fhiA | fhiA | b0229 JW5811 | integral IM protein (SEC in IM), Putative truncated export/assembly LfhA | Integral Inner Membrane | Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) | PMID: 15911532 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | pseudogene (Uniprot) | yes | no | N | 59 | 0.236 | CYT | 0 | -0.200913 | - | 3 | 3 | Y | n7-17c21/22o86-106i127-148o168-199i | CytoplasmicMembrane | 10 | 8 | |||
| ARNE_ECOLI | Q47377 | arnE pmrL yfbW | pmrL yfbW | b4544 JW2252 | integral IM protein (SEC in IM), Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/out | IM (predicted) | Cell inner membrane; Multi-pass membrane protein | Integral Membrane Protein | SRP | SEC | yes | yes | N | 16 | 0.131 | CYT | 0 | -0.200913 | - | 3 | 3 | Y | n4-15c21/22o37-58i65-85o91-110i | CytoplasmicMembrane | 10 | 77 | |||||
| YAIO_ECOLI | Q47534 | yaiO | b0358 JW0349 | periplasmic protein (SEC through IM), YaiO | <a href="http://beta-barrel.tulane.edu/">TMBB-DB</a> tool predicts this protein as an outer membrane beta barrel protein. | Periplasmic | G | N/A | Cell outer membrane | Periplasmic | SEC | no | yes | Y | 20 | 0.841 | SpI | 19 | 12.701 | - | 1 | 0 | Y | n5-15c19/20o | Unknown | 2 | 5 | ||||||||||
| YAIP_ECOLI | Q47536 | yaiP | b0363 JW0355 | integral IM protein (SEC in IM), glycosyltransferase YaiP | Integral Inner Membrane | B | Bpoly | out/out | IM (predicted) | Integral Membrane Protein | SRP | SEC | no | yes | N | 47 | 0.167 | CYT | 0 | -0.200913 | - | 4 | 3 | Y | n7-18c23/24o270-294i306-329o341-363i | CytoplasmicMembrane | 10 | 39 | |||||||||
| TAUA_ECOLI | Q47537 | tauA ssiA yaiR | ssiA yaiR | b0365 JW0357 | periplasmic protein (SEC through IM), Taurine-binding periplasmic TauA | Periplasmic | PMID: 8774726 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | no | yes | Y | 23 | 0.816 | SpI | 22 | 16.0488 | - | 0 | 0 | Y | n8-18c22/23o | Periplasmic | 9 | |||||||||
| TAUC_ECOLI | Q47539 | tauC ssiC yaiJ | ssiC yaiJ | b0367 JW0359 | integral IM protein (SEC in IM), Taurine transport system permease TauC | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | no | yes | N | 43 | 0.113 | TMH | 0 | 4.41917 | - | 6 | 6 | N | i20-41o87-109i121-140o146-165i186-207o236-256i | CytoplasmicMembrane | 10 | 9 | |||||
| SAPA_ECOLI | Q47622 | sapA | b1294 JW1287 | periplasmic protein (SEC through IM), Probable ABC transporter periplasmic-binding SapA | Periplasmic | Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9593292 | PMID: 18498364 PMID: 9593292 | Periplasmic | G | N/A | Periplasm | Periplasmic (Experimental) | SEC | SURA | yes | yes | Y | 22 | 0.865 | SpI | 21 | 14.8036 | - | 0 | 0 | Y | n4-15c21/22o | Periplasmic | 10 | 30 | |||||||
| MMUP_ECOLI | Q47689 | mmuP ykfD | ykfD | b0260 JW5027 | integral IM protein (SEC in IM), Probable S-methylmethionine permease MmuP | Integral Inner Membrane | PMID: 15919996 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted) | Cell inner membrane | Integral Membrane Protein | SRP | SEC | Prophage Integrase (EcoGene) | yes | no | N | 34 | 0.108 | TMH | 0 | 11.5259 | - | 12 | 12 | N | i20-40o46-63i97-121o127-149i161-182o202-227i248-270o290-315i335-356o362-387i407-428o434-452i | CytoplasmicMembrane | 10 | |||||
| YFEK_ECOLI | Q47702 | yfeK | b2419 JW2412 | periplasmic protein (SEC through IM), YfeK | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 20 | 0.758 | SpI | 19 | 2.85333 | - | 0 | 0 | Y | n4-15c19/20o | Unknown | 2 | 77 | ||||||||||||
| UIDC_ECOLI | Q47706 | uidC gusC | gusC | b1615 JW1607 | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Membrane-associated UidC UidC | Outer Membrane b-barrel protein | PMID: 15774881 | Outer Membrane b-barrel protein | H | N/A | Cell outer membrane | Outer Membrane ??-barrel protein (Experimental) | SEC | BAM | no | yes | Y | 24 | 0.665 | SpI | 23 | 13.3065 | - | 1 | 0 | Y | n4-15c23/24o | OuterMembrane | 9 | 3 | |||||||
| YQJK_ECOLI | Q47710 | yqjK | b3100 JW3071 | integral IM protein (SEC in IM), YqjK | Integral Inner Membrane | B | Binout | in/out | IM (predicted), Detected in IM Fraction | Membrane anchored | SRP | SEC | yes | yes | N | 62 | 0.14 | CYT | 0 | -0.200913 | - | 1 | 1 | N | i47-65o | Unknown | 2 | 30 | |||||||||
| COPA_ECOLI | Q59385 | copA atcU f834 ybaR | atcU f834 ybaR | b0484 JW0473 | integral IM protein (SEC-YidC in IM), Copper-exporting P-type ATPase CopA | Integral Inner Membrane | Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 10639134 Disulfide bond-containing protein PMID: 25664544 | PMID: 10639134 PMID: 15919996 PMID: 22108384 PMID: 25664544 | Integral Inner Membrane | B | Bpoly | in/in | IM (predicted), Detected in IM Fraction | Copper-exporting P-type ATPase: Cell inner membrane | Integral Membrane Protein (Experimental) | SRP | SEC-YidC | no | yes | N | 50 | 0.162 | CYT | 0 | -0.200913 | - | 8 | 8 | N | i185-205o217-238i245-264o284-302i436-458o464-487i778-797o803-824i | CytoplasmicMembrane | 10 | 21 | ||||
| YJDP_ECOLI | Q6BEX5 | yjdP | b4487 JW5890 | periplasmic protein (SEC through IM), YjdP | Periplasmic | G | N/A | Periplasmic | SEC | no | yes | Y | 23 | 0.721 | SpI | 22 | 14.9551 | - | 0 | 0 | Y | n6-17c22/23o | Unknown | 2 | |||||||||||||
| LDRD_ECOLI | Q6BF25 | ldrD | b4453 JW5966 | integral IM protein (SEC in IM), Small toxic polypeptide LdrD | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 21 | 0.155 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o14-31i | CytoplasmicMembrane | 9 | ||||||
| LDRB_ECOLI | Q6BF87 | ldrB | b4421 JW5958 | integral IM protein (SEC in IM), Small toxic polypeptide LdrB | Integral Inner Membrane | Potentially toxic protein. | PMID: 19121005 | Integral Inner Membrane | B | Binout | out/in | IM (predicted) | Cell inner membrane | Cytoplasmic | SRP | SEC | yes | yes | N | 21 | 0.121 | CYT | 0 | -0.200913 | - | 1 | 1 | N | o14-31i | CytoplasmicMembrane | 9 | ||||||
| YMGG_ECOLI | Q7DFV3 | ymgG | b1172 JW5178 | integral IM protein (SEC in IM), UPF0757 YmgG | Integral Inner Membrane | Belongs to the UPF0757 family. | PMID: 17787032 PMID: 18192383 | Integral Inner Membrane | B | Bpoly | in/in | N/A | Membrane anchored | SRP | SEC | no | yes | Y | 23 | 0.871 | SpI | 22 | 23.9513 | - | 2 | 0 | Y | n5-16c22/23o | Unknown | 2 | 98 |